Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Cell Science

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.171843PMID 26275827PMCID PMC4610210
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin.

  2014influential reference
• Interphase phosphorylation of lamin A

  2014cited by this paper
• From lamins to lamina: a structural perspective

  2013cited by this paper
• Partners and post-translational modifications of nuclear lamins

  2013cited by this paper
• Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling.

  2013influential reference
• Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

  2013cited by this paper
• Design, construction, and characterization of a second‐generation DARPin library with reduced hydrophobicity

  2013influential reference
• Nuclear lamins

  2012cited by this paper
• Nuclear lamins and laminopathies

  2012influential reference
• The nuclear lamins: flexibility in function

  2012cited by this paper
• supp lemental materi al to

  2012cited by this paper
• Phosphatases: providing safe passage through mitotic exit

  2011cited by this paper
• Biophysical assays to probe the mechanical properties of the interphase cell nucleus: substrate strain application and microneedle manipulation.

  2011cited by this paper
• Clinical and genetic heterogeneity in laminopathies.

  2011cited by this paper
• Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells

  2011influential reference
• Nuclear lamins.

  2010cited by this paper
• Characterization of the head-to-tail overlap complexes formed by human lamin A, B1 and B2 "half-minilamin" dimers.

  2010influential reference
• Lamina-independent lamins in the nuclear interior serve important functions.

  2010influential reference
• Induction of a Massive Endoplasmic Reticulum and Perinuclear Space Expansion by Expression of Lamin B Receptor Mutants and the Related Sterol Reductases TM7SF2 and DHCR7

  2010cited by this paper
• Oocytes as an experimental system to analyze the ultrastructure of endogenous and ectopically expressed nuclear envelope components by field-emission scanning electron microscopy.

  2010cited by this paper
• A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

  2009influential reference
• The LINC-less granulocyte nucleus.

  2009cited by this paper
• The supramolecular organization of the C. elegans nuclear lamin filament.

  2009cited by this paper
• Filaments made from A- and B-type lamins differ in structure and organization

  2008cited by this paper
• The lamin B receptor under transcriptional control of C/EBPepsilon is required for morphological but not functional maturation of neutrophils.

  2008influential reference
• Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin.

  2008cited by this paper
• HGPS and related premature aging disorders: from genomic identification to the first therapeutic approaches.

  2008cited by this paper
• Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia

  2008cited by this paper
• The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription.

  2008influential reference
• Nucleoplasmic lamins and their interaction partners, LAP2α, Rb, and BAF, in transcriptional regulation

  2007cited by this paper
• Nucleoplasmic LAP2α–lamin A complexes are required to maintain a proliferative state in human fibroblasts

  2007cited by this paper
• Faculty Opinions recommendation of Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts.

  2007influential reference
• Regulation of actin filament assembly by Arp2/3 complex and formins.

  2007cited by this paper
• The Last Twenty Residues in the Head Domain of Mouse Lamin A Contain Important Structural Elements for Formation of Head-to-Tail Polymers in Vitro

  2007cited by this paper
• Intermediate filaments: from cell architecture to nanomechanics

  2007cited by this paper
• Crystal structure of a consensus‐designed ankyrin repeat protein: Implications for stability

  2006cited by this paper
• Identification of a novel, highly variable amino‐terminal amino acid sequence element in the nuclear intermediate filament protein lamin B2 from higher vertebrates

  2006cited by this paper
• Lamins A and C but Not Lamin B1 Regulate Nuclear Mechanics*

  2006cited by this paper
• Lamina-associated polypeptide 2α regulates cell cycle progression and differentiation via the retinoblastoma–E2F pathway

  2006cited by this paper
• The lethal phenotype of a homozygous nonsense mutation in the lamin A/C gene

  2005cited by this paper
• Microdissection of the sequence and structure of intermediate filament chains.

  2005cited by this paper
• PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.

  2005cited by this paper
• Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells

  2005influential reference
• Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery–Dreifuss muscular dystrophy

  2005cited by this paper
• Isolation, characterization, and in vitro assembly of intermediate filaments.

  2004cited by this paper
• Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations

  2004influential reference
• Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.

  2004cited by this paper
• High-affinity binders selected from designed ankyrin repeat protein libraries

  2004cited by this paper
• Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo

  2003cited by this paper
• Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins.

  2003cited by this paper
• Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular Scaffolds.

  2003influential reference
• Structure of the Globular Tail of Nuclear Lamin*

  2002cited by this paper
• Investigation of nuclear architecture with a domain-presenting expression system.

  2002cited by this paper
• Characterization of early assembly intermediates of recombinant human keratins.

  2002cited by this paper
• Drosophila syntaxin 16 is a Q-SNARE implicated in Golgi dynamics

  2002cited by this paper
• The Crystal Structure of Uncomplexed Actin in the ADP State

  2001cited by this paper
• Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy.

