Nitrite Reductase and Nitric-oxide Synthase Activity of the Mitochondrial Molybdopterin Enzymes mARC1 and mARC2*

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Biological Chemistry

• Publication date

  2014-02-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1074/jbc.M114.555177PMID 24500710PMCID PMC4036158
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Nitrate-nitrite-nitric oxide pathway in pulmonary arterial hypertension therapeutics.

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  2011cited by this paper
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• The fourth mammalian molybdenum enzyme mARC: current state of research

  2011influential reference
• The structures of the C185S and C185A mutants of sulfite oxidase reveal rearrangement of the active site.

  2010cited by this paper
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  2010cited by this paper
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  2010influential reference
• Characterization of the Magnitude and Mechanism of Aldehyde Oxidase-mediated Nitric Oxide Production from Nitrite*

  2009influential reference
• Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

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• The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

  2008cited by this paper
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  2007cited by this paper
• Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence.

  2007cited by this paper
• Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation.

  2006cited by this paper
• Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes.

  2006influential reference
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  2006cited by this paper
• Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury.

  2005cited by this paper
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  2005cited by this paper
• The existence and significance of a mitochondrial nitrite reductase

  2005cited by this paper
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  2005cited by this paper
• Global gene annotation analysis and transcriptional profiling identify key biological modules in hypoxic pulmonary hypertension.

  2005cited by this paper
• Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics.

  2004influential reference
• Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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• Structure and function of xanthine oxidoreductase: where are we now?

  2002cited by this paper
• Characterization of the Magnitude and Kinetics of Xanthine Oxidase-catalyzed Nitrite Reduction

  2001cited by this paper
• Mitochondria recycle nitrite back to the bioregulator nitric monoxide.

  2000influential reference
• Nitrite reductase activity is a novel function of mammalian mitochondria

  1999cited by this paper
• Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

  1998cited by this paper
• Site-directed Mutagenesis of Recombinant Sulfite Oxidase

  1996cited by this paper
• Xanthine oxidase activity in the circulation of rats following hemorrhagic shock.

  1993cited by this paper
• Expression of human erythrocyte NADH-cytochrome b5 reductase as an alpha-thrombin-cleavable fused protein in Escherichia coli.

  1989cited by this paper
• Use of a chemiluminescence detector for quantitation of nitric oxide produced in assays of denitrifying enzymes.

  1987cited by this paper
• Structural effects in alkyl nitrite oxidation of human hemoglobin.

  1984cited by this paper
• The pterin component of the molybdenum cofactor. Structural characterization of two fluorescent derivatives.

  1984cited by this paper
• Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.

  1981cited by this paper
• Cytochrome b5 from microsomal membranes of equine, bovine, and porcine livers. Isolation and properties of preparations containing the membranous segment.

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