A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Blood

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 11050005
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of breakpoint cluster regions at 1p36.3 and 3q21 in hematologic malignancies with t(1;3)(p36;q21)

  2000cited by this paper
• 3q21 and 3q26 cytogenetic abnormalities in acute myeloblastic leukemia: biological and clinical features.

  1999cited by this paper
• MDS1/EVI1 enhances TGF-β1 signaling and strengthens its growth-inhibitory effect, but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-β1

  1999cited by this paper
• The PR Domain of the Rb-binding Zinc Finger Protein RIZ1 Is a Protein Binding Interface and Is Related to the SET Domain Functioning in Chromatin-mediated Gene Expression*

  1998cited by this paper
• Cloning and characterization of mCtBP2, a co‐repressor that associates with basic Krüppel‐like factor and other mammalian transcriptional regulators

  1998cited by this paper
• Identification of translocational breakpoints within the intron region before the last coding exon (exon 12) of the EVI1 gene in two cases of CML-BC with inv(3)(q21q26).

  1997cited by this paper
• The leukemia-associated gene MDS1/EVI1 is a new type of GATA-binding transactivator

  1997cited by this paper
• Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.

  1997cited by this paper
• A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

  1997cited by this paper
• Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method.

  1997cited by this paper
• Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.

  1996cited by this paper
• Tumor-specific rearrangements of the immunoglobulin heavy-chain gene in B-cell non-Hodgkin's lymphoma detected by in situ hybridization.

  1996cited by this paper
• Establishment of an Undifferentiated Leukemia Cell Line (Kasumi‐3) with t(3;7)(q27;q22) and Activation of the EVI1 Gene

  1996cited by this paper
• Establishment of a myeloid leukaemia cell line (Kasumi‐4) with t(9;22;11)(q34;q11;q13), inv(3)(q21q26) and the EVI1 gene activation from a patient with chronic myelogenous leukaemia in blast crisis

  1996cited by this paper
• The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.

  1995cited by this paper
• Functional characterization of the cis-regulatory elements of the rat ribophorin I gene.

  1995cited by this paper
• Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study

  1995cited by this paper
• Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26).

  1994cited by this paper
• Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26.

  1992cited by this paper
• Characterization of a factor-dependent acute leukemia cell line with translocation (3;3)(q21;q26).

  1990cited by this paper
• Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia

  1989cited by this paper
• Diagnostic and prognostic significance of t(1;3)(p36;q21) in the disorders of hematopoiesis.

  1987cited by this paper
• t(1;3)(p36;q21) in acute nonlymphocytic leukemia: a new cytogenetic-clinicopathologic association.

  1985cited by this paper
• A new translocation, t(1;3) (p36;q21), in myelodysplastic disorders.

  1984cited by this paper
• Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas.

  1980cited by this paper
• Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity.

  1978cited by this paper
• Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes.

  1972cited by this paper

• The oncogenic role of ecotropic viral integration site 1 in hematological malignancies: mechanisms of activation and leukemogenesis.

  2026cites this paper
• DNA Methylation Episignature as a Novel Diagnostic Tool for Diamond‐Blackfan Anemia Syndrome

  2025cites this paper
• Patterns and drivers of 43,617 mosaic chromosomal alterations in blood

  2025cites this paper
• Metabolic reprogramming by PRDM16 drives cytarabine resistance in acute myeloid leukemia

  2025cites this paper
• PRDM16, a new kid on the block in cardiovascular health and disease

  2025cites this paper
• Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q

  2025cites this paper
• DNA methylation-induced suppression of PRDM16 in colorectal cancer metastasis through the PPARγ/EMT pathway.

  2025cites this paper
• Unravelling the function of prdm16 in human tumours: A comparative analysis of haematologic and solid tumours.

