Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Human Molecular Genetics

• Publication date

  2002-10-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/11.21.2607PMID 12354786
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Risk factors for worsening to diabetes in subjects with impaired glucose tolerance

  2004cited by this paper
• Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation*

  2002cited by this paper
• Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

  2002influential reference
• ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism.

  2002cited by this paper
• Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.

  2002cited by this paper
• Listening to silence and understanding nonsense: exonic mutations that affect splicing

  2002cited by this paper
• Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes.

  2002cited by this paper
• Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3 q , 15 q , and 20 q and Identifies Two New Candidate Loci on 7 p and 11 p

  2002cited by this paper
• Hydroxylation and Glycosylation of the Four Conserved Lysine Residues in the Collagenous Domain of Adiponectin

  2002cited by this paper
• On the allelic spectrum of human disease.

  2001cited by this paper
• The hormone resistin links obesity to diabetes

  2001cited by this paper
• Are rare variants responsible for susceptibility to complex diseases?

  2001cited by this paper
• Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.

  2001cited by this paper
• Endogenous glucose production is inhibited by the adipose-derived protein Acrp30.

  2001cited by this paper
• The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

  2001influential reference
• Routine mutation screening of HNF-1α and GCK genes in MODY diagnosis: How effective are the techniques of DHPLC and direct sequencing used in combination?

  2001cited by this paper
• Identification and Adipocyte Differentiation-dependent Expression of the Unique Disialic Acid Residue in an Adipose Tissue-specific Glycoprotein, Adipo Q*

  2001cited by this paper
• The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.

  2001cited by this paper
• The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

  2001cited by this paper
• A general test of association for quantitative traits in nuclear families.

  2000cited by this paper
• Genomic structure and mutations in adipose-specific gene, adiponectin

  2000cited by this paper
• Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.

  2000cited by this paper
• Adipose tissue as an endocrine organ.

  2000cited by this paper
• Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

  2000cited by this paper
• Big Dye™ terminator cycle sequencing chemistry: Accuracy of the dilution process and application for screening mutations in the TCF1 and GCK genes

  2000cited by this paper
• Model-Free Analysis and Permutation Tests for Allelic Associations

  1999cited by this paper
• Identification of N-acetyltransferase 2 genotypes by continuous monitoring of fluorogenic hybridization probes.

  1999cited by this paper
• Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

  1999cited by this paper
• Organization of the gene for gelatin-binding protein (GBP28).

  1999cited by this paper
• The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor.

  1998cited by this paper
• Identification and characterization of the human adipocyte apM-1 promoter.

  1998cited by this paper
• The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk.

  1998cited by this paper
• Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty

  1996cited by this paper
• Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

  1995cited by this paper
• A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*)

  1995cited by this paper
• Independence tests for VNTR alleles defined as quantile bins.

  1993cited by this paper
• Cooperative function of two separate enhancers of the human epidermal growth factor receptor proto-oncogene.

  1989cited by this paper
• Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man

  1985cited by this paper
• Insulin Responses in Equivocal and Definite Diabetes, with Special Reference to Subjects Who Had Mild Glucose Intolerance but Later Developed Definite Diabetes

  1977cited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance

  year unknowncited by this paper

• Association of Adiponectin Gene Polymorphism rs266729 in Obese People with Type Two Diabetes Mellitus in North Bulgaria’s Population

  2026cites this paper
• An Exploratory Study of ADIPOQ Polymorphisms, Adiponectin Levels and Metabolic Syndrome in a Vietnamese Population.

  2026cites this paper
• Plasma adiponectin and biomarker‐confirmed Alzheimer's disease in a tertiary memory clinic

  2025cites this paper
• Exploring the impact of ADIPOQ gene variants on plasma adiponectin levels and oxidative stress in type 2 diabetes mellitus and diabetic nephropathy in South Indian population: a case–control study

  2025cites this paper
• ADIPOQ Variants rs1501299 and rs3774261 and Hypoadiponectinemia in Obese Women with PCOS: Genetic and Metabolic Interactions

  2025cites this paper
• Role of the Genetic Variants of Fetuin-A and Adiponectin in Type 2 Diabetes Mellitus: A Narrative Review

