Interactions of HIV-1 NEF with cellular signal transducing proteins.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Frontiers in Bioscience

• Publication date

  2000-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2741/RENKEMAPMID 10704155
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection.

  2000cited by this paper
• Association of Nef with the Human Immunodeficiency Virus Type 1 Core

  1999cited by this paper
• Identification of the Nef-associated kinase as p21-activated kinase 2.

  1999cited by this paper
• The primate lentivirus-encoded Nef protein can regulate several steps of the viral replication cycle.

  1999cited by this paper
• The HIV Nef Protein Alters Ca2+ Signaling in Myelomonocytic Cells through SH3-mediated Protein-Protein Interactions*

  1999cited by this paper
• Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB*

  1999cited by this paper
• Nef-Induced CD4 and Major Histocompatibility Complex Class I (MHC-I) Down-Regulation Are Governed by Distinct Determinants: N-Terminal Alpha Helix and Proline Repeat of Nef Selectively Regulate MHC-I Trafficking

  1999cited by this paper
• Induction of Fas Ligand Expression by HIV Involves the Interaction of Nef with the T Cell Receptor ζ Chain

  1999cited by this paper
• Two elements target SIV Nef to the AP‐2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis

  1999cited by this paper
• Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Nef Proteins Show Distinct Patterns and Mechanisms of Src Kinase Activation

  1999cited by this paper
• Lack of negative influence on the cellular transcription factors NF-kappaB and AP-1 by the nef protein of human immunodeficiency virus type 1.

  1999cited by this paper
• SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques.

  1999cited by this paper
• The Human Immunodeficiency Virus Type 1nef Gene Can to a Large Extent Replace Simian Immunodeficiency Virus nef In Vivo

  1999cited by this paper
• Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4.

  1999cited by this paper
• Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1

  1999cited by this paper
• Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events.

  1999cited by this paper
• p21-activated protein kinase: a crucial component of morphological signaling?

  1999cited by this paper
• Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein.

  1999cited by this paper
• Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions.

  1999influential reference
• The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes.

  1999cited by this paper
• HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.

  1999cited by this paper
• The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells.

  1999cited by this paper
• Cell Surface CD4 Inhibits HIV-1 Particle Release by Interfering with Vpu Activity*

  1999cited by this paper
• HIV-1 Nef increases T cell activation in a stimulus-dependent manner.

  1999cited by this paper
• Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway.

  1999cited by this paper
• HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages

  1999cited by this paper
• Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.

  1999cited by this paper
• Costimulatory Pathways in Lymphocyte Proliferation Induced by the Simian Immunodeficiency Virus SIVsmmPBj14

  1998cited by this paper
• Functions of SH2 and SH3 domains.

  1998cited by this paper
• Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation.

  1998influential reference
• Lymphocyte signalling: a coordinating role for Vav?

  1998cited by this paper
• The Proteolytic Cleavage of Human Immunodeficiency Virus Type 1 Nef Does Not Correlate with Its Ability To Stimulate Virion Infectivity

  1998cited by this paper
• A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.

  1998cited by this paper
• Grossly Defective nef Gene Sequences in a Human Immunodeficiency Virus Type 1-Seropositive Long-Term Nonprogressor

  1998cited by this paper
• Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice.

  1998cited by this paper
• A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.

  1998cited by this paper
• Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules.

  1998cited by this paper
• Zeta Chain of the T-Cell Receptor Interacts with nef of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2

  1998cited by this paper
• Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation.

  1998cited by this paper
• Nef--an adaptor adaptor?

  1998cited by this paper
• HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

  1998cited by this paper
• Mechanism of Nef‐induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes

  1998cited by this paper
• Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.

  1998cited by this paper
• The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism.

  1998cited by this paper
• RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.

  1998influential reference
• The p21Rac/Cdc42-activated kinases (PAKs).

  1998cited by this paper
• Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14.

  1998cited by this paper
• Virion Incorporation of Human Immunodeficiency Virus Type 1 Nef Is Mediated by a Bipartite Membrane-Targeting Signal: Analysis of Its Role in Enhancement of Viral Infectivity

  1998cited by this paper
• The SH3 domain‐binding surface and an acidic motif in HIV‐1 Nef regulate trafficking of class I MHC complexes

  1998cited by this paper
• Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4.

  1998cited by this paper
• Binding of c-Raf1 Kinase to a Conserved Acidic Sequence within the Carboxyl-terminal Region of the HIV-1 Nef Protein*

  1998cited by this paper
• SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase.

