In vitro metabolism of 2-ethylhexyldiphenyl phosphate (EHDPHP) by human liver microsomes.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Toxicology Letters

• Publication date

  2015-01-05

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.toxlet.2014.11.007PMID 25448284
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Priority and emerging flame retardants in rivers: occurrence in water and sediment, Daphnia magna toxicity and risk assessment.

  2013cited by this paper
• EU-wide monitoring survey on emerging polar organic contaminants in wastewater treatment plant effluents.

  2013cited by this paper
• In silico and in vitro metabolism studies support identification of designer drugs in human urine by liquid chromatography/quadrupole-time-of-flight mass spectrometry

  2013cited by this paper
• First insights in the metabolism of phosphate flame retardants and plasticizers using human liver fractions.

  2013cited by this paper
• Liquid chromatography quadrupole time-of-flight mass spectrometry characterization of metabolites guided by the METLIN database

  2013cited by this paper
• Microwave-assisted extraction combined with gel permeation chromatography and silica gel cleanup followed by gas chromatography-mass spectrometry for the determination of organophosphorus flame retardants and plasticizers in biological samples.

  2013cited by this paper
• Development and validation of a multiresidue method for the analysis of polybrominated diphenyl ethers, new brominated and organophosphorus flame retardants in sediment, sludge and dust.

  2013cited by this paper
• Organophosphorus flame retardants in house dust from the Philippines: occurrence and assessment of human exposure

  2013cited by this paper
• Phosphorus flame retardants: Properties, production, environmental occurrence, toxicity and analysis

  2012cited by this paper
• After the PBDE Phase-Out: A Broad Suite of Flame Retardants in Repeat House Dust Samples from California

  2012cited by this paper
• Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis.

  2012cited by this paper
• Evaluation of Three State-of-the-Art Metabolite Prediction Software Packages (Meteor, MetaSite, and StarDrop) through Independent and Synergistic Use

  2011cited by this paper
• Organophosphorus flame retardants and plasticizers in marine and fresh water biota and in human milk.

  2010cited by this paper
• The Biochemistry of Drug Metabolism: Conjugations, Consequences of Metabolism, Influencing Factors

  2010cited by this paper
• In silico methods for predicting metabolism and mass fragmentation applied to quetiapine in liquid chromatography/time-of-flight mass spectrometry urine drug screening.

  2009cited by this paper
• Predicting Drug Metabolism – An Evaluation of the Expert System METEOR

  2005cited by this paper
• Isolation and identification of metabolites of 2-ethylhexyl diphenyl phosphate in rats

  2004cited by this paper
• In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

  2000cited by this paper
• FDA Total Diet Study, July 1986-April 1991, dietary intakes of pesticides, selected elements, and other chemicals.

  1995cited by this paper
• FDA Total Diet Study, April 1982-April 1984, dietary intakes of pesticides, selected elements, and other chemicals.

  1988cited by this paper

• Plasma organophosphate ester exposure-associated microRNA expression profiles and their functional analysis in Chinese healthy adults.

  2026cites this paper
• Organophosphate Esters in Breast Milk from Beijing, China.

  2026cites this paper
• Comprehensive investigation on organophosphate esters and their metabolites in human milk from China: occurrence, profile, and health risk assessment.

  2026cites this paper
• Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort

  2025cites this paper
• Prenatal Persistent Exposure to Organophosphate Esters and Early Childhood Brain Development: A Longitudinal Analysis

  2025cites this paper
• Trends of Organophosphate Ester Flame Retardant Metabolites in Age- and Sex-Stratified Pooled Australian Urine Samples from the Past Decade (2012-2023).

  2025cites this paper
• Nationwide investigation on organophosphate esters and di-esters in raw grains from China: Distribution, sources, and implications for risk assessment.

  2025cites this paper
• National urinary metabolites of organophosphate flame retardants in urban Chinese residents.

  2025cites this paper
• Trace analysis method for the determination of organophosphate esters based on solid-phase extraction-UPLC-MS/MS and its application to blood

  2025cites this paper
• Environmental Safety Perspectives on Organophosphate Flame Retardants: Current strategies and advancements in their environmental removal and detection

  2025cites this paper
• Estrogenic and anti-estrogenic assessment of the flame retardant, 2-ethylhexyl diphenyl phosphate (EHDPP), and its metabolites: Evidence from in vitro, in silico, and transcriptome studies.

