Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking Pathways

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Microbiology and Molecular Biology Reviews

• Publication date

  2006-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MMBR.00042-05PMID 16760313PMCID PMC1489538
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Infection of Dendritic Cells (DCs), Not DC-SIGN-Mediated Internalization of Human Immunodeficiency Virus, Is Required for Long-Term Transfer of Virus to T Cells

  2006cited by this paper
• HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment.

  2006cited by this paper
• HIV-1 Selectively Infects a Subset of Nonmaturing BDCA1-Positive Dendritic Cells in Human Blood1

  2006cited by this paper
• Intracellular Versus Cell Surface Assembly of Retroviral Pseudotypes Is Determined by the Cellular Localization of the Viral Glycoprotein, Its Capacity to Interact with Gag, and the Expression of the Nef Protein*

  2006cited by this paper
• Human Immunodeficiency Virus Type 1 Nef Domains Required for Disruption of Major Histocompatibility Complex Class I Trafficking Are Also Necessary for Coprecipitation of Nef with HLA-A2

  2005influential reference
• Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.

  2005cited by this paper
• Detection of Human Immunodeficiency Virus Type 1 Nef and CD4 Physical Interaction in Living Human Cells by Using Bioluminescence Resonance Energy Transfer

  2005cited by this paper
• Nef-induced Alteration of the Early/Recycling Endosomal Compartment Correlates with Enhancement of HIV-1 Infectivity*

  2005influential reference
• The Nef Protein of HIV-1 Induces Loss of Cell Surface Costimulatory Molecules CD80 and CD86 in APCs1

  2005cited by this paper
• CD4 Down-regulation by HIV-1 and Simian Immunodeficiency Virus (SIV) Nef Proteins Involves Both Internalization and Intracellular Retention Mechanisms*

  2005cited by this paper
• Human Immunodeficiency Virus Nef Induces Rapid Internalization of the T-Cell Coreceptor CD8αβ

  2005cited by this paper
• HIV‐1 Nef mediates post‐translational down‐regulation and redistribution of the mannose receptor

  2005cited by this paper
• HIV-1 Nef Disrupts Antigen Presentation Early in the Secretory Pathway*

  2005influential reference
• Granzyme B, a New Player in Activation-Induced Cell Death, Is Down-Regulated by Vasoactive Intestinal Peptide in Th2 but Not Th1 Effectors1

  2005cited by this paper
• HIV Nef-Mediated CD4 Down-Regulation Is Adaptor Protein Complex 2 Dependent1

  2005cited by this paper
• Adaptable adaptors for coated vesicles.

  2004cited by this paper
• HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis

  2004cited by this paper
• Nef Binds p6* in GagPol during Replication of Human Immunodeficiency Virus Type 1

  2004cited by this paper
• PI-loting membrane traffic

  2004cited by this paper
• HIV-1 Nef Enhances Both Membrane Expression and Virion Incorporation of Env Products A MODEL FOR THE NEF-DEPENDENT INCREASE OF HIV-1 INFECTIVITY*

  2004cited by this paper
• ARF1 regulates Nef-induced CD4 degradation.

  2004cited by this paper
• HIV-1 Nef Enhances Both Membrane Expression and Virion Incorporation of Env Products

  2004cited by this paper
• Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins

  2004cited by this paper
• CD4 Phosphorylation Partially Reverses Nef Down-Regulation of CD41

  2004cited by this paper
• HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail

  2004cited by this paper
• Crystal structure of the clathrin adaptor protein 1 core.

  2004cited by this paper
• Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus

  2004cited by this paper
• Induction of Direct Endosome to Endoplasmic Reticulum Transport in Chinese Hamster Ovary (CHO) Cells (LdlF) with a Temperature-sensitive Defect in ϵ-Coatomer Protein (ϵ-COP)*

  2003cited by this paper
• Proline 78 Is Crucial for Human Immunodeficiency Virus Type 1 Nef To Down-Regulate Class I Human Leukocyte Antigen

  2003cited by this paper
• HIV-1 Nef Stabilizes the Association of Adaptor Protein Complexes with Membranes*

  2003influential reference
• HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.

  2003influential reference
• HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

  2003cited by this paper
• Visualization of TGN to endosome trafficking through fluorescently labeled MPR and AP-1 in living cells.

  2003cited by this paper
• Induction of direct endosome to endoplasmic reticulum transport in Chinese hamster ovary (CHO) cells (LdlF) with a temperature-sensitive defect in epsilon-coatomer protein (epsilon-COP).

