Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Cell Science

• Publication date

  2010-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.060772PMID 20197404
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell cycle: Cell division brought down to size

  2009cited by this paper
• Interaction between PAR-3 and the aPKC–PAR-6 complex is indispensable for apical domain development of epithelial cells

  2009cited by this paper
• Activation of the WAVE complex by coincident signals controls actin assembly.

  2009cited by this paper
• Genetic and cell biological analysis of integrin outside-in signaling.

  2009cited by this paper
• Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis

  2008cited by this paper
• Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.

  2008cited by this paper
• Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability.

  2008influential reference
• The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.

  2008influential reference
• Polarization of the C. elegans Embryo by RhoGAP-Mediated Exclusion of PAR-6 from Cell Contacts

  2008cited by this paper
• Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis.

  2008cited by this paper
• On the Rho'd: The regulation of membrane protrusions by Rho‐GTPases

  2008cited by this paper
• HSPC300 and its role in neuronal connectivity

  2007cited by this paper
• Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs

  2007cited by this paper
• Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6–aPKC

  2007cited by this paper
• Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types.

  2007cited by this paper
• aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion.

  2007cited by this paper
• The PAR proteins: fundamental players in animal cell polarization.

  2007cited by this paper
• The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity.

  2007cited by this paper
• The many faces of actin: matching assembly factors with cellular structures

  2007influential reference
• Multicellular rosette formation links planar cell polarity to tissue morphogenesis.

  2006cited by this paper
• The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis

  2006influential reference
• Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.

  2006cited by this paper
• The PAR-aPKC system: lessons in polarity

  2006cited by this paper
• Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.

  2006cited by this paper
• Regulation of cadherin-mediated adhesion in morphogenesis

  2005cited by this paper
• Par-3 controls tight junction assembly through the Rac exchange factor Tiam1

  2005influential reference
• Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic

  2005cited by this paper
• Compartmentalized morphogenesis in epithelia: From cell to tissue shape

  2005cited by this paper
• PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1

  2005influential reference
• Endocytic control of epithelial polarity and proliferation in Drosophila

  2005cited by this paper
• The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

  2005influential reference
• Cascade pathway of filopodia formation downstream of SCAR

  2004cited by this paper
• Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis.

  2004cited by this paper
• Parsing the Polarity Code

  2004cited by this paper
• The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

  2004influential reference
• Sra‐1 and Nap1 link Rac to actin assembly driving lamellipodia formation

  2004cited by this paper
• Beta1-integrin orients epithelial polarity via Rac1 and laminin.

  2004cited by this paper
• Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila.

  2003cited by this paper
• Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions.

  2003influential reference
• Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila

  2003cited by this paper
• A conserved oligomerization domain in drosophila Bazooka/PAR-3 is important for apical localization and epithelial polarity.

  2003cited by this paper
• PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium.

  2003cited by this paper
• Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1

  2003cited by this paper
• Molecular requirements for actin-based lamella formation in Drosophila S2 cells

  2003cited by this paper
• Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila

  2003cited by this paper
• Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila

  2003cited by this paper
• Regulation of Tiam1–Rac signalling

  2003cited by this paper
• A Photoactivatable GFP for Selective Photolabeling of Proteins and Cells

  2002cited by this paper
• A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex

  2002cited by this paper
• Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

  2002cited by this paper
• Composition and Formation of Intercellular Junctions in Epithelial Cells

  2002cited by this paper
• Rac function and regulation during Drosophila development

  2002influential reference
• SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila

  2002cited by this paper
• Spatial control of the actin cytoskeleton in Drosophila epithelial cells

  2001cited by this paper
• Wasp, the Drosophila Wiskott-Aldrich Syndrome Gene Homologue, Is Required for Cell Fate Decisions Mediated by Notch Signaling

  2001cited by this paper
• Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development.

  2001cited by this paper
• Scar/WAVE is localised at the tips of protruding lamellipodia in living cells

  2001cited by this paper
• scabrous modifies epithelial cell adhesion and extends the range of lateral signalling during development of the spaced bristle pattern in Drosophila.

  2001cited by this paper
• Directed actin polymerization is the driving force for epithelial cell-cell adhesion.

