Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Blood

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/blood.v96.12.3801.h8003801_3801_3808PMID 11090063
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Endothelial Cells Modify the Costimulatory Capacity of Transmigrating Leukocytes and Promote Cd28-Mediated Cd4+ T Cell Alloactivation

  1999cited by this paper
• Peripheral blood mononuclear cells from patients with rheumatoid arthritis spontaneously secrete vascular endothelial growth factor (VEGF): specific up‐regulation by tumour necrosis factor‐alpha (TNF‐α) in synovial fluid

  1999cited by this paper
• The allogeneic response to cultured human skin equivalent in the hu-PBL-SCID mouse model of skin rejection.

  1999cited by this paper
• Angiogenesis in the huPBL-SCID model of human transplant rejection.

  1999cited by this paper
• Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation.

  1999cited by this paper
• T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism: implications for tubule formation.

  1999cited by this paper
• Vascular endothelial growth factor expression in human chronic renal allograft rejection.

  1999cited by this paper
• Effect of a topically applied neutralizing antibody against vascular endothelial growth factor on corneal allograft rejection of rat.

  1998cited by this paper
• Central role for CD40/CD40 ligand (CD154) interactions in transplant rejection.

  1998cited by this paper
• CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

  1998cited by this paper
• The role of T-cell costimulatory activation pathways in transplant rejection.

  1998cited by this paper
• Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells.

  1998cited by this paper
• Reduction of atherosclerosis in mice by inhibition of CD40 signalling

  1998cited by this paper
• Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine.

  1997cited by this paper
• Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins.

  1997cited by this paper
• The biology of vascular endothelial growth factor.

  1997cited by this paper
• The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity

  1997cited by this paper
• CD40 and CD40 ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection.

  1997cited by this paper
• CD40-CD40 ligand: a multifunctional receptor-ligand pair.

  1996cited by this paper
• Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

  1996cited by this paper
• Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1.

  1996cited by this paper
• Vascular endothelial growth factor and its receptors.

  1996cited by this paper
• A central role of CD40 ligand in the regulation of CD4+ T-cell responses.

  1996cited by this paper
• Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis.

  1995cited by this paper
• Oncogenes as inducers of tumor angiogenesis

  1995cited by this paper
• CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.

  1995cited by this paper
• Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

  1995cited by this paper
• Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1

  1995cited by this paper
• Expression of functional CD40 by vascular endothelial cells

  1995cited by this paper
• Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals

  1995cited by this paper
• Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia (*)

  1995cited by this paper
• Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue

  1994cited by this paper
• Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.

  1994cited by this paper
• CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40

  1993cited by this paper
• Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

  1992cited by this paper
• A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

  1992cited by this paper
• A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

  1992cited by this paper
• Vascular endothelial growth factor is a secreted angiogenic mitogen.

  1989cited by this paper
• Angiogenesis induction by CD-4 positive lymphocytes.

  1988cited by this paper
• Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

  1987cited by this paper
• Inflammation and Repair

  1987cited by this paper
• Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

  1987cited by this paper
• Induction of Neovascularization by Activated Human Monocytes

  1986cited by this paper
• Activated macrophages induce vascular proliferation

  1977cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Angiogenesis induction by tumors, embryonic tissues, and lymphocytes.

  1976cited by this paper
• Culture of vascular endothelium.

  1976cited by this paper
• Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction

  1975cited by this paper

• IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma

  2025cites this paper
• CD40–CD154 Interactions Induced Progressive Neurodegeneration in Acute Ocular Hypertension Mice

  2025cites this paper
• Targeting AXL can effectively overcome c-Met-induced therapeutic resistance in renal cancer and promote tumor cell death through increased oxidative stress.

  2025cites this paper
• CD40 Ligand and CD40: Expression, Regulation, and Function at the Maternal-Conceptus Interface in Pigs.

  2025cites this paper
• CD40 Gene Variants and Disease Susceptibility: A Comprehensive Review of Associations with Immune-Mediated Inflammatory Diseases, Cancer, and Infectious Diseases

  2025cites this paper
• Vascular leak in sepsis: physiological basis and potential therapeutic advances

  2024cites this paper
• Platelet-Rich Plasma Impact on Healing of Experimentally Induced Full-Thickness Skin Wound in Adult Male Albino Rats: Histological and Immunohistochemical Study

  2024cites this paper
• Association of Donor Vascular Endothelial Growth Factor Gene Polymorphism With Acute Renal Allograft Rejection

  2024cites this paper
• CD40 Ligand–CD40 Interaction Is an Intermediary between Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy

  2023cites this paper
• Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during postnatal growth

  2023cites this paper
• Changes in aqueous and vitreous inflammatory cytokine levels in proliferative diabetic retinopathy: a systematic review and meta-analysis

  2022cites this paper
• Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during a period of rapid postnatal growth