  2025cites this paper
• Quantitative Toxicokinetic Investigation of Emerging Aryl Organophosphate Esters in Rats.

  2025cites this paper
• A comprehensive review of contents, toxic effects, metabolisms, and environmental behaviors of brominated and organophosphorus flame retardants.

  2025cites this paper
• First Insight into Fetal Exposure to Legacy and Emerging Plasticizers Revealed by Infant Hair and Meconium: Occurrence, Biotransformation, and Accumulation.

  2024cites this paper
• Affecting factors and health risks of organophosphate esters in urban soil and surface dust in a typical river valley city based on local bivariate Moran's I and Monte-Carlo simulation.

  2024cites this paper
• Identification of candidate exposure biomarkers for acetyl tributyl citrate and acetyl triethyl citrate using suspect screening in human liver microsomes.

  2024cites this paper
• Organophosphate esters and their metabolites in silver pomfret (Pampus argenteus) of the Vietnamese coastal areas: Spatial-temporal distribution and exposure risk.

  2024cites this paper
• Transformation of 6:6 PFPiA in the gut of Xenopus laevis: Synergistic effects of CYP450 enzymes and gut microflora.

  2024cites this paper
• Biodegradation of aryl-organophosphate flame retardants by Rhodococcus pyridinivorans YC-MTN: Performance, pathway and potential in environmental remediation

  2024cites this paper
• Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program

  2024cites this paper
• An overview of current knowledge on organophosphate di-esters in environment: Analytical methods, sources, occurrence, and behavior.

  2023cites this paper
• Ecological and human health risk of aryl-phosphate flame retardants (APFRs): Sources, distribution, and toxicity

  2023cites this paper
• Organophosphorus flame retardants and their metabolites in paired human blood and urine.

  2023cites this paper
• Nuclear Receptors-Mediated Endocrine Disrupting Effects of Non-Phthalate Plasticizers: A Review.

  2023cites this paper
• Exposure to organophosphate flame retardants and plasticizers is positively associated with wheeze and FeNO and eosinophil levels among school-aged children: The Hokkaido study.

  2023cites this paper
• Activation of LXRα attenuates 2-Ethylhexyl diphenyl phosphate (EHDPP) induced placental dysfunction.

  2023cites this paper
• Determinants of organophosphate esters exposure in pregnant women from East China.

  2023cites this paper
• Organophosphate diesters (DAPs) and hydroxylated organophosphate flame retardants (HO-OPFRs) as biomarkers of OPFR contamination in a typical freshwater food chain.

  2023cites this paper
• Sex-specific effects of organophosphate ester exposure on child growth trajectories in the first two years

  2023cites this paper
• Descriptive analysis of organophosphate ester metabolites in a pan-Canadian pregnancy cohort.

  2023cites this paper
• First insight into the sex-dependent accumulation, tissue distribution and potential toxicities of 2-ethylhexyl diphenyl phosphate and its metabolites in adult zebrafish.

  2023cites this paper
• Bioaccumulation and Trophic Transfer of Organophosphate Flame Retardants and Their Metabolites in the Estuarine Food Web of the Pearl River, China.

  2023cites this paper
• Replacement Flame-Retardant 2-Ethylhexyldiphenyl Phosphate (EHDPP) Disrupts Hepatic Lipidome: Evidence from Human 3D Hepatospheroid Cell Culture

  2023cites this paper
• Organophosphate esters and their diester metabolites in infant formulas and baby supplementary foods collected in Beijing, China: Occurrence and the implications for infant exposure.

  2022cites this paper
• First Insight into the Formation of In Vivo Transformation Products of 2-Ethylhexyl diphenyl phosphate in Zebrafish and Prediction of Their Potential Toxicities.

  2022cites this paper
• Gestational organophosphate ester exposure and preschool attention-deficit/hyperactivity disorder in the Norwegian Mother, Father, and Child cohort study.

  2022cites this paper
• Prenatal Exposure of Organophosphate Esters and Its Trimester-Specific and Gender-Specific Effects on Fetal Growth.

  2022cites this paper
• Oxidative stress and ferroptosis involved in 2-ethylhexyl diphenyl phosphate -induced hepatotoxicity in chicken.

  2022cites this paper
• A QuEChERS-based UPLC-MS/MS method for rapid determination of organophosphate flame retardants and their metabolites in human urine.

  2022cites this paper
• A global survey of organophosphate esters and their metabolites in milk: Occurrence and dietary intake via milk consumption.

