Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Steroid Biochemistry and Molecular Biology

• Publication date

  2002-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0960-0760(02)00118-8PMID 12361719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modulation of Estrogen Receptor-mediated Transactivation by Orphan Receptor TR4 in MCF-7 Cells*

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• Spermatogenesis and Testis Development Are Normal in Mice Lacking Testicular Orphan Nuclear Receptor 2

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• The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases.

  2001cited by this paper
• Feedback Regulation between Orphan Nuclear Receptor TR2 and Human Papilloma Virus Type 16

  2001cited by this paper
• TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif.

  2001cited by this paper
• Nuclear Orphan Receptors Regulate Transcription of the Gene for the Human Luteinizing Hormone Receptor*

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• The p53/Retinoblastoma-mediated Repression of Testicular Orphan Receptor-2 in the Rhesus Monkey with Cryptorchidism*

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• Review: chromatin structural features and targets that regulate transcription.

  2000cited by this paper
• Identification of an essential cis-acting element (TR2-PACE) in the 5′ promoter of human TR2 orphan receptor gene

  2000cited by this paper
• Characterization of the mouse nuclear orphan receptor TR2-11 gene promoter and its potential role in retinoic acid-induced P19 apoptosis.

  2000cited by this paper
• Expression of the orphan receptor TR4 during brain development of the rat.

  2000cited by this paper
• Constitutive Activation of Retinoic Acid Receptor β2 Promoter by Orphan Nuclear Receptor TR2*

  2000cited by this paper
• Recent advances in understanding thyroid hormone receptor coregulators.

  1999cited by this paper
• Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor

  1999cited by this paper
• Cloning and characterization of two nuclear receptors from the filarial nematode Brugia pahangi.

  1999cited by this paper
• Characterization of an inverted repeat with a zero spacer (IR0)-type retinoic acid response element from the mouse nuclear orphan receptor TR2-11 gene.

  1999cited by this paper
• Differential Regulation of Direct Repeat 3 Vitamin D3and Direct Repeat 4 Thyroid Hormone Signaling Pathways by the Human TR4 Orphan Receptor*

  1999cited by this paper
• A unified nomenclature system for the nuclear receptor superfamily

  1999cited by this paper
• A unified nomenclature system for the nuclear receptor superfamily.

  1999cited by this paper
• Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes.

  1999cited by this paper
• Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription.

  1999cited by this paper
• Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily.

  1999cited by this paper
• Cloning and characterization of new orphan nuclear receptors and their developmental profiles during Tenebrio metamorphosis.

  1999cited by this paper
• Thyroid hormone direct repeat 4 response element is a positive regulatory element for the human TR2 orphan receptor, a member of steroid receptor superfamily

  1998cited by this paper
• Regulation of Peroxisome Proliferator-activated Receptor α-Induced Transactivation by the Nuclear Orphan Receptor TAK1/TR4*

  1998cited by this paper
• TR4 orphan receptor crosstalks to chicken ovalbumin upstream protein-transcription factor and thyroid hormone receptor to induce the transcriptional activity of the human immunodeficiency virus type 1 long-terminal repeat

  1998cited by this paper
• The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis.

  1998cited by this paper
• Induction of an intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRα) gene by the TR3 orphan receptor

  1998cited by this paper
• A Bidirectional Regulation between the TR2/TR4 Orphan Receptors (TR2/TR4) and the Ciliary Neurotrophic Factor (CNTF) Signaling Pathway*

  1998cited by this paper
• Cloning of rabbit TR4 and its bone cell-specific activity to suppress estrogen receptor-mediated transactivation.

  1998cited by this paper
• Cloning of a cDNA for xDOR2, a novel TR2-related nuclear orphan receptor, expressed during neurulation in Xenopus laevis embryos.

