Gene methylation and early detection of genitourinary cancer: the road ahead

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature Reviews. Cancer

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrc2170PMID 17585333
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The health economics of bladder cancer

  2012cited by this paper
• Cancer Statistics, 2007

  2007cited by this paper
• Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.

  2007cited by this paper
• Circulating nucleic acids in plasma/serum

  2007cited by this paper
• Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI's EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and Tools.

  2007cited by this paper
• Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care.

  2006cited by this paper
• Hypermethylation of ASC / TMS 1 Is a Sputum Marker for Late-Stage Lung Cancer

  2006cited by this paper
• Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis.

  2006cited by this paper
• Methylational urinalysis: a prospective study of bladder cancer patients and age stratified benign controls

  2006cited by this paper
• Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer.

  2006cited by this paper
• The diagnosis and staging of bladder cancer: from RBCs to TURs.

  2006cited by this paper
• Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection.

  2006cited by this paper
• Testicular germ-cell cancer.

  2006cited by this paper
• Identification of novel target genes by an epigenetic reactivation screen of renal cancer.

  2006cited by this paper
• Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms.

  2006cited by this paper
• Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer.

  2006cited by this paper
• Gene promoter methylation in prostate tumor-associated stromal cells.

  2006cited by this paper
• A single nucleotide polymorphism chip-based method for combined genetic and epigenetic profiling: validation in decitabine therapy and tumor/normal comparisons.

  2006cited by this paper
• Preoperative Serum DNA GSTP1 CpG Island Hypermethylation and the Risk of Early Prostate-Specific Antigen Recurrence Following Radical Prostatectomy

  2005cited by this paper
• Cancer nanotechnology: opportunities and challenges

  2005cited by this paper
• Functional epigenomics identifies genes frequently silenced in prostate cancer.

  2005cited by this paper
• Urological Survey UROLOGICAL ONCOLOGY: RENAL, URETERAL AND RETROPERITONEAL TUMORS Quantitative Detection of Promoter Hypermethylation of Multiple Genes in the Tumor, Urine, and Serum DNA of Patients With Renal Cancer

  2005cited by this paper
• Promoter hypermethylation profile of kidney cancer.

  2005cited by this paper
• Renal-cell carcinoma.

  2005cited by this paper
• Detection and quantification of mutations in the plasma of patients with colorectal tumors.

  2005cited by this paper
• Detection and interpretation of altered methylation patterns in cancer cells

  2005cited by this paper
• Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects.

  2005cited by this paper
• Promoter hypermethylation is associated with tumor location, stage, and subsequent progression in transitional cell carcinoma.

  2005cited by this paper
• Aberrant methylation of Reprimo in human malignancies

  2005cited by this paper
• Circulating tumor-specific DNA: a marker for monitoring efficacy of adjuvant therapy in cancer patients.

  2005cited by this paper
• Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma.

  2005cited by this paper
• Promoter Hypermethylation as an Independent Prognostic Factor for Relapse in Patients with Prostate Cancer Following Radical Prostatectomy

  2005cited by this paper
• Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci.

  2005cited by this paper
• Rules of evidence for cancer molecular-marker discovery and validation

  2004cited by this paper
• Prostate cancer molecular markers GSTP1 and hTERT in expressed prostatic secretions as predictors of biopsy results.

  2004cited by this paper
• Detection of Bladder Cancer in Urine by a Tumor Suppressor Gene Hypermethylation Panel

  2004cited by this paper
• Optimal Use of a Panel of Methylation Markers with GSTP1 Hypermethylation in the Diagnosis of Prostate Adenocarcinoma

  2004cited by this paper
• Molecular Detection of Noninvasive and Invasive Bladder Tumor Tissues and Exfoliated Cells by Aberrant Promoter Methylation of Laminin-5 Encoding Genes

  2004cited by this paper
• A Quantitative Promoter Methylation Profile of Prostate Cancer

  2004cited by this paper
• Cancer genes and the pathways they control

  2004cited by this paper
• XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer.

  2004cited by this paper
• Detection of Methylated Apoptosis-Associated Genes in Urine Sediments of Bladder Cancer Patients

  2004cited by this paper
• Detection of GSTP1 methylation in prostatic secretions using combinatorial MSP analysis.

  2004cited by this paper
• Quantitative GSTP1 methylation levels correlate with Gleason grade and tumor volume in prostate needle biopsies.

  2004cited by this paper
• Promoter Hypermethylation Profile of Kidney Cancer

  2004cited by this paper
• Genetic Basis of Cancer of the Kidney

  2004cited by this paper
• Quantitative Multiplex Methylation-Specific PCR Assay for the Detection of Promoter Hypermethylation in Multiple Genes in Breast Cancer

  2004cited by this paper
• Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumours

  2003cited by this paper
• Differential distribution of DNA methylation within the RASSF1A CpG island in breast cancer.

