Stably transfected common fragile site sequences exhibit instability at ectopic sites

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Genes, Chromosomes and Cancer

• Publication date

  2008-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/gcc.20591PMID 18615677
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Replication stress induces tumor-like microdeletions in FHIT/FRA3B

  2008cited by this paper
• Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

  2008cited by this paper
• Chromosome fragile sites.

  2007cited by this paper
• Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.

  2007cited by this paper
• An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae.

  2007cited by this paper
• Replication Fork Stalling at Natural Impediments

  2007cited by this paper
• Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.

  2006cited by this paper
• SMC1 inhibition results in FRA3B expression but has no effect on its delayed replication.

  2006cited by this paper
• Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites

  2006cited by this paper
• The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.

  2005cited by this paper
• Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites.

  2005cited by this paper
• SMC1 involvement in fragile site expression.

  2005cited by this paper
• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

  2005cited by this paper
• Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

  2005cited by this paper
• Common chromosomal fragile site FRA16D mutation in cancer cells.

  2005cited by this paper
• Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.

  2005cited by this paper
• Inverted repeat structure of the human genome: the X-chromosome contains a preponderance of large, highly homologous inverted repeats that contain testes genes.

  2004cited by this paper
• The role of late/slow replication of the FRA16D in common fragile site induction

  2004cited by this paper
• Conservation of aphidicolin-induced fragile sites in Papionini (Primates) species and humans

  2004cited by this paper
• Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

  2004cited by this paper
• Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13.

  2004cited by this paper
• BRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function

  2004cited by this paper
• Rare fragile sites

  2003cited by this paper
• Cancer and the FRA3B/FHIT fragile locus: it's a HIT

  2003cited by this paper
• Characterization of the human common fragile site FRA2G.

  2003cited by this paper
• Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors.

  2002cited by this paper
• Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements

  2002cited by this paper
• Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae

  2002cited by this paper
• Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells

  2002cited by this paper
• Preparation of Genomic DNA from Bacteria

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit

  2001cited by this paper
• WWOX, the FRA16D gene, behaves as a suppressor of tumor growth.

  2001cited by this paper
• An efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection.

  2001cited by this paper
• Replication Delay along FRA7H, a Common Fragile Site on Human Chromosome 7, Leads to Chromosomal Instability

  2000cited by this paper
• Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.

  2000cited by this paper
• Allele-specific late replication and fragility of the most active common fragile site, FRA3B.

  1999cited by this paper
• Tandem repeats finder: a program to analyze DNA sequences.

  1999cited by this paper
• Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction.

  1998cited by this paper
• Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site.

  1998influential reference
• The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region.

  1998cited by this paper
• Modification of bacterial artificial chromosome clones using Cre recombinase: introduction of selectable markers for expression in eukaryotic cells.

  1998cited by this paper
• Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons.

  1997influential reference
• Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas

  1997cited by this paper
• Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B.

  1997cited by this paper
• How common are common fragile sites: variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse (Peromyscus maniculatus)

  1997cited by this paper
• The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.

  1996influential reference
• FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.

  1996cited by this paper
• Integrated YAC contig containing the 3pl4.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B

  1994cited by this paper
• Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells

  1994cited by this paper
• Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma.

  1994cited by this paper
• Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site.

  1993cited by this paper
• Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites.

  1991cited by this paper
• Animal model: Chromosomal fragile site expression in dogs: I. Breed specific differences

  1991cited by this paper
• Chromosomal fragile site expression in dogs: II. Expression in boxer dogs with mast cell tumors.

  1991cited by this paper
• Formation of (dA-dT)n cruciforms in Escherichia coli cells under different environmental conditions

  1991cited by this paper
• Common fragile sites in man and three closely related primate species.

  1990cited by this paper
• Rodent common fragile sites: Are they conserved? Evidence from mouse and rat

  1989cited by this paper
• Chromosome breakage and recombination at fragile sites.

  1988cited by this paper
• Induction of sister chromatid exchanges at common fragile sites.

  1987cited by this paper
• Chromosome fragile sites.

  1985cited by this paper
• A cytogenetic survey of 110 baboons (Papio cynocephalus).

  1981cited by this paper
• DNA rearrangements associated with a transposable element in yeast.

  1980cited by this paper

• A predictive chromatin architecture nexus regulates transcription and DNA damage repair

  2025cites this paper
• Microsatellite break-induced replication generates highly mutagenized extrachromosomal circular DNAs

  2024cites this paper
• Fragile sites, chromosomal lesions, tandem repeats, and disease

  2022cites this paper
• AT-dinucleotide rich sequences drive fragile site formation

  2019cites this paper
• Investigating transcription, replication and chromatin structure in determining common fragile site instability

  2017cites this paper
• Replication Through Repetitive DNA Elements and Their Role in Human Diseases.

  2017cites this paper
• Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma

  2015cites this paper
• Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes

  2014cites this paper
• Visualizing chromosomal rearrangements caused by replication fork stalling in a single cell

  2014cites this paper
• Human Common Fragile Site FRA16D Flexibility Peak Is Not a Strong Mitotic Recombination Hotspot in Saccharomyces cerevisiae

  2014influential citation
• Replication fork recovery and regulation of common fragile sites stability

  2014cites this paper
• Human common fragile sites, identification, and analysis of breaks using saccharomyces cerevisiae

  2013influential citation
• Genome Instability at Common Fragile Sites: Searching for the Cause of Their Instability

  2013cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology Common fragile sites and genomic instability

  2013cites this paper
• Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer.

  2013cites this paper
• Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication.

  2013cites this paper
• Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats

  2012cites this paper
• A TRF1-controlled common fragile site containing interstitial telomeric sequences

  2012cites this paper
• Plant 45S rDNA Clusters Are Fragile Sites and Their Instability Is Associated with Epigenetic Alterations

  2012cites this paper
• Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis

  2012cites this paper
• A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

  2012cites this paper
• determine chromosomal instability in the human genome ? A genome-wide analysis of common fragile sites : What features Material Supplemental

  2012cites this paper
• The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers.

  2011cites this paper
• Understanding the molecular basis of common fragile sites instability: Role of the proteins involved in the recovery of stalled replication forks

  2011cites this paper
• Detection and Analysis of Common Fragile Sites in Drosophila melanogaster

  2011influential citation
• Secondary structure formation and DNA instability at fragile site FRA16B

  2010cites this paper
• Allelic imbalance and abnormal expression of FHIT in endemic nasopharyngeal carcinoma: association with clinicopathological features

  2010cites this paper
• DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

  2009cites this paper
• Fragile Sites in Domestic Animal Chromosomes: Molecular Insights and Challenges

  2009cites this paper
• Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae

  2009cites this paper