  2000cited by this paper
• DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

  2000cited by this paper
• Drosophila Atypical Protein Kinase C Associates with Bazooka and Controls Polarity of Epithelia and Neuroblasts

  2000cited by this paper
• Actin machinery: pushing the envelope.

  2000cited by this paper
• Synaptic development is controlled in the periactive zones of Drosophila synapses.

  2000cited by this paper
• Irregular chiasm-C-roughest, a member of the immunoglobulin superfamily, affects sense organ spacing on the Drosophila antenna by influencing the positioning of founder cells on the disc ectoderm

  1999cited by this paper
• Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division.

  1999cited by this paper
• Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.

  1998cited by this paper
• WAVE, a novel WASP‐family protein involved in actin reorganization induced by Rac

  1998cited by this paper
• GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila.

  1997cited by this paper
• Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.

  1997cited by this paper
• armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila

  1996cited by this paper
• Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.

  1995cited by this paper
• Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

  1994cited by this paper
• Analysis of genetic mosaics in developing and adult Drosophila tissues.

  1993cited by this paper
• The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

  1992cited by this paper
• Characterization of mutant alleles of myospheroid, the gene encoding the beta subunit of the Drosophila PS integrins.

  1992cited by this paper

• Quantifying bristle cell organization in Drosophila melanogaster using spatial clustering features

  2025cites this paper
• A computational analysis of the role of integrins and Rho-GTPases in the emergence and disruption of apical-basal polarization in renal epithelial cells

  2024cites this paper
• Systematic analysis of RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division

  2023cites this paper
• SCAR and the Arp2/3 complex polarise the actomyosin cortex and plasma membrane organization in asymmetrically dividing neuroblasts

  2023cites this paper
• Scabrous is distributed via signaling filopodia to modulate Notch response during bristle patterning in Drosophila

  2023influential citation
• Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.

  2023cites this paper
• Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition

  2023cites this paper
• Polarized SCAR and the Arp2/3 complex regulate apical cortical remodeling in asymmetrically dividing neuroblasts

  2023cites this paper
• Apical–basal polarity and the control of epithelial form and function

  2022cites this paper
• Cytoneme-like protrusion formation induced by LAR is promoted by receptor dimerization

  2022cites this paper
• Juvenile hormone promotes paracellular transport of yolk proteins via remodeling zonula adherens at tricellular junctions in the follicular epithelium

  2022cites this paper
• Systematic characterization of Drosophila RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division

  2022cites this paper
• Comparative transcriptional analysis uncovers molecular processes in early and mature somatic cyst cells of Drosophila testes.

  2022cites this paper
• Rac1 promotes kidney collecting duct integrity by limiting actomyosin activity

  2021cites this paper
• Generation and live imaging of tumors with specific genotypes in the living fly pupa

  2021cites this paper
• A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis

  2021cites this paper
• The vertebrate epithelial apical junctional complex: Dynamic interplay between Rho GTPase activity and cell polarization processes.

  2020cites this paper
• A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion

  2020cites this paper
• The cellular and molecular mechanisms that establish the mechanics of Drosophila gastrulation.

  2020cites this paper
• CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity

  2020cites this paper
• Cytonemes, Their Formation, Regulation, and Roles in Signaling and Communication in Tumorigenesis

  2019cites this paper
• The cytoneme connection: direct long-distance signal transfer during development

  2019cites this paper
• Isotropic myosin-generated tissue tension is required for the dynamic orientation of the mitotic spindle

  2018cites this paper
• From top to bottom: Cell polarity in Hedgehog and Wnt trafficking

  2018cites this paper
• Polarized Organization of the Cytoskeleton: Regulation by Cell Polarity Proteins.

  2018cites this paper
• Long-range Notch-mediated tissue patterning requires actomyosin contractility

  2018cites this paper
• [Influence of dexamethasone on the cell polarity and PAR complex of the embryonic epithelial cells in the palate].

  2018cites this paper
• Cell Polarity and PAR Complex Likely to Be Involved in Dexamethasone-Induced Cleft Palate

  2017cites this paper
• Role of the Crumbs proteins in ciliogenesis, cell migration and actin organization.

