Fat and Iron Quantification in the Liver: Past, Present, and Future

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Topics in Magnetic Resonance Imaging (TMRI)

• Publication date

  2014-04-01

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1097/RMR.0000000000000016PMID 24690618
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• R2* as a surrogate measure of ferriscan iron quantification in thalassemia

  2014cited by this paper
• Fat fraction bias correction using T1 estimates and flip angle mapping

  2014cited by this paper
• Effect of flip angle on the accuracy and repeatability of hepatic proton density fat fraction estimation by complex data‐based, T1‐independent, T2*‐corrected, spectrum‐modeled MRI

  2014cited by this paper
• Inter‐examination precision of magnitude‐based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects

  2014cited by this paper
• Comparison of serial serum ferritin measurements and liver iron concentration assessed by MRI in adult transfused patients with sickle cell disease

  2014cited by this paper
• Evaluation of MRI fat fraction in the liver and spine pre and post SPIO infusion.

  2013cited by this paper
• Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis.

  2013cited by this paper
• Hepatic steatosis: quantification by proton density fat fraction with MR imaging versus liver biopsy.

  2013cited by this paper
• Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994.

  2013cited by this paper
• MR quantitative biomarkers of non-alcoholic fatty liver disease: technical evolutions and future trends.

  2013cited by this paper
• Comparison of brown and white adipose tissues in infants and children with chemical‐shift‐encoded water‐fat MRI

  2013cited by this paper
• Multicenter Validation of Spin-Density Projection-Assisted R2-MRI for the Noninvasive Measurement of Liver Iron Concentration

  2013cited by this paper
• Markers in nonalcoholic steatohepatitis.

  2013cited by this paper
• Hereditary hemochromatosis.

  2013cited by this paper
• Quantification of muscle fat in patients with low back pain: comparison of multi-echo MR imaging with single-voxel MR spectroscopy.

  2013cited by this paper
• Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging

  2013cited by this paper
• Liver steatosis correlates with iron overload but not with HFE gene mutations in chronic hepatitis C.

  2013cited by this paper
• Report Title: The burden of liver disease in Europe: a review of available epidemiological data

  2013cited by this paper
• Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload

  2013cited by this paper
• A Low-Glycemic-Load versus Low-Fat Diet in the Treatment of Fatty Liver in Obese Children

  2013cited by this paper
• Comparison of R2* correction methods for accurate fat quantification in fatty liver

  2013cited by this paper
• Water–fat MRI for assessing changes in bone marrow composition due to radiation and chemotherapy in gynecologic cancer patients

  2013cited by this paper
• Comparison between multi-echo T2* with and without fat saturation pulse for quantification of liver iron overload.

  2013cited by this paper
• Multipeak fat‐corrected complex R2* relaxometry: Theory, optimization, and clinical validation

  2013cited by this paper
• Simultaneous quantification of fat content and fatty acid composition using MR imaging

  2013cited by this paper
• Estimation of liver T*2 in transfusion‐related iron overload in patients with weighted least squares T*2 IDEAL

  2012cited by this paper
• On the performance of T2* correction methods for quantification of hepatic fat content

  2012cited by this paper
• Hepatic MR imaging for in vivo differentiation of steatosis, iron deposition and combined storage disorder: single-ratio in/opposed phase analysis vs. dual-ratio Dixon discrimination.

  2012cited by this paper
• Room-temperature susceptometry predicts biopsy-determined hepatic iron in patients with elevated serum ferritin.

  2012cited by this paper
• Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?

  2012cited by this paper
• How I treat transfusional iron overload.

  2012cited by this paper
• Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population.

  2012cited by this paper
• Toward absolute quantification of iron oxide nanoparticles as well as cell internalized fraction using multiparametric MRI.

  2012cited by this paper
• Use of fat suppression in R₂ relaxometry with MRI for the quantification of tissue iron overload in beta-thalassemic patients.

  2012cited by this paper
• Systematic investigation of various strategies for T2* mapping for liver iron quantification in the presence of noise

  2012cited by this paper
• Proton density fat‐fraction: A standardized mr‐based biomarker of tissue fat concentration

  2012cited by this paper
• Model‐based mapping of fat unsaturation and chain length by chemical shift imaging—phantom validation and in vivo feasibility

  2012cited by this paper
• Simultaneous field and R  2* mapping to quantify liver iron content using autoregressive moving average modeling

  2012cited by this paper
• The Pathology of Hepatic Iron Overload

  2012cited by this paper
• Correlation between liver histology and novel magnetic resonance imaging in adult patients with non‐alcoholic fatty liver disease – MRI accurately quantifies hepatic steatosis in NAFLD

  2012cited by this paper
• Effect of multipeak spectral modeling of fat for liver iron and fat quantification: correlation of biopsy with MR imaging results.