  2003cited by this paper
• Down-Modulation of Mature Major Histocompatibility Complex Class II and Up-Regulation of Invariant Chain Cell Surface Expression Are Well-Conserved Functions of Human and Simian Immunodeficiency Virus nef Alleles

  2003cited by this paper
• Induction of Direct Endosome to Endoplasmic Reticulum Transport in Chinese Hamster Ovary (CHO) Cells (LdlF) with a Temperature-sensitive Defect in (cid:1) -Coatomer Protein ( (cid:1) -COP)*

  2003cited by this paper
• Nef-Mediated Disruption of HLA-A2 Transport to the Cell Surface in T Cells

  2003influential reference
• Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ–σ1 and AP-3 δ–σ3 hemicomplexes

  2003cited by this paper
• Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi.

  2003cited by this paper
• Sorting it out

  2003cited by this paper
• Signals for sorting of transmembrane proteins to endosomes and lysosomes.

  2003cited by this paper
• Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions

  2003cited by this paper
• AP‐1 recruitment to VAMP4 is modulated by phosphorylation‐dependent binding of PACS‐1

  2003cited by this paper
• EpsinR: an ENTH domain-containing protein that interacts with AP-1.

  2003cited by this paper
• The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation.

  2003cited by this paper
• Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase.

  2003cited by this paper
• Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain

  2003cited by this paper
• Effects of HIV‐1 Nef on Retrograde Transport from the Plasma Membrane to the Endoplasmic Reticulum

  2003cited by this paper
• Cooperative Interactions of Simian Immunodeficiency Virus Nef, AP-2, and CD3-ζ Mediate the Selective Induction of T-Cell Receptor-CD3 Endocytosis

  2003cited by this paper
• Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.

  2002cited by this paper
• Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins.

  2002influential reference
• Subunit H of the V-ATPase Involved in Endocytosis Shows Homology to β-Adaptins

  2002cited by this paper
• Nef: agent of cell subversion.

  2002cited by this paper
• HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread.

  2002cited by this paper
• Human Immunodeficiency Virus Type 1 Nef Binds to Tumor Suppressor p53 and Protects Cells against p53-Mediated Apoptosis

  2002cited by this paper
• Subunit H of the V-ATPase Binds to the Medium Chain of Adaptor Protein Complex 2 and Connects Nef to the Endocytic Machinery*

  2002influential reference
• Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics.

  2002cited by this paper
• HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.

  2002influential reference
• The HIV-1 Nef Protein and Phagocyte NADPH Oxidase Activation*

  2002cited by this paper
• Cooperation of GGAs and AP-1 in Packaging MPRs at the Trans-Golgi Network

  2002cited by this paper
• ARF1.GTP, tyrosine-based signals, and phosphatidylinositol 4,5-bisphosphate constitute a minimal machinery to recruit the AP-1 clathrin adaptor to membranes.

  2002cited by this paper
• Direct Binding of Human Immunodeficiency Virus Type 1 Nef to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail Disrupts MHC-I Trafficking

  2002influential reference
• HIV-1 Nef associated PAK and PI3-Kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

  2001cited by this paper
• An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC).

  2001cited by this paper
• Modulation of Different Human Immunodeficiency Virus Type 1 Nef Functions during Progression to AIDS

  2001cited by this paper
• PACS‐1 binding to adaptors is required for acidic cluster motif‐mediated protein traffic

  2001cited by this paper
• Structure–function relationships in HIV‐1 Nef

  2001influential reference
• HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.

  2001cited by this paper
• Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity.

  2001influential reference
• Domain assembly, surface accessibility and sequence conservation in full length HIV‐1 Nef

  2001cited by this paper
• Efficient Class I Major Histocompatibility Complex Down-Regulation by Simian Immunodeficiency Virus Nef Is Associated with a Strong Selective Advantage in Infected Rhesus Macaques

  2001cited by this paper
• Nef increases infectivity of HIV via lipid rafts.

  2001cited by this paper
• Mechanism for down‐regulation of CD28 by Nef

  2001cited by this paper
• HIV Nef-mediated Cellular Phenotypes Are Differentially Expressed as a Function of Intracellular NEF Concentrations*

  2001cited by this paper
• Recruitment of coat-protein-complex proteins on to phagosomal membranes is regulated by a brefeldin A-sensitive ADP-ribosylation factor.

