The philosophy of scientific experimentation: a review

Practicing and studying automated experimentation may benefit from philosophical reflection on experimental science in general. This paper reviews the relevant literature and discusses central issues in the philosophy of scientific experimentation. The first two sections present brief accounts of the rise of experimental science and of its philosophical study. The next sections discuss three central issues of scientific experimentation: the scientific and philosophical significance of intervention and production, the relationship between experimental science and technology, and the interactions between experimental and theoretical work. The concluding section identifies three issues for further research: the role of computing and, more specifically, automating, in experimental research, the nature of experimentation in the social and human sciences, and the significance of normative, including ethical, problems in experimental science.

• Publication year

  2009

• Venue

  Automated Experimentation

• Publication date

  2009-10-29

• Fields of study

  Medicine, Philosophy, Computer Science

• Identifiers
  DOI 10.1186/1759-4499-1-2PMID 20098589PMCID 2809324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Packaging Data for Re-Use: Databases in Model Organism Biology.

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  2009cited by this paper
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  2009cited by this paper
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  2009cited by this paper
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  2008cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1988cited by this paper
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  1986cited by this paper
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  1986cited by this paper
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  1985cited by this paper
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