  2012cited by this paper
• Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review.

  2012cited by this paper
• Iron and steatohepatitis

  2012cited by this paper
• Iron overload: accuracy of in-phase and out-of-phase MRI as a quick method to evaluate liver iron load in haematological malignancies and chronic liver disease.

  2012cited by this paper
• ISMRM workshop on fat–water separation: Insights, applications and progress in MRI

  2012cited by this paper
• Effect of Colesevelam on Liver Fat Quantified by Magnetic Resonance in Nonalcoholic Steatohepatitis: A Randomized Controlled Trial

  2012cited by this paper
• The Relationship between Nonalcoholic Fatty Liver Disease and Colorectal Cancer: The Future Challenges and Outcomes of the Metabolic Syndrome

  2012cited by this paper
• The epidemiology, pathogenesis and histopathology of fatty liver disease

  2012cited by this paper
• Validation of MRI biomarkers of hepatic steatosis in the presence of iron overload in the ob/ob mouse

  2012cited by this paper
• Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy.

  2011cited by this paper
• Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

  2011cited by this paper
• In vivo characterization of the liver fat 1H MR spectrum

  2011cited by this paper
• Gadolinium-Enhanced Liver Magnetic Resonance Imaging Using a 2-Point Dixon Fat-Water Separation Technique: Impact Upon Image Quality and Lesion Detection

  2011cited by this paper
• Diagnosis and Management of Hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases

  2011cited by this paper
• Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy

  2011cited by this paper
• MR properties of brown and white adipose tissues

  2011cited by this paper
• Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States.

  2011cited by this paper
• Hepatic fat quantification using chemical shift MR imaging and MR spectroscopy in the presence of hepatic iron deposition: Validation in phantoms and in patients with chronic liver disease

  2011cited by this paper
• Quantification of Absolute Fat Mass by Magnetic Resonance Imaging: a Validation Study against Chemical Analysis.

  2011cited by this paper
• Mechanisms of Lipotoxicity in NAFLD and Clinical Implications

  2011cited by this paper
• Mapping the double bonds in triglycerides.

  2011cited by this paper
• Bone marrow fat quantification of osteoporotic vertebral compression fractures: comparison of multi-voxel proton MR spectroscopy and chemical-shift gradient-echo MR imaging

  2011cited by this paper
• A simulation-based comparison of two methods for determining relaxation rates from relaxometry images.

  2011cited by this paper
• Dual‐echo Dixon imaging with flexible choice of echo times

  2011cited by this paper
• Accelerated cardiac T2 mapping using breath‐hold multiecho fast spin‐echo pulse sequence with k‐t FOCUSS

  2011cited by this paper
• Estimation of Hepatic Proton-Density Fat Fraction by Using MR Imaging at 3.0 T 1

  2011cited by this paper
• Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T.

  2011cited by this paper
• Magnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin iron

  2010cited by this paper
• A position statement on NAFLD/NASH based on the EASL 2009 special conference.

  2010cited by this paper
• Pioglitazone in the treatment of NASH: the role of adiponectin

  2010cited by this paper
• Compressed sensing reconstruction for magnetic resonance parameter mapping

  2010cited by this paper
• Nontriglyceride Hepatic Lipotoxicity: The New Paradigm for the Pathogenesis of NASH

  2010cited by this paper
• Separate MRI quantification of dispersed (ferritin‐like) and aggregated (hemosiderin‐like) storage iron

  2010cited by this paper
• Chemical shift–based water/fat separation: A comparison of signal models

  2010cited by this paper
• International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers

  2010cited by this paper
• Myocardial fat quantification in humans: Evaluation by two‐point water‐fat imaging and localized proton spectroscopy

  2010cited by this paper
• The importance of fatty liver disease in clinical practice

  2010cited by this paper
• Quantification of hepatic iron deposition in patients with liver disease: comparison of chemical shift imaging with single-echo T2*-weighted imaging.

  2010cited by this paper
• Pathology of nonalcoholic fatty liver disease

  2010cited by this paper
• Assessment of liver fat quantification in the presence of iron.

  2010cited by this paper
• Pilot study assessing differentiation of steatosis hepatis, hepatic iron overload, and combined disease using two-point dixon MRI at 3 T: in vitro and in vivo results of a 2D decomposition technique.

