Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Nature Cell Biology

• Publication date

  2003-07-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/ncb1001PMID 12833065
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Direct coupling of the cell cycle and cell death machinery by E2F

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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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