MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Histopathology

• Publication date

  2015-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/his.12712PMID 25855048PMCID PMC4996373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors

  2015influential reference
• Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations

  2014cited by this paper
• Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas

  2014cited by this paper
• Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma

  2014influential reference
• Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

  2014cited by this paper
• MED12 and HMGA2 mutations: Two independent genetic events in uterine leiomyoma and leiomyosarcoma

  2014cited by this paper
• Integrated genomic characterization of adrenocortical carcinoma

  2014cited by this paper
• Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas

  2014cited by this paper
• MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors.

  2014cited by this paper
• Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

  2014cited by this paper
• Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

  2014cited by this paper
• MED12 mutations in leiomyosarcoma and extrauterine leiomyoma

  2013cited by this paper
• Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours

  2013cited by this paper
• MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors

  2013cited by this paper
• Characterization of uterine leiomyomas by whole-genome sequencing.

  2013cited by this paper
• Whole Exome Sequencing in a Random Sample of North American Women with Leiomyomas Identifies MED12 Mutations in Majority of Uterine Leiomyomas

  2012cited by this paper
• Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors

  2012cited by this paper
• Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

  2012cited by this paper
• Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer

  2012cited by this paper
• WHO classification of tumours of the breast

  2012influential reference
• MED12 exon 2 mutations are common in uterine leiomyomas from South African patients

  2011cited by this paper
• Interactions between subunits of the Mediator complex with gene-specific transcription factors.

  2011cited by this paper
• MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas

  2011cited by this paper
• Integrated Genomic Analyses of Ovarian Carcinoma

  2011cited by this paper
• CDK8 is a stimulus-specific positive coregulator of p53 target genes.

  2007cited by this paper
• Estrogen receptor-β is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast

  2006cited by this paper
• Phyllodes Tumor of the Breast: The Challenge Persists

  2006cited by this paper
• Hormonal receptors expression in epithelial cells of mammary phyllodes tumors correlates with pathologic grade of the tumor: a multicenter study of 143 cases.

  2002cited by this paper
• The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro

  2002cited by this paper
• The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.

  2002cited by this paper
• Fibroadenoma and Phyllodes Tumor

  1995cited by this paper
• Fibroadenoma of the breast: a clinical and pathological study.

  1988cited by this paper
• Three-dimensional reconstruction of a human mammary fibroadenoma.

  1958cited by this paper
• Three-dimensional reconstruction of a human mammary fibroadenoma.

  1958cited by this paper

• Molecular pathology of phyllodes tumours of the breast-much more than MED12.

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• Genetic profiling of mammary periductal stromal tumors with histologic correlation highlights high-grade and low-grade groups and similarities to phyllodes tumors.

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• Recent Advances in Malignant Phyllodes Tumors of the Breast

  2025cites this paper
• Benign tumors broaden the field of application for immunotherapy

  2025cites this paper
• Borderline Phyllodes Breast Tumors: A Comprehensive Review of Recurrence, Histopathological Characteristics, and Treatment Modalities

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• Contemporary management of phyllodes tumours of the breast: recommendations from the UK Association of Breast Surgery

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• Immunoexpression of MED12 in lobular carcinoma in situ confined within fibroadenoma of breast

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• Genomic Profiling of Cardiac Angiosarcoma Reveals Novel Targetable KDR Variants, Recurrent MED12 Mutations and a High Burden of Germline POT1Alterations.

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• MED12 dysregulation: insights into cancer and therapeutic resistance

  2025cites this paper
• Classification of fibroepithelial lesions of the breast in core needle biopsy with implications for further management.

  2025cites this paper
• Contemporary Management of Phyllodes Tumors

  2024cites this paper
• Targeted DNA sequencing in diagnosis of malignant phyllodes tumors with emphasis on tumors with keratin and p63 expression.

