Role of nanoparticle size, shape and surface chemistry in oral drug delivery.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Controlled Release

• Publication date

  2016-09-28

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1016/j.jconrel.2016.07.051PMID 27480450PMCID PMC5289391
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intestinal mucoadhesive devices for oral delivery of insulin

  2016cited by this paper
• Evidence does not support absorption of intact solid lipid nanoparticles via oral delivery.

  2016cited by this paper
• Principles of nanoparticle design for overcoming biological barriers to drug delivery

  2015cited by this paper
• Shape and size-dependent immune response to antigen-carrying nanoparticles.

  2015cited by this paper
• Development of an advanced intestinal in vitro triple culture permeability model to study transport of nanoparticles.

  2014cited by this paper
• Nanoparticle penetration of human cervicovaginal mucus: the effect of polyvinyl alcohol.

  2014cited by this paper
• Enhanced hypoglycemic effect of biotin-modified liposomes loading insulin: effect of formulation variables, intracellular trafficking, and cytotoxicity

  2014cited by this paper
• Formulation and characterization of 5-Fluorouracil enteric coated nanoparticles for sustained and localized release in treating colorectal cancer

  2014cited by this paper
• Enhanced Oral Bioavailability of Efavirenz by Solid Lipid Nanoparticles: In Vitro Drug Release and Pharmacokinetics Studies

  2014cited by this paper
• Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery.

  2013cited by this paper
• Targeted nanoparticles with novel non-peptidic ligands for oral delivery.

  2013cited by this paper
• Oral lipid-based drug delivery systems – an overview

  2013cited by this paper
• Towards the characterization of an in vitro triple co-culture intestine cell model for permeability studies.

  2013cited by this paper
• Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs.

  2013cited by this paper
• Simvastatin Solid Lipid Nanoparticles for Oral Delivery: Formulation Development and In vivo Evaluation

  2013cited by this paper
• Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

  2013cited by this paper
• Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms

  2013cited by this paper
• The influence of size, shape and vessel geometry on nanoparticle distribution

  2013cited by this paper
• Particle shape enhances specificity of antibody-displaying nanoparticles

  2013cited by this paper
• The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells.

  2013cited by this paper
• Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs.

  2012cited by this paper
• Polyelectrolyte stabilized multilayered liposomes for oral delivery of paclitaxel.

  2012cited by this paper
• Oral delivery of doxorubicin using novel polyelectrolyte-stabilized liposomes (layersomes).

  2012cited by this paper
• Peptide delivery using phospholipid micelles.

  2012cited by this paper
• pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs.

  2012cited by this paper
• Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models.

  2012cited by this paper
• Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.

  2012cited by this paper
• Micelles/sodium-alginate composite gel beads: A new matrix for oral drug delivery of indomethacin.

  2012cited by this paper
• Oral drug delivery research in Europe.

  2012cited by this paper
• A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery.

  2011cited by this paper
• Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia

  2011cited by this paper
• Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery.

  2010cited by this paper
• Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes.

  2010cited by this paper
• Macrophages Recognize Size and Shape of Their Targets

  2010cited by this paper
• New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

  2010cited by this paper
• Polymeric micelles for oral drug delivery.

  2010cited by this paper
• Polymer particle shape independently influences binding and internalization by macrophages.

  2010cited by this paper
• Recent trends in oral drug delivery: a review.

  2009cited by this paper
• Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel.

  2009cited by this paper
• Impact of fear of insulin or fear of injection on treatment outcomes of patients with diabetes

  2009cited by this paper
• The Caco-2 cell monolayer: usefulness and limitations

  2008cited by this paper
• The Caco-2 cell monolayer: usefulness and limitations.

  2008cited by this paper
• Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery.

  2008cited by this paper
• Design and Development of Mixed Film of Pectin: Ethyl Cellulose for Colon Specific Drug Delivery of Sennosides and Triphala

  2008cited by this paper
• Shape Induced Inhibition of Phagocytosis of Polymer Particles

  2008cited by this paper
• Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.

  2008cited by this paper
• PLGA nanoparticles for oral delivery of cyclosporine: nephrotoxicity and pharmacokinetic studies in comparison to Sandimmune Neoral.

  2007cited by this paper
• Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery.

  2007cited by this paper
• Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers.

  2007cited by this paper
• An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells.

  2007cited by this paper
• Chitosan nanoparticles for oral drug and gene delivery

  2006cited by this paper
• Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.

  2006cited by this paper
• Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin.

  2006cited by this paper
• Role of target geometry in phagocytosis.

  2006cited by this paper
• Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs.

  2005cited by this paper
• Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies.

  2005cited by this paper
• Development of acrylic-based copolymers for oral insulin delivery.