  2025cites this paper
• Association between adiponectin single nucleotide polymorphisms and the risk of diabetic polyneuropathy

  2025cites this paper
• Adiponectin gene polymorphism and TyPE 2 diabetes MellitUS: Contrasting genetic RISKS in overdominant vs recessive and allele models – an updated meta – analysis

  2025cites this paper
• The Role of Adiponectin and ADIPOQ Variation in Metabolic Syndrome: A Narrative Review

  2025cites this paper
• Diabetes in China: epidemiology, pathophysiology and multi-omics

  2025cites this paper
• Development of a rapid and ultrasensitive magnetic chemiluminescence immunoassay for the detection of adiponectin and its clinical application.

  2024cites this paper
• INSULIN RESISTANCE, SERUM ADIPONECTIN AND ADIPONECTIN GENE POLYMORPHISM IN FIRST-DEGREE RELATIVES OF INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS

  2024cites this paper
• Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk

  2024influential citation
• Identification of circulating apolipoprotein M as a new determinant of insulin sensitivity and relationship with adiponectin

  2024cites this paper
• Association study between adiponectin gene variants, serum levels and the risk of type 2 diabetes in Tunisian women: Insights from BMI stratification.

  2024cites this paper
• Host genetics and nutrition.

  2024cites this paper
• A Systematic Narrative Review on ADIPOQ Gene Variants and its Association with T2DM in the Indian Population.

  2024cites this paper
• Current Data and New Insights into the Genetic Factors of Atherogenic Dyslipidemia Associated with Metabolic Syndrome

  2023cites this paper
• Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review

  2023cites this paper
• The Polymorphism rs17300539 in the Adiponectin Promoter Gene Is Related to Metabolic Syndrome, Insulin Resistance, and Adiponectin Levels in Caucasian Patients with Obesity

  2023cites this paper
• Integrating Common Risk Factors with Polygenic Scores Improves the Prediction of Type 2 Diabetes

  2023cites this paper
• Association of circulating levels of apolipoprotein M and adiponectin with insulin sensitivity in overweight subjects and obese patients with weight loss surgery

  2023cites this paper
• Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

  2023cites this paper
• Анализ вариантов генов адипокинов методом таргетного секвенирования

  2023cites this paper
• Single Nucleotide Polymorphisms at +45 T>G and at +276 G>T of the Adiponectin Gene and Plasma Adiponectin Level in Myanmar Type 2 Diabetic Patients

  2022cites this paper
• Effect of 8 Weeks Aerobic Training and Saffron Supplementation on Inflammation and Metabolism in Middle-Aged Obese Women with Type 2 Diabetes Mellitus

  2022influential citation
• Genetic and Functional Effects of Adiponectin in Type 2 Diabetes Mellitus Development

  2022cites this paper
• The Effects of BMI and Genetic Variation of Adipokines on Serum Concentrations of Hormones in Untreated Individuals with Breast Cancer; a Pilot Study

  2022cites this paper
• A dominant negative ADIPOQ mutation in a diabetic family with renal disease, hypoadiponectinemia, and hyperceramidemia

  2022cites this paper
• The Effects of BMI and Genetic Variation of Adipokines on Serum Concentrations of Hormones in Untreated Individuals with Breast Cancer; a Pilot Study

  2022cites this paper
• Association of ADIPOQ rs266729 and rs1501299 gene polymorphisms and circulating adiponectin level with the risk of type 2 diabetes in a population of Iran: a case-control study

  2021cites this paper
• The impact of promoter single nucleotide polymorphism (-11391 G/A) on type II diabetes mellitus in Iraqi population

  2021cites this paper
• No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women

  2021cites this paper
• Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review

  2021cites this paper
• Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

  2021cites this paper
• DMSO_A_294328 791..800

  2021cites this paper
• Polymorphism analysis of ADIPOQ gene in Greek patients with diabetic retinopathy

  2021cites this paper
• Relation of a variant in adiponectin gene (rs266729) with metabolic syndrome and diabetes mellitus type 2 in adult obese subjects.