  2001cited by this paper
• HIV-1 Nef impairs MHC class II antigen presentation and surface expression

  2001cited by this paper
• Hck SH3 domain‐dependent abrogation of Nef‐induced class 1 MHC down‐regulation

  2001cited by this paper
• Nef-Induced CD4 Downregulation: a Diacidic Sequence in Human Immunodeficiency Virus Type 1 Nef Does Not Function as a Protein Sorting Motif through Direct Binding to β-COP

  2001cited by this paper
• Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein.

  2001cited by this paper
• Direct In Vitro Binding of Full-Length Human Immunodeficiency Virus Type 1 Nef Protein to CD4 Cytoplasmic Domain

  2001cited by this paper
• HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

  2001cited by this paper
• Traffic COPs of the Early Secretory Pathway

  2000cited by this paper
• The plasma membrane as a combat zone in the HIV battlefield.

  2000cited by this paper
• Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif.

  2000influential reference
• Phosphorylation of class I MHC molecules in the absence of phorbol esters is an intracellular event and may be characteristic of trafficking molecules.

  2000cited by this paper
• ARF1 Regulates pH-dependent COP Functions in the Early Endocytic Pathway*

  2000cited by this paper
• Human Immunodeficiency Virus Type 1 Nef Mediates Sustained Membrane Expression of Tumor Necrosis Factor and the Related Cytokine LIGHT on Activated T Cells

  2000cited by this paper
• Nef-Induced Major Histocompatibility Complex Class I Down-Regulation Is Functionally Dissociated from Its Virion Incorporation, Enhancement of Viral Infectivity, and CD4 Down-Regulation

  2000cited by this paper
• HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

  2000influential reference
• Role of COPI in Phagosome Maturation*

  2000cited by this paper
• Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression

  2000cited by this paper
• p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef

  2000cited by this paper
• Distinct Trafficking Pathways Mediate Nef-Induced and Clathrin-Dependent Major Histocompatibility Complex Class I Down-Regulation

  2000cited by this paper
• Two Independent Regions of HIV‐1 Nef are Required for Connection with the Endocytic Pathway Through Binding to the μ1 Chain of AP1 Complex

  2000cited by this paper
• HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.

  1999cited by this paper
• Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions.

  1999cited by this paper
• Induction of Fas Ligand Expression by HIV Involves the Interaction of Nef with the T Cell Receptor ζ Chain

  1999cited by this paper
• Nef-Induced CD4 and Major Histocompatibility Complex Class I (MHC-I) Down-Regulation Are Governed by Distinct Determinants: N-Terminal Alpha Helix and Proline Repeat of Nef Selectively Regulate MHC-I Trafficking

  1999influential reference
• Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking.

  1999cited by this paper
• Identification of the Nef-associated kinase as p21-activated kinase 2.

  1999cited by this paper

• Using common features of viruses and EVs for a novel EV-based lateral flow test for HIV

  2025cites this paper
• HIV-1 Nef activates proviral DNA transcription by recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive function

  2025cites this paper
• Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors

  2025cites this paper
• Reporter-expressing viruses for antiviral drug discovery research

  2025cites this paper
• Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication

  2025cites this paper
• Involvement of Human Cellular Proteins and Structures in Realization of the HIV Life Cycle: A Comprehensive Review, 2024

  2024cites this paper
• HIV vaccination: Navigating the path to a transformative breakthrough—A review of current evidence

  2024cites this paper
• HIV–Host Cell Interactions

  2023cites this paper
• Single Nucleotide Polymorphisms of EXOC1, BCL2, CCAT2, and CARD8 Genes and Susceptibility to Cervical Cancer in the Northern Chinese Han Population

  2022cites this paper
• Analysis of the Cytopathogenic Effect of Different HIV-1 Vpr Isoforms on Primary Human CD4+ T Cells and a Model Cell Line

  2022cites this paper
• Inhibition of HIV-1 immune modulation by small molecules targeting viral Nef-host CD80 interface

  2021cites this paper
• Computational Analysis of Dynamical Fluctuations of Oncoprotein E7 (HPV 16) for the Hot Spot Residue Identification Using Elastic Network Model

  2020cites this paper
• HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation

  2020cites this paper
• Convergent Evolution by Cancer and Viruses in Evading the NKG2D Immune Response

  2020cites this paper
• Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5

  2020cites this paper
• Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques

  2020cites this paper
• Potential of the NKG2D/NKG2DL Axis in NK Cell-Mediated Clearance of the HIV-1 Reservoir

  2019cites this paper
• HIV‐1 Nef and host proteome analysis: Current perspective

  2019cites this paper
• HIV-1 Nef interacts with LMP7 to attenuate immunoproteasome formation and MHC-I antigen presentation

  2019cites this paper
• Multifaceted Roles of TIM-Family Proteins in Virus-Host Interactions.

