Zeta Chain of the T-Cell Receptor Interacts with nef of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Virology

• Publication date

  1998-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.72.12.9827-9834.1998PMID 9811718PMCID PMC110494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

  1998cited by this paper
• Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

  1997cited by this paper
• The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase.

  1997cited by this paper
• A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation

  1997cited by this paper
• Binding of HIV-1 Nef to a Novel Thioesterase Enzyme Correlates with Nef-mediated CD4 Down-regulation*

  1997cited by this paper
• CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

  1996cited by this paper
• Nef-CD4 physical interaction sensed with the yeast two-hybrid system.

  1996influential reference
• Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

  1996cited by this paper
• Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

  1996cited by this paper
• Physical and Functional Interaction of Nef with Lck

  1996cited by this paper
• Requirements for lymphocyte activation by unusual strains of simian immunodeficiency virus

  1996cited by this paper
• T cell antigen receptor signal transduction pathways.

  1996cited by this paper
• The HIV Nef Protein Associates with Protein Kinase C Theta*

  1996cited by this paper
• Proline‐rich (PxxP) motifs in HIV‐1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down‐regulation of CD4.

  1995cited by this paper
• Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection.

  1995cited by this paper
• Identification of Lck-binding Elements in Tip of Herpesvirus Saimiri (*)

  1995cited by this paper
• Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).

  1995cited by this paper
• Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys.

  1995influential reference
• Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines

  1995cited by this paper
• Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

  1995cited by this paper
• A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV‐1 Nef protein.

  1995cited by this paper
• Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

  1995cited by this paper
• Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex

  1995cited by this paper
• Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

  1995cited by this paper
• The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction.

  1994cited by this paper
• The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells.

  1994cited by this paper
• HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization.

  1994cited by this paper
• Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

  1994cited by this paper
• NF-AT components define a family of transcription factors targeted in T-cell activation

  1994cited by this paper
• The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

  1994cited by this paper
• Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.

  1994cited by this paper
• The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes

  1994cited by this paper
• Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes.

  1994cited by this paper
• T cell receptor-associated alpha-phosphatidylinositol 3-kinase becomes activated by T cell receptor cross-linking and requires pp56lck.

  1994cited by this paper
• Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

  1994cited by this paper
• Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4

  1994cited by this paper
• Altered T cell activation and development in transgenic mice expressing the HIV‐1 nef gene.

  1993cited by this paper
• Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain

  1993cited by this paper
• Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.

  1993cited by this paper
• HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells.

  1993cited by this paper
• Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two‐hybrid system

  1993cited by this paper
• The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

  1993cited by this paper
• Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo

  1993cited by this paper
• Mammalian Ras interacts directly with the serine/threonine kinase Raf.

  1993cited by this paper
• Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells

  1992cited by this paper
• ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.

  1992cited by this paper
• Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

  1992cited by this paper
• Sequence requirements for induction of cytolysis by the T cell antigen Fc receptor ζ chain

  1992cited by this paper
• ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

  1992cited by this paper
• Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain.

  1992cited by this paper
• Nef Proteins of the Human Immunodeficiency Viruses (HIV-1 and HIV-2) and Simian Immunodeficiency Virus (SIV) Are Structurally Similar to Leucine Zipper Transcriptional Activation Factors

  1991cited by this paper
• Importance of the nef gene for maintenance of high virus loads and for development of AIDS.

  1991cited by this paper
• The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways.

  1991cited by this paper
• Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

  1991cited by this paper
• The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency Virus

  1990cited by this paper
• The structure and signalling functions of the invariant T cell receptor components.

  1990cited by this paper
• An African primate lentivirus (SIVsmclosely related to HIV-2

  1989cited by this paper
• Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.

  1988cited by this paper
• Disulfide Linkage of the ( and q Chains of the T Cell Receptor

  1988cited by this paper
• The T cell receptor/CD3 complex: a dynamic protein ensemble.

  1988cited by this paper
• Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors.

  1988cited by this paper
• Molecular cloning of the zeta chain of the T cell antigen receptor.

  1988cited by this paper
• Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

  1987cited by this paper
• Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity

  1986cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Ancestral reconstruction supports that loss of Nef-mediated T cell modulation coincided with the emergence of pathogenic lentiviruses

  2025cites this paper
• Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques.

  2021cites this paper
• Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques

  2020cites this paper
• Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2

  2018cites this paper
• Combined single-cell quantitation of host and SIV genes and proteins ex vivo reveals host-pathogen interactions in individual cells

  2017cites this paper
• Rhesus Macaques Sufficient for Effective Viral Replication in Immunodeficiency Virus Nef but Is Not Selected In Vivo Function of Simian T-Cell Receptor:CD3 Down-Regulation Is a

  2014cites this paper
• HIV-1 Nef and T-cell activation: a history of contradictions.