  2003cited by this paper
• Quantitative GSTP1 methylation and the detection of prostate adenocarcinoma in sextant biopsies.

  2003cited by this paper
• Aberrant promoter methylation of laminin-5-encoding genes in prostate cancers and its relationship to clinicopathological features.

  2003cited by this paper
• Quantitative GSTP1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma.

  2003cited by this paper
• The genetic basis of cancer of the kidney.

  2003cited by this paper
• Promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients.

  2003cited by this paper
• Prostate cancer detection by GSTP1 methylation analysis of postbiopsy urine specimens.

  2003cited by this paper
• Prospective analysis of computerized tomography and needle biopsy with permanent sectioning to determine the nature of solid renal masses in adults.

  2003cited by this paper
• Early detection: The power and the promise of DNA methylation markers

  2003cited by this paper
• Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis.

  2002cited by this paper
• Emerging molecular markers of cancer

  2002cited by this paper
• The Tobacco Atlas

  2002cited by this paper
• Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features.

  2002cited by this paper
• p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.

  2002cited by this paper
• Quantitative GSTP1 hypermethylation in bodily fluids of patients with prostate cancer.

  2002cited by this paper
• Methylation‐specific PCR for detection of neoplastic DNA in biopsy washings

  2002cited by this paper
• Assessing the use of p16(INK4a) promoter gene methylation in serum for detection of bladder cancer.

  2002cited by this paper
• Serial biopsy results in prostate cancer screening study.

  2002cited by this paper
• The fundamental role of epigenetic events in cancer

  2002cited by this paper
• Prostate cancer incidence, mortality, and survival trends in the United States: 1981-2001.

  2002cited by this paper
• Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer.

  2002cited by this paper
• Quantitative assessment of promoter hypermethylation during breast cancer development.

  2002cited by this paper
• Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine.

  2002cited by this paper
• Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients.

  2002cited by this paper
• Phases of biomarker development for early detection of cancer.

  2001cited by this paper
• A gene hypermethylation profile of human cancer.

  2001cited by this paper
• Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features.

  2001cited by this paper
• DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.

  2001cited by this paper
• Molecular detection of prostate cancer in urine by GSTP1 hypermethylation.

  2001cited by this paper
• Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival

  2001cited by this paper
• Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma.

  2001cited by this paper
• The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis

  2001cited by this paper
• DNA-based detection of prostate cancer in urine after prostatic massage.

  2001cited by this paper
• Global cancer statistics in the year 2000.

  2001cited by this paper
• Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma.

  2001cited by this paper
• Circulating nucleic acids in plasma or serum.

  2001cited by this paper
• Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas

  2001cited by this paper
• DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.

  2001cited by this paper
• Prostate cancer mortality after introduction of prostate-specific antigen mass screening in the Federal State of Tyrol, Austria.

  2001cited by this paper
• Epigenetic Inactivation of the RASSF 1 A 3 p 21 . 3 Tumor Suppressor Gene in Both Clear Cell and Papillary Renal Cell Carcinoma 1

  2001cited by this paper
• Prostate cancer detection at low prostate specific antigen.

  2000cited by this paper
• Predicting lung cancer by detecting aberrant promoter methylation in sputum.

  2000cited by this paper
• Aberrant methylation of gene promoters in cancer---concepts, misconcepts, and promise.

  2000cited by this paper
• Comparison of telomerase activity and GSTP1 promoter methylation in ejaculate as potential screening tests for prostate cancer.

  2000cited by this paper
• Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

  2000cited by this paper
• MethyLight: a high-throughput assay to measure DNA methylation.

  2000cited by this paper
• Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.

  2000cited by this paper
• A radical solution to death

  2000cited by this paper
• Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids.

  2000cited by this paper
• Histopathology and molecular genetics of renal tumors toward unification of a classification system.

  1999cited by this paper
• Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.

  1999cited by this paper
• Efficiency of prostate‐specific antigen and digital rectal examination in screening, using 4.0 ng/ml and age‐specific reference range as a cutoff for abnormal values

  1999cited by this paper

• Golden eyes on pollutants: colorimetric detection of emerging contaminants with AuNPs

  2025cites this paper
• Occurrence, analysis and removal of pesticides, hormones, pharmaceuticals, and other contaminants in soil and water streams for the past two decades: a review

  2022cites this paper
• Roles of circulating tumor DNA in PD-1/PD-L1 immune checkpoint Inhibitors: Current evidence and future directions.