  2022cites this paper
• Characterization of the phosphotriesterase capable of hydrolyzing aryl-organophosphate flame retardants

  2022cites this paper
• Comprehensive suspect screening for the identification of contaminants of emerging concern in urine of Flemish adolescents by liquid chromatography high-resolution mass spectrometry.

  2022cites this paper
• Development of magnetic molecularly imprinted solid-phase extraction and ultra-high performance liquid chromatography tandem mass spectrometry for rapid and selective determination of urinary diphenyl phosphate of college students.

  2022cites this paper
• Computational Insight into Biotransformation Profiles of Organophosphorus Flame Retardants to Their Diester Metabolites by Cytochrome P450

  2022cites this paper
• A review of organophosphate esters in indoor dust, air, hand wipes and silicone wristbands: Implications for human exposure.

  2021cites this paper
• Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14-15 years) from the Flemish Environment and Health Study.

  2021cites this paper
• Organophosphate flame retardants and diesters in the urine of e-waste dismantling workers: associations with indoor dust and implications for urinary biomonitoring.

  2021cites this paper
• In vitro metabolic kinetics of cresyl diphenyl phosphate (CDP) in liver microsomes of crucian carp (Carassius carassius).

  2021cites this paper
• Evaluation of hepatotoxicity induced by 2-ethylhexyldiphenyl phosphate based on transcriptomics and its potential metabolism pathway in human hepatocytes.

  2021cites this paper
• First Insight on in vitro Metabolism of Three Newly Identified Aryl Organophosphate Esters via a Suspect Coupled with Nontarget Screening Approach.

  2021cites this paper
• 液液提取-固相萃取-高效液相色谱-串联质谱测定人体血液中16种有机磷酸酯

  2021cites this paper
• Human internal exposure to organophosphate esters: A short review of urinary monitoring on the basis of biological metabolism research.

  2021cites this paper
• Human CYP enzyme-activated clastogenicity of 2-ethylhexyl diphenyl phosphate (a flame retardant) in mammalian cells.

  2021cites this paper
• Exposure to organophosphate esters in elderly people: Relationships of OPE body burdens with indoor air and dust concentrations and food consumption.

  2021cites this paper
• Identifying Dermal Uptake as a Significant Pathway for Human Exposure to Typical Semivolatile Organic Compounds in an E-Waste Dismantling Site: The Relationship of Contaminant Levels in Handwipes and Urine Metabolites.

  2021cites this paper
• In vitro biotransformation of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate by mouse liver microsomes: Kinetics and key CYP isoforms.

  2021cites this paper
• In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

  2020cites this paper
• In Vitro Metabolism of ITPs and TBPPs Using Human Liver Subcellular Fractions.

  2020cites this paper
• Comparing the use of silicone wristbands, hand wipes, and dust to evaluate children's exposure to flame retardants and plasticizers.

  2020cites this paper
• Functional Group-Dependent Screening of Organophosphate Esters (OPEs), and Discovery of an Abundant OPE Bis-(2-Ethylhexyl)-Phenyl Phosphate (BEHPP) in Indoor Dust.

  2020cites this paper
• Combined exposure to phthalate esters and phosphate flame retardants and plasticizers and their associations with wheeze and allergy symptoms among school children.

  2020cites this paper
• Organophosphate esters and their metabolites in paired human whole blood, serum, and urine as biomarkers of exposure.

  2020cites this paper
• Elevated occupational exposure to chlorinated phosphate esters at a construction materials manufacturing plant.

  2020cites this paper
• Occurrence and air-soil exchange of organophosphate flame retardants in the air and soil of Dalian, China.

  2020cites this paper
• Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes.

  2020cites this paper
• 2-Ethylhexyl Diphenyl Phosphate and its Hydroxylated Metabolites are Anti-Androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes).

  2020cites this paper
• A broad range of organophosphate tri- and di-esters in house dust from Adelaide, South Australia: Concentrations, compositions, and human exposure risks.

  2020cites this paper
• Pet hair as a potential sentinel of human exposure: Investigating partitioning and exposures from OPEs and PAHs in indoor dust, air, and pet hair from China.

  2020cites this paper
• Wastewater-based epidemiology to assess human exposure to personal care and household products – A review of biomarkers, analytical methods, and applications

  2020cites this paper
• Metabolic Forest: Predicting the Diverse Structures of Drug Metabolites

  2020cites this paper
• Short-term temporal variability of urinary biomarkers of organophosphate flame retardants and plasticizers.