  1998influential reference
• Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation

  1997cited by this paper
• Nef-mediated Clathrin-coated Pit Formation

  1997cited by this paper
• The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix

  1997cited by this paper
• Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

  1997influential reference
• Crystal structure of the Src family tyrosine kinase Hck

  1997cited by this paper
• Three-dimensional structure of the tyrosine kinase c-Src

  1997influential reference
• SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1*

  1997influential reference
• The nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable

  1997cited by this paper
• Protein Kinase C-mediated Phosphorylation of HIV-I Nef in Human Cell Lines*

  1997cited by this paper
• The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane.

  1997cited by this paper
• Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques

  1997cited by this paper
• Human immunodeficiency virus type I Nef independently affects virion incorporation of major histocompatibility complex class I molecules and virus infectivity.

  1997cited by this paper
• HIV‐1 Nef protein: Purification, crystallizations, and preliminary X‐ray diffraction studies

  1997cited by this paper
• The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase.

  1997cited by this paper
• Evasion of Cytotoxic T Lymphocyte (CTL) Responses by Nef-dependent Induction of Fas Ligand (CD95L) Expression on Simian Immunodeficiency Virus–infected Cells

  1997cited by this paper
• Co‐localization of HIV‐1 Nef with the AP‐2 adaptor protein complex correlates with Nef‐induced CD4 down‐regulation

  1997cited by this paper
• Macrophages as a source of HIV during opportunistic infections.

  1997cited by this paper
• Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4

  1997cited by this paper
• A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation

  1997cited by this paper
• Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate

  1997cited by this paper
• Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4.

  1997cited by this paper
• Intravirion generation of the C-terminal core domain of HIV-1 Nef by the HIV-1 protease is insufficient to enhance viral infectivity.

  1997cited by this paper
• The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.

  1997influential reference
• Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus

  1997cited by this paper
• Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

  1997influential reference
• Nef and the Nef-associated kinase.

  1997cited by this paper
• Interference of HIV‐1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor‐α in human glial cells

  1997cited by this paper
• Emerging from the Pak: the p21-activated protein kinase family.

  1997cited by this paper
• Structures of Src-family tyrosine kinases.

  1997cited by this paper
• Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

  1997cited by this paper
• Binding of HIV-1 Nef to a Novel Thioesterase Enzyme Correlates with Nef-mediated CD4 Down-regulation*

  1997cited by this paper
• Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

  1996cited by this paper
• Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.

  1996influential reference
• The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

  1996cited by this paper
• Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

  1996cited by this paper
• Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation.

  1996cited by this paper
• The HIV Nef Protein Associates with Protein Kinase C Theta*

  1996cited by this paper
• Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase.

  1996cited by this paper
• Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.

  1996cited by this paper
• Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques.

  1996cited by this paper
• Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

  1996cited by this paper
• Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family

  1996cited by this paper
• Replication of HIV-1 in Dendritic Cell-Derived Syncytia at the Mucosal Surface of the Adenoid

  1996cited by this paper
• Physical and Functional Interaction of Nef with Lck

  1996influential reference
• The HIV-1 Nef Protein Interferes with Phosphatidylinositol 3-Kinase Activation 1 (*)

  1996cited by this paper
• CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

  1996influential reference
• Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways.

  1996cited by this paper
• Evidence for intact CD28 signaling in T cell hyporesponsiveness induced by the HIV‐1 nef gene

  1996cited by this paper

• Novel role of HIV-1 Nef in regulating the ubiquitination of cellular proteins

  2023cites this paper
• Computer-aided de novo design and optimization of novel potential inhibitors of HIV-1 Nef protein

  2023cites this paper
• Apoptosis regulation by the tyrosine-protein kinase CSK

  2022cites this paper
• Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes

  2020cites this paper
• Post-translational modifications inducing proteasomal degradation to counter HIV-1 infection.

  2020cites this paper
• Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

  2019cites this paper
• Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers.

  2019cites this paper
• HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection

  2019cites this paper
• T cell polarization and immunological synapses : from antigen recognition to virus spread

  2018cites this paper
• Determining the Molecular Mechanisms of PACS-1-mediated Protein Sorting

  2018cites this paper
• The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis.

  2017cites this paper
• SERINC as a Restriction Factor to Inhibit Viral Infectivity and the Interaction with HIV

  2017cites this paper
• HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.

  2016cites this paper
• Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

  2016cites this paper
• Proline-rich peptides: multifunctional bioactive molecules as new potential therapeutic drugs.

  2015cites this paper
• Viral Bimolecular Fluorescence Complementation: A Novel Tool to Study Intracellular Vesicular Trafficking Pathways

  2015cites this paper
• Nef, the shuttling molecular adaptor of HIV, influences the cytokine network.

  2015cites this paper
• Viremic long-term nonprogressive HIV-1 infection is not associated with abnormalities in known Nef functions

  2014cites this paper
• Plasma membrane signaling in HIV-1 infection.

