Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  American Journal of Pathology

• Publication date

  2008-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2353/ajpath.2008.080684PMID 19008375PMCID PMC2626391
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Huntington disease

  2010cited by this paper
• Structure and Function of the NMDA Receptor

  2008cited by this paper
• ESCRTs and Fab1 regulate distinct steps of autophagy.

  2007cited by this paper
• Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

  2007cited by this paper
• Role of Hrs in maturation of autophagosomes in mammalian cells.

  2007cited by this paper
• Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

  2007cited by this paper
• ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration.

  2007cited by this paper
• Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?

  2007cited by this paper
• Excitotoxic and excitoprotective mechanisms

  2007cited by this paper
• Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

  2007cited by this paper
• Loss of autophagy in the central nervous system causes neurodegeneration in mice

  2006cited by this paper
• NMDA receptor function: subunit composition versus spatial distribution

  2006cited by this paper
• New approaches to antidepressant drug discovery: beyond monoamines

  2006cited by this paper
• Synapse-specific regulation of AMPA receptor function by PSD-95

  2006cited by this paper
• Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice.

  2006cited by this paper
• Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

  2006cited by this paper
• The roles of intracellular protein-degradation pathways in neurodegeneration

  2006cited by this paper
• A Protein's Final ESCRT

  2005cited by this paper
• Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination.

  2005cited by this paper
• KEL-8 is a substrate receptor for CUL3-dependent ubiquitin ligase that regulates synaptic glutamate receptor turnover.

  2005cited by this paper
• Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases.

  2005cited by this paper
• Pharmacological effects of carcinine on histaminergic neurons in the brain

  2004cited by this paper
• NMDA Receptor GluRϵ/NR2 Subunits Are Essential for Postsynaptic Localization and Protein Stability of GluRζ1/NR1 Subunit

  2004cited by this paper
• Widespread Expression of the AMPA Receptor GluR2 Subunit at Glutamatergic Synapses in the Rat Spinal Cord and Phosphorylation of GluR1 in Response to Noxious Stimulation Revealed with an Antigen-Unmasking Method

  2004cited by this paper
• Deconstructing the axon: Wallerian degeneration and the ubiquitin-proteasome system.

  2004cited by this paper
• Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

  2004cited by this paper
• Molecular mechanisms underlying specificity of excitotoxic signaling in neurons.

  2004cited by this paper
• Protein sorting into multivesicular endosomes.

  2003cited by this paper
• Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice

  2003cited by this paper
• Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.

  2003cited by this paper
• Bringing order to the glutamate chaos in schizophrenia.

  2003cited by this paper
• Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

  2003cited by this paper
• Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

  2003cited by this paper
• Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

  2003influential reference
• Glutamatergic mechanisms in different disease states: overview and therapeutical implications – An introduction

  2002cited by this paper
• Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms

  2002cited by this paper
• Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall

  2002cited by this paper
• Loss of Hippocampal CA3 Pyramidal Neurons in Mice Lacking STAM1

  2001cited by this paper
• Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain.

  2001cited by this paper
• Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA

  2000cited by this paper
• “Fatal Attractions” of Proteins: A Comprehensive Hypothetical Mechanism Underlying Alzheimer's Disease and Other Neurodegenerative Disorders

  2000cited by this paper
• Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis.

  1999cited by this paper
• Possible Involvement of a Novel STAM-associated Molecule “AMSH” in Intracellular Signal Transduction Mediated by Cytokines*

  1999cited by this paper
• Huntington disease.

  1998cited by this paper
• Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule

  1997cited by this paper
• A low-cost method to analyse footprint patterns.

  1997cited by this paper
• Mice lacking both subunits of lysosomal β–hexosaminidase display gangliosidosis and mucopolysaccharidosis

  1996cited by this paper
• Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.

  1996cited by this paper
• Structure and function of the NMDA receptor channel.

  1995cited by this paper
• A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

  1993cited by this paper
• A novel ES cell line, TT2, with high germline-differentiating potency.

  1993cited by this paper

• Novel SCYL2 Mutations and Arthrogryposis Multiplex Congenita 4: Case Report and Review of the Literature

  2025cites this paper
• Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2bintron5

  2025cites this paper
• Organelle homeostasis requires ESCRTs.