  2024cites this paper
• Acute myeloid leukemia with rare recurring translocations—an overview of the entities included in the international consensus classification

  2024cites this paper
• Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q

  2024influential citation
• Directly targeting PRDM16 in thermogenic adipose tissue to treat obesity and its related metabolic diseases

  2024cites this paper
• A PRDM16-driven signal regulates body composition in testosterone-treated hypogonadal men

  2024cites this paper
• Genocopy of EVI1‐AML with paraneoplastic diabetes insipidus: PRDM16 overexpression by t(1;2)(p36;p21) and enhancer hijacking

  2024cites this paper
• PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm

  2023cites this paper
• Pan-cancer analysis of positive regulatory domain-containing 16 in human tumors

  2023cites this paper
• The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis

  2023cites this paper
• MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma

  2022cites this paper
• Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia

  2022cites this paper
• PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes

  2022cites this paper
• Prognostic impact of homeobox and PR domain containing protein 16 genes expressions in patients with acute myeloid leukemia

  2021cites this paper
• Prdm16 Supports Arterial Flow Recovery by Maintaining Endothelial Function

  2021cites this paper
• Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia

  2021cites this paper
• Only SF3B1 mutation involving K700E independently predicts overall survival in myelodysplastic syndromes

  2021cites this paper
• Only SF3B1 Mutation involving K700E (And Not Other Codons), Independently Predicts Overall Survival in Myelodysplastic Syndromes

  2020cites this paper
• High PRDM16 expression predicts poor outcomes in adult acute myeloid leukemia patients with intermediate cytogenetic risk: a comprehensive cohort study from a single Chinese center

  2020cites this paper
• PRDM16 orchestrates angiogenesis via neural differentiation in the developing brain

  2020cites this paper
• Insights into the genetic architecture of the human face

  2020cites this paper
• Multifaceted Role of PRDM Proteins in Human Cancer

  2020influential citation
• Emerging Roles of PRDM Factors in Stem Cells and Neuronal System: Cofactor Dependent Regulation of PRDM3/16 and FOG1/2 (Novel PRDM Factors)

  2020cites this paper
• The important roles of protein SUMOylation in the occurrence and development of leukemia and clinical implications

  2020cites this paper
• Genome-wide assessment of DNA methylation in mouse oocytes reveals effects associated with in vitro growth, superovulation, and sexual maturity

  2019cites this paper
• GENETIC ANALYSES OF DENTAL ANOMALIES AND DENTAL CARIES IN MULTIETHNIC POPULATIONS

  2019cites this paper
• Correction to: Genome-wide assessment of DNA methylation in mouse oocytes reveals effects associated with in vitro growth, superovulation, and sexual maturity

  2019cites this paper
• The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development

  2019cites this paper
• PRDM16s transforms megakaryocyte-erythroid progenitors to acute myeloid leukemia-initiating cells.

  2019cites this paper
• Characterization of a t(1;2)(p36;p21) involving the PRDM16 gene region by mate-pair sequencing (MPseq) in a patient with newly diagnosed acute myeloid leukemia with myelodysplasia-related changes

  2019cites this paper
• Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors

  2018cites this paper
• Genome-wide identification of transcription factors that are critical to non-small cell lung cancer.

  2018influential citation
• Acute myeloid leukemia with translocation (1;21)

  2018cites this paper
• PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature

  2018cites this paper
• Advances and Prospects of Brown Adipocyte-Specific Gene PRDM16

  2018cites this paper
• Differential Roles of PRDM16 Isoforms in Normal and Malignant Hematopoiesis

  2018cites this paper
• Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping

  2017cites this paper
• Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia

  2017cites this paper
• Generation of a multipurpose Prdm 16 allele by targeted trapping

  2017cites this paper
• Diagnostic Yield of Whole Exome Sequencing in Pediatric Dilated Cardiomyopathy

  2017cites this paper
• The Role of Adipocyte Lipid Droplet Lipolysis in Thermogenesis and Metabolic Health

  2017cites this paper
• Prdm16 is required for the maintenance of neural stem cells in the postnatal forebrain and their differentiation into ependymal cells

  2017cites this paper
• PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity.

  2016cites this paper
• High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3‐ITD, KMT2A‐PTD, and NUP98‐NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML‐05 trial

  2016cites this paper
• The Multifaceted Roles of PRDM16: Adipose Biology and Beyond.

