Cell Cycle Regulation by Oncogenic Tyrosine Kinases in Myeloid Neoplasias: From Molecular Redox Mechanisms to Health Implications

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2008-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/ars.2008.2071PMID 18593226
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protein Carbonylation as a Novel Mechanism in Redox Signaling

  2008cited by this paper
• Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML.

  2008cited by this paper
• Shared principles in NF-kappaB signaling.

  2008cited by this paper
• DNA Damage and Repair: From Molecular Mechanisms to Health Implications

  2008cited by this paper
• The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.

  2008cited by this paper
• Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.

  2007influential reference
• Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy.

  2007cited by this paper
• FOXO3a Induces Differentiation of Bcr-Abl-transformed Cells through Transcriptional Down-regulation of Id1*

  2007cited by this paper
• Foxo3 is required for the regulation of oxidative stress in erythropoiesis.

  2007cited by this paper
• Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

  2007cited by this paper
• Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2.

  2007cited by this paper
• Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death.

  2007cited by this paper
• Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

  2007cited by this paper
• Differential Toxic Mechanisms of 2-Deoxy-D-Glucose versus 2-Fluorodeoxy-D -Glucose in Hypoxic and Normoxic Tumor Cells

  2007cited by this paper
• Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor.

  2007cited by this paper
• Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas‐ and mitochondria‐mediated pathway

  2007cited by this paper
• FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.

  2007cited by this paper
• Regulation of Nox and Duox enzymatic activity and expression.

  2007cited by this paper
• Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha.

  2007cited by this paper
• Role of NF‐κB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor‐α

  2007cited by this paper
• The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.

  2007cited by this paper
• A redox cycle within the cell cycle: ring in the old with the new

  2007cited by this paper
• The cellular basis for diverse responses to oxygen.

  2007cited by this paper
• Hypoxic Suppression of the Cell Cycle Gene CDC25A in Tumor Cells

  2007cited by this paper
• Oxidative stress and cancer: have we moved forward?

  2007cited by this paper
• Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

  2007cited by this paper
• Reactive oxygen species and cellular oxygen sensing.

  2007cited by this paper
• Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1.

  2007influential reference
• Persistent Cdk2 inactivation drives growth arrest of BCR-ABL-expressing cells in response to dual inhibitor of SRC and ABL kinases SKI606.

  2007cited by this paper
• HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation.

  2007influential reference
• Abnormal hematopoiesis in Gab2 mutant mice.

  2007cited by this paper
• CDC25 phosphatases in cancer cells: key players? Good targets?

  2007cited by this paper
• HIF-dependent antitumorigenic effect of antioxidants in vivo.

  2007cited by this paper
• Elimination of damaged proteins during differentiation of embryonic stem cells

  2006cited by this paper
• Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

  2006cited by this paper
• NF-κB activation by reactive oxygen species: Fifteen years later

  2006cited by this paper
• Lipid Raft Clustering and Redox Signaling Platform Formation in Coronary Arterial Endothelial Cells

  2006cited by this paper
• Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

  2006cited by this paper
• Identification of transcriptional targets associated with the expression of p210 Bcr‐Abl

  2006cited by this paper
• Loss of p53 impedes the antileukemic response to BCR-ABL inhibition.

  2006cited by this paper
• Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells.

  2006cited by this paper
• Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1α expression through activation of AKT and P70S6K1 in human ovarian cancer cells

  2006cited by this paper
• Redefining Oxidative Stress

  2006cited by this paper
• Activated Jak2 with the V617F Point Mutation Promotes G1/S Phase Transition*

  2006influential reference
• Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

  2006cited by this paper
• Redox regulation of the hypoxia-inducible factor

  2006cited by this paper
• Localizing NADPH Oxidase–Derived ROS

  2006cited by this paper
• c-Myc phosphorylation is required for cellular response to oxidative stress.

  2006cited by this paper
• BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance.

