Distribution of mast-cell precursors in hematopoeitic and lymphopoietic tissues of mice

Two experimental systems were used to investigate the origin of precursor cells which differentiate into tissue mast cells in vivo. (a) Increase of mast cell number was examined in the skin, stomach, cecum, and mesentery of genetically mast cell-depleted WBB6F1 (WB X C57BL/6)- W/WV mice after the injection of various hematolymphoid cells of congenic +/+ mice. (b) Appearance of mast cells with giant granules was studied in irradiated C57BL/6-+/+ mice after the injection of lymphoid cells of C57BL/6-bgJ/bgJ (beige, Chediak-Higashi syndrome) mice. Concentrations of mast cell precursors in the thymus, lymph node and Peyer's patch were less than 0.1% of the concentration in the bone marrow. Neither treatment of donor bone marrow cells with anti-Thy-1.2 serum and complement nor thymectomy of the recipient mice affects the development of mast cells in the skin, stomach, cecum, and mesentery. Moreover, the number of mast cells increased to normal level when the skin of WBB6F1-W/WV mice was grafted on the back of nude athymic (BALB/c-nu/nu) mice. These results indicate that mast cell precursors are derived from hematopoietic tissues rather than lymphopoetic ones and that the differentiation of the precursor cells does not depend on T lymphocytes or the thymus.

• Publication year

  1979

• Venue

  Journal of Experimental Medicine

• Publication date

  1979-09-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.150.3.482PMID 383876PMCID 2185650
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Presence of mast cell precursors in fetal liver of mice.

  1979cited by this paper
• Decreased production of mast cells in S1/S1d anemic mice.

  1979cited by this paper
• Presence of mast cell precursors in peripheral blood of mice demonstrated by parabiosis.

  1979cited by this paper
• Local development of mast cells from bone marrow-derived precursors in the skin of mice.

  1979cited by this paper
• Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation.

  1978cited by this paper
• Differentiation and activity of mast cells following immunization in cultures of lymph-node cells.

  1978cited by this paper
• Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow

  1978cited by this paper
• The probable relationship of some or all mast cells to the T-cell system.

  1977influential reference
• Development of hematopoietic spleen colonies in nonirradiated genetically normal mice.

  1977cited by this paper
• Development of mast cells in vitro. II. Biologic function of cultured mast cells.

  1977influential reference
• Theta-sensitive cell and erythropoiesis: identification of a defect in W/Wv anemic mice.

  1977cited by this paper
• Development of mast cells from grafted bone marrow cells in irradiated mice

  1977cited by this paper
• Development of rat mast cells in vitro. I. Differentiation of mast cells from thymus cells.

  1976cited by this paper
• Further studies on Th-B, a cell surface antigenic determinant present on mouse B cells, plasma cells and immature thymocytes.

  1976influential reference
• Text-Atlas of Hematology

  1975cited by this paper
• The expression on mouse lymphoid cells of Th-B, an antigen common to mouse B cells and thymus cells.

  1975cited by this paper
• On the origin of mast cells in adult life.

  1973cited by this paper
• Giant granules of beige mice. A quantitative marker for granulocytes in bone marrow transplantation.

  1973cited by this paper
• CHANGED DIFFERENTIATION PATTERN OF PARENTAL COLONY‐FORMING CELLS IN F1 HYBRID MICE SUFFERING FROM GRAFT‐VERSUS-HOST DISEASE

  1970cited by this paper
• THE IN VITRO DIFFERENTIATION OF MAST CELLS

  1967cited by this paper
• FORMATION OF PURE SUSPENSIONS OF MAST CELLS IN TISSUE CULTURE BY DIFFERENTIATION OF LYMPHOID CELLS FROM THE MOUSE THYMUS.

  1963cited by this paper
• An experimental study of mast cell degranulation and regeneration

  1955cited by this paper
• An improved method of staining leucocyte granules with Sudan black B.

  1947cited by this paper

• Mast Cell Repopulating Ability Is Lost During the Transition From Pre-HSC to FL HSC

  2022cites this paper
• Aloe-emodin, a naturally occurring anthraquinone, is a highly potent mast cell stabilizer through activating mitochondrial calcium uniporter.

  2021cites this paper
• The Possible Uses and Challenges of Nanomaterials in Mast Cell Research

  2020cites this paper
• Mast Cells, Basophils, and Mastocytosis

  2019cites this paper
• Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells

  2018cites this paper
• Recombinant ArtinM activates mast cells

  2016cites this paper
• Mast cells are crucial in the resistance against Toxoplasma gondii oral infection

  2014cites this paper
• Transformation of human mast cells by interferon-gamma and the potential role of myeloid derived suppressor cells in mastocytosis.

