Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neuroscience

• Publication date

  2002-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.22-15-06415.2002PMID 12151521PMCID PMC6758133
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila.

  2002influential reference
• Synaptic strength regulated by palmitate cycling on PSD-95.

  2002cited by this paper
• Craniofacial Dysmorphogenesis Including Cleft Palate in Mice with an Insertional Mutation in the discs large Gene

  2001cited by this paper
• PDZ domains and the organization of supramolecular complexes.

  2001cited by this paper
• Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins.

  2001cited by this paper
• Rapid formation and remodeling of postsynaptic densities in developing dendrites

  2001cited by this paper
• PDZ Protein Interactions Regulating Glutamate Receptor Function and Plasticity

  2001cited by this paper
• Regulation of dendritic spine morphology and synaptic function by Shank and Homer.

  2001cited by this paper
• Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.

  2001cited by this paper
• An Intramolecular Interaction between Src Homology 3 Domain and Guanylate Kinase-Like Domain Required for Channel Clustering by Postsynaptic Density-95/SAP90

  2000cited by this paper
• Synaptic Targeting of the Postsynaptic Density Protein PSD-95 Mediated by a Tyrosine-based Trafficking Signal*

  2000cited by this paper
• hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions*

  2000cited by this paper
• Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.

  2000cited by this paper
• GAKIN, a Novel Kinesin-like Protein Associates with the Human Homologue of the Drosophila Discs Large Tumor Suppressor in T Lymphocytes*

  2000cited by this paper
• Development of neuron-neuron synapses.

  2000cited by this paper
• Synaptic targeting and localization of discs-large is a stepwise process controlled by different domains of the protein.

  2000cited by this paper
• Dual Palmitoylation of Psd-95 Mediates Its Vesiculotubular Sorting, Postsynaptic Targeting, and Ion Channel Clustering

  2000cited by this paper
• Signal-processing machines at the postsynaptic density.

  2000cited by this paper
• PDZ domains in synapse assembly and signalling.

  2000cited by this paper
• Endosomal Localization and Receptor Dynamics Determine Tyrosine Phosphorylation of Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate

  2000cited by this paper
• Ion Channel Clustering by Membrane-associated Guanylate Kinases

  2000influential reference
• Hrs-2 Regulates Receptor-mediated Endocytosis via Interactions with Eps15*

  2000influential reference
• Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

  2000cited by this paper
• L27, a novel heterodimerization domain in receptor targeting proteins Lin-2 and Lin-7.

  2000influential reference
• LTP mechanisms: from silence to four-lane traffic.

  2000cited by this paper
• PSD-95 involvement in maturation of excitatory synapses.

  2000cited by this paper
• Characterization of MALS/Velis-1, -2, and -3: a Family of Mammalian LIN-7 Homologs Enriched at Brain Synapses in Association with the Postsynaptic Density-95/NMDA Receptor Postsynaptic Complex

  1999cited by this paper
• Molecular Analysis of the X11–mLin-2/CASK Complex in Brain

  1999cited by this paper
• Long-term potentiation--a decade of progress?

  1999cited by this paper
• Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis.

  1999influential reference
• Identification of an Intramolecular Interaction between the SH3 and Guanylate Kinase Domains of PSD-95*

  1999cited by this paper
• Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.

  1999influential reference
• The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.

  1998cited by this paper
• Rapid actin-based plasticity in dendritic spines.

  1998cited by this paper
• Localization of Postsynaptic Density-93 to Dendritic Microtubules and Interaction with Microtubule-Associated Protein 1A

  1998cited by this paper
• Murine CASK is disrupted in a sex-linked cleft palate mouse mutant.

  1998cited by this paper
• Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

  1998cited by this paper
• Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in Culture

  1998cited by this paper
• Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane.

  1998cited by this paper
• A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.

  1998cited by this paper
• N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4.

  1998cited by this paper
• Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues.

  1997cited by this paper
• GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules

  1997cited by this paper
• Hrs-2 is an ATPase implicated in calcium-regulated secretion

  1997cited by this paper
• SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.

  1997cited by this paper
• Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95.

  1997cited by this paper
• Interaction of ion channels and receptors with PDZ domain proteins.