  2024cites this paper
• Integrated multi-omics profiling reveals a clinically relevant molecular feature and potential therapeutic target on phyllodes tumors of breast

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• Using the DNA Integrity Number to Analyze DNA Quality in Specimens Collected from Liquid-Based Cytology after Fine-Needle Aspiration of Breast Tumors and Lesions

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• Association of fibroids, endometriosis, and gynecologic surgeries with breast cancer incidence and hormone receptor subtypes.

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• Stromal Ki67 Expression Might be a Useful Marker for Distinguishing Fibroadenoma From Benign Phyllodes Tumor of the Breast

  2023cites this paper
• A Comprehensive Review of Breast Fibroadenoma: Correlating Clinical and Pathological Findings

  2023cites this paper
• FIBROADENOMA MAMÁRIO: O QUE HÁ DE NOVO NA LITERATURA?

  2023cites this paper
• FIBROADENOMA: ETIOLOGIJA, KLINIKA, DIAGNOSTIKA, DIFERENCINĖ DIAGNOSTIKA, GYDYMAS

  2023cites this paper
• Changes in the mammary gland during aging and its links with breast diseases

  2023cites this paper
• Periductal Stromal Tumor of the Breast with a TERT Promoter Mutation: First Case Report with Comprehensive Molecular Analysis

  2023cites this paper
• Low-risk triple-negative breast cancers: clinico-pathological and molecular features.

  2022cites this paper
• MED 12 gene mutation in a case of bilateral giant juvenile fibroadenoma

  2022cites this paper
• Next‐generation sequencing in breast pathology: real impact on routine practice over a decade since its introduction

  2022influential citation
• Survey of recurrent diagnostic challenges in breast phyllodes tumours

  2022cites this paper
• Fibroepithelial lesions of the breast: A review of recurring diagnostic issues.

  2022cites this paper
• High-Grade Spindle Cell Lesions of the Breast: Key Pathologic and Clinical Updates.

  2022cites this paper
• Effects of miRNA-199a-5p on cell proliferation and apoptosis of uterine leiomyoma by targeting MED12

  2022cites this paper
• Malignant Phyllodes Tumor With Metastases to the Femur the Lung and Bilateral Axillas: A Case Report and Review of Literature

  2021cites this paper
• A giant fibroadenoma in a mature woman: diagnosis and treatment in a limited resource environment (a case report)

  2021cites this paper
• Multiple Mutations in Exon-2 of Med-12 Identified in Uterine Leiomyomata

  2021cites this paper
• Integrated mutational landscape analysis of uterine leiomyosarcomas

  2021cites this paper
• Retrospective study of malignant phyllodes tumors of the breast: Younger age, prior fibroadenoma surgery, malignant heterologous elements and surgical margins may predict recurrence

  2021cites this paper
• Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing

  2021cites this paper
• Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

  2021cites this paper
• Spindle cell lesions of the breast: a diagnostic approach

  2021cites this paper
• Droplet-digital PCR reveals frequent mutations in TERT promoter region in breast fibroadenomas and phyllodes tumours, irrespective of the presence of MED12 mutations

  2020cites this paper
• Histopathologic, immunophenotypic, and proteomics characteristics of low-grade phyllodes tumor and fibroadenoma: more similarities than differences

  2020cites this paper
• Histopathologic, immunophenotypic, and proteomics characteristics of low-grade phyllodes tumor and fibroadenoma: more similarities than differences

  2020cites this paper
• Fibroepithelial lesions revisited: implications for diagnosis and management

  2020cites this paper
• Genotype‐phenotype associations in breast pathology: Achievements of the past quarter century

  2020cites this paper
• Droplet-digital PCR reveals frequent mutations in TERT promoter region in breast fibroadenomas and phyllodes tumours, irrespective of the presence of MED12 mutations

  2020cites this paper
• Morphologic and genetic heterogeneity in breast fibroepithelial lesions—a comprehensive mapping study

  2020cites this paper
• Stromal MED12 exon 2 mutations in complex fibroadenomas of the breast

  2020cites this paper
• Tubular Adenoma of the Breast

  2019cites this paper
• Fibroepithelial Breast Lesion: When Sequencing Can Help to Make a Clinical Decision. A Case Report

  2019cites this paper
• The genomic mutation spectrums of breast fibroadenomas in Chinese population by whole exome sequencing analysis

  2019cites this paper
• Myome – was liegt da in der DNA?