  2014cites this paper
• Rat Embryonic Mast Cells Originate in the AGM

  2013cites this paper
• Mutation D816V Alters the Internal Structure and Dynamics of c-KIT Receptor Cytoplasmic Region: Implications for Dimerization and Activation Mechanisms

  2011cites this paper
• Origin, maturation and recruitment of mast cell precursors.

  2011cites this paper
• Resident and circulating mast cells in propulsative organs of frog Rana temporaria

  2010cites this paper
• Pillars article: fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient w/wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.

  2009cites this paper
• Development of mast cells

  2007cites this paper
• Increased mast cell density and microvessel density in the thymus of patients with myasthenia gravis.

  2007cites this paper
• Pathogenesis, clinical features, and treatment advances in mastocytosis.

  2006cites this paper
• Mast cell mediators in allergic inflammation and mastocytosis.

  2006cites this paper
• Mechanisms of action of anti-immunoglobulin E therapy.

  2006cites this paper
• Lymphocyte-independent connective tissue mast cells populate murine synovium.

  2006cites this paper
• Evaluating the effectiveness of a Mexican strain of Duddingtonia flagrans as a biological control agent against gastrointestinal nematodes in goat faeces

  2005cites this paper
• Mast Cells Limit Systemic Bacterial Dissemination but Not Colitis in Response to Citrobacter rodentium

  2005cites this paper
• Clonality and Molecular Pathogenesis of Mastocytosis

  2005cites this paper
• The K/BxN mouse: a model of human inflammatory arthritis.

  2004cites this paper
• Differentiation of mast cells during postnatal development of neonatally estrogen-treated rats

  2004cites this paper
• Mucosal mast cells and nematode infection: strain-specific differences in mast cell precursor frequency revisited

  2003cites this paper
• Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

  2002cites this paper
• Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria.

  2001cites this paper
• Les mastocytes Origine, cytologie, localisation et variétés, propriétés

  1997cites this paper
• Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

  1996cites this paper
• Brief Communication

  1996cites this paper
• Mast cell growth factor enhances multilineage hematopoietic recovery in vivo following radiation-induced aplasia.

  1994cites this paper
• Infection of Nippostrongylus brasiliensis induces normal increase of basophils in mast cell-deficient Ws/Ws rats with a small deletion at the kinase domain of c-kit.

  1993cites this paper
• Tobacco smoke exposure suppresses radiation-induced inflammation in the lung: a study of bronchoalveolar lavage and ultrastructural morphology in the rat.

  1993cites this paper
• Microenvironmental Factors that Influence Mast Cell Phenotype and Function

  1992cites this paper
• Long-term cultured mouse mast cells: ultrastructure, histamine and leukotriene levels.

  1992cites this paper
• Effects of tobacco-smoke on radiation-induced pneumonitis in rats.

  1992cites this paper
• Mast cells and their mediators in immediate and delayed immune reactions.

  1991cites this paper
• Fluctuation of fetal rat hepatic histidine decarboxylase activity through the glucocorticoid-ACTH system.

  1991cites this paper
• Establishment and characterization of hybrid rat mast cells.

  1991cites this paper
• [Systemic mastocytosis and malignant hemopathies. Review of the literature apropos of a case].

  1991cites this paper
• Mastocytoses systémiques et hémopathies malignes. Revue de la littérature à propos d'un cas

  1991cites this paper
• Fibroblast-dependent differentiation/proliferation of mast cells.

  1991cites this paper
• [Intestinal cellular reaction of cattle after infection by Fasciola hepatica].

  1991cites this paper
• Fluctuation of fetal rat hepatic histidine decarboxylase activity through the glucocorticoid-ACTH system.

  1991cites this paper
• A mast cell secretagogue, compound 48/80, prevents the accumulation of hyaluronan in lung tissue injured by ionizing irradiation.

  1990cites this paper
• Characterization of rat tissue cultured mast cells

  1990cites this paper
• Studies of connective tissue mast cell-mediated cytotoxicity.

  1989cites this paper
• Hemopoietic Microenvironments: Historical Perspectives, Status, and Projections

  1989cites this paper
• Isolation and characterization of lung mast cells from rats with bleomycin-induced pulmonary fibrosis.

  1989cites this paper
• Investigation of mast cell differentiation in vivo by use of monoclonal antibodies.

  1989cites this paper
• Population of the diaphragm by mast cells in growing rats.

  1989cites this paper
• Present status of paraneuron concept.

  1989cites this paper
• Mast cells are important in the development of hypersensitivity pneumonitis. A study with mast-cell-deficient mice.