  2025cites this paper
• Neuronal Deletion of Tumor Susceptibility Gene 101 (Tsg101) Causes Rapid Apoptotic Loss of Hippocampal CA3 Neurons

  2025cites this paper
• Analysis of the neuromuscular deficits caused by STAM1 deficiency

  2024cites this paper
• Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration

  2023cites this paper
• Mammalian microautophagy: mechanism and roles in disease

  2022cites this paper
• Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation

  2022cites this paper
• The Rab11-regulated endocytic pathway and BDNF/TrkB signaling: Roles in plasticity changes and neurodegenerative diseases.

  2022cites this paper
• Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis

  2022cites this paper
• The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways

  2021cites this paper
• Mitochondrial dysfunction and autophagy in neurodegeneration

  2021cites this paper
• Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca2+/CaMKII signal pathway

  2021cites this paper
• Axonal transport of Hrs is activity-dependent and rate limiting for synaptic vesicle protein degradation

  2020cites this paper
• The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention?

  2020cites this paper
• Loss of tumor susceptibility gene 101 (TSG101) perturbs endoplasmic reticulum structure and function.

  2020cites this paper
• Protection effect of gastrodin on learning and memory ability in vascular dementia by promoting autophagy flux via Ca2+/CaMKII signal pathway

  2020cites this paper
• Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells

  2019cites this paper
• Live Imaging of ESCRT Proteins in Microfluidically Isolated Hippocampal Axons.

  2019cites this paper
• Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.

  2018cites this paper
• Endosomal sorting complexes required for ESCRTing cells toward death during neurogenesis, neurodevelopment and neurodegeneration

  2018cites this paper
• Lysosomal Quality Control in Prion Diseases

  2018cites this paper
• Deregulation of LRSAM1 expression impairs the levels of TSG101, UBE2N, VPS28, MDM2 and EGFR

  2018cites this paper
• Coordination of synaptic vesicle trafficking and turnover by the Rab35 signaling network

  2017cites this paper
• Gene expression profiles of autophagy-related genes in multiple sclerosis.

  2016cites this paper
• ESCRTs and associated proteins in lysosomal fusion with endosomes and autophagosomes.

  2016cites this paper
• ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

  2016cites this paper
• Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway

  2016cites this paper
• REGULATION OF NOTCH SIGNALING BY THE ENDO-LYSOSOMAL SYSTEM IN DROSOPHILA: THE ROLE OF ESCRT-0 AND V-ATPASE

  2016cites this paper
• Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility

  2015cites this paper
• STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons.

  2015influential citation
• Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS

  2015influential citation
• SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus

  2015cites this paper
• Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101

  2015cites this paper
• ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein

  2014cites this paper
• Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells.

  2014influential citation
• Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway.

  2014cites this paper
• Neuronal Functions of ESCRTs

  2014cites this paper
• Membrane fission reactions of the mammalian ESCRT pathway.

  2013cites this paper
• Identification and analysis of Rab8 mutants: genetic enhancers of a Drosophila model of Frontotemporal Dementia

  2013cites this paper
• AUTOPHAGOSOME MATURATION, ENDOCYTOSIS AND NEURODEGENERATIVE DISEASE

  2012cites this paper
• Stam2 expression pattern during embryo development.

  2012cites this paper
• Neurons and a Subset of Interstitial Cells of Cajal in the Enteric Nervous System Highly Express Stam2 Gene

  2012cites this paper
• Neuronal Functions of ESCRTs

  2012cites this paper
• Pharmacological and genetic manipulation of autophagy and its impact on diverse prion infection scenarios

  2012cites this paper
• Alzheimer's disease as homeostatic responses to age-related myelin breakdown.

  2011cites this paper
• AMSH is required to degrade ubiquitinated proteins in the central nervous system.

  2011cites this paper
• Multivesicular bodies in neurons: distribution, protein content, and trafficking functions.

  2011cites this paper
• ESCRT & Co

  2010cites this paper
• Impact de la protéine CHMP2B et de ses variants pathogènes sur le modelage des membranes biologiques

  2010cites this paper
• Autophagy in the central nervous system: implications for neurodegenerative disorders.

  2010cites this paper
• Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein.

  2010cites this paper
• Prominent expression of FRS2β protein in neural cells and its association with intracellular vesicles

  2009cites this paper
• All-you-can-eat: autophagy in neurodegeneration and neuroprotection

  2009cites this paper
• How do ESCRT proteins control autophagy?

  2009cites this paper
• Autophagy in neurodegeneration: two sides of the same coin.

  2009cites this paper
• Signaling by Neuronal Tyrosine Kinase Receptors: Relevance for Development and Regeneration

  2009cites this paper