  2020cites this paper
• A Metabolically Unhealthy Phenotype Is Associated with ADIPOQ Genetic Variants and Lower Serum Adiponectin Levels

  2020cites this paper
• Quantile-dependent expressivity of plasma adiponectin concentrations may explain its sex-specific heritability, gene-environment interactions, and genotype-specific response to postprandial lipemia

  2020cites this paper
• Association of adiponectin gene polymorphisms and their haplotypes with type 2 diabetes and related metabolic traits in an Iranian population

  2020cites this paper
• T45G Adiponectin Gene Polymorphism and its Association with Hyperglycemia in Adult Filipinos Seen at the Philippine General Hospital – A Pilot Study

  2020cites this paper
• Hypothalamic POMC deficiency increases circulating adiponectin despite obesity

  2020cites this paper
• A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

  2020cites this paper
• The rs822396 Polymorphism of the ADIPOQ Gene Is Associated with Anthropometric, Clinical, and Biochemical Alterations Related to the Metabolic Syndrome in the Mexican Population

  2020cites this paper
• Insulin resistance in diabetes: The promise of using induced pluripotent stem cell technology

  2020cites this paper
• Single nucleotide polymorphisms at the ADIPOQ gene locus rs1501299 interact with different type of dietary fatty acids in two hypocaloric diets.

  2019cites this paper
• Heritability of hypoadiponectinemia in first-degree relatives of Indian population

  2019cites this paper
• [Association of adiponectin gene alleles with type 2 diabetes mellitus in residents of Bashkortostan].

  2019cites this paper
• Polymorphism Of The APM1 Gene In Subjects With Central Obesity Related To Lower High-Density Lipoprotein Cholesterol

  2019cites this paper
• The effect of single-nucleotide polymorphisms at the ADIPOQ gene locus rs1501299 on metabolic parameters after 9 mo of a high-protein/low-carbohydrate versus a standard hypocaloric diet.

  2019cites this paper
• Association study of the single‐nucleotide polymorphisms −3971G/A and +276G/T in the adiponectin gene with type 2 diabetes in a North Indian Punjabi population

  2019influential citation
• Polymorphism Of The APM1 Gene In Subjects With Central Obesity Related To Lower High-Density Lipoprotein Cholesterol Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

  2019cites this paper
• Adiponectin gene polymorphisms and risk of gestational diabetes mellitus: A meta-analysis

  2019cites this paper
• Polymorphism Of The APM1 Gene In Subjects With Central Obesity Related To Lower High-Density Lipoprotein Cholesterol Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

  2019cites this paper
• Adiponectin and human eating behaviour: a Mendelian randomization study

  2019cites this paper
• Genetic and epigenetic modifications of adiponectin gene: Potential association with breast cancer risk

  2019cites this paper
• Gene-Environment Interactions and the Risk of Barrett's Esophagus in Three US Cohorts.

  2019cites this paper
• Adiponectin is associated with cardio-metabolic traits in Mexican children

  2019cites this paper
• Association between adiponectin rs17300539 and rs266729 gene polymorphisms with serum adiponectin level in an Iranian diabetic/pre-diabetic population

  2018cites this paper
• +45T>G single nucleotide polymorphism of adiponectin gene: Is it a factor in childhood obesity?

  2018cites this paper
• Leptin gene variants and colorectal cancer risk: Sex-specific associations

  2018cites this paper
• The Relationship of adiponectin level and ADIPOQ gene variants with BMI among young adult women

  2018cites this paper
• Gender‐Specific Association of Leptin and Adiponectin Genes With Multiple Sclerosis

  2018cites this paper
• Association between the −11377 C/G and −11391 G/A polymorphisms of adiponectin gene and adiponectin levels with susceptibility to type 1 and type 2 diabetes mellitus in population from the west of Iran, correlation with lipid profile

  2018cites this paper
• Association between Interleukin-10 Gene (-1082g/A) Polymorphism and Type 2 Diabetes, Diabetes-Related Traits, and Microvascular Complications in the Croatian Population

  2018cites this paper
• Genetic association of ADIPOQ gene variants (-3971A>G and +276G>T) with obesity and metabolic syndrome in North Indian Punjabi population

  2018cites this paper
• The relationship between circulating adiponectin, ADIPOQ variants and incident cardiovascular disease in type 2 diabetes: The Fremantle Diabetes Study.

