D. Bredt

Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas
202163 citationsauthor #4
Natural products in drug discovery: advances and opportunities
20213,698 citationsauthor #55
Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
202030 citationsauthor #7
NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly.
202021 citationsauthor #8
Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties.
202012 citationsauthor #9
Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
20200 citationsauthor #7
Targeting receptor complexes: a new dimension in drug discovery
202060 citationsauthor #3
Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products
202032 citationsauthor #8
Modulation of TARP γ8–Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain
201917 citationsauthor #26
α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins
201925 citationsauthor #8
α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components.
201923 citationsauthor #6
Cell-specific splicing of neuronal calcium channels : mechanism , function and disease
20180 citationsauthor #1
Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins.
201758 citationsauthor #5
160. NACHO Mediates Nicotinic Acetylcholine Receptor Expression and Function in the Brain
20170 citationsauthor #6
A Genome-Wide Arrayed cDNA Screen to Identify Functional Modulators of α7 Nicotinic Acetylcholine Receptors
201711 citationsauthor #4
NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain.
201776 citationsauthor #7
Patent Number : 45 Date of Patent : 5 , 439 , 938 Aug . 8 , 1995 Human Isolated Corpus Cavernosum
20170 citationsauthor #4
Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism
201681 citationsauthor #27
Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.
201650 citationsauthor #28
Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission.
201643 citationsauthor #7
Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO.
2016146 citationsauthor #7
mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons , and Canonical Transient Receptor Potential 3 and Regulates
20150 citationsauthor #4
Enhancing synaptic plasticity can rapidly improve mood in refractory patients Translating Depression Biomarkers for Improved Targeted Therapies
201521 citationsauthor #1
Acute Inactivation of PSD-95 Destabilizes AMPA Receptors at Hippocampal Synapses
201336 citationsauthor #5
Perspectives Series : Nitric Oxide and Nitric Oxide Synthases Nitric Oxide in Excitable Tissues : Physiological Roles and Disease
2013166 citationsauthor #2
Glutamate Receptor δ2 Associates with Metabotropic Glutamate Receptor 1 (mGluR1), Protein Kinase Cγ, and Canonical Transient Receptor Potential 3 and Regulates mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons
201254 citationsauthor #6
AMPA receptor modulation by cornichon‐2 dictated by transmembrane AMPA receptor regulatory protein isoform
201251 citationsauthor #4
An Emerging Role for TARPs in Neuropsychiatric Disorders
201112 citationsauthor #2
PDZ binding of TARP©-8 controls synaptic transmission, but not synaptic plasticity
201163 citationsauthor #4
MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis
201120 citationsauthor #5
Cornichon-2 dictates physical and pharmacological properties of AMPA receptors by controlling AMPA receptor-TARP assembly
20110 citationsauthor #5
Cornichon-2 Modulates AMPA Receptor–Transmembrane AMPA Receptor Regulatory Protein Assembly to Dictate Gating and Pharmacology
201174 citationsauthor #7
Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators*
201120 citationsauthor #9
TARPs differentially decorate AMPA receptors to specify neuropharmacology.
2010149 citationsauthor #5
Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.
2010170 citationsauthor #11
Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95
2009223 citationsauthor #12
Fibroblast Growth Factor-Regulated Palmitoylation of the Neural Cell Adhesion Molecule Determines Neuronal Morphogenesis
200876 citationsauthor #9
TARP Redundancy Is Critical for Maintaining AMPA Receptor Function
200872 citationsauthor #4
AGPAT 6 Is a Novel Microsomal Glycerol-3-Phosphate Acyltransferase ( GPAT ) *
20088 citationsauthor #11
Postsynaptic Density-93 Clusters Kv1 Channels at Axon Initial Segments Independently of Caspr2
2008132 citationsauthor #4
Identification and Characterization of a Major Liver Lysophosphatidylcholine Acyltransferase*
2008175 citationsauthor #4
Identification and Characterization of a Lysophosphatidylcholine Acyltransferase That is Primarily Expressed in Metabolic Tissues
20084 citationsauthor #4
MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex
200824 citationsauthor #5
Multiple Molecular Interactions Determine the Clustering of Caspr2 and Kv1 Channels in Myelinated Axons
2008115 citationsauthor #4
Alaa El-Din El-Husseini (1962–2007) Visionary Neurobiologist and Revered Mentor
20080 citationsauthor #1
AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase*
2008144 citationsauthor #11
Acknowledgement to the Reviewers
20070 citationsauthor #77
Renal cysts and fibrosis caused by epithelial cell polarity defects in mice lacking mammalian Lin‐7c (MALS‐3)
20070 citationsauthor #7
New Transmembrane AMPA Receptor Regulatory Protein Isoform, γ-7, Differentially Regulates AMPA Receptors
2007124 citationsauthor #11
AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity
200750 citationsauthor #10
Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice
200752 citationsauthor #12
TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.
