Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Phytomedicine

• Publication date

  2007-12-04

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.PHYMED.2007.04.003PMID 17689939
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TNF‐α Mediates p38 MAP Kinase Activation and Negatively Regulates Bone Formation at the Injured Growth Plate in Rats

  2006cited by this paper
• MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation.

  2006cited by this paper
• Resveratrol prevents CsA inhibition of proliferation and osteoblastic differentiation of mouse bone marrow-derived mesenchymal stem cells through an ER/NO/cGMP pathway.

  2006cited by this paper
• Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture

  2005cited by this paper
• Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells.

  2005cited by this paper
• Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition.

  2005cited by this paper
• Resveratrol and Estradiol Rapidly Activate MAPK Signaling through Estrogen Receptors α and β in Endothelial Cells*

  2005cited by this paper
• Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury.

  2004cited by this paper
• Differential effects of PD98059 and U0126 on osteogenesis and adipogenesis

  2004cited by this paper
• Mechanical Strain Differentially Regulates Endothelial Nitric-oxide Synthase and Receptor Activator of Nuclear κB Ligand Expression via ERK1/2 MAPK*

  2003cited by this paper
• Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway.

  2003cited by this paper
• Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways.

  2002cited by this paper
• Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation.

  2002cited by this paper
• Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism.

  2002cited by this paper
• Effect of resveratrol on platelet aggregation in vivo and in vitro.

  2002cited by this paper
• Resveratrol and cancer: a review.

  2002cited by this paper
• Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP‐2

  2002cited by this paper
• Stress-induced Inhibition of ERK1 and ERK2 by Direct Interaction with p38 MAP Kinase*

  2001cited by this paper
• Effect of asymmetric dimethylarginine on osteoblastic differentiation.

  2001cited by this paper
• Erk Is Essential for Growth, Differentiation, Integrin Expression, and Cell Function in Human Osteoblastic Cells*

  2001cited by this paper
• Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats.

  2000cited by this paper
• Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.

  2000cited by this paper
• Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase*

  2000cited by this paper
• Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol.

  2000cited by this paper
• MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1*

  2000cited by this paper
• Resveratrol Acts as a Mixed Agonist/Antagonist for Estrogen Receptors α and β.

  2000cited by this paper
• Why do postmenopausal women discontinue hormone replacement therapy?

  1999cited by this paper
• Three isolation techniques for primary culture of human osteoblast-like cells: a comparison.

  1999cited by this paper
• A review of clinical trials of therapies for osteoporosis using fracture as an end point.

  1999cited by this paper
• One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade.

  1999cited by this paper
• Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.

  1998cited by this paper
• Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor.

  1997cited by this paper
• Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

  1997cited by this paper
• Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation.

  1997cited by this paper
• Diagnosis of Osteoporosis

  1992cited by this paper
• The Minimum Effective Dose of Estrogen for Prevention of Postmenopausal Bone Loss

  1984cited by this paper

• Plant-derived food bioactives in bone health: from multi-targeted roles to molecular mechanisms in osteoporosis

  2026cites this paper
• Glycosylation Matters: Network Pharmacology-Based and Molecular Docking Analysis of Resveratrol Glycosylated Derivatives on Parkinson’s Disease

  2026cites this paper
• Squid Skin Decellularised Dermal Matrix for Enhancing Repair of Acute Cranial Injuries in Rabbit Model

  2025cites this paper
• Hormesis and health: molecular mechanisms and the key role of polyphenols

  2025cites this paper
• Salvianolic acid-A alleviates oxidative stress-induced osteoporosis.

  2025cites this paper
• Fabrication and evaluation of a host-guest polylactic acid/gelatin-hydroxyapatite-blueberry scaffold for bone regeneration

  2025cites this paper
• Regulation of Human Stem Cells by Functional Food Components: How Vitamins, Minerals and Phytochemicals Influence Mesenchymal Stem Cells’ Fate and Function

  2025cites this paper
• Effects of Resveratrol Supplementation as an Adjunct to Nonsurgical Periodontal Therapy: A Systematic Review and Meta-analysis

  2025cites this paper
• Influence of Wine on Bone Mineral Density

  2025cites this paper
• Natural bioactive compounds modified with mesenchymal stem cells: new hope for regenerative medicine

  2025cites this paper
• Versatile bioactive polyphenolic coatings for bone tissue regeneration: from assembly strategies to biointerface interactions.

  2025cites this paper
• In Vitro Antiviral Activity of Eugenol on Singapore Grouper Iridovirus.

  2024cites this paper
• Resveratrol enhances the protective effects of calcium supplements on spinal cord injury–induced osteoporosis by targeting the SIRT1/FOXO3a pathway

  2024cites this paper
• The Role of Mitochondrial Homeostasis in Mesenchymal Stem Cell Therapy—Potential Implications in the Treatment of Osteogenesis Imperfecta

  2024cites this paper
• The relationship between caffeine and its metabolites and bone mineral density in postmenopausal women: a cross-sectional analysis from the NHANES database

  2024cites this paper
• Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review

  2024cites this paper
• Microbiota and Resveratrol: How Are They Linked to Osteoporosis?