  2001cited by this paper
• Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

  1999cited by this paper
• Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy

  1999cited by this paper
• Detergent–salt resistance of LAP2α in interphase nuclei and phosphorylation‐dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics

  1998cited by this paper
• Identification of Protein Phosphatase 1 as a Mitotic Lamin Phosphatase*

  1997cited by this paper
• Disruption of Nuclear Lamin Organization Alters the Distribution of Replication Factors and Inhibits DNA Synthesis

  1997cited by this paper
• Emerin deficiency at the nuclear membrane in patients with Emery-Dreifuss muscular dystrophy

  1996cited by this paper
• Emerin deficiency at the nuclear membrane in patients with Emery-Dreif uss muscular dystrophy

  1996cited by this paper
• Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C.

  1993cited by this paper
• Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.

  1990cited by this paper
• A second higher vertebrate B-type lamin. cDNA sequence determination and in vitro processing of chicken lamin B2.

  1989cited by this paper
• Cloning and sequencing of cDNA clones encoding chicken lamins A and B1 and comparison of the primary structures of vertebrate A- and B-type lamins.

  1989cited by this paper
• Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm.

  1988cited by this paper
• Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins and variations in lamin B phosphorylation.

  1988cited by this paper
• The nuclear lamins. A multigene family of proteins in evolution and differentiation.

  1986cited by this paper
• The nuclear lamina is a meshwork of intermediate-type filaments

  1986influential reference

• A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites.

  2026influential citation
• The Deformability of the Mammalian Cell Nucleus is Determined by the Identity of the Lamin Rod Domain

  2025cites this paper
• A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites

  2025cites this paper
• Phase Behavior and Dissociation Kinetics of Lamins in a Polymer Model of Progeria

  2025cites this paper
• N-terminal tags impair the ability of Lamin A to provide structural support to the nucleus.

  2024cites this paper
• N-terminal tags impair the ability of Lamin A to provide structural support to the nucleus

  2024cites this paper
• PIGB maintains nuclear lamina organization in skeletal muscle of Drosophila

  2024cites this paper
• Lamin A K97E leads to NF‐κB‐mediated dysfunction of inflammatory responses in dilated cardiomyopathy

  2024cites this paper
• Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture

  2024cites this paper
• Advances in research on the relationship between the LMNA gene and human diseases (Review)

  2024cites this paper
• The nuclear lamin network passively responds to both active or passive cell movement through confinements

  2024cites this paper
• SUMO protease SENP6 protects the nucleus from hyperSUMOylation-induced laminopathy-like alterations.

  2023cites this paper
• Scaffold, mechanics and functions of nuclear lamins

  2023cites this paper
• Title : Comprehensive analysis of A-type lamin tail region for repairing the nuclear 1 lamina 2

  2023cites this paper
• The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding

  2023cites this paper
• A deep hybrid learning pipeline for accurate diagnosis of ovarian cancer based on nuclear morphology

  2022cites this paper
• Lamin A and telomere maintenance in aging: Two to Tango.

  2022cites this paper
• Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS

  2022influential citation
• Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

  2021cites this paper
• Lamin A/C Mechanotransduction in Laminopathies

  2020cites this paper
• Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C

  2020cites this paper
• Lamin A/C Assembly Defects in LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery–Dreifuss Muscular Dystrophy

  2020cites this paper
• Phenotypic evolution of cancer cells: structural requirements for survival

  2020cites this paper
• Nuclear Membrane Rupture and Its Consequences.

  2020cites this paper
• Structure and unique mechanical aspects of nuclear lamin filaments.

  2020cites this paper
• Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells

  2020cites this paper
• Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation

  2019cites this paper
• Lamin A/C Cardiomyopathy: Implications for Treatment

  2019cites this paper
• Emerging views of the nucleus as a cellular mechanosensor

  2018cites this paper
• Transient Nuclear Envelope Rupture during Cell Migration: A Cause of Genomic Instability and a Novel Opportunity for Therapeutic Intervention

  2018cites this paper
• A novel photoactivatable tool for intermediate filament disruption indicates a role for keratin filaments in early embryogenesis

  2018cites this paper
• Modeling Skeletal Muscle Laminopathies Using Human Induced Pluripotent Stem Cells Carrying Pathogenic LMNA Mutations

  2018cites this paper
• Tiopronin-Protected Gold Nanoparticles as a Potential Marker for Cryo-EM and Tomography.

  2018cites this paper
• Loss of Nuclear Envelope Integrity in Aging and Disease.

  2018cites this paper
• Insight into the functional organization of nuclear lamins in health and disease.

  2018cites this paper
• Nuclear Lamins: Thin Filaments with Major Functions.

  2018cites this paper
• Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins

  2018cites this paper
• Lamins in the nuclear interior − life outside the lamina

  2017influential citation
• Biotinylation by antibody recognition - A method for proximity labeling

  2017cites this paper
• PKC-mediated phosphorylation of nuclear lamins at a single serine residue regulates interphase nuclear size in Xenopus and mammalian cells

  2017cites this paper
• Biotinylation by antibody recognition - A novel method for proximity labeling

  2016cites this paper
• A model for coordinating nuclear mechanics and membrane remodeling to support nuclear integrity.

  2016cites this paper
• Simple Separation of Functionally Distinct Populations of Lamin-Binding Proteins.

  2016cites this paper
• 2015 Winner: Monika Zwerger

  2016cites this paper
• Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments.

  2015cites this paper
• The Influence of Lamina-Associated Polypeptide 2α on the Assembly Properties of A-type Lamins

  2015cites this paper