  2013cites this paper
• Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

  2013cites this paper
• Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef.

  2012cites this paper
• Functions of the Lentiviral Accessory Protein Nef During the Distinct Steps of HIV and SIV Replication Cycle

  2011cites this paper
• Selektiver Verlust der Nef-vermittelten CD3-Modulation in SIVsmm-infizierten Rauchgrauen Mangaben mit niedrigen CD4+ T-Zellzahlen

  2011cites this paper
• Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRζ fragments

  2010cites this paper
• Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.

  2010cites this paper
• The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

  2009cites this paper
• Inhibition of T-Cell Receptor-Induced Actin Remodeling and Relocalization of Lck Are Evolutionarily Conserved Activities of Lentiviral Nef Proteins

  2009cites this paper
• Characterization of the Nef-TCR Zeta Interaction and Its Role in Modulation of Src Family Kinase Activity: A Dissertation

  2009influential citation
• Implications of Nef: host cell interactions in viral persistence and progression to AIDS.

  2009cites this paper
• HIV-1 accessory proteins--ensuring viral survival in a hostile environment.

  2008cites this paper
• HIV Nef: role in pathogenesis and viral fitness.

  2008cites this paper
• Role of Nef in primate lentiviral immunopathogenesis

  2008cites this paper
• Nef-Mediated Enhancement of Virion Infectivity and Stimulation of Viral Replication Are Fundamental Properties of Primate Lentiviruses

  2007cites this paper
• Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

  2007cites this paper
• Altered expression of the tetraspanin CD81 on B and T lymphocytes during HIV‐1 infection

  2006cites this paper
• Importance of the N-Distal AP-2 Binding Element in Nef for Simian Immunodeficiency Virus Replication and Pathogenicity in Rhesus Macaques

  2006cites this paper
• Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.

  2006cites this paper
• Pathogenicity in Rhesus Macaques Immunodeficiency Virus Replication and Element in Nef for Simian Importance of the N-Distal AP-2 Binding

  2006cites this paper
• Nef Proteins from Diverse Groups of Primate Lentiviruses Downmodulate CXCR4 To Inhibit Migration to the Chemokine Stromal Derived Factor 1

  2005cites this paper
• HLA‐A2 down‐regulation on primary human macrophages infected with an M‐tropic EGFP‐tagged HIV‐1 reporter virus

  2005cites this paper
• Co‐translational myristoylation alters the quaternary structure of HIV‐1 Nef in solution

  2005cites this paper
• Primary Sooty Mangabey Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2 nef Alleles Modulate Cell Surface Expression of Various Human Receptors and Enhance Viral Infectivity and Replication

  2005cites this paper
• Expression of CD154 by a Simian Immunodeficiency Virus Vector Induces Only Transitory Changes in Rhesus Macaques

  2005cites this paper
• Human N-Myristoyltransferases Form Stable Complexes with Lentiviral Nef and Other Viral and Cellular Substrate Proteins

  2005cites this paper
• Mechanism and mediated mechanistic analysis of HIV Nef

  2004cites this paper
• Multiple human immunodeficiency virus type 1 Nef functions contribute to efficient replication in primary human macrophages.

  2004cites this paper
• HIV Type 1 Nef Increases the Association of T Cell Receptor (TCR)-Signaling Molecules with T Cell Rafts and Promotes Activation-Induced Raft Fusion

  2004cites this paper
• Other Viral and Cellular Substrate Proteins Stable Complexes with Lentiviral Nef and Myristoyltransferases Form-N Human

  2004cites this paper
• Nef Proteins from Simian Immunodeficiency Virus-Infected Chimpanzees Interact with p21-Activated Kinase 2 and Modulate Cell Surface Expression of Various Human Receptors

  2004cites this paper
• Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus

  2004cites this paper
• Comprehensive Analysis of Nef Functions Selected in Simian Immunodeficiency Virus-Infected Macaques

  2004cites this paper
• Heterogeneous pathogenicity of retroviruses: lessons from birds, primates, and rodents.

  2003cites this paper
• The role of Vif during HIV-1 infection: interaction with novel host cellular factors.

  2003cites this paper
• Vav exchange factor counteracts the HIV‐1 Nef‐mediated decrease of plasma membrane GM1 and NF‐AT activity in T cells

  2003cites this paper
• Down-Modulation of Mature Major Histocompatibility Complex Class II and Up-Regulation of Invariant Chain Cell Surface Expression Are Well-Conserved Functions of Human and Simian Immunodeficiency Virus nef Alleles

  2003influential citation
• CD4+ T cell signaling in the natural SIV host--implications for disease pathogenesis.

  2003cites this paper
• Cooperative Interactions of Simian Immunodeficiency Virus Nef, AP-2, and CD3-ζ Mediate the Selective Induction of T-Cell Receptor-CD3 Endocytosis

  2003influential citation
• The physiological relevance of CD4 receptor down-modulation during HIV infection.

