Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Frontiers in Bioscience

• Publication date

  2008-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2741/3182PMID 18508688
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• aPKCζ cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia

  2007influential reference
• The Gap Junction Protein Connexin32 Interacts with the Src Homology 3/Hook Domain of Discs Large Homolog 1*

  2007cited by this paper
• The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity

  2007cited by this paper
• The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation.

  2007cited by this paper
• Abnormal development of urogenital organs in Dlgh1-deficient mice

  2007cited by this paper
• Human scribble accumulates in colorectal neoplasia in association with an altered distribution of beta-catenin.

  2007cited by this paper
• Tight junctions/adherens junctions: basic structure and function.

  2007cited by this paper
• Spatial regulation of exocytosis and cell polarity: Yeast as a model for animal cells

  2007cited by this paper
• The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

  2007influential reference
• Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice

  2007cited by this paper
• p32 is a novel mammalian Lgl binding protein that enhances the activity of protein kinase Cζ and regulates cell polarity

  2007cited by this paper
• The Nuclear RhoA Exchange Factor Net1 Interacts with Proteins of the Dlg Family, Affects Their Localization, and Influences Their Tumor Suppressor Activity

  2007cited by this paper
• The Stardust Family Protein MPP7 Forms a Tripartite Complex with LIN7 and DLG1 That Regulates the Stability and Localization of DLG1 to Cell Junctions*

  2007cited by this paper
• Mammalian Lin-7 Stabilizes Polarity Protein Complexes*

  2006cited by this paper
• Expression of Hugl-1 is strongly reduced in malignant melanoma

  2006cited by this paper
• The PAR-aPKC system: lessons in polarity

  2006cited by this paper
• Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity

  2006cited by this paper
• Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter

  2006cited by this paper
• Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation

  2006cited by this paper
• Scribble associates with two polarity proteins, lgl2 and vangl2, via distinct molecular domains

  2006cited by this paper
• Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression

  2006cited by this paper
• Asymmetric Localization of Vangl2 and Fz3 Indicate Novel Mechanisms for Planar Cell Polarity in Mammals

  2006cited by this paper
• aPKC, Crumbs3 and Lgl2 control apicobasal polarity in early vertebrate development

  2005influential reference
• Zebrafish penner/lethal giant larvae 2 functions in hemidesmosome formation, maintenance of cellular morphology and growth regulation in the developing basal epidermis

  2005cited by this paper
• Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

  2005cited by this paper
• PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells

  2005cited by this paper
• The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

  2005influential reference
• Par-3 controls tight junction assembly through the Rac exchange factor Tiam1

  2005cited by this paper
• Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.

  2005cited by this paper
• Regulation of Lethal giant larvae by Dishevelled

  2005cited by this paper
• Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.

  2005cited by this paper
• PATJ regulates tight junction formation and polarity in mammalian epithelial cells

  2005cited by this paper
• Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells

  2005cited by this paper
• Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer

  2005cited by this paper
• Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

  2005influential reference
• Endocytic control of epithelial polarity and proliferation in Drosophila

  2005cited by this paper
• Roles and modes of action of nectins in cell-cell adhesion.

  2004cited by this paper
• Isoforms of the Polarity Protein Par6 Have Distinct Functions*

  2004cited by this paper
• aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

  2004cited by this paper
• Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble

  2004influential reference
• Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity

  2004cited by this paper
• Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis.

  2004cited by this paper
• Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97

  2004cited by this paper
• The human protein Hugl-1 substitutes for Drosophila Lethal giant larvae tumour suppressor function in vivo

  2004cited by this paper
• Asymmetric cell division.

  2004cited by this paper
• Loss of PALS1 expression leads to tight junction and polarity defects.

  2004cited by this paper
• Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

  2004cited by this paper
• Human Homolog of Disc-large Is Required for Adherens Junction Assembly and Differentiation of Human Intestinal Epithelial Cells*

  2004cited by this paper
• Parsing the Polarity Code

  2004cited by this paper
• Differential expression of human Dlg in cervical intraepithelial neoplasias.

  2004cited by this paper
• Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.

  2004cited by this paper
• Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix

  2004cited by this paper
• A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl

  2003cited by this paper
• The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells

  2003cited by this paper
• Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).