  2004cited by this paper
• Challenges for the oral delivery of macromolecules

  2003cited by this paper
• Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles.

  2002cited by this paper
• The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration.

  2000cited by this paper
• Role of M Cells in Intestinal Barrier Function

  2000cited by this paper
• Recent technological advances in oral drug delivery - a review.

  2000cited by this paper
• Molecular mechanism of the intestinal biotin transport process.

  1999cited by this paper
• Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics.

  1998cited by this paper
• Human intestinal cell line Caco-2: a useful model for studying cellular and molecular regulation of biotin uptake.

  1994cited by this paper

• Analysis of morphological and morphometric characteristics of the mouse stomach wall after oral administration of iron oxide nanoparticles

  2026cites this paper
• Nanoparticle surface properties and their role at the intestinal interface: transport and cellular uptake

  2026influential citation
• An advanced nanocarrier‐based drug delivery approach utilizing vancomycin‐loaded cerium oxide nanoparticles with dual antibiotic and anti‐inflammatory activities for the management of pulmonary‐associated sepsis

  2026cites this paper
• Exosome-functionalized carbonate apatite nanoparticles as potential immunomodulatory mucosal vaccine adjuvant: physicochemical characterization and cytocompatibility on macrophages and buccal epithelial cells

  2026cites this paper
• Drag-minimising bodies in confined Stokes flows

  2026cites this paper
• Liposomal Hydrogel-Based Oral Vaccine Delivery for Targeted Induction of Intestinal Mucosal Immunity

  2026cites this paper
• Development of a Stabilized Alginate-based Hydrogel for Oral Delivery of Encapsulated Live Cultures and Allowing their Intact Passage Through the Digestive System

  2026cites this paper
• Oral anticancer drug delivery: Strategies for improving bioavailability

  2026cites this paper
• Chitosan-Alginate-Loaded Spinosad: Enhanced Cytotoxicity and Insecticidal Activity against Spodoptera frugiperda.

  2026cites this paper
• Nano–Micronutrients of Iron and Copper for Improved Human Nutrition: A Narrative Review

  2026cites this paper
• SCaN: A Screening and Characterization Platform for Nanosuspensions Enables In Vivo Delivery of a Crystalline hRpn13Pru Degrader.

  2026cites this paper
• Effects of Calcination Time and Sulfonation on Silica Particles Synthesised Using the Stober and Sol–Gel Methods for Fuel Cell Applications

  2025influential citation
• Nanotechnology-Driven Advances in Magnetic Hyperthermia: A Comprehensive Review

  2025cites this paper
• Fermented Yeast Complex Extract Promotes Hair Regrowth by Decreasing Oxidative Stress

  2025cites this paper
• Smart Supramolecular Core-Shell Aggregates with Mucin-Triggered Surface Switch for Effectively Overcoming Contradictory Mucus and Epithelium Barriers.

  2025cites this paper
• Bright Photoluminescent Gd-MXene Quantum Dots for Cell Imaging with Synergistic MRI/CT Capability.

  2025cites this paper
• Rutin‐Loaded Dextran Selenium Nanoparticles as a Protective Strategy Against Paracetamol‐Induced Hepatotoxicity

  2025cites this paper
• Nanoassemblies for oral protein delivery - The case of monoclonals for inflammatory bowel disease.

  2025cites this paper
• Eco-friendly fabrication of silver nanoparticles from the red macroalga Scinaia moniliformis and evaluation of their biomedical activities

  2025cites this paper
• Fluorinated polymer self-assembled nanomaterials: advances and biomedical applications.

  2025cites this paper
• Comparative effects of two different aluminium nanoparticle formulations on the histological and physiological aspects of Drosophila melanogaster (Diptera: Drosophilidae) as a model

  2025cites this paper
• Biosynthesis of iron oxide nanoparticles and their antimicrobial and biocompatibility studies: a sustainable approach

  2025influential citation
• Radioprotection and enhanced efficacy by curcumin-loaded chitosan nanoparticles in mitigating radiation-induced liver injury.

  2025cites this paper
• Nanoparticle-enhanced drug delivery systems: An up-to-date review

  2025cites this paper
• Characterization of nano encapsulated cinnamon bark extract (Cinnamomum burmannii) based on chitosan alginate as a potential drug delivery system for cervical cancer therapy

  2025influential citation
• Potential role of NSAIDs loaded nano-formulations to treat inflammatory diseases

  2025cites this paper
• The blood–brain barriers: novel nanocarriers for central nervous system diseases

  2025cites this paper
• The dark matter in water, air and land: from microplastic to invisible nanoplastics.

  2025cites this paper
• Oral delivery of ultra-small zwitterionic nanoparticles to overcome mucus and epithelial barriers for macrophage modulation and colitis therapy.

