Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2017-11-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.bbrc.2017.09.008PMID 28882589
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

  2017cited by this paper
• Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells

  2017cited by this paper
• The role of lysosome in cell death regulation

  2016cited by this paper
• Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling.

  2016cited by this paper
• Rag GTPase in amino acid signaling

  2016cited by this paper
• Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.

  2016cited by this paper
• The lysosome as a command-and-control center for cellular metabolism

  2016cited by this paper
• Direct and precise length measurement of single, stretched DNA fragments by dynamic molecular combing and STED nanoscopy

  2016cited by this paper
• Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.

  2016cited by this paper
• Multiple amino acid sensing inputs to mTORC1

  2015cited by this paper
• Differential regulation of mTORC1 by leucine and glutamine

  2015cited by this paper
• Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.

  2014cited by this paper
• mTOR and lysosome regulation

  2014cited by this paper
• Current Models of Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation by Growth Factors and Amino Acids

  2014cited by this paper
• Autophagy regulation by nutrient signaling

  2013cited by this paper
• Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

  2013cited by this paper
• STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria

  2013cited by this paper
• Amino acids and mTORC1: from lysosomes to disease.

  2012cited by this paper
• Glutaminolysis activates Rag-mTORC1 signaling.

  2012cited by this paper
• Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.

  2012cited by this paper
• Leucyl-tRNA synthetase: double duty in amino acid sensing

  2012cited by this paper
• Icy: an open bioimage informatics platform for extended reproducible research

  2012cited by this paper
• Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

  2011cited by this paper
• Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

  2010cited by this paper
• Monitoring autophagy by electron microscopy in Mammalian cells.

  2009cited by this paper
• Bidirectional transport of amino acids regulates mTOR and autophagy.

  2009cited by this paper
• To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells

  2008cited by this paper
• Two-color far-field fluorescence nanoscopy.

  2007cited by this paper
• Extraction of spots in biological images using multiscale products

  2002cited by this paper
• Leucine Limitation Induces Autophagy and Activation of Lysosome-dependent Proteolysis in C2C12 Myotubes through a Mammalian Target of Rapamycin-independent Signaling Pathway*

  2000cited by this paper
• Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism*

  1998cited by this paper
• Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.

  1994cited by this paper

• Photophysics of Organic Fluorophore Photobluing and Its Applications in Fluorescence and Super-Resolution Microscopy.

  2026cites this paper
• Leucyl-tRNA synthetase promotes malignant progression in diffuse large B-cell lymphoma by regulating glycolysis via the LRPPRC/HIF-1α/HK2 axis

  2025cites this paper
• White Adipocyte Stem Cell Expansion Through Infant Formula Feeding: New Insights into Epigenetic Programming Explaining the Early Protein Hypothesis of Obesity

  2025cites this paper
• Leucyl-tRNA synthetase regulates casein synthesis in dairy cows via the mTORC1-LAT1 pathway

  2025cites this paper
• Animal amino acid sensor — A review

  2024cites this paper
• Branched-chain amino acids: physico-chemical properties, industrial synthesis and role in signaling, metabolism and energy production

  2024cites this paper
• Analysis of Fluorescent Proteins for Observing Single Gene Locus in a Live and Fixed Escherichia coli Cell

  2024cites this paper
• Nutrient sensors and their crosstalk

  2023cites this paper
• Influence of mTOR-regulated anabolic pathways on equine skeletal muscle health.

  2023cites this paper
• O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine

  2022cites this paper
• The endocrine and epigenetic impact of persistent cow milk consumption on prostate carcinogenesis

  2022cites this paper
• The human LAT1–4F2hc (SLC7A5–SLC3A2) transporter complex: Physiological and pathophysiological implications

  2022cites this paper
• Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

  2021cites this paper
• Aminoacyl-tRNA synthetases in cell signaling.

  2020cites this paper
• Regulation of Body Size and Growth Control

  2020cites this paper
• Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

  2020cites this paper
• Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation

  2018cites this paper
• LRRK2 impairs autophagy by mediating phosphorylation of leucyl‐tRNA synthetase

  2018cites this paper
• Three human aminoacyl-tRNA synthetases have distinct sub-mitochondrial localizations that are unaffected by disease-associated mutations

  2018cites this paper
• Characterization of the human mitochondrial Arginyl-tRNA synthetase and contribution to the général understanding of pathologies linked to mutations on mitochondrial aminoacyl-tRNA synthetases

  2018cites this paper
• Adaptations of Amino Acid Transporters and Sestrins to Exercise, Nutrition and Ageing in Human Skeletal Muscle

  2018cites this paper
• Super-resolution imaging and real-time tracking lysosome in living cells by a fluorescent probe

  2018cites this paper