  2019cites this paper
• The role of exosomal transport of viral agents in persistent HIV pathogenesis

  2018cites this paper
• SERINC5: Its Sensitivity to Nef and Restriction of HIV-1

  2018influential citation
• Determining the Molecular Mechanisms of PACS-1-mediated Protein Sorting

  2018cites this paper
• Computational Analysis of Dynamical Fluctuations of Oncoprotein E7 (HPV) for the Hot Spot Residue Identification Using Elastic Network Model

  2018cites this paper
• HIV-1 Nef CAWLEAQ motif: a regulator of monocytes invasion through ENO1 modulation

  2018cites this paper
• Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses

  2018cites this paper
• Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV‐1 CRF01_AE to downmodulate CD4

  2017cites this paper
• The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis.

  2017influential citation
• Construcción de un Vector de Virus de Planta Portando una Secuencia Mutagenizada del GEN NEF Del HIV-1

  2017cites this paper
• The histone deacetylase inhibitor SAHA simultaneously reactivates HIV-1 from latency and up-regulates NKG2D ligands sensitizing for natural killer cell cytotoxicity.

  2017cites this paper
• S 2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC 5 and SERINC 3

  2017cites this paper
• Dysregulation of neurogranin, a neuron specific factor, in HIV-1 positive subjects and its implications in HIV-1 associated neurocognitive disorders

  2017cites this paper
• Exosomes from Nef expressing monocytic cells restrict HIV-1 replication in infected cells through the assembly of stress granules

  2017cites this paper
• The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild.

  2016cites this paper
• Role of Serum Adenosine Deaminase Activity as a Prognostic Marker in HIV Patients on Antiretroviral Therapy : A Prospective Study

  2016cites this paper
• S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3

  2016cites this paper
• Construction and characterization of HIV type 1 CRF07_BC infectious molecular clone from men who have sex with men.

  2016cites this paper
• HIV Genome-Wide Protein Associations: a Review of 30 Years of Research

  2016cites this paper
• Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex

  2016cites this paper
• Tools and applications for DNA sequencing in the clinical management of viral infectious diseases : examples from HIV-1 and HCV

  2015influential citation
• Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor

  2015cites this paper
• HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes

  2015influential citation
• AP-2 Is the Crucial Clathrin Adaptor Protein for CD4 Downmodulation by HIV-1 Nef in Infected Primary CD4+ T Cells

  2015cites this paper
• Roles of autophagy in HIV infection

  2015influential citation
• UC Office of the President Recent Work Title Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

  2015cites this paper
• Nef, the shuttling molecular adaptor of HIV, influences the cytokine network.

  2015cites this paper
• Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors

  2015cites this paper
• Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1 ?

  2015cites this paper
• Viral Bimolecular Fluorescence Complementation: A Novel Tool to Study Intracellular Vesicular Trafficking Pathways

  2015cites this paper
• Proteomic Profiling of SupT1 Cells Reveal Modulation of Host Proteins by HIV-1 Nef Variants

  2015cites this paper
• Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

  2015cites this paper
• HIV-1 Nef and Vpu Are Functionally Redundant Broad-Spectrum Modulators of Cell Surface Receptors, Including Tetraspanins

  2014cites this paper
• Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication.

  2014cites this paper
• Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection

  2014cites this paper
• Targeting of CD 4 Receptor Host Protein Alix Promotes Lysosomal Interaction of HIV-1 Nef Protein with the Cell Biology :

  2014cites this paper
• Interaction of HIV-1 Nef Protein with the Host Protein Alix Promotes Lysosomal Targeting of CD4 Receptor*

  2014cites this paper
• HIV-1 accessory proteins: Nef.