  2025cites this paper
• Flexibility-powered Pickering emulsion enhances mucus permeability to alleviate ulcerative colitis

  2025cites this paper
• Green solvent-based synthesis of diclofenac diethylamine-loaded PCL nanoparticles for sustained drug delivery.

  2025cites this paper
• Chlorocatechol-Functionalized Gelatin Nanoparticles as a Hemostatic Agent with Antimicrobial Properties.

  2025cites this paper
• Immunofunctions of Protein and Carbohydrate Assemblies Modulated by Structures Acrossing Scales as Biomaterials.

  2025cites this paper
• Bee venom loaded nanomaterials for cancer therapy: a novel approach

  2025cites this paper
• Brownian dynamics simulation of the diffusion of rod-like nanoparticles in polymeric gels.

  2025cites this paper
• Polymer-Based Designer Particles as Drug Carriers: Strategies to Construct and Modify.

  2025cites this paper
• Animal vaccine revolution: Nanoparticle adjuvants open the future of vaccinology.

  2025cites this paper
• Exploring the Subcellular Localization and Degradation of Spherical Nucleic Acids Using Fluorescence Lifetime Imaging Microscopy

  2025cites this paper
• Engineered Nanomaterials for Overcoming Multifaceted Gastrointestinal Barriers: Toward Precision Oral Delivery of Therapeutics.

  2025cites this paper
• Impact of micro- and nanoplastics on gastrointestinal diseases: Recent advances.

  2025cites this paper
• Effect of nanomicelle morphology on peptide activity and ROS generation for enhancing chemotherapy efficacy in breast cancer.

  2025cites this paper
• Precision targeted delivery based on PUFAs: Overview, strategies and applications.

  2025cites this paper
• Comprehensive review of cellulose nanocrystals: preparation, properties, modifications and applications

  2025cites this paper
• Research progress on the in vivo fate of self-assembled traditional Chinese medicine ingredients: Absorption, transportation and distribution

  2025cites this paper
• Cerium-based nanoparticles for neurodegeneration: emerging redox therapeutics beyond pharmaceuticals

  2025cites this paper
• Current state-of-the-art in multi-scale modeling in nano-cancer drug delivery: role of AI and machine learning

  2025cites this paper
• Design and evaluation of a multi-responsive dual-modality bone-targeted drug delivery vehicle for the treatment of osteosarcoma.

  2025cites this paper
• Application of Nano‐Drug Delivery Systems in Lung Cancer Diagnosis and Treatment

  2025cites this paper
• Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development

  2025cites this paper
• Design, Current States, and Challenges of Nanomaterials in Anti-Neuroinflammation: A Perspective on Alzheimer's Disease.

  2025cites this paper
• Flavonoids and Flavonoid-Based Nanopharmaceuticals as Promising Therapeutic Strategies for Colorectal Cancer—An Updated Literature Review

  2025cites this paper
• Universal Light-Induced Solid-State Single-Step Approach for the In-Situ Synthesis of Porous Graphene-Embedded Nanoparticles

  2025cites this paper
• Ursolic acid- betulinic acid-CCM NPs: A delivery system for improving the stability and bioavailability of CCM.

  2025cites this paper
• In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems

  2025cites this paper
• "Actual" peptide properties required for nanoparticle development in precision cancer therapeutic delivery.

  2025cites this paper
• Food-derived β-lactoglobulin nanofibrils: An efficacy, safe, and scalable solution to overcome oral insulin delivery challenges

  2025cites this paper
• Supramolecular self-assembly of enzymatically hydrolyzed food protein polypeptides: Versatile architecture for enhancing the intestinal absorption of natural bioactive compounds.

  2025cites this paper
• Monometal-doped nanozymes ameliorate rheumatoid arthritis by regulating neutrophil ferroptosis via the MDM2–P53–SLC7A11 pathway

  2025cites this paper
• Advances in alginate-based nanoformulations: Innovative and effective strategies for targeting and treating brain disorders.

  2025cites this paper
• The Construction Strategy of Curcumin Nanomedicine Delivery System and Its Application in the Treatment of Ulcerative Colitis

  2025cites this paper
• Utilizing tomato pomace-based pectins in the fabrication of selenium nanoformulations - Functional characterization and gastrointestinal stability.

  2025cites this paper
• Synergistic potential of clindamycin hydrochloride loaded on zinc oxide nanoparticles: A novel approach to combat multidrug-resistant infections

  2025cites this paper
• Enhanced Drug Delivery Using Surface-Roughened MgO@Silica Nanoparticles Loaded with Doxorubicin

  2025cites this paper
• The Journey and Modes of Action of Therapeutic Nanomaterials in Cells.