  1998cited by this paper
• The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily

  1998cited by this paper
• Negative Feedback Control of the Retinoid-Retinoic Acid/Retinoid X Receptor Pathway by the Human TR4 Orphan Receptor, a Member of the Steroid Receptor Superfamily*

  1998cited by this paper
• Molecular cloning from neurulating Ambystoma mexicanum embryos of the cDNA encoding an orphan nuclear receptor (aDOR1) closely related to TR2-11.

  1998cited by this paper
• Polymorphism in the murine Tr2-11 gene encoding an orphan receptor, and its exclusion as a candidate gene for the cataract mutation Cat3.

  1998cited by this paper
• Striking evolutionary conservation of a cis-element related to nuclear receptor target sites and present in TR2 orphan receptor genes.

  1998cited by this paper
• A Novel Nuclear Receptor Heterodimerization Pathway Mediated by Orphan Receptors TR2 and TR4*

  1998cited by this paper
• A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2.

  1998cited by this paper
• Mechanisms of the Mouse Orphan Nuclear Receptor TR2-11-mediated Gene Suppression*

  1998cited by this paper
• Cloning and Characterization of Mouse RIP140, a Corepressor for Nuclear Orphan Receptor TR2

  1998cited by this paper
• Embryonic and post-embryonic utilization and subcellular localization of the nuclear receptor SpSHR2 in the sea urchin.

  1998cited by this paper
• Identification of Direct Repeat 4 as a Positive Regulatory Element for the Human TR4 Orphan Receptor

  1997cited by this paper
• Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor.

  1997cited by this paper
• Distinct expression patterns and biological activities of two isoforms of the mouse orphan receptor TR2.

  1997cited by this paper
• Differential regulation of the pre-C and pregenomic promoters of human hepatitis B virus by members of the nuclear receptor superfamily

  1997cited by this paper
• Induction of the Intronic Enhancer of the Human Ciliary Neurotrophic Factor Receptor (CNTFRα) Gene by the TR4 Orphan Receptor

  1997cited by this paper
• The orphan nuclear receptor TR2 suppresses a DR4 hormone response element of the mouse CRABP-I gene promoter.

  1997cited by this paper
• Identification of the human aldolase A gene as the first induced target for the TR2 orphan receptor, a member of the steroid hormone receptor superfamily.

  1997cited by this paper
• Identification of Natural Monomeric Response Elements of the Nuclear Receptor RZR/ROR. THEY ALSO BIND COUP-TF HOMODIMERS*

  1996cited by this paper
• Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors.

  1996cited by this paper
• Interaction of steroid hormone receptors with the transcription initiation complex.

  1996cited by this paper
• Suppression of the Human Erythropoietin Gene Expression by the TR2 Orphan Receptor, a Member of the Steroid Receptor Superfamily (*)

  1996cited by this paper
• Molecular cloning and characterization of a mouse nuclear orphan receptor expressed in embryos and testes

  1996cited by this paper
• Distal cis-acting elements restrict expression of the CyIIIb actin gene in the aboral ectoderm of the sea urchin embryo.

  1996cited by this paper
• A novel sea urchin nuclear receptor encoded by alternatively spliced maternal RNAs.

  1996cited by this paper
• Nuclear receptor coactivators and corepressors.

  1996cited by this paper
• Molecular mechanisms of COUP-TF-mediated transcriptional repression: evidence for transrepression and active repression

  1996cited by this paper
• New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene.

  1996cited by this paper
• Splice variants of rat TR4 orphan receptor: differential expression of novel sequences in the 5'-untranslated region and C-terminal domain.

  1996cited by this paper
• Orphan nuclear receptors--the first eight years.

  1996cited by this paper
• p53 Is a Mediator for Radiation-repressed Human TR2 Orphan Receptor Expression in MCF-7 Cells, a New Pathway from Tumor Suppressor to Member of the Steroid Receptor Superfamily*

  1996cited by this paper
• The RXR heterodimers and orphan receptors.

