[Gene-nutrient interaction and its association with obesity and diabetes mellitus].

Nutritional genomics evaluates the effects of genetic variation in the interaction between diet and chronic diseases. The aim of this manuscript was to review the most important genetic polymorphisms associated with obesity, diabetes mellitus, and dietary factors. The main interactions among genetic polymorphisms and diet were: for obesity: interleukin-6 (IL-6) with daily intake; peroxisome proliferator-activated receptor gamma 2 (PPAR-gama2) and fat mass and obesity associated (FTO) with fat intake; beta-adrenergic receptor 2 (ADRB2) and melanocortin receptor 4 (MCR4) with carbohydrate intake; or reduction in body weight: uncoupling proteins (UCPs) with restriction of energy; for leptinemia: leptin receptor (LEPR) with restriction of energy; for diabetes mellitus: PPAR-gama2 with fat intake; for hypertriglyceridemia: fatty acid-binding protein 2 (FABP2) with fat intake. The data demonstrated suggest that nutritional genomics is important for the development of obesity and diabetes mellitus.

• Publication year

  2009

• Venue

  Arquivos brasileiros de endocrinologia e metabologia

• Publication date

  2009-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1590/S0004-27302009000500003PMID 19768241
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians

  2009cited by this paper
• Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample

  2008cited by this paper
• The fat mass- and obesity-associated locus and dietary intake in children.

  2008cited by this paper
• Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1alpha gene.

  2008cited by this paper
• Influence of Lys656Asn Polymorphism of Leptin Receptor Gene on Leptin Response Secondary to Two Hypocaloric Diets: A Randomized Clinical Trial

  2008cited by this paper
• Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population

  2008cited by this paper
• The − 11391 G/A Polymorphism of the Adiponectin Gene Promoter is Associated with Metabolic Syndrome Traits and the Outcome of an Energy-restricted Diet in Obese Subjects

  2008cited by this paper
• Obesity associated genetic variation in FTO is associated with diminished satiety.

  2008cited by this paper
• Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.

  2008cited by this paper
• Variations in the FTO gene are associated with severe obesity in the Japanese

  2008cited by this paper
• Association of the FTO Gene With BMI

  2008cited by this paper
• The Pro12Ala polymorphism of the PPAR-γ2 gene affects associations of fish intake and marine n−3 fatty acids with glucose metabolism

  2008cited by this paper
• Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons.

  2008cited by this paper
• The interaction between the interleukin 6 receptor gene genotype and dietary energy intake on abdominal obesity in Japanese men.

  2007cited by this paper
• Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta −87T>C polymorphism and dietary fat in French-Canadians

  2007cited by this paper
• The PPARγ Pro12Ala Polymorphism Is Not Associated with Body Mass Index or Waist Circumference among Hispanics from Colorado

  2007cited by this paper
• The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals

  2007cited by this paper
• A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

  2007cited by this paper
• Effect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity.

  2007cited by this paper
• Effect of the melanocortin-3 receptor C 17 A and G 241 A variants on weight loss in childhood obesity 1 – 3

  2007cited by this paper
• Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus.

  2007cited by this paper
• The obesity epidemic.

  2007cited by this paper
• Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease

  2007cited by this paper
• Impact of interleukin 6 -174G>C polymorphism on obesity-related metabolic disorders in people with excess in body weight.

  2007cited by this paper
• The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects.

  2006cited by this paper
• Nutrigenomics: from molecular nutrition to prevention of disease.

  2006cited by this paper
• Leptin receptor Lys656Asn polymorphism is associated with decreased leptin response and weight loss secondary to a lifestyle modification in obese patients.

  2006cited by this paper
• Weight regain after slimming induced by an energy-restricted diet depends on interleukin-6 and peroxisome-proliferator-activated-receptor-γ2 gene polymorphisms

  2006cited by this paper
• Genotype-by-nutrient interactions assessed in European obese women

  2006cited by this paper
• Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity.

  2005cited by this paper
• Nutrigenomics: The Impact of Biomics Technology on Nutrition Research

  2005cited by this paper
• Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men.

  2005cited by this paper
• The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes.

  2005cited by this paper
• The Ala54Thr polymorphism of the fatty acid-binding protein 2 gene is associated with a change in insulin sensitivity after a change in the type of dietary fat.

  2005cited by this paper
• The apolipoprotein E gene promoter (-219G/T) polymorphism determines insulin sensitivity in response to dietary fat in healthy young adults.

  2005cited by this paper
• Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.

  2004cited by this paper
• Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes.

  2004cited by this paper
• The Obesity Epidemic

  2004cited by this paper
• Additive effect of the mutations in the β3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome

  2004cited by this paper
• Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.

  2004cited by this paper
• High incidence of type 2 diabetes in peroxisome proliferator-activated receptor gamma2 Pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids.

