The interdependence of the Rho GTPases and apicobasal cell polarity

Signaling via the Rho GTPases provides crucial regulation of numerous cell polarization events, including apicobasal (AB) polarity, polarized cell migration, polarized cell division and neuronal polarity. Here we review the relationships between the Rho family GTPases and epithelial AB polarization events, focusing on the 3 best-characterized members: Rho, Rac and Cdc42. We discuss a multitude of processes that are important for AB polarization, including lumen formation, apical membrane specification, cell-cell junction assembly and maintenance, as well as tissue polarity. Our discussions aim to highlight the immensely complex regulatory mechanisms that encompass Rho GTPase signaling during AB polarization. More specifically, in this review we discuss several emerging common themes, that include: 1) the need for Rho GTPase activities to be carefully balanced in both a spatial and temporal manner through a multitude of mechanisms; 2) the existence of signaling feedback loops and crosstalk to create robust cellular responses; and 3) the frequent multifunctionality that exists among AB polarity regulators. Regarding this latter theme, we provide further discussion of the potential plasticity of the cell polarity machinery and as a result the possible implications for human disease.

• Publication year

  2014

• Venue

  Small GTPases

• Publication date

  2014-04-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/21541248.2014.973768PMID 25469537PMCID 4601375
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation

  2014cited by this paper
• Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation

  2014cited by this paper
• Expression of Tiam1 predicts lymph node metastasis and poor survival of lung adenocarcinoma patients

  2014cited by this paper
• Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer.

  2014cited by this paper
• Rho-directed forces in collective migration

  2014cited by this paper
• The role of the non-canonical Wnt-planar cell polarity pathway in neural crest migration.

  2014cited by this paper
• Elevated expression of T-lymphoma invasion and metastasis inducing factor 1 in squamous-cell carcinoma of the head and neck and its clinical significance.

  2014cited by this paper
• TEM4 is a junctional Rho GEF required for cell–cell adhesion, monolayer integrity and barrier function

  2013cited by this paper
• MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma.

  2013cited by this paper
• ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation

  2013cited by this paper
• Par1b links lumen polarity with LGN–NuMA positioning for distinct epithelial cell division phenotypes

  2013cited by this paper
• Wnt5a signaling promotes apical and basolateral polarization of single epithelial cells

  2013influential reference
• LKB1 Controls Human Bronchial Epithelial Morphogenesis through p114RhoGEF-Dependent RhoA Activation

  2013cited by this paper
• The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation

  2013cited by this paper
• β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity

  2012influential reference
• Chimaerin Suppresses Rac1 Activation at the Apical Membrane to Maintain the Cyst Structure

  2012cited by this paper
• At the leading edge of three-dimensional cell migration

  2012cited by this paper
• Apicobasal polarity and its role in cancer progression

  2012cited by this paper
• Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration

  2012cited by this paper
• Small GTPase Rho regulates R-cadherin through Dia1/profilin-1.

  2012cited by this paper
• The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity

  2012cited by this paper
• Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

  2012cited by this paper
• Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex

  2012cited by this paper
• Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion

  2012cited by this paper
• Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-Myosin II signaling

  2012cited by this paper
• Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance

  2012cited by this paper
• Assembly of Bazooka polarity landmarks through a multifaceted membrane-association mechanism

  2012cited by this paper
• Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium

  2012cited by this paper
• Analysis of the role of RhoGDI1 and isoprenylation in the degradation of RhoGTPases.

  2012cited by this paper
• ARHGAP21 Protein, a New Partner of α-Tubulin Involved in Cell-Cell Adhesion Formation and Essential for Epithelial-Mesenchymal Transition*

  2012cited by this paper
• Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis.

  2011cited by this paper
• Rho GTPases and exocytosis: what are the molecular links?

  2011cited by this paper
• Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation

  2011cited by this paper
• Faculty Opinions recommendation of Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.

  2011cited by this paper
• Epithelial cell polarity: a major gatekeeper against cancer?

  2011cited by this paper
• Elaborating polarity: PAR proteins and the cytoskeleton

  2011cited by this paper
• The Small GTPase RhoA Is Required to Maintain Spinal Cord Neuroepithelium Organization and the Neural Stem Cell Pool

  2011cited by this paper
• Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF

  2011cited by this paper
• Ajuba is required for Rac activation and maintenance of E-cadherin adhesion

  2011cited by this paper
• SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

  2011cited by this paper
• Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling

  2011cited by this paper
• Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling

  2011cited by this paper
• Rapid Suppression of Activated Rac1 by Cadherins and Nectins during De Novo Cell-Cell Adhesion

  2011cited by this paper
• Crumbs/DaPKC-dependent apical exclusion of Bazooka promotes photoreceptor polarity remodeling.