  2022cites this paper
• Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis

  2021cites this paper
• Rationale and clinical development of CD40 agonistic antibodies for cancer immunotherapy

  2021cites this paper
• Phenotypic diversity and sensitivity to injury of the pulmonary endothelium during a period of rapid postnatal growth

  2021cites this paper
• NOS1‐mediated macrophage and endothelial cell interaction in the progression of atherosclerosis

  2021cites this paper
• Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus on Molecular and Cellular Mechanisms

  2021cites this paper
• Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

  2020cites this paper
• Circulating CX3CR1+CD163+ M2 monocytes markedly elevated and correlated with cardiac markers in patients with acute myocardial infarction

  2020cites this paper
• The Role of Macrophages in Aortic Dissection

  2020cites this paper
• Characterization of Growth Factors, Cytokines, and Chemokines in Bone Marrow Concentrate and Platelet-Rich Plasma: A Prospective Analysis

  2019cites this paper
• Comparison of the Effect of Two Hyaluronic Acid Preparations on Fibroblast and Endothelial Cell Functions Related to Angiogenesis

  2019cites this paper
• Decreased serum levels of sCD40L and IL-31 correlate in treated patients with Relapsing-Remitting Multiple Sclerosis.

  2018cites this paper
• The role of shear stress and NF-κB in regulating endothelial dysfunction and atherosclerosis

  2017influential citation
• Mathematical models of anti-angiogenic therapy and vessel normalisation

  2017cites this paper
• Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients.

  2017cites this paper
• CD4+ and Perivascular Foxp3+ T Cells in Glioma Correlate with Angiogenesis and Tumor Progression

  2017cites this paper
• Plaquettes sanguines et insuffisance rénale aiguë : rôle du couple CD154/CD40 dans la constitution des lésions tubulaires

  2017cites this paper
• The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance

  2016cites this paper
• Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4.

  2016cites this paper
• Evaluation of sCD40L in heart regeneration after cryoinjury-induced myocardial infarction in zebrafish: methodological approach

  2016cites this paper
• Bone Marrow–Derived Cells: From the Laboratory to the Clinic

  2016cites this paper
• CD40 in coronary artery disease: a matter of macrophages?

  2016cites this paper
• Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes.

  2016cites this paper
• Somatic environment and germinal differentiation in antral follicle: The effect of FSH withdrawal and basal LH on oocyte competence acquisition in cattle.

  2016cites this paper
• Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo

  2016cites this paper
• This information is current as Response In Vivo Cells In Vitro and Elicits a Proinflammatory T + Netrin-1 Augments Chemokinesis in CD 4

  2016cites this paper
• Lymphatic Endothelium in Terminal Heart Failure and after Heart and Lung Transplantation

  2016cites this paper
• Association of CD40 polymorphisms and haplotype with risk of systemic lupus erythematosus

  2015cites this paper
• Translational implications of endothelial cell dysfunction in association with chronic allograft rejection

  2015cites this paper
• Changes of soluble CD40 ligand in the progression of acute myocardial infarction associate to endothelial nitric oxide synthase polymorphisms and vascular endothelial growth factor but not to platelet CD62P expression.

  2015cites this paper
• Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells

  2015cites this paper
• New frontiers for platelet CD154

  2015cites this paper
• Multifaceted antitumor responses to activating anti-CD40 antibody therapy combined with immunomodulatory or targeted agents

  2014cites this paper
• Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma

  2014influential citation
• [The role of vascular endothelial growth factor in inflammatory processes].

  2014cites this paper
• The role of monocytes in angiogenesis and atherosclerosis.

  2014cites this paper
• Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair.

  2014cites this paper
• Anti‐VEGF antibody enhances the antitumor effect of CD40

  2014cites this paper
• Potential Role of Soluble CD40 Ligand as Inflammatory Biomarker in Colorectal Cancer Patients

  2014cites this paper
• A study of the role of monocyte functional subpopulations in patients with carotid atherosclerosis and coronary artery disease

  2014cites this paper
• secretion in human multiple myeloma cells CD40 activation induces p53-dependent vascular endothelial growth factor

  2013cites this paper
• Understanding the Pathogenesis of Kawasaki Disease by Network and Pathway Analysis

  2013cites this paper
• Clinical implications and diagnostic usefulness of correlation between soluble major histocompatibility complex class I chain‐related molecule a and protumorigenic cytokines in pancreatic ductal adenocarcinoma

  2013cites this paper
• Endothelial-Smooth Muscle Cell Interaction CD40-Dependent Angiogenesis and Platelet-Activating Factor Mediates

  2013cites this paper
• Deregulated notch and CD40 signaling in murine B lymphocytes

  2013cites this paper
• VEGF Receptor Signaling in the Cardiac Lymphatics

  2013cites this paper
• Upregulation of CD40/CD40L system in rheumatic mitral stenosis with or without atrial fibrillation

  2013cites this paper
• Identification of VEGF-independent cytokines in proliferative diabetic retinopathy vitreous.

