Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

Mee-Sup Yoon,G. Du,J. Backer,M. Frohman,Jie Chen

Published 2011 in Journal of Cell Biology

ABSTRACT

In response to amino acid availability, the class III PI-3-kinase hVps34 activates the phospholipase PLD and mTORC1 signaling to regulate mammalian cell size.

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