  2003cited by this paper
• Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia

  2003cited by this paper
• Basolateral targeting by leucine‐rich repeat domains in epithelial cells

  2003cited by this paper
• Identification of Vangl2 and Scrb1 as planar polarity genes in mammals

  2003cited by this paper
• Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry

  2003cited by this paper
• Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions*

  2003cited by this paper
• Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization

  2003cited by this paper
• CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells.

  2003cited by this paper
• Protein 4.1-mediated Membrane Targeting of Human Discs Large in Epithelial Cells*

  2003cited by this paper
• Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse.

  2003cited by this paper
• Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.

  2003influential reference
• Interaction of lp-dlg/KIAA0583, a Membrane-associated Guanylate Kinase Family Protein, with Vinexin and β-Catenin at Sites of Cell-Cell Contact*

  2003cited by this paper
• Integrated activity of PDZ protein complexes regulates epithelial polarity

  2003cited by this paper
• Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

  2003influential reference
• hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

  2003cited by this paper
• Composition and function of PDZ protein complexes during cell polarization.

  2003cited by this paper
• The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl

  2003cited by this paper
• Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms

  2002cited by this paper
• Interaction between Erbin and a Catenin-related Protein in Epithelial Cells*

  2002cited by this paper
• Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein.

  2002cited by this paper
• Composition and Formation of Intercellular Junctions in Epithelial Cells

  2002cited by this paper
• The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost

  2002cited by this paper
• A Novel and Conserved Protein-Protein Interaction Domain of Mammalian Lin-2/CASK Binds and Recruits SAP97 to the Lateral Surface of Epithelia

  2002influential reference
• Assembly of epithelial tight junctions is negatively regulated by Par6.

  2002cited by this paper
• Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells.

  2002influential reference
• aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization

  2002cited by this paper
• Changes in expression of the human homologue of the Drosophila discs large tumour suppressor protein in high-grade premalignant cervical neoplasias.

  2002cited by this paper
• hINADl/PATJ, a Homolog of Discs Lost, Interacts with Crumbs and Localizes to Tight Junctions in Human Epithelial Cells*

  2002cited by this paper
• A Functional Interaction between CD46 and DLG4

  2002cited by this paper
• Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation.

  2002cited by this paper
• Identification of Multiple Binding Partners for the Amino-terminal Domain of Synapse-associated Protein 97*

  2002cited by this paper
• A Functional Interaction between CD46 and DLG4 A ROLE FOR DLG4 IN EPITHELIAL POLARIZATION*

  2002cited by this paper
• Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia

  2001influential reference
• Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures

  2001cited by this paper
• Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts

  2001cited by this paper
• Cell division: Asymmetric cell division during animal development

  2001cited by this paper
• Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

  2001cited by this paper
• DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation.

  2001cited by this paper
• Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification.

  2001cited by this paper
• Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail

  2001cited by this paper
• Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity

  2001cited by this paper
• PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex

  2001cited by this paper
• Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large.

  2001cited by this paper
• Asymmetric cell division: fly neuroblast meets worm zygote.

  2001cited by this paper
• Molecular Cloning and Characterization of Pals, Proteins Associated with mLin-7*

  2000cited by this paper
• Localization of apical epithelial determinants by the basolateral PDZ protein Scribble

  2000influential reference

• The Versatile Roles of Retinal Pigment Epithelium in the Pathophysiology of Retinitis Pigmentosa.

  2025cites this paper
• Unveiling the Tumor Suppressors: Insights from Drosophila.

  2025cites this paper
• Confrontation with kidney inflammation through a HMGB1-targeted peptide augments anti-fibrosis therapy.

  2024cites this paper
• DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2

  2024cites this paper
• Truncated SCRIB isoform promotes breast cancer metastasis through HNRNP A1 mediated exon 16 skipping

  2023cites this paper
• DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2

  2023cites this paper
• Identification of Novel Risk Variants of Non-Syndromic Cleft Palate by Targeted Gene Panel Sequencing

  2023cites this paper
• Cell polarity signalling at the birth of multicellularity: What can we learn from the first animals

  2022cites this paper
• Integrated Analyses of Transcriptome and Chlorophyll Fluorescence Characteristics Reveal the Mechanism Underlying Saline–Alkali Stress Tolerance in Kosteletzkya pentacarpos

  2022cites this paper
• Scribble basal polarity acquisition in RPE cells and its mislocalization in a pathological AMD-like model

  2022influential citation
• Identification of the genes encoding candidate septate junction components expressed during early development of the sea urchin, Strongylocentrotus purpuratus, and evidence of a role for Mesh in the formation of the gut barrier.