  2025cites this paper
• Theranostic performance of EGFR-targeted ceria-based nanoparticles on EGFR-positive cancers

  2025cites this paper
• Optimising Cannabidiol Delivery: Improving Water Solubility and Permeability Through Phospholipid Complexation

  2025cites this paper
• Neuroprotective role of Origanum majorana essential oil loaded in mixed surfactants based nano emulsion against lipopolysaccharide-induced Alzheimer in mice

  2025cites this paper
• Exploring the influence of polystyrene-nanoplastics on two distinct in vitro systems in farm animals: A pilot study.

  2025cites this paper
• Nanoparticle recrystallization: kinetics and size-dependent behavior

  2025cites this paper
• Protein-based nanocarriers for paclitaxel (PTX) delivery in cancer treatment: A review.

  2025cites this paper
• Quercetin nanocrystals stabilized by glycyrrhizic acid for liver targeted drug delivery: impact of glycyrrhizic acid concentrations

  2025cites this paper
• Rational Design of Inner Ear Drug Delivery Systems

  2025cites this paper
• Preparation and evaluation of oral enteric sustained-release liquid formulations of aspirin.

  2025cites this paper
• Mucoadhesive Boronated‐Chitosan Nanoparticles for Cisplatin Delivery: A Novel Approach for Localized Cervical Cancer Therapy

  2025cites this paper
• Isorhamnetin-lignin nanoparticles: green preparation, characterization, remarkable bioavailability and long-lasting bioactivity in vivo

  2025cites this paper
• A Systematic Review of the Toxicokinetics of Micro- and Nanoplastics in Mammals Following Digestive Exposure

  2025cites this paper
• Quality-by-Design-Assisted Laboratory Scale-Up of Lipid Nanoparticles of Stearic Acid-Raloxifene Hydrochloride Conjugate: A Pathway for Enhanced Oral Bioavailability via Lymphatic Uptake.

  2025cites this paper
• Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells

  2025cites this paper
• Breaking biological barriers: Engineering polymeric nanoparticles for cancer therapy

  2025cites this paper
• Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease

  2025cites this paper
• A Review on QbD-Driven Optimization of Lipid Nanoparticles for Oral Drug Delivery: From Framework to Formulation

  2025cites this paper
• Smart micro/nanorobots for drug delivery in the brain

  2025cites this paper
• Ethnobotanical survey of medicinal plants used in the management of asthma in North-Western Nigeria

  2025cites this paper
• In Vitro Assessment of a Paclitaxel-Poly(Caprolactone) Drug Delivery System in Endometrial Cancer.

  2025cites this paper
• Green synthesized selenium nanoparticles using Trigonellafoenum–graecum exhibit antioxidant and anti-inflammatory effects against acetaminophen-induced nephrotoxicity in mice

  2025cites this paper
• Nanomaterial scaffolds for enzymatic polymer degradation: a tool to advance current biodegradation assessments of polymers in liquid formulation

  2025cites this paper
• Development of Nanostructured Lipid Carrier (NLC) as a Promising Carrier for Capsanthin

  2025cites this paper
• Colloidal Interactions in Simulated Intestinal Fluids: Implications for Oral Drug Delivery at the Nanoscale

  2025cites this paper
• Strategies for delivering drugs across the blood-brain barrier for the treatment of neurodegenerative diseases

  2025cites this paper
• Enhancing Doxorubicin Efficacy with a Novel Lipid-Polymer Nanosystem Containing Melatonin: Formulation, Characterization and in Vitro Study

  2025cites this paper
• Harnessing Microfluidics for the Effective and Precise Synthesis of Advanced Materials

  2025cites this paper
• Natural Enzymes and Nanozymes: A Comparative Review of Structure, Mechanism and Kinetics

  2025cites this paper
• Advanced nanoparticles for osteoarthritis: a review

  2025cites this paper
• Exploring the potential of polymers: advancements in oral nanocarrier technology

  2025cites this paper
• Polymeric Nanosystems: A Breakthrough Approach to Treating Inflammation and Inflammation Related Diseases

  2025cites this paper
• One‐Step Biosynthesis of Iron Oxide Nanoparticles and Their Nonantibacterial, Nonantifungal, and Biocompatibility Properties

  2025cites this paper
• Exploring the Role of Nanoparticles in Dental Materials: A Comprehensive Review

  2025cites this paper
• Anticancer Nanoparticle Carriers of the Proapoptotic Protein Cytochrome c

  2025influential citation
• Advanced Carriers for Precise Delivery and Therapeutic Mechanisms of Traditional Chinese Medicines: Integrating Spatial Multi‐Omics and Delivery Visualization

  2025cites this paper
• Nanozyme-functionalized microalgal biohybrid microrobots in inflammatory bowel disease treatment.

  2025cites this paper