Transferrin/transferrin receptor‐mediated drug delivery

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Medicinal research reviews (Print)

• Publication date

  2002-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/med.10008PMID 11933019
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differentiation

  2021cited by this paper
• 97Ru-transferrin uptake in tumor and abscess

  2004cited by this paper
• [Liposomes in gene therapy].

  2003cited by this paper
• Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

  2001cited by this paper
• The roles of iron in health and disease.

  2001cited by this paper
• Competitive Binding of Bismuth to Transferrin and Albumin in Aqueous Solution and in Blood Plasma*

  2001cited by this paper
• Interactions of bismuth with human lactoferrin and recognition of the Bi(III)-lactoferrin complex by intestinal cells.

  2001cited by this paper
• Novel gene delivery systems: complexes of fusigenic polymer-modified liposomes and lipoplexes

  2001cited by this paper
• Cellular effects of transferrin coordinated to [Cl(NH3)5Ru]Cl2 and cis-[Cl2(NH3)4Ru]Cl

  2001cited by this paper
• Brain iron transport and neurodegeneration.

  2001cited by this paper
• Receptor mediated endocytosis and cytotoxicity of transferrin-mitomycin C conjugate in the HepG2 cell and primary cultured rat hepatocyte.

  2001cited by this paper
• Ligand-receptor-mediated drug delivery: an emerging paradigm in cellular drug targeting.

  2001cited by this paper
• Cellular effects of transferrin coordinated to.

  2001cited by this paper
• Transferrin Receptor 2-α Supports Cell Growth Both in Iron-chelated Cultured Cells and in Vivo *

  2000cited by this paper
• Doxorubicin-gallium-transferrin conjugate overcomes multidrug resistance: evidence for drug accumulation in the nucleus of drug resistant MCF-7/ADR cells.

  2000cited by this paper
• A spectroscopic study of the reaction of NAMI, a novel ruthenium(III)anti-neoplastic complex, with bovine serum albumin.

  2000cited by this paper
• Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE*

  2000influential reference
• Noninvasive gene targeting to the brain.

  2000cited by this paper
• Competitive binding of the anticancer drug titanocene dichloride to N,N′-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for TiIV uptake and release by transferrin

  2000cited by this paper
• Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats.

  2000cited by this paper
• Efficient gene transfer by transferrin lipoplexes in the presence of serum.

  2000cited by this paper
• Transferrin and Transferrin Receptor Function in Brain Barrier Systems

  2000influential reference
• Ti(IV) uptake and release by human serum transferrin and recognition of Ti(IV)-transferrin by cancer cells: understanding the mechanism of action of the anticancer drug titanocene dichloride.

  2000cited by this paper
• Antitumour metallocenes: structure-activity studies and interactions with biomolecules.

  2000cited by this paper
• Targeted drug delivery to C6 glioma by transferrin-coupled liposomes.

  2000cited by this paper
• Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis.

  2000cited by this paper
• The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

  2000cited by this paper
• Effects of epidermal growth factor, transferrin, and insulin on lipofection efficiency in human lung carcinoma cells

  2000cited by this paper
• Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

  2000influential reference
• Human NRAMP2/DMT1, Which Mediates Iron Transport across Endosomal Membranes, Is Localized to Late Endosomes and Lysosomes in HEp-2 Cells*

  2000cited by this paper
• Endogenous carriers and ligands in non-immunogenic site-specific drug delivery.

  2000cited by this paper
• Study of the binding of 114mIn radiotracer to human serum components by ultrafiltration and chromatography

  2000cited by this paper
• Formation of titanium(IV) transferrin by reaction of human serum apotransferrin with titanium complexes

  1999cited by this paper
• Possibility of active targeting to tumor tissues with liposomes.

  1999cited by this paper
• Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis.

  1999cited by this paper
• Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum.

  1999cited by this paper
• PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

  1999cited by this paper
• Disorders of iron metabolism.

  1999influential reference
• The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells*

  1999cited by this paper
• Bismuth compounds and preparations with biological or medicinal relevance.

  1999cited by this paper
• Non-platinum chemotherapeutic metallopharmaceuticals.