  2024cites this paper
• Advances in mesenchymal stem cell therapy and natural antioxidants for hepatic fibrosis: A comprehensive review

  2024cites this paper
• Resveratrol facilitates bone formation in high-glucose conditions

  2024cites this paper
• Evaluation of the Effects of Locally Applied Resveratrol and Cigarette Smoking on Bone Healing

  2024cites this paper
• Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

  2024cites this paper
• Resveratrol alleviates thiram-induced tibial dyschondroplasia by regulating BMP-2, RUNX-2 and HIF-1α expressions in broiler chickens

  2024cites this paper
• RESVERATROL SUPPLEMENTATION AS A NON-SURGICAL TREATMENT IN PERIODONTITIS AND RELATED SYSTEMIC CONDITIONS

  2024cites this paper
• The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

  2024cites this paper
• Systems genetics and bioinformatics analyses using ESR1-correlated genes identify potential candidates underlying female bone development

  2023cites this paper
• Resveratrol May Reduce the Degree of Periodontitis by Regulating ERK Pathway in Gingival-Derived MSCs

  2023cites this paper
• Benefits of bone marrow-derived mesenchymal stem cells primed with estradiol in alleviating collagen-induced arthritis

  2023cites this paper
• Effects of adipose derived stem cells pretreated with resveratrol on sciatic nerve regeneration in rats

  2023cites this paper
• Expected and Unexpected Effects of Pharmacological Antioxidants

  2023cites this paper
• Sustainable Bioactive Composite of Glehnia littoralis Extracts for Osteoblast Differentiation and Bone Formation

  2023cites this paper
• Effects of resveratrol and its analogues on the cell cycle of equine mesenchymal stem/stromal cells

  2023influential citation
• Revisiting Resveratrol as an Osteoprotective Agent: Molecular Evidence from In Vivo and In Vitro Studies

  2023cites this paper
• Proanthocyanidin enhances the endogenous regeneration of alveolar bone by elevating the autophagy of PDLSCs.

  2023cites this paper
• Estrogen receptor-mediated health benefits of phytochemicals: a review.

  2023cites this paper
• Resveratrol modulates the inflammatory response in hPDLSCs via the NRF2/HO-1 and NF-κB pathways and promotes osteogenic differentiation.

  2023cites this paper
• Resveratrol promotes the osteogenic differentiation of human amniotic epithelial cells via Sirt-1/PPAR-α pathway

  2023cites this paper
• Resveratrol-loaded co-axial electrospun poly(ε-caprolactone)/chitosan/polyvinyl alcohol membranes for promotion of cells osteogenesis and bone regeneration.

  2023cites this paper
• Low concentrations of grape seed extract maintain osteoblast morphology, cell adhesion, and mineralization

  2023cites this paper
• Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies

  2023cites this paper
• Polymeric Membranes for Biomedical Applications

  2023cites this paper
• Resveratrol Modulates Bone Mineral Density and Bone Mineral Content in A Rat Model of Male Hypogonadism

  2022cites this paper
• Biomolecules resveratrol + coenzyme Q10 recover the cell state of human mesenchymal stem cells after 1-methyl-4-phenylpyridinium-induced damage and improve proliferation and neural differentiation

  2022cites this paper
• Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature

  2022cites this paper
• The potential of plant extracts in cell therapy

  2022cites this paper
• [Experimental study of resveratrol-solid lipid nanoparticles in promotion of osteogenic differentiation of bone marrow mesenchymal stem cells].

  2022cites this paper
• Effects of phytoestrogens on reproductive organ health.

  2022cites this paper
• Design and development of biomimetic electrospun sulphonated polyether ether ketone nanofibrous scaffold for bone tissue regeneration applications: in vitro and in vivo study

  2022cites this paper
• The Role of Histone Acetylation Modification in Dental Tissue-Derived Mesenchymal Stem Cells and Odontogenesis

  2022cites this paper
• Osteogenic differentiation of human induced pluripotent stem cell in the presence of testosterone and 17 β-estradiol in vitro

  2022cites this paper
• Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration

  2022cites this paper
• Greater habitual resveratrol intakes were associated with lower risk of hip fracture‐ a 1:1 matched case–control study in Chinese elderly

  2022cites this paper
• Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways

  2022cites this paper
• Phoenix dactilyfera L. Pits Extract Restored Bone Homeostasis in Glucocorticoid-Induced Osteoporotic Animal Model through the Antioxidant Effect and Wnt5a Non-Canonical Signaling

  2022cites this paper
• Reversal of Doxorubicin-Induced Bone Loss and Mineralization by Supplementation of Resveratrol and MitoTEMPO in the Early Development of Sparus aurata

  2022cites this paper
• Resveratrol protects MC3T3-E1 cells against cadmium-induced suppression of osteogenic differentiation by modulating the ERK1/2 and JNK pathways.