  2003cites this paper
• T-Cell Receptor:CD3 Down-Regulation Is a Selected In Vivo Function of Simian Immunodeficiency Virus Nef but Is Not Sufficient for Effective Viral Replication in Rhesus Macaques

  2002cites this paper
• The conserved process of TCR/CD3 complex down-modulation by SIV Nef is mediated by the central core, not endocytic motifs.

  2002cites this paper
• Envelope Glycoprotein Cytoplasmic Domains from Diverse Lentiviruses Interact with the Prenylated Rab Acceptor

  2002cites this paper
• Interaction with simian Hck tyrosine kinase reveals convergent evolution of the Nef protein from simian and human immunodeficiency viruses despite differential molecular surface usage.

  2002cites this paper
• Simian Immunodeficiency Virus Nef Protein Delays the Progression of CD4+ T Cells through G1/S Phase of the Cell Cycle

  2002cites this paper
• Identification of Three NFAT Binding Motifs in the 5′-Upstream Region of the Human CD3γ Gene That Differentially Bind NFATc1, NFATc2, and NF-κB p50*

  2002cites this paper
• Granzyme B-mediated Degradation of T-Cell Receptor Chain1

  2002cites this paper
• Expression of Simian Immunodeficiency Virus nef in Immune Cells of Transgenic Mice Leads to a Severe AIDS-Like Disease

  2002cites this paper
• Granzyme B-mediated degradation of T-cell receptor zeta chain.

  2002cites this paper
• Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes.

  2001cites this paper
• Immune evasion strategies of the primate lentiviruses

  2001cites this paper
• Apoptosis in AIDS

  2001cites this paper
• Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein.

  2001cites this paper
• The HIV-1 Nef protein as a target for antiretroviral therapy

  2001cites this paper
• Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.

  2001cites this paper
• Mechanism for down‐regulation of CD28 by Nef

  2001cites this paper
• Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor.

  2001cites this paper
• Persistence of Pathogenic Challenge Virus in Macaques Protected by Simian Immunodeficiency Virus SIVmacΔnef

  2001cites this paper
• Down-modulation of the costimulatory molecule, CD28, is a conserved activity of multiple SIV Nefs and is dependent on histidine 196 of Nef.

  2001cites this paper
• Cellular Functions of the Human Immunodeficiency Virus Type 1 (HIV-1) Nef Protein

  2001influential citation
• Identification of Protein Kinases Dysregulated in CD4+ T Cells in Pathogenic versus Apathogenic Simian Immunodeficiency Virus Infection

  2001cites this paper
• Down‐modulation of TCR/CD3 surface complexes after HIV‐1 infection is associated with differential expression of the viral regulatory genes

  2001cites this paper
• Mutation of a Conserved Residue (D123) Required for Oligomerization of Human Immunodeficiency Virus Type 1 Nef Protein Abolishes Interaction with Human Thioesterase and Results in Impairment of Nef Biological Functions

  2000cites this paper
• Induction of long-term protective effects against heterologous challenge in SIVhu-infected macaques.

  2000cites this paper
• Characterization and molecular basis of the oligomeric structure of HIV‐1 Nef protein

  2000cites this paper
• HIV accessory proteins: multifunctional components of a complex system.

  2000cites this paper
• Interactions of HIV-1 NEF with cellular signal transducing proteins.

  2000cites this paper
• HIV auxiliary proteins: an interface between the virus and the host.

  2000cites this paper
• The T-Cell Receptor ζ Chain Contains Two Homologous Domains with Which Simian Immunodeficiency Virus Nef Interacts and Mediates Down-Modulation

  2000influential citation
• Activation of the PAK-Related Kinase by Human Immunodeficiency Virus Type 1 Nef in Primary Human Peripheral Blood Lymphocytes and Macrophages Leads to Phosphorylation of a PIX-p95 Complex

  1999cites this paper
• Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1

  1999cites this paper
• The Human Immunodeficiency Virus Type 1nef Gene Can to a Large Extent Replace Simian Immunodeficiency Virus nef In Vivo

  1999cites this paper
• Induction of Fas Ligand Expression by HIV Involves the Interaction of Nef with the T Cell Receptor (cid:122) Chain By

  1999cites this paper
• HIV and SIV Nef modulate signal transduction and protein sorting in T cells.

  1999cites this paper
• Pathogenesis of simian immunodeficiency virus infection.

  1999influential citation
• Induction of Fas Ligand Expression by HIV Involves the Interaction of Nef with the T Cell Receptor ζ Chain

  1999cites this paper
• Send Orders of Reprints at Reprints@benthamscience.net T-cell Signaling in Hiv-1 Infection

  year unknowncites this paper