  2010cited by this paper
• Cdc42 Regulates Apical Junction Formation in Human Bronchial Epithelial Cells through PAK4 and Par6B

  2010cited by this paper
• The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila

  2010cited by this paper
• The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis

  2010cited by this paper
• The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation

  2010cited by this paper
• A molecular network for de novo generation of the apical surface and lumen

  2010cited by this paper
• SUMOylation of the GTPase Rac1 is required for optimal cell migration

  2010cited by this paper
• Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions

  2010cited by this paper
• aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells

  2010cited by this paper
• Cdc42 localization and cell polarity depend on membrane traffic

  2010cited by this paper
• Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation

  2010cited by this paper
• Spatially restricted activation of RhoA at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

  2010cited by this paper
• Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens

  2010cited by this paper
• Mechanical tugging force regulates the size of cell–cell junctions

  2010cited by this paper
• Rho GTPases: regulation of cell polarity and growth in yeasts.

  2010cited by this paper
• Newly formed E‐cadherin contacts do not activate Cdc42 or induce filopodia protrusion in human keratinocytes 1

  2010cited by this paper
• Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly.

  2010cited by this paper
• Rho signaling and tight junction functions.

  2010cited by this paper
• Interaction between PAR-3 and the aPKC–PAR-6 complex is indispensable for apical domain development of epithelial cells

  2009cited by this paper
• SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.

  2009cited by this paper
• Prognostic Value of Tiam1 and Rac1 Overexpression in Nasopharyngeal Carcinoma

  2009cited by this paper
• Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1.

  2009cited by this paper
• FERM proteins in animal morphogenesis.

  2009cited by this paper
• Endocytosis is required for E-cadherin redistribution at mature adherens junctions

  2009cited by this paper
• Mechanical control of global cell behaviour during dorsal closure in Drosophila

  2009cited by this paper
• VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation.

  2009cited by this paper
• Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells

  2009cited by this paper
• Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia

  2009cited by this paper
• Coordination of Rho GTPase activities during cell protrusion

  2009cited by this paper
• Yurt, Coracle, Neurexin IV and the Na+,K+-ATPase form a novel group of epithelial polarity proteins

  2009cited by this paper
• Pulsed contractions of an actin–myosin network drive apical constriction

  2009cited by this paper
• Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation.

  2009cited by this paper
• Pulsed forces timed by a ratchet-like mechanism drive directed tissue movement during dorsal closure.

  2009cited by this paper
• Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension

  2009cited by this paper
• Neuronal polarity.

  2009cited by this paper
• The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription

  2009cited by this paper
• Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

  2008cited by this paper
• A two-tiered mechanism for stabilization and immobilization of E-cadherin

  2008cited by this paper
• Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability.

  2008influential reference
• Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis.

  2008cited by this paper
• Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.

  2008cited by this paper
• Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity

  2008cited by this paper
• Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.

  2008cited by this paper
• Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.

  2008cited by this paper
• Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis

  2008cited by this paper
• Polarity complex proteins.

  2008cited by this paper
• [Neuronal polarity].

  2008cited by this paper
• International Seminars in Surgical Oncology the Expression and Prognostic Value of the Guanine Nucleotide Exchange Factors (gefs) Trio, Vav1 and Tiam-1 in Human Breast Cancer

  2008cited by this paper
• Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling

  2008cited by this paper
• Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth.

  2008cited by this paper
• PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac

  2008cited by this paper
• RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.

  2008cited by this paper
• Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions.

  2007cited by this paper
• C‐terminal Src kinase controls development and maintenance of mouse squamous epithelia

  2007cited by this paper
• Mechanism and function of formins in the control of actin assembly.