  2022cites this paper
• Scribble downregulation in adenomyosis compromises endometrial stromal decidualization by decreasing FOXO1 expression.

  2021cites this paper
• miRNAs: Critical mediators of breast cancer metastatic programming.

  2021cites this paper
• The hippo pathway: A master regulator of liver metabolism, regeneration, and disease

  2021cites this paper
• Viral PDZ Binding Motifs Influence Cell Behavior Through the Interaction with Cellular Proteins Containing PDZ Domains.

  2021cites this paper
• Construction of a ceRNA Network and Analysis of Tumor Immune Infiltration in Pancreatic Adenocarcinoma

  2021cites this paper
• In depth study of transmembrane mucins in association with intestinal barrier dysfunction during the course of T cell transfer and DSS-induced colitis.

  2020cites this paper
• Par protein localization during the early development of Mnemiopsis leidyi suggests different modes of epithelial organization in the metazoa

  2020cites this paper
• The vertebrate epithelial apical junctional complex: Dynamic interplay between Rho GTPase activity and cell polarization processes.

  2020cites this paper
• Scaffolding proteins of vertebrate apical junctions: Structure, functions and biophysics.

  2020cites this paper
• Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn’s Disease

  2020cites this paper
• Breaking symmetry - cell polarity signaling pathways in growth cone guidance and synapse formation.

  2020cites this paper
• Loss of Crb2b-lf leads to anterior segment defects in old zebrafish

  2020cites this paper
• New insights into apical-basal polarization in epithelia.

  2020cites this paper
• Switching States: dynamic remodelling of polarity complexes as a toolkit for cell polarization

  2019cites this paper
• Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

  2019cites this paper
• PDZ Domains as Drug Targets

  2019cites this paper
• DLGAP1 directs megakaryocytic growth and differentiation in an MPL dependent manner in hematopoietic cells

  2019cites this paper
• Par protein localization during the early development of Mnemiopsis leidyi suggests different modes of epithelial organization in Metazoa

  2018cites this paper
• The transcriptional co-activator YAP: A new player in head and neck cancer.

  2018cites this paper
• Par-Cteno-Genesis or Cteno Par-Genesis

  2018cites this paper
• Context-Specific Mechanisms of Cell Polarity Regulation.

  2018cites this paper
• Discs large 1 controls daughter-cell polarity after cytokinesis in vertebrate morphogenesis

  2018cites this paper
• Common variants in DLG1 locus are associated with non‐syndromic cleft lip with or without cleft palate

  2018cites this paper
• PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarization

  2018cites this paper
• LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling

  2018influential citation
• Molecular targets of developmental exposure to bisphenol A in diabesity: a focus on endoderm‐derived organs

  2017cites this paper
• Expression of cell polarity protein scribble differently affects prognosis in primary tumor and lymph node metastasis of breast cancer patients

  2017cites this paper
• Epithelial Organization: The Gut and Beyond.

  2017cites this paper
• APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells.

  2017cites this paper
• Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis.

  2017cites this paper
• The asymmetric cell division machinery in early annelid embryogenesis: Maternal and embryonic contributions

  2017cites this paper
• Role of the Crumbs proteins in ciliogenesis, cell migration and actin organization.

  2017cites this paper
• The cell polarity protein Scrib functions as a tumor suppressor in liver cancer

  2017cites this paper
• Adhesion GPCR-Related Protein Networks.

  2016cites this paper
• Global proteomic profiling identifies etoposide chemoresistance markers in non-small cell lung carcinoma.

  2016cites this paper
• Complex Polarity: Building Multicellular Tissues Through Apical Membrane Traffic

  2016cites this paper
• A study of PDZ protein expression during the human papillomavirus life cycle

  2015influential citation
• Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer.

  2015cites this paper
• Lethal (2) Giant Larvae: An Indispensable Regulator of Cell Polarity and Cancer Development

  2015cites this paper
• Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule.

  2015cites this paper
• Drosophila Myc: A master regulator of cellular performance.

  2015cites this paper
• The Mammalian Blood-Testis Barrier: Its Biology and Regulation.