  2016cites this paper
• Functions of Prdm16 in thermogenic fat cells

  2015cites this paper
• Digging deep into “dirty” drugs – modulation of the methylation machinery

  2015cites this paper
• SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia

  2015influential citation
• High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML

  2015cites this paper
• The closely related rare and severe acute myeloid leukemias carrying EVI1 or PRDM16 rearrangements share singular biological features

  2015cites this paper
• Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

  2014cites this paper
• Recent advances in brown adipose tissue biology

  2014cites this paper
• PRDM16 in Development and Disease

  2014cites this paper
• Downregulation of prdm16 is critical for HOXB4-mediated benign HSC expansion in vivo

  2014cites this paper
• PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation

  2013cites this paper
• Redundant roles of PRDM family members in zebrafish craniofacial development

  2013cites this paper
• Adaptive thermogenesis in adipocytes: is beige the new brown?

  2013cites this paper
• Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males

  2013cites this paper
• Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy.

  2013cites this paper
• Role of PRDM16 in the activation of brown fat programming. Relevance to the development of obesity.

  2013cites this paper
• The shortest isoform of C/EBPβ, liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model.

  2013cites this paper
• Insertional activation of myb by F-MuLV in SCID mice induces myeloid leukemia.

  2013cites this paper
• NUP98‐NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia

  2013cites this paper
• Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?

  2013cites this paper
• Investigating the mechanism underlying modulation of ATRA response by the transcription factor EVI1

  2013cites this paper
• hypomethylation in adult T-cell leukemia cells Aberrant expression of the MEL1S gene identified in association with

  2013cites this paper
• Brown Adipose Tissue Differentiation and Control Mechanism #

  2013cites this paper
• Identification of genetic aberrations in myelodysplastic syndromes

  2012cites this paper
• Chromatin immunoprecipitation-promoter microarray identification of genes regulated by PRDM16 in murine embryonic palate mesenchymal cells

  2012cites this paper
• Hypomethylation and Over-Expression of the Beta Isoform of BLIMP1 is Induced by Epstein-Barr Virus Infection of B Cells; Potential Implications for the Pathogenesis of EBV-Associated Lymphomas

  2012cites this paper
• The Prdm family: expanding roles in stem cells and development

  2012cites this paper
• murine embryonic palate mesenchymal cells Chromatin immunoprecipitation-promoter microarray identification of genes regulated by PRDM 16 in

  2012cites this paper
• Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

  2012cites this paper
• PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.

  2012cites this paper
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

  2012cites this paper
• EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1.

  2011cites this paper
• Dominant-negative C/ebpα and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis.

  2011cites this paper
• PRDM16 (PR domain containing 16)

  2011cites this paper
• PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignancies

  2011cites this paper
• PRDM16 expression in the developing mouse embryo.

  2011influential citation
• Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation

  2011cites this paper
• Prdm16 is a physiologic regulator of hematopoietic stem cells.

  2011cites this paper
• An update on the molecular pathogenesis of myelodysplastic syndromes.

  2011cites this paper
• Estudi de l’expressió i funció del gen SIRT3 en el teixit adipós marró

  2011cites this paper
• lethal dyserythropoiesis short-lived hematopoietic stem/progenitor cell life span and induce and polycomb group protein Bmi1 extend α Dominant-negative C/ebp

  2011cites this paper
• Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies

  2011influential citation
• Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation

  2011cites this paper
• Prdm 16 is a physiologic regulator of hematopoietic stem cells

  2011cites this paper
• An investigation of the regulation of BLIMP1 by the epstein-barr virus in B cells

  2011cites this paper
• Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-β2 and FLT3 in hematopoiesis.

  2011cites this paper
• Identifikation und Charakterisierung neuer ETV6-assoziierter Translokationen bei drei Patienten mit akuter myeloischer Leukämie

  2010cites this paper
• Transcriptional control of brown fat development.

  2010cites this paper
• Acetylation of Lysine 564 Adjacent to the C-terminal Binding Protein-binding Motif in EVI1 Is Crucial for Transcriptional Activation of GATA2*

  2010cites this paper
• A Transient Transgenic RNAi Strategy for Rapid Characterization of Gene Function during Embryonic Development

  2010cites this paper