  2014cites this paper
• Examining the function of primary HIV-1 Nef isolates in the setting of viral control

  2014cites this paper
• Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment*

  2014cites this paper
• Development and Validation of a High-Content Bimolecular Fluorescence Complementation Assay for Small-Molecule Inhibitors of HIV-1 Nef Dimerization

  2014cites this paper
• The Accessory Factor Nef Links HIV-1 to Tec/Btk Kinases in an Src Homology 3 Domain-dependent Manner*♦

  2014cites this paper
• Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.

  2013cites this paper
• Conformational transition of membrane-associated terminally acylated HIV-1 Nef.

  2013cites this paper
• HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

  2012cites this paper
• HIV-1 Nef-mediated T-cell activation and chemotaxis are decoupled using a HIV-1/SIVpbj1.9. chimeric nef variant

  2012cites this paper
• HIV-1 Nef-Src Family Kinase Interaction: A Novel Target for the Inhibition of HIV-1 Pathogenesis

  2012cites this paper
• Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive Manner

  2012cites this paper
• Natural SIV Infection

  2012cites this paper
• HIV-1 NEF: THERAPEUTIC STRATEGIES AND VIROLOGICAL SYNAPSE-MEDIATED INFECTION

  2011cites this paper
• Conformation of the Dileucine‐Based Sorting Motif in HIV‐1 Nef Revealed by Intermolecular Domain Assembly

  2011cites this paper
• The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes.

  2011cites this paper
• Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2

  2011cites this paper
• HIV-1 Nef Transfer and Intracellular Signalling in Uninfected Cells

  2011cites this paper
• Tetherin antagonism by primate lentiviral nef proteins.

  2011cites this paper
• Structure, dynamics, and Hck interaction of full‐length HIV‐1 Nef

  2011cites this paper
• Human immunodeficiency virus‐1 Nef suppresses Hsp70‐mediated Tat activation

  2011cites this paper
• Exogenous Nef Is an Inhibitor of Mycobacterium tuberculosis-induced Tumor Necrosis Factor-α Production and Macrophage Apoptosis*

  2010cites this paper
• Inhibition of Human Immunodeficiency Virus Type 1 by Triciribine Involves the Accessory Protein Nef

  2010cites this paper
• HIV-1 NEF: THERAPEUTIC STRATEGIES AND VIROLOGICAL

  2010cites this paper
• Single Vector System for Efficient N-myristoylation of Recombinant Proteins in E. coli

  2010cites this paper
• HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.

  2009cites this paper
• Combined effects of hyperglycemic conditions and HIV-1 Nef: a potential model for induced HIV neuropathogenesis

  2009cites this paper
• The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

  2009cites this paper
• Sam68, stress granules, and translational control of HIV-1 nef mRNA

  2009cites this paper
• Nef-mediated primate lentiviral immune evasion mechanisms

  2009cites this paper
• Expression, localisation and functional activation of NFAT-2 in normal human skin, psoriasis, and cultured keratocytes.

  2009cites this paper
• Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds.

  2009cites this paper
• Implications of Nef: host cell interactions in viral persistence and progression to AIDS.

  2009influential citation
• Conservation of Nef function across highly diverse lineages of SIVsmm

  2009cites this paper
• Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?

  2009cites this paper
• At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.

  2009cites this paper
• Bimolecular Fluorescence Complementation Reveals that HIV-1 Nef Oligomerization is Essential for CD4 Downregulation and Viral Replication

  2009cites this paper
• PAPEL DE LAS PROTEÍNAS REGULADORAS Y ACCESORIAS DEL VIH-1 EN LA PATOGÉNESIS DE ESA INFECCIÓN Role of the regulatory and accesory proteins of HIV-1 in its pathogenisis

  2009cites this paper
• Insights into the selective activation of alternatively used splice acceptors by the human immunodeficiency virus type-1 bidirectional splicing enhancer

  2008cites this paper
• Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?

  2008cites this paper
• Role of Nef in primate lentiviral immunopathogenesis

  2008cites this paper
• Structure and dynamic regulation of Src-family kinases

  2008cites this paper
• HIV-1 Transmission, Replication Fitness and Disease Progression

  2008cites this paper
• HIV-1 Nef Binds PACS-2 to Assemble a Multikinase Cascade That Triggers Major Histocompatibility Complex Class I (MHC-I) Down-regulation

  2008cites this paper
• HIV Nef: role in pathogenesis and viral fitness.

  2008cites this paper
• Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?

  2008cites this paper
• The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages.