  2022cites this paper
• Meta-analysis of the Association Between APC Promoter Methylation and Bladder Cancer

  2021cites this paper
• A novel DNA methylation biosensor by combination of isothermal amplification and lateral flow device

  2021cites this paper
• Precision DNA Mixture Interpretation with Single-Cell Profiling

  2021cites this paper
• The Mediterranean diet: an epigenetic diet model for MEN1 patients?

  2021cites this paper
• The Association Between RAPSN Methylation in Peripheral Blood and Early Stage Lung Cancer Detected in Case–Control Cohort

  2020cites this paper
• CMAR_A_275321 11063..11075

  2020cites this paper
• A PNA‐DNA2 Triple‐Helix Molecular Switch‐Based Colorimetric Sensor for Sensitive and Specific Detection of microRNAs from Cancer Cells

  2020cites this paper
• DNA-Methylation-Based Detection of Urological Cancer in Urine: Overview of Biomarkers and Considerations on Biomarker Design, Source of DNA, and Detection Technologies

  2019cites this paper
• 5HmC-MIQuant: Ultrasensitive quantitative detection of 5-hydroxymethylcytosine in low-input cell-free DNA samples.

  2019cites this paper
• Cancer Epigenomics on Precision Medicine and Immunotherapy

  2019cites this paper
• 12 Potential Tumor Biomarkers for Ovarian Cancer

  2018cites this paper
• The association between breast cancer and S100P methylation in peripheral blood by multicenter case–control studies

  2017cites this paper
• Promoter hypermethylation of LGALS4 correlates with poor prognosis in patients with urothelial carcinoma

  2017cites this paper
• Circulating Tumor DNA as Biomarkers for Cancer Detection

  2017cites this paper
• Surface plasmon resonance in gold nanoparticles: a review

  2017cites this paper
• Evaluation of Urinary DNA Methylation as a Marker for Recurrent Bladder Cancer: A 2-Center Prospective Study.

  2017cites this paper
• Molecular Detection and Diagnosis of Cancer

  2017cites this paper
• Hypermethylation of adjacent CpG sites is negatively correlated with the expression of lineage oncogene ASCL1 in pulmonary neuroendocrine tumors

  2017cites this paper
• Development of an electrochemical detection system for measuring DNA methylation levels using methyl CpG-binding protein and glucose dehydrogenase-fused zinc finger protein.

  2017cites this paper
• Clinical potential of TCF21 methylation in the diagnosis of renal cell carcinoma

  2016cites this paper
• Filtration Device for On-Site Collection, Storage and Shipment of Cells from Urine and Its Application to DNA-Based Detection of Bladder Cancer

  2015cites this paper
• Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma

  2015cites this paper
• Sporadic RCC: Abnormalities in Histone-Modifying Genes

  2015cites this paper
• Epigenetic Study of Plasma Circulating DNA in Prostate Cancer

  2015cites this paper
• Methylated +58CpG site decreases DCN mRNA expression and enhances TGF-β/Smad signaling in NSCLC cells with high metastatic potential.

  2014cites this paper
• Evaluation of diagnostic accuracy of DNA methylation biomarkers for bladder cancer: a systematic review and meta-analysis

  2014cites this paper
• A global profile of gene promoter methylation in treatment-naïve urothelial cancer

  2014cites this paper
• Size-Based Enrichment of Exfoliated Tumor Cells in Urine Increases the Sensitivity for DNA-Based Detection of Bladder Cancer

  2014cites this paper
• Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer

  2014cites this paper
• An Epigenetic Screen Unmasks Metallothioneins as Putative Contributors to Renal Cell Carcinogenesis

  2014cites this paper
• Early Biomarkers in Breast Cancer

  2014cites this paper
• Significant association of 5p15.33 (TERT–CLPTM1L genes) with lung cancer in Chinese Han population

  2013cites this paper
• Epigenetics and MicroRNAs in Renal Cancer

  2013cites this paper
• Methylation of a panel of microRNA genes is a novel biomarker for detection of bladder cancer.

  2013cites this paper
• Feasibility of Whole RNA Sequencing from Single-Cell mRNA Amplification

  2013cites this paper
• Extraction and processing of circulating DNA from large sample volumes using methylation on beads for the detection of rare epigenetic events.

  2013cites this paper
• Reconstruction algorithms based on l1-norm and l2-norm for two imaging models of fluorescence molecular tomography: a comparative study

  2013cites this paper
• Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC

  2013cites this paper
• Potential Tumor Biomarkers for Ovarian Cancer

  2012cites this paper
• The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer

  2012cites this paper
• High Resolution Size Analysis of Fetal DNA in the Urine of Pregnant Women by Paired-End Massively Parallel Sequencing

  2012cites this paper
• Gold nanoparticles in chemical and biological sensing.