  2014cites this paper
• High levels of anti-Nef antibodies may prevent AIDS disease progression in vertically HIV-1-infected infants

  2014cites this paper
• HIV-1 Protein Nef Inhibits Activity of ATP-binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin*

  2014cites this paper
• Modulating Autophagy to Cure Human Immunodeficiency Virus type‐1

  2014cites this paper
• Body Pathway Protein Targets CD4 to the Multivesicular Human Immunodeficiency Virus Type 1 Nef

  2014cites this paper
• Systematic Analysis of Intracellular Trafficking Motifs Located within the Cytoplasmic Domain of Simian Immunodeficiency Virus Glycoprotein gp41

  2014cites this paper
• Hipertensión pulmonar asociada a HIV

  2014cites this paper
• Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

  2014cites this paper
• A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

  2013cites this paper
• Inhibition of human immunodeficiency virus type-1 through autophagy.

  2013cites this paper
• Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis

  2013influential citation
• Development of strategies to find inhibitors of HIV-1 Nef cellular interaction partners

  2013cites this paper
• Innate immune mechanisms in limiting HIV-1 pathogenesis among South African adults and mother-infant pairs.

  2013cites this paper
• Quantitative Proteomic Analysis of HIV Infection

  2013cites this paper
• Identification of a Novel Binding Site Between HIV Type 1 Nef C-Terminal Flexible Loop and AP2 Required for Nef-Mediated CD4 Downregulation

  2013cites this paper
• Feline restriction factors to lentiviral replication

  2013cites this paper
• The frantic play of the concealed HIV envelope cytoplasmic tail

  2013cites this paper
• HIV-1 Infection of T Cells and Macrophages Are Differentially Modulated by Virion-Associated Hck: A Nef-Dependent Phenomenon

  2013cites this paper
• Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.

  2012cites this paper
• Brain Transcriptome-Wide Screen for HIV-1 Nef Protein Interaction Partners Reveals Various Membrane-Associated Proteins

  2012cites this paper
• Novel Determinant of Binding to AP-2 Immunodeficiency Virus Type 1 Nef Is a A Diacidic Motif in Human

  2012cites this paper
• Miniseries : Illustrating the Machinery of Life : Viruses *

  2012cites this paper
• Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation

  2012influential citation
• HIV-1 Nef Impairs Heterotrimeric G-protein Signaling by Targeting Gαi2 for Degradation through Ubiquitination*

  2012cites this paper
• Dual role of autophagy in HIV-1 replication and pathogenesis

  2012cites this paper
• Evolutionary Models for the Human Immunodeficiency Virus with Applications to Epitope Prediction and the Natural Selection of Escape Variants

  2012cites this paper
• The Human Immunodeficiency Virus Type 1 Nef and Vpu Proteins Downregulate the Natural Killer Cell-Activating Ligand PVR

  2012cites this paper
• The Determinants of CD8+ Cytotoxic T Lymphocyte Antiviral Activity Against Human Immunodeficiency Virus Type 1

  2012cites this paper
• HIV‐1, ubiquitin and ubiquitin‐like proteins: the dialectic interactions of a virus with a sophisticated network of post‐translational modifications

  2012cites this paper
• Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling

  2012cites this paper
• THE ROLE OF EARLY CYTOTOXIC LYMPHOCYTE (CTL) ESCAPE IN THE PATHOGENESIS OF HIV-1 SUBTYPE C INFECTION

  2012cites this paper
• HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux[S]

  2012cites this paper
• Natural SIV Infection

  2012cites this paper
• Proteomic analysis of HIV–T cell interaction: an update

  2012cites this paper
• Structural Studies of Saccharomyces cerevisiae V1-ATPase in the Stationary Phase of Yeast Cell Culture

  2012cites this paper
• Pathogenesis of HIV-Associated Pulmonary Hypertension

  2012cites this paper
• Exogenous Nef Induces Proinflammatory Signaling Events in Murine Macrophages

  2012cites this paper
• HIV-1 Nef: a multifaceted modulator of T cell receptor signaling

  2012cites this paper
• HIV immune evasion disruption of antigen presentation by the HIV Nef protein.

  2011cites this paper
• Nef does not inhibit F-actin remodelling and HIV-1 cell-cell transmission at the T lymphocyte virological synapse.

  2011cites this paper
• Role of the CD4 down-modulation activity of Nef in HIV-1 infectivity.

  2011cites this paper
• HIV-1 NEF: THERAPEUTIC STRATEGIES AND VIROLOGICAL SYNAPSE-MEDIATED INFECTION

  2011cites this paper
• Functions of the Lentiviral Accessory Protein Nef During the Distinct Steps of HIV and SIV Replication Cycle

  2011influential citation
• HIV-1 Nef Transfer and Intracellular Signalling in Uninfected Cells

  2011cites this paper