Lamins in the nuclear interior − life outside the lamina

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Cell Science

• Publication date

  2017-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.203430PMID 28668931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanosensing by the nucleus: From pathways to scaling relationships

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  2017influential reference
• Nuclear envelope localization of LEMD2 is developmentally dynamic and lamin A/C dependent yet insufficient for heterochromatin tethering.

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• Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay

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  2016influential reference
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  2016cited by this paper
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  2016influential reference
• Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man

  2016cited by this paper
• A-type Lamins Form Distinct Filamentous Networks with Differential Nuclear Pore Complex Associations.

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• A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

  2016influential reference
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• Lamins at the crossroads of mechanosignaling

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• Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation.

  2015influential reference
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• Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos.

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• Mechanisms and dynamics of nuclear lamina-genome interactions.

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• Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

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• Nuclear lamin stiffness is a barrier to 3D-migration, but softness can limit survival

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• Stochastic genome-nuclear lamina interactions

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• Interphase phosphorylation of lamin A

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• Chromatin De-Compaction By The Nucleosomal Binding Protein HMGN5 Impairs Nuclear Sturdiness

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• Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease☆

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• High Mobility Group Protein N5 (HMGN5) and Lamina-associated Polypeptide 2α (LAP2α) Interact and Reciprocally Affect Their Genome-wide Chromatin Organization*

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• Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence

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• When lamins go bad: nuclear structure and disease.

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  2012cited by this paper
• supp lemental materi al to

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