  2019cites this paper
• The utility of a targeted gene mutation panel in refining the diagnosis of breast phyllodes tumours.

  2019cites this paper
• Genomic characterisation of breast fibroepithelial lesions in an international cohort

  2019cites this paper
• Malignant phyllodes tumors of the breast: A comprehensive literature review

  2019cites this paper
• A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions

  2019cites this paper
• MED12, TERT and RARA in fibroepithelial tumours of the breast

  2019cites this paper
• Reasons to Reconsider Risk Associated With Power Morcellation of Uterine Fibroids

  2019cites this paper
• Factors targeting MED12 to drive tumorigenesis?

  2018cites this paper
• Recurrent MED12 exon 2 mutations in benign breast fibroepithelial lesions in adolescents and young adults

  2018cites this paper
• MED12 somatic mutations encompassing exon 2 associated with benign breast fibroadenomas and not breast carcinoma in Indian women

  2018cites this paper
• An application study of low-dose computed tomography perfusion imaging (LDCTPI) in breast cancer and breast fibroadenoma

  2018cites this paper
• MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours

  2018cites this paper
• Size and heterologous elements predict metastases in malignant phyllodes tumours of the breast

  2018cites this paper
• Molecular insights into paediatric breast fibroepithelial tumours

  2018cites this paper
• The Spectrum of Risk Lesions in Breast Pathology: Risk Factors or Cancer Precursors?

  2018cites this paper
• Myxoid fibroadenomas differ from conventional fibroadenomas: a hypothesis‐generating study

  2017cites this paper
• Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K–AKT pathway

  2017cites this paper
• Pathology and Molecular Pathology of Breast Cancer

  2017cites this paper
• A Diagnostic Approach to Fibroepithelial Breast Lesions.

  2017cites this paper
• Genetic and Clinical Characteristics of Phyllodes Tumors of the Breast

  2017cites this paper
• High-grade Müllerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations and Aggressive Behavior

  2017cites this paper
• Recurrent NAB2–STAT6 gene fusions and oestrogen receptor‐α expression in pulmonary adenofibromas

  2017cites this paper
• Lipomatous tumors of the breast: A contemporary review.

  2017cites this paper
• Fibroepithelial lesions; The WHO spectrum.

  2017cites this paper
• Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways

  2017cites this paper
• Genetics and genomics of breast fibroadenomas

  2017cites this paper
• Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor.

  2017cites this paper
• Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg †

  2017cites this paper
• Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade

  2016influential citation
• Phyllodes tumours of the breast: a consensus review

  2016cites this paper
• Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.

  2016cites this paper
• Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression

  2016cites this paper
• THE ROLE OF MED 12 IN TUMORIGENESIS

  2016cites this paper
• MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression

  2016cites this paper
• MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways

  2016cites this paper
• The Role of Mediator Complex Subunit 12 in Leiomyoma Biology

  2016cites this paper
• Massively parallel sequencing analysis of synchronous fibroepithelial lesions supports the concept of progression from fibroadenoma to phyllodes tumor

  2016cites this paper
• Phyllodes Tumors of the Breast: Challenges and Diagnostic Recommendations

  2016cites this paper
• Molecular classification of uterine leiomyomas by genome-wide methods

  2016cites this paper
• MED12 exon 2 mutation as a highly sensitive and specific marker in distinguishing phyllodes tumours from other spindle neoplasms of the breast

  2016cites this paper
• The role of mediator complex subunit 12 (MED12) in the murine reproductive tract

  2015cites this paper
• Genomic landscapes of breast fibroepithelial tumors

  2015cites this paper
• Mediator kinase module and human tumorigenesis

  2015cites this paper
• The Contrasting Role of p16Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations

  2015cites this paper
• MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases

  2015cites this paper
• Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing

  2015influential citation
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