Mechanism of Nef‐induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes

No abstract is available for this paper.

• Publication year

  1998

• Venue

  EMBO Journal

• Publication date

  1998-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/17.9.2472PMID 9564030PMCID PMC1170589
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

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• Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

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• The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane.

  1997cited by this paper
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  1997cited by this paper
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• Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin

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• Nef-mediated Clathrin-coated Pit Formation

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• Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

  1996cited by this paper
• Interaction of Shc with Adaptor Protein Adaptins (*)

  1996cited by this paper
• Nef-CD4 physical interaction sensed with the yeast two-hybrid system.

  1996cited by this paper
• The Ear of -Adaptin Interacts with the COOH-terminal Domain of the Eps15 Protein (*)

  1996cited by this paper
• Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor.

  1996influential reference
• NEF-CD 4 Physical Interaction Sensed with the Yeast Two-Hybrid System

  1996cited by this paper
• Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation.

  1996cited by this paper
• Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

  1996cited by this paper
• Structural Determinants of Interaction of Tyrosine-based Sorting Signals with the Adaptor Medium Chains*

  1996cited by this paper
• The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

  1996cited by this paper
• The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.

  1996cited by this paper
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  1995influential reference
• Analyzing protein-protein interactions using two-hybrid system.

  1995cited by this paper
• Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection.

  1995cited by this paper
• Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail.

  1995cited by this paper
• Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines

  1995cited by this paper
• Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

  1995cited by this paper
• Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

  1995cited by this paper
• Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

  1995cited by this paper
• Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4

  1994cited by this paper
• Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.

  1994cited by this paper
• The role of clathrin, adaptors and dynamin in endocytosis.

  1994cited by this paper
• Myristoylation-dependent binding of HIV-1 Nef to CD4.

  1994cited by this paper
• Endocytosis of ß2 integrins by stimulated human neutrophils analyzed by flow cytometry

  1993cited by this paper
• The appendage domain of the AP-2 subunit is not required for assembly or invagination of clathrin-coated pits

  1993cited by this paper
• Signal-dependent membrane protein trafficking in the endocytic pathway.

  1993cited by this paper
• The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

  1993cited by this paper
• The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.

  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
• Importance of the nef gene for maintenance of high virus loads and for development of AIDS.

  1991cited by this paper
• Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells

  1991cited by this paper
• Endocytosis and transcytosis.

  1990cited by this paper
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  1989influential reference
• Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infection.

  1989cited by this paper
• HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

  1987cited by this paper
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  1985cited by this paper

• Assembly of CCR5 with gp120 inhibits the HIV infectivity specifically in T cells

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• Post-translational modifications inducing proteasomal degradation to counter HIV-1 infection.

  2020cites this paper
• HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection

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• Multifunctional Roles of the N-Terminal Region of HIV-1SF2Nef Are Mediated by Three Independent Protein Interaction Sites

  2019cites this paper
• HIV‐1 Nef and host proteome analysis: Current perspective

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• Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle

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• Anti-HIV microRNA expression in a novel Indian cohort

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• HIV‐1 Nef: Taking Control of Protein Trafficking

  2016cites this paper
• HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms

  2015cites this paper
• Roles of autophagy in HIV infection

  2015cites this paper
• The human homologue of the bovine leukemia virus receptor BLVRcp1 is the δ-subunit of adaptor-related AP-3 protein that does not bind the BVLgp51

  2014cites this paper
• Functional Comparison of HIV-1 Vpu Alleles Derived from Elite Controller and Chronic Progressor Patients

  2014cites this paper
• The activity of Nef on HIV-1 infectivity

  2014cites this paper
• HIV-1 Nef Down-Modulates C-C and C-X-C Chemokine Receptors via Ubiquitin and Ubiquitin-Independent Mechanism

  2014cites this paper
• Replication In Vivo Attenuates Simian Immunodeficiency Virus Enhancement of Virion Infectivity Downregulation of CD4 and for Disrupting Surfaces of Nef Required for