  1999cited by this paper
• Interactions of Bismuth Complexes with Metallothionein(II)*

  1999cited by this paper
• Gene delivery mediated by cationic liposomes: from biophysical aspects to enhancement of transfection.

  1999cited by this paper
• Iron metabolism.

  1999cited by this paper
• Bismuth antiulcer complexes

  1999cited by this paper
• Molecular Cloning of Transferrin Receptor 2

  1999influential reference
• Transferrin As A targeting ligand for liposomes and anticancer drugs.

  1999cited by this paper
• An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain.

  1999cited by this paper
• Transferrin as a metal ion mediator.

  1999influential reference
• Coordination chemistry of metals in medicine: target sites for bismuth

  1999cited by this paper
• Gene-delivery systems using cationic polymers.

  1999cited by this paper
• N-lobe versus C-lobe complexation of bismuth by human transferrin.

  1999cited by this paper
• The transferrin receptor binding site on HFE, the class I MHC-related protein mutated in hereditary hemochromatosis.

  1999cited by this paper
• Crystal structure of the ectodomain of human transferrin receptor.

  1999influential reference
• A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin.

  1999cited by this paper
• Transferrin Trojan Horses as a Rational Approach for the Biological Delivery of Therapeutic Peptide Domains*

  1999cited by this paper
• The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor.

  1999influential reference
• Genetically engineered brain drug delivery vectors: cloning, expression and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein.

  1999cited by this paper
• Serum proteins as drug carriers of anticancer agents: a review.

  1998cited by this paper
• Bacterial lactoferrin receptors.

  1998cited by this paper
• The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.

  1998influential reference
• Transferrin, the transferrin receptor, and the uptake of iron by cells.

  1998cited by this paper
• The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells

  1998cited by this paper
• Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders.

  1998cited by this paper
• Production and characterization of fusion proteins containing transferrin and nerve growth factor.

  1998cited by this paper
• The G185R mutation disrupts function of the iron transporter Nramp2.

  1998cited by this paper
• Mechanisms of therapeutic activity for gallium.

  1998cited by this paper
• Polylysine-based transfection systems utilizing receptor-mediated delivery.

  1998cited by this paper
• Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil.

  1998cited by this paper
• Binding and Transport of Nonferrous Metals by Serum Transferrin

  1998cited by this paper
• Intracellular disposition and cytotoxicity of transferrin-mitomycin C conjugate in HL60 cells as a receptor-mediated drug targeting system.

  1998cited by this paper
• Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides

  1998cited by this paper
• Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

  1998cited by this paper
• Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron Regulation*

  1998influential reference
• Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.

  1998cited by this paper
• [1H,13C] NMR determination of the order of lobe loading of human transferrin with iron: comparison with other metal ions

  1998cited by this paper
• The First Specific TiIV -Protein Complex: Potential Relevance to Anticancer Activity of Titanocenes.

  1998cited by this paper
• Drug delivery and targeting.

  1998cited by this paper
• Liposomal delivery of alpha-Interferon to murine bladder tumor cells via transferrin receptor-mediated endocytosis.

  1998cited by this paper
• Global prevalence of putative haemochromatosis mutations.

  1997cited by this paper
• The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells.

  1997cited by this paper
• Transferrin–Liposome-Mediated p53 Sensitization of Squamous Cell Carcinoma of the Head and Neck to Radiation In Vitro

  1997cited by this paper
• Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis.

  1997cited by this paper
• Cloning and characterization of a mammalian proton-coupled metal-ion transporter

  1997cited by this paper
• Three-dimensional structure of diferric bovine lactoferrin at 2.8 A resolution.

  1997cited by this paper
• THE BIOLOGICAL AND MEDICINAL CHEMISTRY OF BISMUTH

  1997cited by this paper
• Receptor recognition sites reside in both lobes of human serum transferrin.

  1997cited by this paper
• Regulation of intestinal non-haem iron absorption.

  1997cited by this paper
• Mechanism of action and spectrum of cell lines sensitive to a doxorubicin–transferrin conjugate

  1997cited by this paper
• Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

  1997cited by this paper
• Demonstration and Characterization of the Iron Regulatory Protein in Human Brain

  1996influential reference
• Liposomal targeting of leukaemia HL60 cells induced by transferrin‐receptor endocytosis

  1996cited by this paper
• Retroviral targeted delivery.