  2013cites this paper
• HCD122, on human chronic lymphocytic leukemia cells The antileukemia activity of a human anti-CD40 antagonist antibody,

  2013cites this paper
• The Multitasking Role of Macrophages in Stanford Type A Acute Aortic Dissection

  2013cites this paper
• Increased concentrations of soluble CD40 ligand platelet in patients with primary antiphospholipidic syndrome.

  2013cites this paper
• Identification of a novel CD40 ligand for targeted imaging of inflammatory plaques by phage display

  2013cites this paper
• Incremento en las concentraciones de ligando CD40 soluble plaquetario en pacientes con síndrome antifosfolipídico primario

  2013cites this paper
• proinflammatory and angiogenic responses DEPTOR regulates vascular endothelial cell activation and

  2013cites this paper
• Nanoparticules polymères de deuxième et troisième générations pour des applications thérapeutiques anti-cancer et anti-HIV

  2013cites this paper
• DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses.

  2013cites this paper
• The interleukin-6 and vascular endothelial growth factor in hematopoietic stem cell transplantation.

  2012cites this paper
• Le rôle biologique de l’interaction du CD40L avec l’intégrine α5β1 des lymphocytes T

  2012cites this paper
• CD40 Ligand and Its Receptors in Atherothrombosis

  2012cites this paper
• UNIVERSIDAD DE ALCALÁ DEPARTAMENTO DE MEDICINA UNIDAD I+D ASOCIADA AL CNB-CSIC PATRONES DE INFILTRACIÓN LEUCOCITARIA Y DE EXPRESIÓN TISULAR DE QUIMIOQUINAS, FACTOR DE CRECIMIENTO ENDOTELIAL VASCULAR Y MEDIADORES DEL METABOLISMO OXIDATIVO EN LESIONES INFLAMATORIAS Y NEOPLÁSICAS DEL

  2012cites this paper
• CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema.

  2012cites this paper
• Platelets in angiogenesis.

  2012cites this paper
• Serum concentrations and clinical significance of soluble CD40 ligand in patients with multiple myeloma

  2012cites this paper
• Traditional and Novel Risk Factors in Atherothrombosis

  2012cites this paper
• CD40 signal regulates CXCR4 mediating ovarian carcinoma cell migration: implications for extrapelvic metastastic factors.

  2012cites this paper
• Alternative activation of macrophages in rhesus macaques (Macaca mulatta) with endometriosis.

  2012cites this paper
• Targeting the intragraft microenvironment and the development of chronic allograft rejection.

  2012cites this paper
• TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor.

  2012cites this paper
• CD40 ligand: a neo-inflammatory molecule in vascular diseases.

  2012cites this paper
• Soluble VEGF receptor 1 promotes endothelial injury in children and adolescents with lupus nephritis

  2012cites this paper
• Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans.

  2012cites this paper
• Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation

  2012cites this paper
• Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role.

  2012cites this paper
• Transplantation of amniotic membrane in corneal ulcers and persistant epithelial defects.

  2011cites this paper
• Association of CD40 Gene Polymorphisms with Sporadic Breast Cancer in Chinese Han Women of Northeast China

  2011cites this paper
• Vascular endothelial growth factor in pathogenesis of psoriasis

  2011cites this paper
• The expression of interleukin-1 alpha, TNF and VEGF in corneal cells of patients with bullous keratopathy.

  2011cites this paper
• Microparticles, Vascular Function, and Atherothrombosis

  2011cites this paper
• CD40 is overexpressed by HPV16/18-E6 positive cervical carcinoma and correlated with clinical parameters and vascular density.

  2011cites this paper
• Functional characterization of the PlGF-2 heparin-binding domain

  2011cites this paper
• A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis

  2011cites this paper
• The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis

  2011cites this paper
• Flow Cytometric Investigation of CD40-CD40 Ligand System in Preeclampsia and Normal Pregnancy

  2010cites this paper
• Enhanced platelet adhesion induces angiogenesis in intestinal inflammation and inflammatory bowel disease microvasculature

  2010cites this paper
• Effect of vascular endothelial growth factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo.

  2010cites this paper
• The Sequential Expression of CD40 and Icam2 Defines Progressive Steps in the Formation of Blood Precursors from the Mesoderm Germ Layer

  2010cites this paper
• Memory T cells in Rhesus macaques.

  2010cites this paper
• CD40 is a regulator for vascular endothelial growth factor in the tumor microenvironment of glioma.

  2010cites this paper
• Soluble CD146 displays angiogenic properties and promotes neovascularization in experimental hind-limb ischemia.

  2010cites this paper