Cytoskeletal control of nuclear morphology and chromatin organization.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Molecular Biology

• Publication date

  2015-02-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jmb.2014.09.008PMID 25281900
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Exploiting Cell-To-Cell Variability To Detect Cellular Perturbations

  2014cited by this paper
• Population Distribution Analyses Reveal a Hierarchy of Molecular Players Underlying Parallel Endocytic Pathways

  2014cited by this paper
• The regulation of dynamic mechanical coupling between actin cytoskeleton and nucleus by matrix geometry.

  2014cited by this paper
• Functional implications of genome topology

  2013cited by this paper
• Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

  2013cited by this paper
• Lamin A/C and emerin regulate MKL1/SRF activity by modulating actin dynamics

  2013cited by this paper
• Nuclear positioning.

  2013cited by this paper
• Lamins in development, tissue maintenance and stress

  2012cited by this paper
• Mechanical activation of cells induces chromatin remodeling preceding MKL nuclear transport.

  2012cited by this paper
• Lamin B1 Polymorphism Influences Morphology of the Nuclear Envelope, Cell Cycle Progression, and Risk of Neural Tube Defects in Mice

  2012cited by this paper
• LMNA Knock-Down Affects Differentiation and Progression of Human Neuroblastoma Cells

  2012cited by this paper
• The nuclear lamins: flexibility in function

  2012cited by this paper
• Spatial coordination between cell and nuclear shape within micropatterned endothelial cells

  2012cited by this paper
• The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton*

  2011cited by this paper
• Nuclear mechanics in disease.

  2011cited by this paper
• The nucleoskeleton as a genome-associated dynamic 'network of networks'

  2011cited by this paper
• Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos

  2011cited by this paper
• Mechanosignaling to the cell nucleus and gene regulation.

  2011cited by this paper
• Emergence of a prestressed eukaryotic nucleus during cellular differentiation and development

  2010cited by this paper
• A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis

  2010cited by this paper
• Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.

  2010cited by this paper
• The nuclear envelope at a glance

  2010cited by this paper
• Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

  2010cited by this paper
• The nuclear envelope in genome organization, expression and stability

  2010cited by this paper
• The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus

  2010cited by this paper
• Spatio-temporal plasticity in chromatin organization in mouse cell differentiation and during Drosophila embryogenesis.

  2009cited by this paper
• Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

  2009cited by this paper
• The nuclear envelope--a scaffold for silencing?

  2009cited by this paper
• Mechanotransduction gone awry

  2009cited by this paper
• A perinuclear actin cap regulates nuclear shape

  2009cited by this paper
• Histones: annotating chromatin.

  2009cited by this paper
• Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis.

  2009cited by this paper
• A network of nuclear envelope membrane proteins linking centromeres to microtubules.

  2008cited by this paper
• Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

  2008cited by this paper
• The nuclear envelope as an integrator of nuclear and cytoplasmic architecture

  2008cited by this paper
• Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression

  2007cited by this paper
• Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions

  2007cited by this paper
• Force fluctuations and polymerization dynamics of intracellular microtubules

  2007cited by this paper
• Drosophila klaroid Encodes a SUN Domain Protein Required for Klarsicht Localization to the Nuclear Envelope and Nuclear Migration in the Eye

  2007cited by this paper
• The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner

  2007cited by this paper
• Physical plasticity of the nucleus in stem cell differentiation

  2007cited by this paper
• Role of nuclear lamina-cytoskeleton interactions in the maintenance of cellular strength.

  2007cited by this paper
• Gold-nanoparticle-assisted laser perturbation of chromatin assembly reveals unusual aspects of nuclear architecture within living cells.

  2007cited by this paper
• The nuclear envelope and transcriptional control

  2007cited by this paper
• Human laminopathies: nuclei gone genetically awry

  2006cited by this paper
• SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

  2006cited by this paper
• Chromatin architecture.

  2006cited by this paper
• Cellular mechanotransduction: putting all the pieces together again

  2006cited by this paper
• Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics.