  1996cited by this paper
• Binding of ruthenium(III) anti-tumor drugs to human lactoferrin probed by high resolution X-ray crystallographic structure analyses

  1996cited by this paper
• The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects.

  1996cited by this paper
• Control of iron absorption

  1996cited by this paper
• Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies.

  1996cited by this paper
• Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding.

  1996cited by this paper
• Synthesis of transferrin-mitomycin C conjugate as a receptor-mediated drug targeting system.

  1996cited by this paper
• Pumping iron in Parkinson's disease

  1996cited by this paper

• Cell swelling and upright mounting-based imaging for high-resolution visualization of intracellular trafficking across the BBB using conventional confocal microscopy

  2026cites this paper
• Protein-based nanocarriers in the management of hard-to-treat solid tumours.

  2026cites this paper
• Recent Advances of the Role of Dl-3-n-Butylphthalide in the Treatment of Alzheimer’s Disease

  2026cites this paper
• Trends in the research and development of peptide drug conjugates: artificial intelligence aided design

  2025cites this paper
• The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

  2025cites this paper
• Targeting and reversing tumor acidic microenvironment with bacterial cellulose-based micelles to enhance immune infiltration.

  2025cites this paper
• Salivary proteome profiling to assess the impact of zero separation in Mother Newborn Care Unit on neonatal growth and stress

  2025cites this paper
• Reversible Ligand-Receptor Interaction-Induced "Tango"-like Dancing of Nanodisks on Living Cell Membrane.

  2025cites this paper
• The Role of Metallodrugs in Enhancing Neuroendocrine Neoplasm Therapies: The Promising Anticancer Potential of Ruthenium-Based Complexes

  2025cites this paper
• Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part I: receptor-mediated nose-to-brain delivery approaches for glioblastoma

  2025cites this paper
• Impact of plant-derived antioxidants on heart aging: a mechanistic outlook

  2025cites this paper
• Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics

  2025cites this paper
• Smart nanocarriers in triple-negative breast cancer: recent advances in targeting and translational application.

  2025cites this paper
• Preparation, expression, and anti-cancer effects of the novel fusion protein rONC-T7-pHLIP

  2025cites this paper
• A dual colorimetric-electrochemical microfluidic paper-based analytical device for point-of-care testing of ischemic strokes.

  2024cites this paper
• Advancements in Iron Oxide Nanoparticles for Multimodal Imaging and Tumor Theranostics.

  2024cites this paper
• Green and shape-tunable synthesis of ellagic acid crystalline particles by tannic acid for neuroprotection against oxidative stress.

  2024cites this paper
• Formulation and optimization of transferrin-modified genistein nanocrystals: In vitro anti-cancer assessment and pharmacokinetic evaluation.

  2024cites this paper
• Whey proteins as multifunctional food materials: Recent advancements in hydrolysis, separation, and peptidomimetic approaches.

  2024cites this paper
• Pathophysiological aspects of transferrin-A potential nano-based drug delivery signaling molecule in therapeutic target for varied diseases

  2024cites this paper
• Current developments and prospects of the antibiotic delivery systems

  2024cites this paper
• Improving drug delivery to the brain: the prodrug approach

  2024cites this paper
• Research Advances in Fusion Protein-Based Drugs for Diabetes Treatment

  2024cites this paper
• Nature-inspired protein mineralization strategies for nanoparticle construction: advancing effective cancer therapy.

  2024cites this paper
• Targeted drug conjugates in cancer therapy: Challenges and opportunities

  2024cites this paper
• Responsively Degradable Nanoarmor‐Assisted Super Resistance and Stable Colonization of Probiotics for Enhanced Inflammation‐Targeted Delivery

  2024cites this paper
• Preparation of dual-functional epitope imprinted polymers for the enrichment of transferrin.

  2024cites this paper
• Blood-brain barrier-crossing dendrimers for glioma theranostics.

  2024cites this paper
• Induction of Ferroptosis by an Amalgam of Extracellular Vesicles and Iron Oxide Nanoparticles Overcomes Cisplatin Resistance in Lung Cancer

  2024cites this paper
• Magnetic modulation of lysosomes for cancer therapy.