  2012cites this paper
• The current status of cancer biomarker research using tumour-associated antigens for minimal invasive and early cancer diagnostics.

  2012cites this paper
• The Association of RAS Association Domain Family Protein1A (RASSF1A) Methylation States and Bladder Cancer Risk: A Systematic Review and Meta-Analysis

  2012cites this paper
• Epigenetic alterations of adenomatous polyposis coli (APC), retinoic acid receptor beta (RARβ) and survivin genes in tumor tissues and voided urine of bladder cancer patients.

  2012cites this paper
• DNA methylation testing and marker validation using PCR: diagnostic applications

  2012cites this paper
• Methylated DNA as Promising Marker for Early Diagnosis of Cancer

  2012cites this paper
• LC‐MS‐based serum metabolic profiling for genitourinary cancer classification and cancer type‐specific biomarker discovery

  2012cites this paper
• Epigenetic Epidemiology of Cancer

  2012cites this paper
• Epigenetics of kidney cancer and bladder cancer.

  2011cites this paper
• Quantitative methylation analysis of BCL2, hTERT, and DAPK promoters in urine sediment for the detection of non-muscle-invasive urothelial carcinoma of the bladder: a prospective, two-center validation study.

  2011cites this paper
• Cancer epigenetics: above and beyond

  2011cites this paper
• Epigenetic diet: impact on the epigenome and cancer.

  2011cites this paper
• TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers

  2011influential citation
• Comprehensive Genome Methylation Analysis in Bladder Cancer: Identification and Validation of Novel Methylated Genes and Application of These as Urinary Tumor Markers

  2011cites this paper
• Translational application of epigenetic alterations: Ovarian cancer as a model

  2011cites this paper
• Aberrant promoter methylation of DLEC1, a critical 3p22 tumor suppressor for renal cell carcinoma, is associated with more advanced tumor stage.

  2010cites this paper
• Renal cell carcinoma.

  2010cites this paper
• Promoter Methylation in Prostate Cancer and its Application for the Early Detection of Prostate Cancer Using Serum and Urine Samples

  2010cites this paper
• Imaging , Diagnosis , Prognosis Three Epigenetic Biomarkers , GDF 15 , TMEFF 2 , and VIM , Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples

  2010cites this paper
• Hyperméthylation et cancer de la prostate

  2010cites this paper
• Epigenetics of renal cell carcinoma: the path towards new diagnostics and therapeutics

  2010cites this paper
• Identification and validation of the methylated TWIST1 and NID2 genes through real-time methylation-specific polymerase chain reaction assays for the noninvasive detection of primary bladder cancer in urine samples.

  2010cites this paper
• Promoter Methylation in Prostate Cancer and its Application for the Early Detection of Prostate Cancer Using Serum and Urine Samples

  2010cites this paper
• [Hypermethylation and prostate cancer].

  2010cites this paper
• Three Epigenetic Biomarkers, GDF15, TMEFF2, and VIM, Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples

  2010cites this paper
• Utility of Promoter Hypermethylation for Differentiating Malignant and Benign Effusions in Liquid-Based Cytology Specimens

  2010cites this paper
• DNA methylation and cancer diagnosis: new methods and applications

  2009cites this paper
• Genetics, epigenetics and angiogenesis in renal cell carcinoma

  2009cites this paper
• DNA methylation changes in prostate cancer: current developments and future clinical implementation

  2009cites this paper
• DNA methylation of cancer genome.

  2009cites this paper
• BAMBI gene is epigenetically silenced in subset of high‐grade bladder cancer

  2009cites this paper
• Promoter methylation and the detection of breast cancer

  2009cites this paper
• CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma

  2009cites this paper
• Identification of candidate epigenetic biomarkers for ovarian cancer detection.

  2009cites this paper
• Predicting disease progression after nephrectomy for localized renal cell carcinoma: The utility of prognostic models and molecular biomarkers

  2008cites this paper
• DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection

  2008cites this paper
• Genetics and epigenetics of renal cell cancer.

  2008cites this paper
• Cancer Prevention: Epigenetics Steps Up to the Plate

  2008cites this paper
• [Value of urinary PCA3 test for prostate cancer diagnosis].

  2008cites this paper
• Promoter Hypermethylation in Tumour Suppressor Genes Shows Association with Stage, Grade and Invasiveness of Bladder Cancer

  2008cites this paper
• Aging by epigenetics--a consequence of chromatin damage?

  2008cites this paper
• DNA Hypermethylation Patterns Detected in Serum as a Tool for Early Breast Cancer Diagnosis

  2007cites this paper
• Análise da expressão de RNAs intrônicos não-codificadores em carcinomas de célula renal

  2007cites this paper