  2006cited by this paper
• Inaugural Article: Insights into the mechanism of microtubule stabilization by Taxol

  2006cited by this paper
• EGFP-tagged core and linker histones diffuse via distinct mechanisms within living cells.

  2006cited by this paper
• The nuclear lamina comes of age

  2005cited by this paper
• The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber

  2004cited by this paper
• Drosophila Klarsicht Has Distinct Subcellular Localization Domains for Nuclear Envelope and Microtubule Localization in the Eye

  2004cited by this paper
• Network of Networks

  2004cited by this paper
• Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking

  2004cited by this paper
• Conserved microtubule–actin interactions in cell movement and morphogenesis

  2003cited by this paper
• Nuclear positioning: the means is at the ends.

  2003cited by this paper
• The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

  2002cited by this paper
• Life at the edge: the nuclear envelope and human disease

  2002cited by this paper
• Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

  2000cited by this paper
• Gene Ontology: tool for the unification of biology

  2000cited by this paper
• Actomyosin-based Retrograde Flow of Microtubules in the Lamella of Migrating Epithelial Cells Influences Microtubule Dynamic Instability and Turnover and Is Associated with Microtubule Breakage and Treadmilling

  1997cited by this paper
• Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure.

  1997cited by this paper
• Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the rho signal cascade.

  1996cited by this paper
• Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain.

  1995cited by this paper
• Rigidity of microtubules is increased by stabilizing agents

  1995cited by this paper
• Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape

  1993cited by this paper
• Nocodazole, a microtubule-active drug, interferes with apical protein delivery in cultured intestinal epithelial cells (Caco-2)

  1989cited by this paper
• Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone

  1988cited by this paper
• Inhibition of actin polymerization by latrunculin A

  1987cited by this paper

• Modulating cell surface chemistry through mild reduction reinforces extracellular-to-intracellular transmission forces and mechano-signaling.

  2026cites this paper
• Perinuclear non-centrosomal microtubules direct nuclei dispersion during epithelial morphogenesis

  2025cites this paper
• MeCP2-driven chromatin organization controls nuclear stiffness

  2025cites this paper
• Osmotic stress suppresses osteogenic differentiation by inhibiting nuclear translocation of YAP via perinuclear actin accumulation.

  2025cites this paper
• Mechanically Regulated Biphasic Chromatin Dynamics during Cellular Necrosis.

  2025cites this paper
• Retinoic Acid Promotes Osteogenic Differentiation of Mesenchymal Stem Cells in the Mouse Facial Suture under Mechanical Stretching via Piezo2

  2025cites this paper
• Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome

  2025cites this paper
• Aging and Altered Gravity: A Cellular Perspective

  2025cites this paper
• Regulation of nuclear deformation via spatiotemporal modulation of cytoskeleton forces on photo-switchable surfaces.

  2025cites this paper
• Image2Reg: Linking chromatin images to gene regulation using genetic and chemical perturbation screens.

  2025cites this paper
• Mechanical Forces in Tumor Growth and Treatment: Perspectives From Biology, Physics, Engineering, and Mathematical Modeling.

  2025cites this paper
• Regulation of chromatin modifications through coordination of nucleus size and epithelial cell morphology heterogeneity

  2025cites this paper
• Probing the physical hallmarks of cancer

  2025cites this paper
• Micropillar-induced changes in cell nucleus morphology enhance bone regeneration by modulating the secretome

  2025cites this paper
• The protective effect of methanolic extract of Verbascum cheiranthifolium and Biebersteinia multifida DC on hippocampus damage induced by diazinon in male Wistar rats: An experimental study.

  2024cites this paper
• Moderate‐ and High‐Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon

  2024cites this paper
• Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation.

  2024cites this paper
• Advances in research on the relationship between the LMNA gene and human diseases (Review)

  2024cites this paper
• Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space.