  2024cites this paper
• Targeted redox-responsive peptide for arterial chemoembolization therapy of orthotropic hepatocellular carcinoma

  2024cites this paper
• Unraveling the impact of different liposomal formulations on the plasma protein corona composition might give hints on the targeting capability of nanoparticles

  2024cites this paper
• Engineered‐Doping Strategy for Self‐Sufficient Reactive Oxygen Species Blossom to Amplify Ferroptosis/Cuproptosis Sensibilization in Hepatocellular Carcinoma Treatment

  2024cites this paper
• Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review

  2023cites this paper
• Proteolysis-targeting chimeras in biotherapeutics: Current trends and future applications.

  2023cites this paper
• Anticancer effect evaluation of nitron complexes

  2023cites this paper
• A Ru(II)-Strained Complex with 2,9-Diphenyl-1,10-phenanthroline Ligand Induces Selective Photoactivatable Chemotherapeutic Activity on Human Alveolar Carcinoma Cells via Apoptosis

  2023cites this paper
• Tumor-Associated Macrophages Regulating a Polymer Nanoplatform for Synergistic Treatment of Breast Tumors.

  2023cites this paper
• Genetically Engineered‐Cell‐Membrane Nanovesicles for Cancer Immunotherapy

  2023cites this paper
• Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: A review.

  2023cites this paper
• Ferroportin1 in the Brain.

  2023cites this paper
• Bioinspired Approaches for Central Nervous System Targeted Gene Delivery.

  2023cites this paper
• Engineered nanomaterials that exploit blood-brain barrier dysfunction fordelivery to the brain.

  2023cites this paper
• Transferrin receptor 1 targeted nanomedicine for brain tumor therapy.

  2023cites this paper
• Holo/apo conversion two-dimensional urea PAGE for speciation of Fe3+-bound transferrin in serum

  2023cites this paper
• Protein-based Nanoparticles: From Drug Delivery to Imaging, Nanocatalysis and Protein Therapy.

  2023cites this paper
• Glycopolymer and Poly(β-amino ester)-Based Amphiphilic Block Copolymer as a Drug Carrier

  2022cites this paper
• Structural changes in selected human proteins induced by exposure to quantum dots, their biological relevance and possible biomedical applications.

  2022cites this paper
• Comparative study on the interaction between transferrin and flavonols: Experimental and computational modeling approaches.

  2022cites this paper
• Nanocarrier-Based Drug Delivery to Brain: Interventions of Surface Modification

  2022cites this paper
• Dynamics of Human Serum Transferrin in Varying Physicochemical Conditions Explored by Using Molecular Dynamics Simulations

  2022cites this paper
• Adenoviral Vector for Enhanced Prostate Cancer Specific Transferrin Conjugated Drug Targeted Therapy.

  2022cites this paper
• Cell Size as a Primary Determinant in Targeted Nanoparticle Uptake.

  2022cites this paper
• Externally Triggered Drug Delivery Techniques Using Micro and Nanoparticles

  2022cites this paper
• Nanotechnology Advances in the Detection and Treatment of Cancer: An Overview

  2022cites this paper
• Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology

  2022cites this paper
• Cetuximab Combined With Sonodynamic Therapy Achieves Dual-Modal Image Monitoring for the Treatment of EGFR-Sensitive Non-Small-Cell Lung Cancer

  2022cites this paper
• Receptor-targeted nanoparticles modulate cannabinoid anticancer activity through delayed cell internalization

  2022cites this paper
• Manganese Pollution and Its Remediation: A Review of Biological Removal and Promising Combination Strategies

  2022cites this paper
• Investigation of Trends in the Research on Transferrin Receptor-Mediated Drug Delivery via a Bibliometric and Thematic Analysis

  2022cites this paper
• Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics

  2022cites this paper
• The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis

  2021cites this paper
• Multiple-mRNA-controlled and heat-driven drug release from gold nanocages in targeted chemo-photothermal therapy for tumors

  2021cites this paper
• Design and Development of Nanomaterial-Based Drug Carriers to Overcome the Blood–Brain Barrier by Using Different Transport Mechanisms