  1997cited by this paper
• Binding of neuroligins to PSD-95.

  1997cited by this paper
• Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases.

  1996cited by this paper
• SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo.

  1996cited by this paper
• Cytoskeletal plasticity in cells expressing neuronal microtubule-associated proteins.

  1996cited by this paper
• Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.

  1996cited by this paper
• Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins.

  1996cited by this paper
• Endosomal Localization of the Autoantigen EEA1 Is Mediated by a Zinc-binding FYVE Finger*

  1996cited by this paper
• Cloning and Characterization of Postsynaptic Density 93, a Nitric Oxide Synthase Interacting Protein

  1996cited by this paper
• The Drosophila tumor suppressor gene, dlg, is involved in structural plasticity at a glutamatergic synapse.

  1996cited by this paper
• CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

  1996cited by this paper
• Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.

  1995cited by this paper
• Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

  1995cited by this paper
• Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein

  1995cited by this paper
• Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain

  1995cited by this paper
• Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

  1995cited by this paper
• Detection of messenger RNA by in situ hybridization.

  1993cited by this paper
• SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A.

  1993cited by this paper
• [Microtubule-associated proteins].

  1993cited by this paper
• The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.

  1992cited by this paper

• A Mouse Photoreceptor Proteome Resource Identifies PALS2/MPP6 as a Novel Pan-Cone Photoreceptor Marker

  2025cites this paper
• Phosphorylation of PSD-95 at serine 73 in dCA1 is required for extinction of contextual fear

  2023cites this paper
• An impaired splicing program underlies differentiation defects in hSOD1^G93A neural progenitor cells

  2023cites this paper
• 7,8-Dihydroxycoumarin Alleviates Synaptic Loss by Activated PI3K-Akt-CREB-BDNF Signaling in Alzheimer’s Disease Model Mice

  2022cites this paper
• Cyclin-dependent kinase 5 phosphorylates the N-terminal domain Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons of the postsynaptic density protein PSD-95 in neurons

  2022influential citation
• Title : Synaptic plasticity regulated by phosphorylation of PSD-95 Serine 73 in dorsal CA 1 is 1 required for contextual fear extinction 2

  2021cites this paper
• PSD-95 in dorsal CA1 contributes to the persistence of fear memory

  2020cites this paper
• A role for alternative splicing in circadian control of exocytosis and glucose homeostasis

  2020cites this paper
• Further identification of a 140bp sequence from amid intron 9 of human FMR1 gene as a new exon

  2020cites this paper
• Monitoring translation in synaptic fractions using a ribosome profiling strategy

  2020cites this paper
• Not Just Another Scaffolding Protein Family: The Multifaceted MPPs

  2020influential citation
• CD40L Reverse Signaling Influences Dendrite Spine Morphology and Expression of PSD-95 and Rho Small GTPases

  2020cites this paper
• Can We Use 2,3,5-Triphenyltetrazolium Chloride-Stained Brain Slices for Other Purposes? The Application of Western Blotting

  2019cites this paper
• PDZ Domains as Drug Targets

  2019cites this paper
• Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity

  2019cites this paper
• Calsyntenin-1 Negatively Regulates ICAM5 Accumulation in Postsynaptic Membrane and Influences Dendritic Spine Maturation in a Mouse Model of Fragile X Syndrome

  2019cites this paper
• A de novo in‐frame deletion of CASK gene causes early onset infantile spasms and supratentorial cerebral malformation in a female patient

  2018cites this paper
• N‐terminal SAP97 isoforms differentially regulate synaptic structure and postsynaptic surface pools of AMPA receptors

  2017cites this paper
• Interference of HTLV-1 Tax Protein with Cell Polarity Regulators: Defining the Subcellular Localization of the Tax-DLG1 Interaction

  2017cites this paper
• Postsynaptic Density-95 Isoform Abnormalities in Schizophrenia

  2017cites this paper
• UvA-DARE ( Digital Academic Repository ) Alternatively spliced isoforms of TRIP 8 b differentially control h channel trafficking and function

  2017cites this paper
• The role of ESCRT during development and functioning of the nervous system.