  2010cited by this paper
• Myocardial fat deposition after left ventricular myocardial infarction: assessment by using MR water-fat separation imaging.

  2009cited by this paper
• Myocardial T2 quantitation in patients with iron overload at 3 Tesla

  2009cited by this paper
• T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: Validation in a fat‐water‐SPIO phantom

  2009cited by this paper
• Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases.

  2009cited by this paper
• Improved fat suppression using multipeak reconstruction for IDEAL chemical shift fat‐water separation: Application with fast spin echo imaging

  2009cited by this paper
• Spectrally-Modeled Hepatic Fat Quantification by Multi-Echo Gradient-Recalled-Echo Magnetic Resonance Imaging at 3.0T

  2009cited by this paper
• Nonalcoholic fatty liver disease: Quantitative assessment of liver fat content by computed tomography, magnetic resonance imaging and proton magnetic resonance spectroscopy

  2009cited by this paper
• Quantification of hepatic steatosis with MRI: The effects of accurate fat spectral modeling

  2009cited by this paper
• Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T.

  2009cited by this paper
• Quantitative liver iron measurement by magnetic resonance imaging: in vitro and in vivo assessment of the liver to muscle signal intensity and the R2* methods.

  2008cited by this paper
• Dysregulation of systemic iron metabolism in alcoholic liver diseases

  2008cited by this paper
• Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?

  2008cited by this paper
• Quantification of Pancreatic Lipomatosis and Liver Steatosis by MRI: Comparison of In/Opposed-Phase and Spectral-Spatial Excitation Techniques

  2008cited by this paper
• Relaxation effects in the quantification of fat using gradient echo imaging.

  2008cited by this paper
• Joint estimation of water/fat images and field inhomogeneity map

  2008cited by this paper
• Magnetic resonance imaging and spectroscopy for monitoring liver steatosis

  2008cited by this paper
• T2* Relaxometry in Liver, Pancreas, and Spleen in a Healthy Cohort of One Hundred Twenty-Nine Subjects–Correlation With Age, Gender, and Serum Ferritin

  2008cited by this paper
• Liver fat content and T2*: simultaneous measurement by using breath-hold multiecho MR imaging at 3.0 T--feasibility.

  2008cited by this paper
• Relationships between MR transverse relaxation parameters R  *2 , R2 and R  ′2 and hepatic iron content in thalassemic mice at 1.5 T and 3 T

  2008cited by this paper

• Evaluation of 0.55T MRI for Simultaneous R2* and Fat Fraction Quantification in the Presence of Hepatic Iron Overload and Steatosis Using Simulations and Phantoms

  2025cites this paper
• Diagnostic Accuracy of Hepatic MRI-PDFF and R2* for the Evaluation of Liver Steatosis and Liver Iron Overload: A Meta-analysis.

  2025cites this paper
• State‐of‐the‐Art Quantification of Liver Iron With MRI—Vendor Implementation and Available Tools

  2024cites this paper
• Free-breathing MRI techniques for fat and R2* quantification in the liver

  2024cites this paper
• Effect of particle size on liver MRI R2* relaxometry: Monte Carlo simulation and phantom studies

  2024cites this paper
• Application of the magnetic resonance 3D multiecho Dixon sequence for quantifying hepatic iron overload and steatosis in patients with thalassemia.

  2024cites this paper
• Prediction of MRI R2*$$ {\mathrm{R}}_2^{\ast } $$ relaxometry in the presence of hepatic steatosis by Monte Carlo simulations

  2024cites this paper
• Value of Quantitative Susceptibility Mapping in Clinical Neuroradiology

  2023cites this paper
• Uncertainty‐aware physics‐driven deep learning network for free‐breathing liver fat and R2* quantification using self‐gated stack‐of‐radial MRI

  2022cites this paper
• Quantitative MRI of diffuse liver diseases: techniques and tissue-mimicking phantoms

  2022cites this paper
• Fat fraction quantification of bone marrow in the lumbar spine using the LiverLab assessment tool in healthy adult volunteers and patients with Gaucher disease

  2022cites this paper
• Quantitative Susceptibility Mapping Using a Multispectral Autoregressive Moving Average Model to Assess Hepatic Iron Overload

  2021cites this paper
• Imaging of the Liver and Intra-hepatic Biliary Tract: Volume 1: Imaging Techniques and Non-tumoral Pathologies

  2021cites this paper
• Free-breathing 3D stack-of-radial MRI quantification of liver fat and R2* in adults with fatty liver disease.