  2006cited by this paper
• Nox2 and Rac1 Regulate H2O2-Dependent Recruitment of TRAF6 to Endosomal Interleukin-1 Receptor Complexes

  2006cited by this paper
• Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance.

  2006cited by this paper
• Role of hypoxia-inducible factor-1alpha as a cancer therapy target.

  2006cited by this paper
• NF‐kB inhibition as a strategy to enhance etoposide‐induced apoptosis in K562 cell line

  2006cited by this paper
• Actions of a Histone Deacetylase Inhibitor NSC3852 (5-Nitroso-8-quinolinol) Link Reactive Oxygen Species to Cell Differentiation and Apoptosis in MCF-7 Human Mammary Tumor Cells

  2006cited by this paper
• Molecular Mechanism of the Reduction of Cysteine Sulfinic Acid of Peroxiredoxin to Cysteine by Mammalian Sulfiredoxin*

  2006cited by this paper
• Restoration of SHIP-1 activity in human leukemic cells modifies NF-κB activation pathway and cellular survival upon oxidative stress

  2006cited by this paper
• The when and wheres of CDC25 phosphatases.

  2006influential reference
• Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction.

  2006cited by this paper
• Survival advantage from imatinib compared with the combination interferon-alpha plus cytarabine in chronic-phase chronic myelogenous leukemia: historical comparison between two phase 3 trials.

  2006cited by this paper
• Cyclin-dependent kinase pathways as targets for cancer treatment.

  2006cited by this paper
• Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML).

  2006cited by this paper
• Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia.

  2006influential reference
• NF-kappaB activation by reactive oxygen species: fifteen years later.

  2006cited by this paper
• C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.

  2006cited by this paper
• 14-3-3 proteins in cell cycle regulation.

  2006cited by this paper
• Expression and Localization of NOX2 and NOX4 in Primary Human Endothelial Cells

  2005cited by this paper
• Increased Nox1 and hydrogen peroxide in prostate cancer

  2005cited by this paper
• Identification of an Acquired JAK2 Mutation in Polycythemia Vera*

  2005cited by this paper
• Role of oxidative carbonylation in protein quality control and senescence

  2005cited by this paper
• Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways

  2005cited by this paper
• Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors.

  2005cited by this paper
• The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes.

  2005cited by this paper
• Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders.

  2005cited by this paper
• A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF‐1α

  2005cited by this paper
• A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance.

  2005cited by this paper
• Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.

  2005cited by this paper
• Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes

  2005cited by this paper
• Mechanism of free radical nitric oxide-mediated Ras guanine nucleotide dissociation.

  2005cited by this paper
• Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

  2005cited by this paper
• ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors.

  2005cited by this paper
• JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.

  2005cited by this paper
• A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.

  2005cited by this paper
• A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

  2005cited by this paper
• CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

  2005cited by this paper
• Controlling tumor growth by modulating endogenous production of reactive oxygen species.

  2005influential reference
• Subcellular targeting of oxidants during endothelial cell migration

  2005cited by this paper
• The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2.

  2005cited by this paper
• Mechanism of Redox-mediated Guanine Nucleotide Exchange on Redox-active Rho GTPases*

  2005cited by this paper
• A gain-of-function mutation of JAK2 in myeloproliferative disorders.

  2005cited by this paper
• A BCR–JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia

  2005cited by this paper
• Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

  2005cited by this paper
• Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

  2005cited by this paper
• Functions and Mechanisms of Redox Regulation of Cysteine-Based Phosphatases

  2005cited by this paper
• Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.

  2005cited by this paper
• Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.

  2005influential reference
• JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.

  2005influential reference
• Superoxide Anion Radical Modulates the Activity of Ras and Ras-related GTPases by a Radical-based Mechanism Similar to That of Nitric Oxide*

  2005influential reference
• Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL – Inhibition of P-glycoprotein function by 17-AAG

  2005cited by this paper
• Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

  2005cited by this paper
• Dysregulated expression of the major telomerase components in leukaemic stem cells

  2005cited by this paper

• The Telomere Length Signature in Leukemias—From Molecular Mechanisms Underlying Telomere Shortening to Immunotherapeutic Options Against Telomerase

  2025cites this paper
• Naochuxue formula attenuates early brain injury following subarachnoid hemorrhage by inhibiting neuronal apoptosis via network pharmacology and in vivo experiments.