  2007cites this paper
• Commitment to Apoptosis in CD4+ T Lymphocytes Productively Infected with Human Immunodeficiency Virus Type 1 Is Initiated by Lysosomal Membrane Permeabilization, Itself Induced by the Isolated Expression of the Viral Protein Nef

  2007cites this paper
• T Cell Polarization and the Formation of Immunological Synapses: From Antigen Recognition to Virus Spread

  2007cites this paper
• Hydrogen/deuterium exchange mass spectrometry: potential for investigating innate immunity proteins.

  2007cites this paper
• Association of Nef with p21-Activated Kinase 2 Is Dispensable for Efficient Human Immunodeficiency Virus Type 1 Replication and Cytopathicity in Ex Vivo-Infected Human Lymphoid Tissue

  2007cites this paper
• POSITIVE AND NEGATIVE REGULATION OF HIV REPLICATION IN MACROPHAGES: ROLE OF RON RECEPTOR TYROSINE KINASE

  2007cites this paper
• Polymorphisms in Nef Associated with Different Clinical Outcomes in HIV Type 1 Subtype C-Infected Children

  2007cites this paper
• Role of Nef in HIV-1 replication and pathogenesis.

  2007cites this paper
• Float on: lipid rafts in the lifecycle of HIV.

  2007cites this paper
• Competitive displacement of full-length HIV-1 Nef from the Hck SH3 domain by a high-affinity artificial peptide

  2007cites this paper
• Nef-Mediated Enhancement of Virion Infectivity and Stimulation of Viral Replication Are Fundamental Properties of Primate Lentiviruses

  2007cites this paper
• Human Immunodeficiency Virus Type 1 Nef Recruits the Guanine Exchange Factor Vav1 via an Unexpected Interface into Plasma Membrane Microdomains for Association with p21-Activated Kinase 2 Activity

  2007cites this paper
• Anti-CD45RO Suppresses Human Immunodeficiency Virus Type 1 Replication in Microglia: Role of Hck Tyrosine Kinase and Implications for AIDS Dementia

  2006cites this paper
• Activation of p21-activated Kinase 2 and Its Association with Nef Are Conserved in Murine Cells but Are Not Sufficient to Induce an AIDS-like Disease in CD4C/HIV Transgenic Mice*

  2006cites this paper
• HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner

  2006cites this paper
• Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef.

  2006cites this paper
• A Hydrophobic Binding Surface on the Human Immunodeficiency Virus Type 1 Nef Core Is Critical for Association with p21-Activated Kinase 2

  2006influential citation
• Protein kinase CK2 phosphorylates the Nef protein from a neurovirulent simian immunodeficiency virus.

  2006cites this paper
• SELECTIVE ACTIVATION OF SRC FAMILY KINASES BY THE HIV-1 NEF PROTEIN

  2006cites this paper
• Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.

  2006cites this paper
• Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, Nef

  2006cites this paper
• Expression of simian immunodeficiency virus Nef protein in CD4+ T cells leads to a molecular profile of viral persistence and immune evasion.

  2006cites this paper
• Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry.

  2006cites this paper
• Production of recombinant HIV‐1 Nef (negative factor) protein using Pichia pastoris and a low‐temperature fed‐batch strategy

  2006cites this paper
• Insights into the membrane proteome of rat liver peroxisomes: Microsomal glutathione‐S‐transferase is shared by both subcellular compartments

  2006cites this paper
• HIV-1 Nef Selectively Activates Src Family Kinases Hck, Lyn, and c-Src through Direct SH3 Domain Interaction*

  2006cites this paper
• Signal transduction induced by apoptotic cells inhibits HIV transcription in monocytes/macrophages

  2006cites this paper
• Ligand Recognition in SH 3-mediated Protein Interactions

  2005influential citation
• Ligand recognition in SH3-mediated protein interactions

  2005cites this paper
• Phosphorylation of HIV Nef by cAMP-dependent protein kinase.

  2005cites this paper
• Mapping the binding site of full length HIV-1 Nef on human Lck SH3 by NMR spectroscopy.

  2005cites this paper
• Genetic analysis of human immunodeficiency virus type 1 nef in portugal: Subtyping, identification of mosaic genes, and amino acid sequence variability

  2005influential citation
• Co‐translational myristoylation alters the quaternary structure of HIV‐1 Nef in solution

  2005cites this paper
• The Pennsylvania State University The Graduate School The Huck Institutes of the Life Sciences REQUIREMENT AND APPROPRIATION OF ACTIVATING SIGNALS BY HIV-1 IN INFECTED CD4+ T CELLS

  2005cites this paper
• REQUIREMENT AND APPROPRIATION OF ACTIVATING SIGNALS BY HIV-1 IN INFECTED CD4+ T CELLS

  2005cites this paper
• Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes.

  2005cites this paper
• Nef protein of human immunodeficiency virus type 1 binds its own myristoylated N-terminus

  2005cites this paper