  2004cited by this paper
• Nutrigenomics and nutrigenetics

  2004cited by this paper
• Higher obesity risk associated with the exon-8 insertion of the UCP2 gene in a Spanish case-control study.

  2004cited by this paper
• Nutrigenomics: exploiting systems biology in the nutrition and health arenas.

  2004cited by this paper
• Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease.

  2004cited by this paper
• Nutrigenomics: the Rubicon of molecular nutrition.

  2003cited by this paper
• Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism.

  2003cited by this paper
• Dietary fat interacts with the -514C>T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey.

  2003cited by this paper
• Nutrigenomics: goals and strategies

  2003cited by this paper
• The PPAR‐gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Québec Family Study

  2003cited by this paper
• Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass.

  2003cited by this paper
• Section IV: Lipid Modulators of Islet Function Update on Adipocyte Hormones Regulation of Energy Balance and Carbohydrate/Lipid Metabolism

  2003cited by this paper
• Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.

  2003cited by this paper
• Nutrient-Gene Interactions Obesity Risk Is Associated with Carbohydrate Intake in Women Carrying the Gln 27 Glu 2-Adrenoceptor Polymorphism

  2003cited by this paper
• Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.

  2002cited by this paper
• Establishing the role of gene-environment interactions in the etiology of type 2 diabetes.

  2002cited by this paper
• Dietary Fat Intake Determines the Effect of a Common Polymorphism in the Hepatic Lipase Gene Promoter on High-Density Lipoprotein Metabolism: Evidence of a Strong Dose Effect in This Gene-Nutrient Interaction in the Framingham Study

  2002cited by this paper
• Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study.

  2002cited by this paper
• Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study.

  2002cited by this paper
• Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

  2002cited by this paper
• A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes

  2002cited by this paper
• The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism

  2002cited by this paper
• Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome.

  2002cited by this paper
• The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism.

  2002cited by this paper
• Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women.

  2002cited by this paper
• Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Gene Locus Associations With Obesity Indices in Middle-Aged Women

  2002cited by this paper
• Studies of the Pro12Ala polymorphism of the ppar-γ gene in the Danish MONICA cohort: Homozygosity of the Ala allele confers a decreased risk of the Insulin Resistance syndrome

  2002cited by this paper
• Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes

  2001cited by this paper
• The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.

  2001cited by this paper
• Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene.

  2001cited by this paper
• Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.

  2001cited by this paper
• Central nervous system control of food intake

  2000cited by this paper
• Hepatic lipase and HDL metabolism.

  2000cited by this paper
• Hepatic lipase: new insights from genetic and metabolic studies.

  1999cited by this paper
• The uncoupling proteins, a review.

  1998cited by this paper
• A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

  1998cited by this paper
• Genetic and Environmental Factors in Relative Body Weight and Human Adiposity

  1997cited by this paper
• Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function.

  1997cited by this paper
• Relation of coronary heart disease and apolipoprotein E phenotype in patients with non-insulin dependent diabetes.

  1991cited by this paper
• Aluminium and cooking

  1987cited by this paper

• Relationship Between the Single Nucleotide Polymorphism A35C in the Cu/Zn-Superoxide Dismutase-1 Gene and Glycemic Control in Individuals with Type 2 Diabetes Mellitus

  2025cites this paper
• Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

  2024cites this paper
• FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial

  2022cites this paper
• Nutrigenomics in Regulating the Expression of Genes Related to Type 2 Diabetes Mellitus

  2021cites this paper
• Association of -174 G>C interleukin-6 gene polymorphism with interleukin-6 and c-reactive protein levels and obesity: A case-control study among people/residents of Western Indonesia.

  2019cites this paper
• Sugar Addiction: From Evolution to Revolution

  2018cites this paper
• [Precision dietary guidelines and ingredients for chronic diseases in pre-senior and senior populations].

  2018cites this paper
• Association Between Polymorphism of Tumor Necrosis Factor Alpha (TNFα) in the Region −308 G/A With Tinnitus in the Elderly With a History of Occupational Noise Exposure

  2018cites this paper
• Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

  2017cites this paper
• Grape Juice, Red Wine, Resveratrol and Exercise, In the Expression of FNDC5 and UCP2 in Cardiac and Skeletal Muscles of Wistar Rats Submitted To High-Fat Diet

  2017cites this paper
• Genetics of Human Obesity

  2016cites this paper
• Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

  2015influential citation
• Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents.

  2015cites this paper
• Study of genetic variants associated with obesity in Portuguese children

  2015cites this paper
• Obesity: genome and environment interactions

  2012cites this paper
• Nutrición personalizada y genes

  2011cites this paper
• Manifestaciones cutáneas en la obesidad

  2011cites this paper
• Nutrigenetics: A Tool to Provide Personalized Nutritional Therapy to the Obese

  2010cites this paper
• Nutrigenetics: a tool to provide personalized nutritional therapy to the obese.

  2010cites this paper