Mammalian cortical voltage imaging using genetically encoded voltage indicators: a review honoring professor Amiram Grinvald

Abstract. The pioneering work of Amiram Grinvald established voltage-sensitive dye imaging (VSDI) in the mammalian cortex in the 1980s and inspired decades of cortical voltage imaging and the associated technological developments. The recent conception and development of genetically encoded voltage indicators (GEVIs) overcome many of the limitations of classical VSDI, and open experimental approaches that provide accruing support for orchestrated neuronal circuit dynamics of spatially distributed neuronal circuit underlying behaviors. We will review recent achievements using GEVIs to optically monitor the cortical activity in mammalian brains in vivo and provide a perspective for potential future directions.

• Publication year

  2017

• Venue

  Neurophotonics

• Publication date

  2017-05-04

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1117/1.NPh.4.3.031214PMID 28491906PMCID 5416838
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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