  2015cites this paper
• Detection of in situ protein-protein complexes at the Drosophila larval neuromuscular junction using proximity ligation assay.

  2015cites this paper
• Presynaptic Terminals

  2015cites this paper
• The PAR3-aPKC-PAR6 Complex

  2015cites this paper
• The Scribble–Dlg–Lgl Module in Cell Polarity Regulation

  2015cites this paper
• The Role and Mechanisms of Dlg5 in the Regulation of the Hippo Signaling Pathway

  2015cites this paper
• Roles of Tomosyn in Neurotransmitter Release

  2015cites this paper
• Mechanisms regulating cxcr4 intracellular traffic and polarization in human hepatocellular carcinoma cells: cross-talk with the tgf-b pathway

  2015cites this paper
• The interdependence of the Rho GTPases and apicobasal cell polarity

  2014cites this paper
• The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization

  2014cites this paper
• DLG5 in Cell Polarity Maintenance and Cancer Development

  2014cites this paper
• Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation

  2014cites this paper
• Role of TGF-β receptor III localization in polarity and breast cancer progression

  2014cites this paper
• DLG5 in Cell Polarity Maintenance and Cancer

  2014cites this paper
• “You Shall Not Pass”—tight junctions of the blood brain barrier

  2014cites this paper
• Unexpected effects of tumor-suppressing genes on fruit fly development

  2014cites this paper
• Signalling at tight junctions during epithelial differentiation and microbial pathogenesis

  2014cites this paper
• The Role of Cell-polarity in Development and Disease

  2014cites this paper
• Regulation of Dlg-containing adhesion complexes during epithelial and synaptic plasticity in Drosophila

  2013cites this paper
• Plasma Membrane Sorting of Muscarinic Acetylcholine Receptors

  2013cites this paper
• Loss of aPKCλ in Differentiated Neurons Disrupts the Polarity Complex but Does Not Induce Obvious Neuronal Loss or Disorientation in Mouse Brains

  2013cites this paper
• A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

  2013cites this paper
• The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers

  2013cites this paper
• The regulation of cell polarity in the progression of lung cancer.

  2013cites this paper
• Three-dimensional epithelial cultures: a tool to model cancer development and progression.

  2013cites this paper
• Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.

  2013influential citation
• [Unexpected effects of genes--tumor suppressors in fruit fly ontogenesis].

  2013cites this paper
• Drosophila: A Model System That Allows in vivo Manipulation and Study of Epithelial Cell Polarity

  2012cites this paper
• Snail Destabilizes Cell Surface Crumbs3a

  2012cites this paper
• New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.

  2012cites this paper
• Refining the role of Lgl, Dlg and Scrib in Tumor Suppression and Beyond: Learning from the Old Time Classics

  2012cites this paper
• Funktionelle Analyse der C. elegans Gene vang-1, atad-3 und mics-1 in Bezug auf Alterung und Stressresistenz

  2012cites this paper
• Epithelial cell polarity, stem cells and cancer

  2012cites this paper
• Tumor suppressor genes

  2012cites this paper
• Scaffolding of the C-terminal Domain of β heavy-spectrin is Involved in Trafficking and the Maintenance of Apicobasal Polarity

  2012cites this paper
• Polarized sorting and trafficking in epithelial cells

  2012cites this paper
• Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

  2012cites this paper
• Uncorking gastrulation: the morphogenetic movement of bottle cells

  2012cites this paper
• The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

  2012influential citation
• Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis

  2012cites this paper
• Recruitment of synaptic vesicles to developing synapses

  2011cites this paper
• Epithelial cell polarity, stem cells and cancer

  2011cites this paper
• Requirements of Lgl in cell differentiation and motility during Drosophila ovarian follicular epithelium morphogenesis

  2011cites this paper
• Rac1 modulation of the apical domain is negatively regulated by β (Heavy)-spectrin.

  2011influential citation
• New Insights into the Biological Effects of Anthrax Toxins: Linking Cellular to Organismal Responses

  2011cites this paper
• An unconventional role for the septate junctions and Gliotactin in cell division

  2011cites this paper
• Mechanisms of cell polarity and aquaporin sorting in the nephron

  2011cites this paper
• Function and regulation of the Drosophila planar polarity effector Multiple Wing Hairs (Mwh)

  2011cites this paper