  2018cites this paper
• Adiponectin gene variants and decreased adiponectin plasma levels are associated with the risk of myocardial infarction in young age.

  2018cites this paper
• Genome-wide association study reveals sex-specific genetic architecture of facial attractiveness

  2018cites this paper
• Recipient But Not Donor Adiponectin Polymorphisms Are Associated With Early Posttransplant Hepatic Steatosis in Patients Transplanted for Non-Nonalcoholic Fatty Liver Disease Indications.

  2018cites this paper
• Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population.

  2018cites this paper
• Association of adiponectin gene polymorphism with type 2 diabetes and metabolic syndrome

  2018cites this paper
• Gene Polymorphism of Adiponectin SNP + 45 with Reference to Thyroid Status - A Comparative Study among Non-Obese, Overweight and Obese Type 2 Diabetics

  2018cites this paper
• Waist Circumference Is an Anthropometric Parameter That Identifies Women with Metabolically Unhealthy Phenotypes

  2018cites this paper
• Investigating the relationship between Body Mass Index (BMI) and C11377G polymorphism of adiponectin gene with breast cancer

  2018cites this paper
• Are leptin and adiponectin involved in recurrent pregnancy loss?

  2018cites this paper
• Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture

  2018cites this paper
• The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.

  2018cites this paper
• The association of SNP276G>T at adiponectin gene with insulin resistance and circulating adiponectin in response to two different hypocaloric diets.

  2018cites this paper
• The Association of SNP276G>T at Adiponectin Gene with Insulin Resistance and Circulating Adiponectin in Morbid Obese Patients After a Biliopancreatic Diversion Surgery

  2017cites this paper
• ADIPOQ polymorphisms are associated with changes in obesity-related traits in response to aerobic training programme in women

  2017cites this paper
• Associations of PPAR-γ, APM1 and APOC1 gene polymorphisms with metabolic syndrome in children: A case-control study

  2017cites this paper
• Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study

  2017cites this paper
• Candidate Genes in Adult Elderly and Adult Intermeddle Diabetes

  2017cites this paper
• CNS Targets of Adipokines.

  2017cites this paper
• Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes: a literature review

  2017cites this paper
• Role of rs1501299 variant in the adiponectin gene on total adiponectin levels, insulin resistance and weight loss after a Mediterranean hypocaloric diet.

  2017cites this paper
• Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis

  2017cites this paper
• Adiponectin isoform patterns in ethnic-specific ADIPOQ mutation carriers: The IRAS Family Study

  2017cites this paper
• Adiponectin and Its Receptors in Diabetic Kidney Disease: Molecular Mechanisms and Clinical Potential.

  2017cites this paper
• C. elegans PAQR-2 ‒ A Regulator of Membrane Homeostasis

  2016cites this paper
• Association of Polycystic Ovary Syndrome and Adiponectin Gene Polymorphisms

  2016cites this paper
• Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study

  2016cites this paper
• Adiponectin: A Mediator of Obesity, Insulin Resistance, Diabetes, and the Metabolic Syndrome

  2016cites this paper
• Inflammatory and Immune Response Genes Polymorphisms are Associated with Susceptibility to Chronic Obstructive Pulmonary Disease in Tatars Population from Russia

  2016cites this paper
• Association of the ADIPOQ Rs 2241766 and Rs 266729 Polymorphisms with Metabolic Syndrome in the Chinese Population : A Meta-analysis *

  2016cites this paper
• ADIPOQ POLYMORPHISMS AMONG THAIS WITH PRE-DIABETES.

  2016cites this paper
• Association of the ADIPOQ Rs2241766 and Rs266729 Polymorphisms with Metabolic Syndrome in the Chinese Population: A Meta-analysis.

  2016cites this paper
• Associations between single-nucleotide polymorphisms of ADIPOQ, serum adiponectin and increased type 2 diabetes mellitus risk in Bahraini individuals.

  2016cites this paper