Expression of Simian Immunodeficiency Virus nef in Immune Cells of Transgenic Mice Leads to a Severe AIDS-Like Disease

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Virology

• Publication date

  2002-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.76.8.3981-3995.2002PMID 11907238PMCID PMC136064
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Distinct regulatory elements are required for faithful expression of human CD4 in T cells, macrophages, and dendritic cells of transgenic mice.

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• Dilated cardiomyopathy associated with simian AIDS in nonhuman primates.

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• The T-Cell Receptor ζ Chain Contains Two Homologous Domains with Which Simian Immunodeficiency Virus Nef Interacts and Mediates Down-Modulation

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• Nef Modulation of HIV Type 1 Gene Expression and Cytopathicity in Tissues of HIV Transgenic Mice

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• Simian Immunodeficiency Virus Disease Course Is Predicted by the Extent of Virus Replication during Primary Infection

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• Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4.

  1999cited by this paper
• Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Nef Proteins Show Distinct Patterns and Mechanisms of Src Kinase Activation

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• Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1

  1999cited by this paper
• Two elements target SIV Nef to the AP‐2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis

  1999cited by this paper
• SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques.

  1999cited by this paper
• The Human Immunodeficiency Virus Type 1nef Gene Can to a Large Extent Replace Simian Immunodeficiency Virus nef In Vivo

  1999cited by this paper
• Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice.

  1998cited by this paper
• Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 in Immune Cells Develop a Severe AIDS-Like Disease

  1998cited by this paper
• Zeta Chain of the T-Cell Receptor Interacts with nef of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2

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• Mice transgenic for simian immunodeficiency virus nef are immunologically compromised.

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• Early Regeneration of Thymic Progenitors in Rhesus Macaques Infected with Simian Immunodeficiency Virus

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• HIV nef: the mother of all evil?

  1998cited by this paper
• Pathogenesis of simian immunodeficiency virus pneumonia: an immunopathological response to virus.

  1998cited by this paper
• Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation.

  1998cited by this paper
• SIV-Associated Nephropathy in Rhesus Macaques Infected with Lymphocyte-Tropic SIVmac239

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• Rhesus Macaques Infected with Macrophage-Tropic Simian Immunodeficiency Virus (SIVmacR71/17E) Exhibit Extensive Focal Segmental and Global Glomerulosclerosis

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• A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques

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• Infection and pathogenicity of chimeric simian-human immunodeficiency viruses in macaques: determinants of high virus loads and CD4 cell killing.

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• The positive influence of Nef on viral infectivity.

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• Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival

  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

  1995cited by this paper
• Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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• Specific expression of the human CD4 gene in mature CD4+ CD8- and immature CD4+ CD8+ T cells and in macrophages of transgenic mice

  1994cited by this paper
• The role of Nef in the replication cycle of the human and simian immunodeficiency viruses.

  1994cited by this paper
• Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene

  1994cited by this paper
• Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4

  1994cited by this paper
• Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene

  1994cited by this paper
• Specific suppression of human CD4 surface expression by Nef from the pathogenic simian immunodeficiency virus SIVmac239open.

  1994cited by this paper
• Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes.

  1994cited by this paper
• Construction and In Vitro Properties of SIVmac Mutants with Deletions in "Nonessential" Genes

  1994cited by this paper
• CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

  1993cited by this paper
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  1989cited by this paper
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  1987cited by this paper
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