  2025cites this paper
• Role of BCR and FNBP1 Proteins in Phagocytosis as a Model of Membrane Rearrangements with Chronic Myelogenous Leukemia

  2023cites this paper
• May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

  2023cites this paper
• Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis

  2022cites this paper
• The Microalga Skeletonema marinoi Induces Apoptosis and DNA Damage in K562 Cell Line by Modulating NADPH Oxidase

  2022cites this paper
• Oxidative stress in leukemia and antioxidant treatment

  2021influential citation
• Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.

  2020cites this paper
• The Involvement of Oxidative Stress in Chronic Myeloid Leukemia

  2020cites this paper
• Serum Level of Xanthine Oxidase, Uric Acid, and NADPH Oxidase 1 in Stage I of Multiple Myeloma

  2020cites this paper
• Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.

  2019cites this paper
• NATURAL ANTIOXIDANTS AS DEFENSE SYSTEM AGAINST CANCER

  2018cites this paper
• Aus der Klinik für Gynäkologie mit Schwerpunkt gynäkologische Onkologie der Medizinischen Fakultät Charité-Universitätsmedizin Berlin DISSERTATION Evaluation of Cytotoxic Effects and Underlying Mechanisms of Disulfiram on Breast Cancer Cell Lines

  2018cites this paper
• Polymer-gold nanoparticulate formulations for combinational photochemotherapy of pancreatic cancer

  2018cites this paper
• The role of NQO2 in tumour growth and response to therapeutic drugs

  2018cites this paper
• Levels of monoamine oxidase activites in childhood acute Lymphoblastic leukemia after chemotherapy

  2017cites this paper
• Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming

  2017cites this paper
• Alterations in the Reactive Oxygen Species in Peripheral Blood of Chronic Myeloid Leukaemia Patients from Northern India.

  2017cites this paper
• Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence

  2017cites this paper
• Current Progresses in Metal-based Anticancer Complexes as Mammalian TrxR Inhibitors.

  2017cites this paper
• Extracellular Matrix Induction of Intracellular Reactive Oxygen Species

  2017cites this paper
• Targeting Cancer Cells using 3-bromopyruvate for Selective Cancer Treatment

  2016cites this paper
• Oxidative stress versus epeginetics - Role in susceptibility, development, and progression of myeloid neoplasms

  2016cites this paper
• Nitric oxide and reactive oxygen species: Clues to target oxidative damage repair defective breast cancers.

  2016cites this paper
• Mycotoxin- A Target for Anticancer Drug Development

  2015cites this paper
• Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

  2015cites this paper
• MYCOTOXIN: AN ALTERNATE SOURCE OF ANTICANCER DRUG

  2015cites this paper
• Selective cancer-killing ability of metal-based nanoparticles: implications for cancer therapy

  2015cites this paper
• Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14: a case report.

  2014cites this paper
• Cell Signaling and Gene Regulation by Oxidative Stress

  2014cites this paper
• Oxidative Medicine and Cellular Longevity

  2014cites this paper
• Dual effect of oxidative stress on leukemia cancer induction and treatment

  2014cites this paper
• On the mechanism of cellular toxicity in breast cancer by ionizing radiation and chemotherapeutic drugs.

  2014cites this paper
• REACTIVE OXYGEN SPECIES AND P21 WAF1/CIP1 ARE BOTH ESSENTIAL FOR

  2014cites this paper
• Fenretinide Targets Chronic Myeloid Leukemia Stem/Progenitor Cells by Regulation of Redox Signaling

  2014cites this paper
• Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment

  2013cites this paper
• The p53-p66Shc apoptotic pathway is dispensable for tumor suppression whereas the p66Shc-generated oxidative stress initiates tumorigenesis.