2007197 citationsauthor #4
The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a
200750 citationsauthor #3
Stargazin interacts functionally with the AMPA receptor glutamate-binding module.
200770 citationsauthor #5
Pharmacological regulation of ion channels by auxiliary subunits.
200712 citationsauthor #2
Epilepsy-Related Ligand/Receptor Complex LGI1 and ADAM22 Regulate Synaptic Transmission
2006381 citationsauthor #4
Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex.
200630 citationsauthor #4
Protein Palmitoylation by DHHC Protein Family
200620 citationsauthor #2
Synaptic transmission regulated by a presynaptic MALS/Liprin-α protein complex
200639 citationsauthor #4
Identiﬁ cation of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
20068 citationsauthor #6
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
2006168 citationsauthor #6
O08. Identification of Golgi localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
20061 citationsauthor #6
[ST8]: PSD‐MAGUK‐specific developmetal regulation of AMPA receptor synaptic expression
20060 citationsauthor #5
Auxiliary Subunits Assist AMPA-Type Glutamate Receptors
2006375 citationsauthor #3
Stargazin controls the pharmacology of AMPA receptor potentiators.
200678 citationsauthor #5
Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.
2006410 citationsauthor #5
Molecular constituents of neuronal AMPA receptors
2005119 citationsauthor #7
Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs.
2005344 citationsauthor #5
Stargazin modulates AMPA receptor gating and trafficking by distinct domains
2005504 citationsauthor #8
Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney.
200518 citationsauthor #4
TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity.
2005123 citationsauthor #9
Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination.
2005156 citationsauthor #4
Spinal cord postsynaptic density-93 protein contributes to the development of opioid tolerance and dependence
20050 citationsauthor #5
Neurotransmitter release regulated by a MALS–liprin-α presynaptic complex
2005131 citationsauthor #11
Interaction with the Unfolded Protein Response Reveals a Role for Stargazin in Biosynthetic AMPA Receptor Transport
2005119 citationsauthor #3
Stargazin is an AMPA receptor auxiliary subunit.
2005175 citationsauthor #3
TARP γ-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity
2005177 citationsauthor #9
Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.
200546 citationsauthor #11
Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions.
2005476 citationsauthor #3
Identification of PSD-95 palmitoylating enzymes.
2004540 citationsauthor #5
Receptors and channels
20040 citationsauthor #2
Calcium channel function regulated by the SH3-GK module in beta subunits.
200441 citationsauthor #6
Calcium Channel Function Regulated by the SH3-GK Module in β Subunits
200470 citationsauthor #6
Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters
200482 citationsauthor #4
Early events in glutamate receptor trafficking.
200427 citationsauthor #2
nNOS at a glance: implications for brain and brawn
2004105 citationsauthor #2
PSD93 Regulates Synaptic Stability at Neuronal Cholinergic Synapses
2004115 citationsauthor #3
Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
2004104 citationsauthor #2
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum ( N-methyl-D-aspartate / arginine / citrulline / climbing fibers / inositol phospholipid cycle )
20042 citationsauthor #1
Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons.
200425 citationsauthor #5
AMPA Receptor Synaptic Targeting Regulated by Stargazin Interactions with the Golgi-Resident PDZ Protein nPIST
200482 citationsauthor #4
Dynamic Interaction of Stargazin-like TARPs with Cycling AMPA Receptors at Synapses
2004241 citationsauthor #4
Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases.
2003103 citationsauthor #5
AMPA receptor trafficking at excitatory synapses.
20031,169 citationsauthor #1
Nitric oxide signaling in brain: potentiating the gain with YC-1.
200335 citationsauthor #1
Nitric oxide signaling specificity — the heart of the problem
2003143 citationsauthor #1
Functional Analysis of the Nucleotide Binding Domain of Membrane-associated Guanylate Kinases*
200345 citationsauthor #2
Lipid- and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networks
200378 citationsauthor #6
Assembly and plasticity of the glutamatergic postsynaptic specialization.
2003108 citationsauthor #2
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
2003543 citationsauthor #7

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