  1995cited by this paper
• Similar Ligand-induced Conformational Changes of Thyroid Hormone Receptors Regulate Homo- and Heterodimeric Functions (*)

  1995cited by this paper
• Cytogenetic findings indicate heterogeneity in patients with blepharophimosis, epicanthus inversus, and developmental delay.

  1995cited by this paper
• Genomic structure, promoter identification, and chromosomal mapping of a mouse nuclear orphan receptor expressed in embryos and adult testes.

  1995cited by this paper
• Multiple Functions of the TR2-11 Orphan Receptor in Modulating Activation of Two Key Cis-acting Elements Involved in the Retinoic Acid Signal Transduction System (*)

  1995cited by this paper
• Structural determinants of nuclear receptor assembly on DNA direct repeats

  1995cited by this paper
• Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand

  1995cited by this paper
• The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation

  1995cited by this paper
• Transcription factors 3: nuclear receptors.

  1995cited by this paper
• Suppression of Gene Expression on the Simian Virus 40 Major Late Promoter by Human TR4 Orphan Receptor

  1995cited by this paper
• Isolation, regulation, and DNA-binding properties of three Drosophila nuclear hormone receptor superfamily members.

  1995cited by this paper
• Unique response pathways are established by allosteric interactions among nuclear hormone receptors.

  1995cited by this paper
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  1995cited by this paper
• The orphan receptor TAK1 acts as a repressor of RAR-, RXR- and T3R-mediated signaling pathways.

  1995cited by this paper
• Identification of Human TR2 Orphan Receptor Response Element in the Transcriptional Initiation Site of the Simian Virus 40 Major Late Promoter (*)

  1995cited by this paper
• Expression of nuclear hormone receptors in the rat supraoptic nucleus.

  1995cited by this paper
• Gene expression of the androgen repressed rat TR2 orphan receptor: a member of steroid receptor superfamily

  1995cited by this paper
• The nuclear receptor superfamily: the second decade.

  1995cited by this paper
• Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis.

  1995cited by this paper
• TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily.

  1994cited by this paper
• Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily.

  1994cited by this paper
• Molecular cloning of a novel member of the nuclear receptor superfamily related to the orphan receptor, TR2.

  1994cited by this paper
• The effects of P-box substitutions in thyroid hormone receptor on DNA binding specificity.

  1994cited by this paper
• Molecular mechanisms of action of steroid/thyroid receptor superfamily members.

  1994cited by this paper
• The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full‐length receptors to direct repeats.

  1994cited by this paper
• Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.

  1994cited by this paper
• Nuclear matrix and the regulation of gene expression: Tissue specificity

  1994cited by this paper
• Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers.

  1994cited by this paper
• The use of a DNA-binding domain replacement method for the detection of a potential TR3 orphan receptor response element in the mouse mammary tumor virus long terminal repeat.

  1993cited by this paper
• Genomic structure, chromosomal localization and expression of an androgen inducible TR3 orphan receptor: A member of the steroid receptor superfamily

  1993cited by this paper
• Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

  1993cited by this paper
• Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences.

  1993cited by this paper
• Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors.

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• The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation

  1993cited by this paper
• Differential modes of activation define orphan subclasses within the steroid/thyroid receptor superfamily.

  1992cited by this paper
• Allelic deletions in the long arm of chromosome 12 identify sites of candidate tumor suppressor genes in male germ cell tumors.

  1992cited by this paper
• Thyroid hormone receptor dimerization function maps to a conserved subregion of the ligand binding domain.

  1992cited by this paper
• Molecular pathways of steroid receptor action.

  1992cited by this paper
• Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.

  1992cited by this paper

• Comparative Evaluation and Profiling of Chemical Tools for the Nuclear Hormone Receptor Family 2

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  2011cites this paper
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  2010cites this paper
• Physiological Functions of TR2 and TR4 Orphan Nuclear Receptor

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• TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation

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  2008cites this paper
• Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a.

  2008cites this paper
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  2008cites this paper
• Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain.

  2007cites this paper
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  2007influential citation
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