  2024cites this paper
• Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application

  2024cites this paper
• Active nematic response to a deformable body or boundary: Elastic deformations and anchoring-induced flow

  2024cites this paper
• Identification and Benchmarking of Myokinasib-II as a Selective and Potent Chemical Probe for Exploring MLCK1 Inhibition.

  2024cites this paper
• The destruction of cytoplasmic skeleton leads to the change of nuclear structure and the looseness of lamin A submicroscopic network

  2024cites this paper
• F‐actin microfilaments affect the LIPUS‐promoted osteogenic differentiation of BMSCs through TRPM7

  2024cites this paper
• Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

  2024cites this paper
• Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation

  2024cites this paper
• A Hierarchical Mechanotransduction System: From Macro to Micro

  2023cites this paper
• Mechanical forces and the 3D genome.

  2023cites this paper
• Cytoskeletal Safeguards: Protecting the Nucleus from Mechanical Perturbations

  2023cites this paper
• Nuclear and chromatin rearrangement associate to epigenome and gene expression changes in a model of in vitro adipogenesis and hypertrophy.

  2023cites this paper
• Aging and injury affect nuclear shape heterogeneity in tendon

  2023cites this paper
• Histone Modification of Osteogenesis Related Genes Triggered by Substrate Topography Promotes Human Mesenchymal Stem Cell Differentiation

  2023cites this paper
• The peritumor microenvironment: physics and immunity.

  2023cites this paper
• Confocal interferometric scattering microscopy reveals 3D nanoscopic structure and dynamics in live cells

  2023cites this paper
• Influence of culture conditions on the secretome of mesenchymal stem cells derived from feline adipose tissue: Proteomics approach.

  2023cites this paper
• Tuning between Nuclear Organization and Functionality in Health and Disease

  2023cites this paper
• Microtubule Assists Actomyosin to Regulate Cell Nuclear Mechanics and Chromatin Accessibility

  2023cites this paper
• MECHANISMS OF THE KEEPING AND CHANGE OF FORMS AND SIZES OF THE CELL NUCLEI (REVIEW)

  2022cites this paper
• Biomechanical regulation of planar cell polarity in endothelial cells.

  2022cites this paper
• Emulsion-templated microparticles with tunable stiffness and topology: Applications as edible microcarriers for cultured meat

  2022cites this paper
• Role of LINC complex proteins in sperm formation

  2022cites this paper
• How is mechanobiology involved in bone regenerative medicine?

  2022cites this paper
• Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis

  2022cites this paper
• Intermediate Filaments in Cellular Mechanoresponsiveness: Mediating Cytoskeletal Crosstalk From Membrane to Nucleus and Back

  2022cites this paper
• Unique Astrocyte Cytoskeletal and Nuclear Morphology in a Three-Dimensional Tissue-Engineered Rostral Migratory Stream

  2022cites this paper
• Architectural control of mesenchymal stem cell phenotype through nuclear actin

  2022cites this paper
• Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

  2022cites this paper
• Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer.

  2022cites this paper
• A comprehensive review of computational and image analysis techniques for quantitative evaluation of striated muscle tissue architecture.

  2022cites this paper
• Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological aging

  2022cites this paper
• Uniaxial Cyclic Stretching Promotes Chromatin Accessibility of Gene Loci Associated With Mesenchymal Stem Cells Morphogenesis and Osteogenesis

  2021cites this paper
• All-optical mechanobiology interrogation of YAP in human cancer and normal cells using a novel multi-functional system

  2021cites this paper
• Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis

  2021cites this paper
• LINCking the Nuclear Envelope to Sperm Architecture

  2021cites this paper
• Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts

  2021cites this paper
• The Plant Nuclear Envelope and Its Role in Gene Transcription

  2021cites this paper
• Biophysical Approaches for Applying and Measuring Biological Forces

  2021cites this paper
• Microscale topographical cues regulate mesenchymal stem cell behaviors

  2021cites this paper
• Nuclear size and shape control.

