Abstracts of the NIH-FDA Conference “Biomarkers and Surrogate Endpoints: Advancing Clinical Research and Applications”

s of the NIH-FDA Conference “Biomarkers and Surrogate Endpoints: Advancing Clinical Research and Applications” Abstracts of the NIH-FDA Conference 188s of the NIH-FDA Conference 188

• Publication year

  2002

• Venue

  Disease Markers

• Publication date

  2002-06-07

• Fields of study

  Medicine

• Identifiers
  DOI 10.1155/1998/698239PMID 10505081PMCID 3850843
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The contribution of clinical pharmacology surrogates and models to drug development--a critical appraisal.

  2003cited by this paper
• Clinical trials in systemic lupus erythematosus

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• The New England Journal

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• In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.

  1999cited by this paper
• Use of electron-beam computed tomography in the evaluation of chest pain patients in the emergency department.

  1999cited by this paper
• Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts.

  1999cited by this paper
• Molecular detection of early lung cancer.

  1999cited by this paper
• Coronary calcification by electron beam computed tomography and obstructive coronary artery disease: a model for costs and effectiveness of diagnosis as compared with conventional cardiac testing methods.

  1999cited by this paper
• Relationship of beta-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: follow-up of the Seattle Family Study.

  1999cited by this paper
• CA repeat allele polymorphism in the first intron of the human interferon-gamma gene is associated with lung allograft fibrosis.

  1999cited by this paper
• Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer.

  1999cited by this paper
• Enrichment of epithelial cells for molecular studies

  1999cited by this paper
• Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer.

  1999cited by this paper
• MRI of entorhinal cortex in mild Alzheimer's disease.

  1999cited by this paper
• Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

  1999cited by this paper
• Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma

  1999cited by this paper
• Determination of biological markers for alcohol abuse.

  1998cited by this paper
• The specificity of the CDT assay in general practice: the influence of common chronic diseases and medication on the serum CDT concentration.

  1998cited by this paper
• Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients.

  1998cited by this paper
• Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric method.

  1998cited by this paper
• Definitions of acute rejection and controlled clinical trials in the medical literature.

  1998cited by this paper
• Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.

  1998cited by this paper
• Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease.

  1998cited by this paper
• Utility of standardized histological classification in the management of acute rejection. 1995 Efficacy Endpoints Conference.

  1998cited by this paper
• Carbohydrate-deficient transferrin and conventional alcohol markers as indicators for brief intervention among heavy drinkers in primary health care.

  1998cited by this paper
• Magnetic resonance imaging in acute stroke

  1998cited by this paper
• Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men.

  1998cited by this paper
• Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy.

  1998cited by this paper
• Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection.

  1998cited by this paper
• Prospective Studies of C-Reactive Protein as a Risk Factor for Cardiovascular Disease

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• Dynamics of intra‐hepatic lymphocytes in chronic hepatitis C: enrichment for Vα24+ T cells and rapid elimination of effector cells by apoptosis

  1998cited by this paper
• Symptoms, cognitive functioning, and adaptive skills in geriatric patients with lifelong schizophrenia: a comparison across treatment sites.

  1998cited by this paper
• Axonal transection in the lesions of multiple sclerosis.

  1998cited by this paper
• Genotyping for polymorphisms in interferon-gamma, interleukin-10, transforming growth factor-beta 1 and tumour necrosis factor-alpha genes: a technical report.

  1998cited by this paper
• Cytokine genotypes in allograft rejection: guidelines for immunosuppression.

  1998cited by this paper
• Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort.

  1998cited by this paper
• Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography.

  1998cited by this paper
• Increased serum levels of soluble CD95 (APO‐1/Fas) in relapsing‐remitting multiple sclerosis

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  1998cited by this paper
• The National Institute on Aging.

  1998cited by this paper
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  1998cited by this paper
• Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

  1998cited by this paper
• Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy.

  1998cited by this paper
• Proposed consensus for definitions and endpoints for clinical trials of acute kidney transplant rejection.

  1998cited by this paper
• Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2).