  2017cites this paper
• Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation

  2016influential citation
• AMPA Receptors as Therapeutic Targets for Neurological Disorders.

  2016cites this paper
• Palmitoylation regulates glutamate receptor distribution in postsynaptic densities by controlling PSD 95 conformation and orientation

  2016influential citation
• Crude Saponins of Panax notoginseng Have Neuroprotective Effects To Inhibit Palmitate-Triggered Endoplasmic Reticulum Stress-Associated Apoptosis and Loss of Postsynaptic Proteins in Staurosporine Differentiated RGC-5 Retinal Ganglion Cells.

  2016cites this paper
• A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator

  2015cites this paper
• Significance of CIN85 Analysis in Nutritional Study Journal of Nutritional Biology

  2015cites this paper
• Wireless tools for neuromodulation

  2015cites this paper
• Dendritic spine dysgenesis in neuropathic pain.

  2015cites this paper
• synapses strength of glutamatergic AMPAR-containing -mediated regulation of the number and β SAP97requirement for NMDAR activity in

  2015cites this paper
• The Role of αSAP97 and βSAP97 at the Glutamatergic Synapse

  2015influential citation
• Chronic Copper Exposure Causes Spatial Memory Impairment, Selective Loss of Hippocampal Synaptic Proteins, and Activation of PKR/eIF2α Pathway in Mice

  2014cites this paper
• Splicing Regulatory Elements and mRNA-abundance of dlg1 and capt, Genetically Interacting with dFMRP in Drosophila Brain

  2014cites this paper
• The Role of Excitotoxicity in Essential Tremor Cerebellum

  2014cites this paper
• Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity

  2014cites this paper
• Differential requirement for NMDAR activity in SAP97β-mediated regulation of the number and strength of glutamatergic AMPAR-containing synapses.

  2013cites this paper
• Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease.

  2013cites this paper
• Differential Roles of Postsynaptic Density-93 Isoforms in Regulating Synaptic Transmission

  2013influential citation
• Emerging role of the scaffolding protein Dlg 1 in interfacing with the vesicle trafficking machinery

  2013cites this paper
• Fmr1 Transcript Isoforms: Association with Polyribosomes; Regional and Developmental Expression in Mouse Brain

  2013cites this paper
• Synaptic State-Dependent Functional Interplay between Postsynaptic Density-95 and Synapse-Associated Protein 102

  2013cites this paper
• Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

  2013cites this paper
• Emerging Role of the Scaffolding Protein Dlg1 in Vesicle Trafficking

  2013cites this paper
• Synaptic function in the hippocampus in neurodegenerative disease

  2013cites this paper
• Role of the maguk protein family in synapse formation and function

  2012cites this paper
• Acute down‐regulation of adenosine A1 receptor activity in status epilepticus

  2012influential citation
• Association of Shank 1A Scaffolding Protein with Cone Photoreceptor Terminals in the Mammalian Retina

  2012cites this paper
• Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity.

  2012cites this paper
• Reconstructing and analysing protein-protein interaction networks of synaptic molecular machines

  2012cites this paper
• Role of the different domains of PSD-95 in basal synaptic transmission

  2011cites this paper
• Signaling pathways involved in enhanced NMDA receptor-dependent excitotoxicity in a mouse model of Huntington disease

  2011cites this paper
• The Role of SAP97 Isoforms in Regulating Synaptic Function in Hippocampal Neurons

  2011influential citation
• Retinal Neuronal Remodelling in a Model of Optic Atrophy

  2011cites this paper
• SAP97 directs NMDA receptor spine targeting and synaptic plasticity

  2011influential citation
• Involvement of neuroligins and associated proteins in synapse development

  2010cites this paper
• A Perisynaptic Ménage à Trois between Dlg, DLin-7, and Metro Controls Proper Organization of Drosophila Synaptic Junctions

  2010cites this paper
• The fast and slow ups and downs of HCN channel regulation

  2010cites this paper
• Expression pattern of membrane‐associated guanylate kinases in interneurons of the visual cortex

  2010influential citation
• The Drosophila Larval Neuromuscular Junction as a Model for Scaffold Complexes at Glutamatergic Synapses: Benefits and Limitations

  2010cites this paper
• Version unknown SOURCE ( OR PART OF THE FOLLOWING SOURCE ) : Type article Title Alternatively spliced isoforms of TRIP 8 b differentially control h channel trafficking and function

  2009cites this paper
• Proteomic analysis of the membrane palmitoylated protein-4 (MPP4)-associated protein complex in the retina.