  2021cites this paper
• Microcarrier-based stem cell bioprocessing: GMP-grade culture challenges and future trends for regenerative medicine

  2021cites this paper
• BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMÁTICAS

  2021cites this paper
• Stem cell culture media enriched with plant‐derived compounds: Cell proliferation enhancement

  2021cites this paper
• Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis

  2021cites this paper
• Noradrenalin inhibiert die Proliferation humaner mesenchymaler Knochenmarksstammzellen über die β 2-Adrenorezeptor-vermittelte ERK 1 / 2-und PKA-Phosphorylierung

  2021cites this paper
• Hormesis and stem cells enhancing cell proliferation, differentiation and resilience to inflammatory stress in bone marrow stem cells and their therapeutic implications.

  2021cites this paper
• Effects of Extracellular Osteoanabolic Agents on the Endogenous Response of Osteoblastic Cells

  2021cites this paper
• Stem cell culture media enriched with plant‐derived compounds: Cell differentiation enhancement

  2021cites this paper
• Gelatin methacrylate hydrogel scaffold carrying resveratrol-loaded solid lipid nanoparticles for enhancement of osteogenic differentiation of BMSCs and effective bone regeneration

  2021cites this paper
• N‐acetylcysteine (NAC) differentially affects arterial medial calcification and bone formation: The role of l‐cysteine and hydrogen sulphide

  2021cites this paper
• Protection and Mitigation by Resveratrol of DNA Damage Induced in Irradiated Human Lymphocytes In Vitro

  2021cites this paper
• PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: Comprehensive physicochemical and biological evaluation

  2020cites this paper
• Regulation of mineralisation in bone and vascular tissue: a comparative review.

  2020cites this paper
• Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells

  2020cites this paper
• Natural Compounds as a Strategy to Optimize “In Vitro” Expansion of Stem Cells

  2020cites this paper
• Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells.

  2020cites this paper
• Resveratrol Rescue Indoxyl Sulfate-Induced Deterioration of Osteoblastogenesis via the Aryl Hydrocarbon Receptor /MAPK Pathway

  2020cites this paper
• Bone marrow fat: friend or foe in people with diabetes mellitus?

  2020cites this paper
• Nanoencapsulated dietary polyphenols for cancer prevention and treatment: successes and challenges.

  2020cites this paper
• The effects of 17 Beta-Estradiol primed mesenchymal stem cells on the biology of co-cultured neutrophil.

  2020cites this paper
• Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via β2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation

  2020cites this paper
• Polyphenols from grape pomace induce osteogenic differentiation in mesenchymal stem cells

  2020cites this paper
• Resveratrol rescues TNF-α-induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway

  2020cites this paper
• Potential Adverse Effects of Resveratrol: A Literature Review

  2020cites this paper
• The Stemness of Human Ovarian Granulosa Cells and the Role of Resveratrol in the Differentiation of MSCs—A Review Based on Cellular and Molecular Knowledge

  2020cites this paper
• The application of resveratrol to mesenchymal stromal cell-based regenerative medicine

  2019cites this paper
• The effect of aging and resveratrol supplementation on bone mass and strength in hindlimb suspended male rats

  2019influential citation
• Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells

  2019cites this paper
• Small molecules for mesenchymal stem cell fate determination

  2019cites this paper
• Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation

  2019cites this paper
• High Mobility Group Box 1: An Immune-regulatory Protein

  2019cites this paper
• A Review on the Effect of Plant Extract on Mesenchymal Stem Cell Proliferation and Differentiation

  2019cites this paper
• Short-Term Protocols to Obtain Insulin-Producing Cells from Rat Adipose Tissue: Signaling Pathways and In Vivo Effect

  2019cites this paper
• Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery

  2019cites this paper
• Resveratrol Promotes in vitro Differentiation of Osteoblastic MC3T3-E1 Cells via Potentiation of the Calcineurin/NFATc1 Signaling Pathway

  2019cites this paper
• Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells

  2019cites this paper
• Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells.

  2019cites this paper
• Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer’s disease

  2019cites this paper
• Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling

  2019cites this paper
• Main Resveratrol Action Mechanisms in Postmenopausal Osteoporosis

  2019cites this paper
• resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells

  2019cites this paper
• Effects of Systemic Administration of Resveratrol on New Bone Formation in Critical-Sized Bone Defects in Rats

  2019cites this paper
• The Therapeutic Potential of Resveratrol in Gliomas

  2019cites this paper
• Multi-effects of Resveratrol on stem cell characteristics: Effective dose, time, cell culture conditions and cell type-specific responses of stem cells to Resveratrol.

  2018cites this paper
• Effect of resveratrol release kinetic from electrospun nanofibers on osteoblast and osteoclast differentiation

  2018cites this paper