In vitro and in vivo formation of two new metabolites of melatonin.

Abstract A partially purified enzyme from rabbit brain catalyzed the oxygenative cleavage of the pyrrole moiety of melatonin yielding Nγ-acetyl-N2-formyl-5-methoxykynurenamine, which was further degraded to Nγ-acetyl-5-methoxykynurenamine by the action of formamidase. Authentic samples of these two metabolites were synthesized by ozonolysis of melatonin and were shown to be indistinguishable from the enzymic products. When [14C]melatonin was injected intracisternally, the major metabolite in the rat brain was shown to be Nγ-acetyl-5-methoxykynurenamine. The results indicate that these two new metabolites are involved in the major metabolic pathway of melatonin in the central nervous system.

• Publication year

  1974

• Venue

  Journal of Biological Chemistry

• Publication date

  1974-02-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0021-9258(19)42976-1PMID 4814344
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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