  2021cites this paper
• A dual-targeted multifunctional nanoformulation for potential prevention and therapy of Alzheimer's disease

  2021cites this paper
• Surface engineered dendrimers as novel option for enhanced pharmaceutical and biomedical potential

  2021cites this paper
• Interaction between DNA, Albumin and Apo-Transferrin and Iridium(III) Complexes with Phosphines Derived from Fluoroquinolones as a Potent Anticancer Drug

  2021cites this paper
• Study of cancer cell cytotoxicity, internalization and modulation of growth factors induced by transferrin-conjugated formulations of metallodrug-functionalized mesoporous silica nanoparticles

  2021cites this paper
• Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods

  2021cites this paper
• Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement.

  2021cites this paper
• Cancer Nanopharmaceuticals: Physicochemical Characterization and In Vitro/In Vivo Applications

  2021cites this paper
• Progress and Principle of Drug Nanocrystals for Tumor Targeted Delivery

  2021cites this paper
• Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

  2021cites this paper
• Stimuli responsive and receptor targeted iron oxide based nanoplatforms for multimodal therapy and imaging of cancer: Conjugation chemistry and alternative therapeutic strategies.

  2021cites this paper
• A dual-targeting ruthenium nanodrug that inhibits primary tumor growth and lung metastasis via the PARP/ATM pathway

  2021cites this paper
• A review on the synthesis, surface modification and drug delivery of nanoparticles

  2021cites this paper
• Human transferrin: An inorganic biochemistry perspective

  2021cites this paper
• The role of transferrins and iron-related proteins in brain iron transport: applications to neurological diseases.

  2021cites this paper
• Molecular imprinting and cladding produces antibody mimics with significantly improved affinity and specificity.

  2021cites this paper
• Brain penetrating peptides and peptide-drug conjugates to overcome the blood-brain barrier and target CNS diseases.

  2021cites this paper
• Iron Metabolism Disorders for Cognitive Dysfunction After Mild Traumatic Brain Injury

  2021cites this paper
• Dual Targeting of Cancer Cells and MMPs with Self-Assembly Hybrid Nanoparticles for Combination Therapy in Combating Cancer

  2021cites this paper
• Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting.

  2021cites this paper
• Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System

  2021cites this paper
• p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides

  2021cites this paper
• Rare-Earth Metal Complexes of the Antibacterial Drug Oxolinic Acid: Synthesis, Characterization, DNA/Protein Binding and Cytotoxicity Studies

  2020cites this paper
• Hepcidin and its therapeutic potential in neurodegenerative disorders

  2020cites this paper
• Strategies for Delivering Nanoparticles across Tumor Blood Vessels

  2020cites this paper
• Liposomes modified with bio-substances for cancer treatment.

  2020cites this paper
• Recent Advancements in Liposome-Targeting Strategies for the Treatment of Gliomas: A Systematic Review.

  2020cites this paper
• Lysosomal Storage Disease-Associated Neuropathy: Targeting Stable Nucleic Acid Lipid Particle (SNALP)-Formulated siRNAs to the Brain as a Therapeutic Approach

  2020cites this paper
• Surface receptor‐mediated targeted drug delivery systems for enhanced cancer treatment: A state‐of‐the‐art review

  2020cites this paper
• Liposomes vs Phytosomes: Principles, Methodologies, and Therapeutic Applications with Emphasis on CNS Disorders

  2020cites this paper
• Transmembrane transport mechanism of n-hexadecane by Candida tropicalis: Kinetic study and proteomic analysis.

  2020cites this paper
• Polymeric Nanoparticles for Drug Delivery

  2020cites this paper
• A Robust Strategy for Antibody-Polymer-Drug Conjugation: Significance of Conjugating Orientation and Linker Charge on Targeting Ability.

  2020cites this paper
• Toxic and Physiological Metal Uptake and Release by Human Serum Transferrin.

  2020cites this paper
• The Case for Enzymatic Competitive Metal Affinity Methods.

  2020cites this paper
• Pharmacological applications of non-radioactive indium(III) complexes: A field yet to be explored

  2020cites this paper
• A Review of Properties, Delivery Systems and Analytical Methods for the Characterization of Monomeric Glycoprotein Transferrin

  2020cites this paper