  2021cites this paper
• Hepatic Iron Quantification Using a Free‐Breathing 3D Radial Gradient Echo Technique and Validation With a 2D Biopsy‐Calibrated R2* Relaxometry Method

  2021cites this paper
• Editorial for “Limits of Fat Quantification With Chemical Shift Encoded”

  2021cites this paper
• Repeatability and accuracy of various region-of-interest sampling strategies for hepatic MRI proton density fat fraction quantification

  2021cites this paper
• MR imaging assessment and quantification of liver iron

  2020cites this paper
• Iron Mapping Techniques and Applications

  2020cites this paper
• Magnetic Resonance Imaging of the Liver: Technical Considerations

  2020cites this paper
• Liver Steatosis and NAFLD

  2020cites this paper
• Twenty-First Century Advances in Multimodality Imaging of Obesity for Care of the Cardiovascular Patient.

  2020cites this paper
• Liver MRI susceptibility-weighted imaging (SWI) compared to T2* mapping in the presence of steatosis and fibrosis.

  2019cites this paper
• 3D Multi-Echo Dixon technique for simultaneous assessment of liver steatosis and iron overload in patients with chronic liver diseases: a feasibility study.

  2019cites this paper
• A hybrid (iron–fat–water) phantom for liver iron overload quantification in the presence of contaminating fat using magnetic resonance imaging

  2019cites this paper
• Liver Iron Quantification with MR Imaging: A Primer for Radiologists.

  2018cites this paper
• Title : Multi-organ quantitative MRI for the assessment of liver disease – a whole much more than the sum of its parts Author names and Degrees :

  2018cites this paper
• Multi-organ quantitative MRI for the assessment of liver disease - A whole much more than the sum of its parts.

  2018cites this paper
• Improved liver R2* mapping by pixel‐wise curve fitting with adaptive neighborhood regularization

  2018cites this paper
• Fat-Containing Liver Lesions on Imaging: Detection and Differential Diagnosis.

  2018cites this paper
• Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease

  2018cites this paper
• Quantitative susceptibility mapping in combination with water-fat separation for simultaneous liver iron and fat fraction quantification

  2018cites this paper
• Liver MRI: From basic protocol to advanced techniques.

  2017cites this paper
• Free‐breathing volumetric fat/water separation by combining radial sampling, compressed sensing, and parallel imaging

  2017cites this paper
• Quantification of liver fat in the presence of iron overload

  2017cites this paper
• Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI

  2017influential citation
• Surveillance liver MRI for monitoring patients with known or suspected chronic liver disease.

  2017cites this paper
• Prevalence of Fatty Liver Disease and Hepatic Iron Overload in a Northeastern German Population by Using Quantitative MR Imaging.

  2017cites this paper
• Use Case VI: Imaging Biomarkers in Diffuse Liver Disease. Quantification of Fat and Iron

  2017cites this paper
• Stany chorobowe związane z nadmiernym gromadzeniem żelaza oraz metody oznaczania zawartości żelaza w wątrobie

  2017cites this paper
• Quantification of MRI-PDFF by complex-based MRI : phantom and rabbit study at 3 . 0 T

  2017cites this paper
• Fat Quantification in the Abdomen

  2017cites this paper
• Prioritization of liver MRI for distinguishing focal lesions

  2017cites this paper
• Improving Detection of Iron Deposition in Cirrhotic Liver Using Susceptibility-Weighted Imaging With Emphasis on Histopathological Correlation

  2017cites this paper
• Noninvasive MRI-Based Liver Iron Quantification: Methodic Approaches, Practical Applicability and Significance

  2016cites this paper
• Magnetic Resonanance Imaging of the Liver (Including Biliary Contrast Agents)-Part 2: Protocols for Liver Magnetic Resonanance Imaging and Characterization of Common Focal Liver Lesions.

  2016cites this paper
• Quantitative Imaging Biomarkers of NAFLD

  2016cites this paper
• Magnetic Resonance of Brown Adipose Tissue: A Review of Current Techniques.

  2015cites this paper
• Genetic testing for hemochromatosis: diagnostic or confirmatory test for iron overload?

  2015cites this paper
• Direct Water–Fat Imaging Methods: Chemical Shift‐Selective and Chemical Shift‐Encoded MRI

  2015cites this paper
• Re: PC Adams. Genetic testing for hemochromatosis: Diagnostic or confirmatory test for iron overload? Can J Gastroenterol Hepatol 2015;29(1):15-6.

  2015cites this paper
• Accuracy of Ultrasound and Noninvasive Markers of Fibrosis to Identify Patients with Cirrhosis

  2015cites this paper