  2007cited by this paper
• Nectin and Nectin-Like Molecules: Biology and Pathology

  2007cited by this paper
• Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell–cell adhesion

  2007influential reference

• RhoGEF2 overexpression induces cell competition dependent on Ptp10D, Crumbs and the Hippo signaling pathway

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• Bulk exocytosis of large intracellular apical precursor organelles establishes apical domain identity during de novo lumen formation

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• P. aeruginosa disrupts ARP-2/3 mediated apical F-actin organization to induce intestinal deformation in C. elegans

  2025cites this paper
• Proteomic analysis uncovers biological diversity in molecularly defined endometrial carcinomas

  2025cites this paper
• RhoGDI1 regulates cell-cell junctions in polarized epithelial cells

  2024cites this paper
• A computational analysis of the role of integrins and Rho-GTPases in the emergence and disruption of apical-basal polarization in renal epithelial cells

  2024cites this paper
• Transcriptomic and western blot characterisation of the human CLEFF4 clone, a new rapid cell line replacement for the Caco2 model.

  2024cites this paper
• Dietary copper improves intestinal structural integrity in juvenile grass carp (Ctenopharyngodon idella) probably related to its increased intestinal antioxidant capacity and apical junction complex

  2024cites this paper
• The Scribble/SGEF/Dlg1 complex regulates the stability of apical junctions in epithelial cells

  2024cites this paper
• Oridonin inhibited epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling

  2024cites this paper
• Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

  2024cites this paper
• Steroid hormone signaling synchronizes cell migration machinery, adhesion, and polarity to direct collective movement.

  2024cites this paper
• Apical‐out Tubuloids for Accurate Kidney Toxicity Studies

  2024cites this paper
• Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse

  2024cites this paper
• The Scribble/SGEF/Dlg1 complex regulates E-cadherin and ZO-1 stability, turnover, and transcription in epithelial cells.

  2024cites this paper
• The role of Motin family proteins in tumorigenesis—an update

  2023cites this paper
• The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during Xenopus gastrulation

  2023cites this paper
• Using Optogenetics to Investigate the Shared Mechanisms of Apical-Basal Polarity and Mitosis

  2023cites this paper
• Genome-wide characterization of the Rho family in cotton provides insights into fiber development

  2022cites this paper
• Addition of ROCK Inhibitors Alleviates Prostaglandin-Induced Inhibition of Adipogenesis in 3T3L-1 Spheroids

  2022cites this paper
• Rho family GTPase signaling through type II p21-activated kinases

  2022cites this paper
• The RhoGEF protein Plekhg5 regulates medioapical actomyosin dynamics of apical constriction during Xenopus gastrulation

  2022cites this paper
• Micro-patterned cell populations as advanced pharmaceutical drugs with precise functional control.

  2022cites this paper
• Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis

  2022cites this paper
• Vectorial Release of Human RNA Viruses from Epithelial Cells

  2022cites this paper
• Specialized protrusions coordinate migratory border cell cluster cohesion via Scribble, Cdep, and Rac

  2022cites this paper
• Differential Expression of Polarization in Odontoblasts and Epithelial cells

  2021cites this paper
• Human giant larvae-1 promotes migration and invasion of malignant glioma cells by regulating N-cadherin

  2021cites this paper
• CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells

  2021cites this paper
• Rac1 promotes kidney collecting duct integrity by limiting actomyosin activity

  2021cites this paper
• Association of the myosin heavy chain 9 gene single nucleotide polymorphism with inflammatory bowel disease

  2021cites this paper
• Cell polarity and cell adhesion associated gene expression differences between invasive micropapillary and no special type breast carcinomas and their prognostic significance

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  2021cites this paper
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• Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis

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• Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death

  2020cites this paper
• The vertebrate epithelial apical junctional complex: Dynamic interplay between Rho GTPase activity and cell polarization processes.

  2020cites this paper
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  2020cites this paper
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• The adenoviral protein E4orf4: a probing tool to decipher mechanical stress-induced nuclear envelope remodeling in tumor cells

  2020cites this paper
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  2020influential citation
• Rho GTPase transcriptional activity and breast cancer risk: A Mendelian randomization analysis

  2020cites this paper
• Ouabain Promotes Gap Junctional Intercellular Communication in Cancer Cells

  2020cites this paper
• Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly

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• SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility

  2019cites this paper
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  2019cites this paper
• Epithelial cell transforming sequence 2 expression is associated with the progression of laryngeal squamous cell carcinoma.

  2019cites this paper
• Cell polarization: From epithelial cells to odontoblasts.

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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Regulation of spermatid polarity by the actin- and microtubule (MT)-based cytoskeletons.

  2018cites this paper
• Rho GTPase signaling complexes in cell migration and invasion

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Spermatid polarity is regulated by the actin- and microtubule (MT)-based cytoskeletons

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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