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Outdoor mosquito control using odour-baited devices: development and evaluation of a potential new strategy to complement indoor malaria prevention methods

F. Okumu,Robert D Sumaye,N. Matowo,Stephen P Mwangungulu,E. Kaindoa,Irene R. Moshi,Edith P. Madumla,D. Lwetoijera

Published 2013 in MalariaWorld Journal

ABSTRACT

A considerable effort is currently underway to develop a malaria vaccine based on live Plasmodium falciparum sporozoites. The first requisite of a sporozoite vaccine is the guarantee of parasite arrest prior to the onset of the pathogenic blood stage. Immunisation with genetically attenuated parasites (GAP) that arrest in the liver forms a promising approach. Work in this thesis describes the development and characterisation of a P. berghei Δb9Δslarp GAP that fully arrests in the liver. Immunisation of multiple mouse strains with low numbers of Δb9Δslarp GAP resulted in sterile protection. The Δb9Δslarp GAP is there- fore the leading GAP vaccine candidate. Work in this the- sis further describes the effect of varying the parameters of sporozoite inoculation on parasite liver load. These findings provide a rationale for the design of clinical trials aimed at the administration of live attenuated P. falciparum sporozoites.

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