  2014cites this paper
• The Nef-Like Effect of Murine Leukemia Virus Glycosylated Gag on HIV-1 Infectivity Is Mediated by Its Cytoplasmic Domain and Depends on the AP-2 Adaptor Complex

  2014cites this paper
• Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania

  2013cites this paper
• Feline restriction factors to lentiviral replication

  2013cites this paper
• HIV’s Nef Interacts with β-Catenin of the Wnt Signaling Pathway in HEK293 Cells

  2013cites this paper
• Advances in HIV-1 Assembly and Release

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• HIV-1 Nef-Src Family Kinase Interaction: A Novel Target for the Inhibition of HIV-1 Pathogenesis

  2012cites this paper
• HIV-1 Nef Disrupts Intracellular Trafficking of Major Histocompatibility Complex Class I, CD4, CD8, and CD28 by Distinct Pathways That Share Common Elements

  2011influential citation
• Caracterização da interação de proteínas celulares envolvidas na degradação de Cd4 mediada por diferentes alelos da proteína Nef do Hiv-1

  2011influential citation
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  2011cites this paper
• Functions of the Lentiviral Accessory Protein Nef During the Distinct Steps of HIV and SIV Replication Cycle

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• Two Sorting Motifs, a Ubiquitination Motif and a Tyrosine Motif, Are Involved in HIV-1 and Simian Immunodeficiency Virus Nef-Mediated Receptor Endocytosis

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• HIV immune evasion disruption of antigen presentation by the HIV Nef protein.

  2011cites this paper
• Mechanisms by which HIV-1 Nef disrupts the intracellular trafficking of host proteins

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• The Vpu protein: new concepts in virus release and CD4 down-modulation.

  2010cites this paper
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  2010cites this paper
• HIV-1 Nef Binds a Subpopulation of MHC-I throughout Its Trafficking Itinerary and Down-regulates MHC-I by Perturbing Both Anterograde and Retrograde Trafficking*

  2010cites this paper
• Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.

  2010cites this paper
• Nef-mediated primate lentiviral immune evasion mechanisms

  2009cites this paper
• Nef-Induced CD 4 Endocytosis in Human Immunodeficiency Virus Type 1 Host Cells : Role of p 56 lck Kinase §

  2009influential citation
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  2009cites this paper
• Implications of Nef: host cell interactions in viral persistence and progression to AIDS.

  2009cites this paper
• Nef-Induced CD4 Endocytosis in Human Immunodeficiency Virus Type 1 Host Cells: Role of p56lck Kinase

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• PAPEL DE LAS PROTEÍNAS REGULADORAS Y ACCESORIAS DEL VIH-1 EN LA PATOGÉNESIS DE ESA INFECCIÓN Role of the regulatory and accesory proteins of HIV-1 in its pathogenisis

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• Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells.

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• Nef-Induced CD4 Endocytosis in Human Immunodeficiency Virus Type 1 Host Cells: Role of p56 lck Kinase (cid:1) §

  2009influential citation
• Conservation of Nef function across highly diverse lineages of SIVsmm

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• Lysine 144, a Ubiquitin Attachment Site in HIV-1 Nef, Is Required for Nef-Mediated CD4 Down-Regulation1

  2008cites this paper
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• Role of HIV-1 Vpu protein for virus spread and pathogenesis.

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• HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

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• Intracellular Trafficking of MHC-I in Normal and HIV-1 Nef Expressing Cells.

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• Role of Nef in primate lentiviral immunopathogenesis

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• CD4 Down-Regulation HIV-1 Nef, Is Required for Nef-Mediated Lysine 144, a Ubiquitin Attachment Site in

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• Downregulation of CD4 by Human Immunodeficiency Virus Type 1 Nef Is Dependent on Clathrin and Involves Direct Interaction of Nef with the AP2 Clathrin Adaptor

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
• In Vitro Treatment of Human Monocytes/Macrophages with Myristoylated Recombinant Nef of Human Immunodeficiency Virus Type 1 Leads to the Activation of Mitogen-Activated Protein Kinases, IκB Kinases, and Interferon Regulatory Factor 3 and to the Release of Beta Interferon

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  2006influential citation
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