  2013cites this paper
• Characterisation of the interactions and biological impacts of cisplatin analogues and metallo-drug complexes with DNA

  2013cites this paper
• FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia

  2013cites this paper
• Characterization of the anti-leukemia stem cell activity of chaetocin

  2013influential citation
• A Study Of Genetic Polymorphism Of Gstm1 And Gstt1 In Healthy Volunteers And Leukemic Patients

  2013cites this paper
• Influence of HOXA9 expression in the P13K-mediated oxidative stress in GBM

  2012cites this paper
• Genetic Mechanisms of Chronic Myeloid Leukemia Blastic Transformation

  2012cites this paper
• Targeting JAK2 in the therapy of myeloproliferative neoplasms

  2012cites this paper
• The c-Met inhibitors: a new class of drugs in the battle against advanced nonsmall-cell lung cancer.

  2012cites this paper
• Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II–IIIc breast cancer

  2012cites this paper
• Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy

  2012cites this paper
• Integrative Gene Expression Profiling Reveals G6PD-Mediated Resistance to RNA-Directed Nucleoside Analogues in B-Cell Neoplasms

  2012cites this paper
• BIOLOGICAL MECHANISMS AND CLINICAL IMPLICATIONS OF BCR-ABL-INDUCED MITOCHONDRIAL OXIDATIVE STRESS AND CELL SURVIVAL IN CHRONIC MYELOID LEUKEMIA

  2012cites this paper
• Targeting Dys-Regulated Reactive Oxygen Species Homeostasis in Cancer as a Selective Chemotherapeutic Approach

  2012cites this paper
• Perturbations du métabolisme oxydatif induites par l’activation de PDGFRα : mécanismes et conséquences dans la leucémie chronique à éosinophiles FIP1L1-PDGFRA

  2011influential citation
• The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity

  2011cites this paper
• New insights into redox-modulated cell signaling.

  2011cites this paper
• Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation*

  2011cites this paper
• Do reactive oxygen species play a role in myeloid leukemias?

  2011cites this paper
• Comparative proteomic analysis of blood eosinophils reveals redox signaling modifications in patients with FIP1L1-PDGFRA-associated chronic eosinophilic leukemia.

  2011cites this paper
• The role of the c-Met pathway in lung cancer and the potential for targeted therapy

  2011cites this paper
• NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases

  2010cites this paper
• Drug resistance in mutant FLT3-positive AML

  2010cites this paper
• Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia*

  2010cites this paper
• Unravelling the mechanisms of resistance to imatinib mesylate in chronic myeloid leukemia: a proteomic approach

  2010cites this paper
• Gaining insights into the Bcr-Abl activity-independent mechanisms of resistance to imatinib mesylate in KCL22 cells: a comparative proteomic approach.

  2010cites this paper
• Chronic myeloid leukemia: mechanisms of blastic transformation.

  2010cites this paper
• Targeting tissue oxidative damage by means of cell signaling modulators: the antioxidant concept revisited.

  2010cites this paper
• Novel Oncogenic Mutations of CBL in Human Acute Myeloid Leukemia That Activate Growth and Survival Pathways Depend on Increased Metabolism*

  2010cites this paper
• Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

  2009cites this paper
• Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-kappaB signaling in the inflammatory process and aging.

  2009cites this paper
• Complex Redundancy between the Mammalian Thioredoxin and Glutathione Systems in Cell Proliferation and Tumorigenesis Thesis

  2009cites this paper
• Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

  2009cites this paper
• Downregulation of the c‐MYC target gene, peroxiredoxin III, contributes to arsenic trioxide‐induced apoptosis in acute promyelocytic leukemia

  2009cites this paper
• BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.

  2009cites this paper
• The MET axis as a therapeutic target.

  2009cites this paper