  2020cites this paper
• A Refined Nontarget Workflow for the Investigation of Metabolites through the Prioritization by in Silico Prediction Tools.

  2019cites this paper
• A nationwide survey of 19 organophosphate esters in soils from China: Spatial distribution and hazard assessment.

  2019cites this paper
• Biosurveillance des retardateurs de flamme organophosphorés chez les travailleurs du recyclage électronique au Québec

  2019cites this paper
• Urinary organophosphate ester concentrations in relation to ultra-processed food consumption in the general US population.

  2019cites this paper
• Organophosphate ester flame retardants and plasticizers in a Chinese population: Significance of hydroxylated metabolites and implication for human exposure.

  2019cites this paper
• Organophosphate di- and tri-esters in indoor and outdoor dust from China and its implications for human exposure.

  2019cites this paper
• In vivo characterisation of the toxicological properties of DPhP, one of the main degradation products of aryl phosphate esters

  2019cites this paper
• Urinary biomarkers for assessment of human exposure to monomeric aryl phosphate flame retardants.

  2019cites this paper
• Organophosphate Ester, 2-Ethylhexyl Diphenyl Phosphate (EHDPP), Elicits Cytotoxic and Transcriptomic Effects in Chicken Embryonic Hepatocytes and Its Biotransformation Profile Compared to Humans.

  2019cites this paper
• Nasal lavages as a tool for monitoring exposure to organic pollutants.

  2019cites this paper
• In vitro metabolic activation of triphenyl phosphate leading to the formation of glutathione conjugates by rat liver microsomes.

  2019cites this paper
• Biomonitoring of organophosphate triesters and diesters in human blood in Jiangsu Province, eastern China: Occurrences, associations, and suspect screening of novel metabolites.

  2019cites this paper
• Towards establishing indicative values for metabolites of organophosphate ester contaminants in human urine.

  2019cites this paper
• Quantification of 16 urinary biomarkers of exposure to flame retardants, plasticizers, and organophosphate insecticides for biomonitoring studies.

  2019cites this paper
• Simultaneous biomonitoring of 15 organophosphate flame retardants metabolites in urine samples by solvent induced phase transition extraction coupled with ultra-performance liquid chromatography-tandem mass spectrometry.

  2019cites this paper
• Study on Biodegradation Characteristics of Aryl Organophosphorus Flame Retardants (aryl-OPFRs) by Sphingobium yanoikuyae YC-XJ2 CURRENT STATUS: UNDER REVIEW

  2019cites this paper
• Investigating the in vitro metabolism of the dental resin monomers BisGMA, BisPMA, TCD-DI-HEA and UDMA using human liver microsomes and quadrupole time of flight mass spectrometry.

  2019cites this paper
• Aryl-phosphorus-containing flame retardants induce oxidative stress, the p53-dependent DNA damage response and mitochondrial impairment in A549 cells.

  2019cites this paper
• Human exposure pathways to organophosphate flame retardants: Associations between human biomonitoring and external exposure.

  2019cites this paper
• Simultaneous determination of 14 urinary biomarkers of exposure to organophosphate flame retardants and plasticizers by LC-MS/MS

  2018cites this paper
• Urinary metabolites of organophosphate esters: Concentrations and age trends in Australian children.

  2018cites this paper
• Bioremediation of triphenyl phosphate by Brevibacillus brevis: Degradation characteristics and role of cytochrome P450 monooxygenase.

  2018cites this paper
• Quantum chemical simulations revealed the toxicokinetic mechanisms of organic phosphorus flame retardants catalyzed by P450 enzymes

  2018cites this paper
• Suspect and non-target screening workflows to investigate the in vitro and in vivo metabolism of the synthetic cannabinoid 5Cl-THJ-018.

  2018cites this paper
• Recent biomonitoring reports on phosphate ester flame retardants: a short review

  2018cites this paper
• Presence of diphenyl phosphate and aryl-phosphate flame retardants in indoor dust from different microenvironments in Spain and the Netherlands and estimation of human exposure.

  2018cites this paper
• In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry

  2018cites this paper
• Concentrations of organophosphate flame retardants and plasticizers in urine from young children in Queensland, Australia and associations with environmental and behavioural factors

  2018cites this paper
• Characterized in Vitro Metabolism Kinetics of Alkyl Organophosphate Esters in Fish Liver and Intestinal Microsomes.

  2018cites this paper