  2009cites this paper
• A missense mutation in CASK causes FG syndrome in an Italian family.

  2009cites this paper
• PSD95beta regulates plasma membrane Ca2+ pump localization at the photoreceptor synapse.

  2009cites this paper
• Aplysia synapse associated protein (APSAP): identification, characterization, and selective interactions with Shaker‐type potassium channels

  2008cites this paper
• Developmental regulation of PSD-95 and nNOS expression in lumbar spinal cord of rats.

  2008cites this paper
• Cell polarity proteins: common targets for tumorigenic human viruses

  2008cites this paper
• Synaptic adhesion molecules and PSD-95.

  2008cites this paper
• The dynamics of synaptic scaffolds

  2008cites this paper
• Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth.

  2008cites this paper
• Formation of aquaporin-4 arrays is inhibited by palmitoylation of N-terminal cysteine residues.

  2008cites this paper
• Exploring the early origins of the synapse by comparative genomics

  2008cites this paper
• Structural and functional roles of KCC2 in developing cortex

  2008cites this paper
• Excitation Control: Balancing PSD-95 Function at the Synapse

  2008cites this paper
• NMDA receptor desensitization regulated by direct binding to PDZ1-2 domains of PSD-95.

  2008cites this paper
• Differential interaction of NMDA receptor subtypes with the post‐synaptic density‐95 family of membrane associated guanylate kinase proteins

  2008cites this paper
• Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration.

  2008cites this paper
• Role of SAP102 in mutant Huntingtin-mediated regulation of NMDA receptor function in the YAC transgenic mouse model of Huntington Disease

  2007cites this paper
• Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3

  2007cites this paper
• ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis.

  2007cites this paper
• La kinase neuronale PAK 3 : Etude des trois mutations reponsables de retard mental non syndronique et mise en évidence de deux nouveaux variants d'épissage

  2007cites this paper
• Activity-dependent Regulation of h Channel Distribution in Hippocampal CA1 Pyramidal Neurons*

  2007cites this paper
• Dual role of CaMKII‐dependent SAP97 phosphorylation in mediating trafficking and insertion of NMDA receptor subunit NR2A

  2007cites this paper
• Catching a GEF by its tail.

  2007cites this paper
• A New Crucial Protein Interaction Element That Targets the Adenovirus E4-ORF1 Oncoprotein to Membrane Vesicles

  2007cites this paper
• Antagonistic effects of TrkB and p75NTR on NMDA receptor currents in post‐synaptic densities transplanted into Xenopus oocytes

  2007cites this paper
• Characterization of the delta2 glutamate receptor-binding protein delphilin: Splicing variants with differential palmitoylation and an additional PDZ domain.

  2006cites this paper
• Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function.

  2006influential citation
• Interaction between SAP97 and PSD-95, Two Maguk Proteins Involved in Synaptic Trafficking of AMPA Receptors*

  2006cites this paper
• Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse.

  2006cites this paper
• Distribution of the scaffolding proteins PSD-95, PSD-93, and SAP97 in isolated PSDs

  2006cites this paper
• Identification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins

  2006cites this paper
• Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions.

  2005cites this paper
• Identification and characterization of a novel Delphilin variant with an alternative N-terminus.

  2005cites this paper
• Characterization of zebrafish PSD-95 gene family members.

  2005cites this paper
• Structural and functional diversity generated by alternative mRNA splicing.

  2005cites this paper
• Analysis of the cell junction proteins CASK and claudin-5 in skeletal and cardiac muscle.

  2005cites this paper
• Analyses of murine postsynaptic density-95 identify novel isoforms and potential translational control elements.

  2005cites this paper
• Neuronal proteins custom designed by alternative splicing.

  2005cites this paper
• Calcium/Calmodulin-dependent Protein Kinase II Phosphorylation Drives Synapse-associated Protein 97 into Spines*

  2004cites this paper