  2017cites this paper
• An apicobasal gradient of Rac activity determines protrusion form and position

  2017cites this paper
• Flow induced adherens junction remodeling driven by cytoskeletal forces

  2017cites this paper
• Scaffolding proteins in the development and maintenance of the epidermal permeability barrier

  2017cites this paper
• Regulation of cortical stability by RhoGEF3 in mitotic Sensory Organ Precursor cells in Drosophila

  2017cites this paper
• Adherens Junction and E-Cadherin complex regulation by epithelial polarity

  2016cites this paper
• Genome Wide Association Studies of Phagocytosis and the Cellular Immune Response in Drosophila melanogaster.

  2016cites this paper
• Rac1/RhoA antagonism defines cell-to-cell heterogeneity during epidermal morphogenesis in nematodes

  2016cites this paper
• Moesin orchestrates the reorganisation of the actin cortex and shape changes during mitotic progression in an epithelium

  2015cites this paper
• Pak 3 regulates apical-basal polarity in migrating border cells during Drosophila oogenesis

  2015cites this paper
• Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation

  2015cites this paper
• Analysis of ROP signaling in the leaf epidermis of mutant tomato with low-energy ion beam.

  2015cites this paper
• Inactivation in Lung Squamous Cell Carcinomas Impairs STAT 3 and Promotes Malignant Invasion

  2015cites this paper
• Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

  2015cites this paper
• PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion.

  2015cites this paper
• Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry

  2015influential citation
• Cell Polarity 1

  2015cites this paper
• 1 1 2 Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in 3 Drosophila 4 5

  2015cites this paper
• Epithelial Apicobasal Polarity in the Drosophila Embryo

  2015cites this paper
• Analysis of matrix metalloproteinases in cancer cell signaling and extracellular behavior

  2015cites this paper
• Pak3 regulates apical-basal polarity in migrating border cells during Drosophila oogenesis

  2015cites this paper
• Epstein-Barr virus encoded deconjugases and AmotL2 in control of cell topology

  2014cites this paper
• The interdependence of the Rho GTPases and apicobasal cell polarity

  2014cites this paper
• Rho GTPases in collective cell migration

  2014cites this paper
• Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3

  2014cites this paper
• PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

  2014cites this paper
• Functional analysis of a Rho GTPase activating protein involved in epithelial differentiation and morphogenesis

  2013cites this paper
• A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization

  2013cites this paper
• Cell polarity in morphogenesis and metastasis

  2013cites this paper
• Par3/Bazooka and phosphoinositides regulate actin protrusion formation during Drosophila dorsal closure and wound healing

  2013cites this paper
• Bazooka and phosphoinositides regulate actin protrusion formation during Drosophila dorsal closure and wound healing

  2013cites this paper
• Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

  2013cites this paper
• Cytoneme-mediated cell-to-cell signaling during development

  2013cites this paper
• Bazooka and atypical Protein Kinase C regulate dynamic actomyosin networks during Drosophila amnioserosa apical constriction

  2013influential citation
• The Wnt signaling pathways and cell adhesion.

  2012cites this paper
• The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42.

  2012cites this paper
• Anterior PAR proteins function during cytokinesis and maintain DYN‐1 at the cleavage furrow in Caenorhabditis elegans

  2012cites this paper
• Functions of Myosin-X in Polarized Epithelial Cells

  2012influential citation
• The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival.

  2012cites this paper
• Apicobasal polarity and its role in cancer progression

  2012cites this paper
• β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity

  2012cites this paper
• Signaling pathways in cell polarity.

  2012cites this paper
• PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit.

  2012cites this paper
• Bazooka mediates secondary axon morphology in Drosophila brain lineages

  2011cites this paper
• Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling

  2011cites this paper
• Phosphoinositides in cell architecture.

  2011cites this paper
• Elaborating polarity: PAR proteins and the cytoskeleton

  2011cites this paper
• Impacts of environmental toxicants on male reproductive dysfunction.

  2011cites this paper
• Extracellular ultrathin fibers sensitive to intracellular reactive oxygen species: formation of intercellular membrane bridges.

  2011cites this paper
• Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions

  2010cites this paper
• Understanding how capping protein cooperates with aPKC to maintain epithelial integrity in Drosophila imaginal disc

  2010influential citation
• Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition.

  2010influential citation