  1998cited by this paper
• Fibrinolytic and Inflammatory Markers for Arterial Occlusion: The Evolving Epidemiology of Thrombosis and Hemostasis

  1997cited by this paper
• Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study.

  1997cited by this paper
• Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives.

  1997cited by this paper
• Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease.

  1997cited by this paper
• Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.

  1997cited by this paper
• Troglitazone Improves Defects in Insulin Action , Insulin Secretion , Ovarian Steroidogenesis , and Fibrinolysis in Women with Polycystic Ovary Syndrome *

  1997cited by this paper
• Acute effects of cocaine on human brain activity and emotion.

  1997cited by this paper
• Cognitive performance and mood after a weekend on call in a surgical unit

  1997cited by this paper
• Moxonidine and cognitive function: interactions with moclobemide and lorazepam

  1997cited by this paper
• Analysis of 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in DNA treated with 2-chlorooxirane by high performance liquid chromatography/electrospray mass spectrometry and comparison of amounts to other DNA adducts.

  1997cited by this paper
• Molecular damage in the bronchial epithelium of current and former smokers.

  1997cited by this paper
• Clonal genetic alterations in the lungs of current and former smokers.

  1997cited by this paper
• Comparison of electron beam computed tomography with intracoronary ultrasound and coronary angiography for detection of coronary atherosclerosis.

  1997cited by this paper
• Noncognitive Disturbances in Alzheimer's Disease: Frequency, Longitudinal Course, and Relationship to Cognitive Symptoms

  1997cited by this paper
• The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis.

  1997cited by this paper
• Changes in arterial expression of fibrinolytic system proteins in atherogenesis.

  1997cited by this paper
• Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival?

  1997cited by this paper
• The role of immune responses in the pathogenesis of hepatitis C virus infection

  1997cited by this paper
• Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections.

  1997cited by this paper
• Selecting and Validating Biologic Markers for Drug Development

  1997cited by this paper
• Patterns of graft infiltration and cytokine gene expression during the first 10 days of kidney transplantation.

  1997cited by this paper
• Staging of Alzheimer-related cortical destruction.

  1997cited by this paper
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  1996cited by this paper
• Ischemia-induced neuronal apoptosis.

  1996cited by this paper
• Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in rats.

  1996cited by this paper
• Strange brew: T cells in the liver.

  1996cited by this paper
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  1996cited by this paper
• The Insulin Resistance Syndrome Revisited

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  1996cited by this paper
• The validity of rodent brain-ischemia models is self-evident.

  1996cited by this paper
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• Ultrafast computed tomography as a diagnostic modality in the detection of coronary artery disease: a multicenter study.

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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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• Asymptomatic cardiac ischemia pilot (ACIP) study.

  1996cited by this paper
• Carbohydrate-deficient transferrin as an indicator of drinking status during a treatment outcome study.

  1996cited by this paper
• Laboratory markers of alcohol abuse.

  1996cited by this paper
• Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group.

  1996cited by this paper
• Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography.

  1996cited by this paper
• Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis

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• Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism.

  1996cited by this paper
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  1996cited by this paper
• Surrogate End Points in Clinical Trials: Are We Being Misled?

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• Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis

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• Longitudinal comparison of carbohydrate-deficient transferrin and gamma-glutamyl transferase: complementary markers of excessive alcohol consumption.

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• Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

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• Variable oral absorption of cyclosporine. A biopharmaceutical risk factor for chronic renal allograft rejection.

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• Characterization of an N6-oxopropenyl-2'-deoxyadenosine adduct in malondialdehyde-modified DNA using liquid chromatography/electrospray ionization tandem mass spectrometry.

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• Nicotinamide's Effects on Glucose Metabolism in Subjects at Risk For IDDM

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• Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand

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• The cognitive effects of recombinant interleukin-2 (rIL-2) therapy: a controlled clinical trial using computerised assessments.

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• A review of molecular imaging studies reaching the clinical stage.

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• In Vivo mouse imaging and spectroscopy in drug discovery

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