  2021cites this paper
• Age-dependent Lamin remodeling induces cardiac dysfunction via dysregulation of cardiac transcriptional programs

  2021cites this paper
• The 3D Genome: From Structure to Function

  2021cites this paper
• Mechanotransduction in fibrosis: Mechanisms and treatment targets.

  2021cites this paper
• Energy Metabolism in Cardiomyocyte

  2021cites this paper
• Two nondimensional parameters for characterizing the nuclear morphology.

  2021cites this paper
• Nuclear Mechanotransduction in Skeletal Muscle

  2021cites this paper
• Programming Evolution: a Crack in Science

  2021cites this paper
• Gravitational Force—Induced 3D Chromosomal Conformational Changes Are Associated with Rapid Transcriptional Response in Human T Cells

  2021cites this paper
• MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

  2021cites this paper
• Spreading Area and Shape Regulate the Apoptosis and Osteogenesis of Mesenchymal Stem Cells on Circular and Branched Micropatterned Islands.

  2020cites this paper
• Dual role of the nucleus in cell migration on planar substrates

  2020cites this paper
• Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma

  2020cites this paper
• Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

  2020cites this paper
• Mechanical memory in cells emerges from mechanotransduction with transcriptional feedback and epigenetic plasticity

  2020cites this paper
• The relative densities of cell cytoplasm, nucleoplasm, and nucleoli are robustly conserved during cell cycle and drug perturbations

  2020cites this paper
• The role of the cell nucleus in mechanotransduction.

  2020cites this paper
• Lamin A/C Mechanotransduction in Laminopathies

  2020cites this paper
• 3D Microwell Platforms for Control of Single Cell 3D Geometry and Intracellular Organization

  2020cites this paper
• Nuclear actin: The new normal.

  2020cites this paper
• It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology

  2020cites this paper
• Nanomechanical properties of enucleated cells: contribution of the nucleus to the passive cell mechanics

  2020cites this paper
• Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation

  2020cites this paper
• The Relative Densities of Cytoplasm and Nuclear Compartments Are Robust against Strong Perturbation

  2020cites this paper
• Predicting the tension in actin cytoskeleton from the nucleus shape

  2020cites this paper
• Physical traits of cancer

  2020cites this paper
• Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton

  2020cites this paper
• Shaping of the 3D genome by the ATPase machine cohesin

  2020cites this paper
• The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior

  2020cites this paper
• Micropatterned Surfaces Expose the Coupling between Actin Cytoskeleton-Lamin/Nesprin and Nuclear Deformability of Breast Cancer Cells with Different Malignancies.

  2020cites this paper
• Correlation between Nuclear Morphology and Adipogenic Differentiation: Application of a Combined Experimental and Computational Modeling Approach

  2019cites this paper
• Signal Transduction across the Nuclear Envelope: Role of the LINC Complex in Bidirectional Signaling

  2019cites this paper
• Reconstructing and Analysing The Genome of The Last Eukaryote Common Ancestor to Better Understand the Transition from FECA to LECA

  2019cites this paper
• Changes of Gene Expression in Euglena gracilis Obtained During the 29th DLR Parabolic Flight Campaign

  2019cites this paper
• Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer

  2019cites this paper
• The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease.

  2019cites this paper
• Chromatin's physical properties shape the nucleus and its functions.

  2019cites this paper
• A Nondimensional Model Reveals Alterations in Nuclear Mechanics upon Hepatitis C Virus Replication.

  2019cites this paper
• Cellular and Molecular Responses to Gravitational Force-Triggered Stress in Cells of the Immune System

  2019cites this paper
• Microtubules deform the nucleus and force chromatin reorganization during early differentiation of human hematopoietic stem cells

  2019cites this paper
• Loss of Nuclear Deformability of Breast Cancer Cells by the Disruption of Actin Filaments

  2019cites this paper
• Quantifying the effects of engineered nanomaterials on endothelial cell architecture and vascular barrier integrity using a cell pair model.

  2019cites this paper