  1989cites this paper
• Hematopoietic growth factor production by cultured cells of human nasal polyp epithelial scrapings: kinetics, cell source, and relationship to clinical status.

  1989cites this paper
• Inhibition of the growth of IL-3-dependent mast cells from murine bone marrow by recombinant granulocyte macrophage-colony-stimulating factor.

  1989cites this paper
• The role of mast cells in thioglycollate-induced inflammation.

  1988cites this paper
• Golgi complex and secretory granules

  1988cites this paper
• Factor-independent tissue cultured mast cells: establishment from rat peritoneal mast cells.

  1988cites this paper
• Interaction Between Mast Cells and Fibroblast in Neurofibroma: A Commentary

  1988cites this paper
• Selected Autacoids as Modulators of Lymphocyte Function

  1988cites this paper
• Hybrid resistance to parental bone marrow-derived cultured mast cells in the skin but not in the peritoneal cavity of (WB X C57BL/6)F1-W/Wv mice.

  1988cites this paper
• Mast cell differentiation in cultures of T cell-depleted mesenteric lymph node cells from Nippostrongylus brasiliensis-infected mice.

  1988cites this paper
• Two populations of mast cells on fibroblast monolayers: correlation of quantitative microscopy and functional activity.

  1988cites this paper
• Electron microscopic changes of bone marrow-derived cultured mast cells after injection into the skin of genetically mast cell-deficient W/Wv mice.

  1988cites this paper
• Identification and characterization of human hemopoietic mast cell colonies.

  1988cites this paper
• Systemic mastocytosis--case report and literature review.

  1987cites this paper
• Involvement of Antigen-Specific T Cell Factors in Regulation of Separate Steps in the Delayed-Type Hypersensitivity Cascade

  1987cites this paper
• Cytogenetic studies and in vitro colony growth in patients with mastocytosis.

  1987cites this paper
• In vivo increase of cutaneous mast cells in response to specific mediators and ascaris antigen.

  1987cites this paper
• The importance of mucosal mast cells in the host response to Hymenolepis diminuta in normal, W/Wv, and nude mice

  1987cites this paper
• Ethanol-induced acute gastric injury in mast cell-deficient and congenic normal mice. Evidence that mast cells can augment the area of damage.

  1987cites this paper
• Hyaluronic acid in bronchoalveolar lavage fluid in patients with sarcoidosis: relationship to lavage mast cells.

  1987cites this paper
• Age-dependent bone marrow mast cell maturation in specific pathogen-free rats.

  1987cites this paper
• The embryonic origin of connective tissue mast cells.

  1987cites this paper
• Metachromatic cell progenitors and specific growth and differentiation factors in human nasal mucosa and polyps.

  1987cites this paper
• Systemic Mastocytosis

  1987cites this paper
• THE SEROTONIN CONTENT AND TRYPTOPHAN 5-MONOOXYGENASE ACTIVITY IN THE STOMACH OF AN ATHYMIC NUDE MOUSE AND MAST CELL-DEEICIENT MOUSE

  1987cites this paper
• Formalin sensitivity and differential staining of mast cells in human dermis

  1987cites this paper
• Effect of a Trichinella spiralis infection on the distribution of mast cell precursors in tissues of thymus-bearing and non-thymus-bearing (nude) mice determined by an in vitro assay.

  1987cites this paper
• Biosynthesis and Release of PAF-Acether by Mouse Bone Marrow-Derived Mast Cells

  1987cites this paper
• Differentiation and transdifferentiation of mast cells; a unique member of the hematopoietic cell family.

  1987cites this paper
• Thymus dependence of compound 48/80-induced mucosal mast cell proliferation.

  1987cites this paper
• Induction of an auto‐anti‐IgE response in rats II. Effects on mast cell populations

  1987cites this paper
• On the heterogeneity of mast cells.

  1986cites this paper
• In vitro andin vivo migratory response of connective tissue mast cells to inflammatory mediators

  1986cites this paper
• Organization of haematopoietic stem cells and their relationship to mastocytopoiesis.

  1986cites this paper
• Immune response potential of mast cell-deficient W/Wv mice.

  1986cites this paper
• Differences between basophils and mast cells: failure to detect Charcot-Leyden crystal protein (lysophospholipase) and eosinophil granule major basic protein in human mast cells.

  1986cites this paper
• Regulatory effects of mast cells on lymphoid cells: the role of histamine type 1 receptors in the interaction between mast cells, helper T cells and natural suppressor cells.

  1986cites this paper
• Appearance of mast cells in bone marrow, peripheral blood and spleen of immunized rats.

  1986cites this paper
• Cutaneous Basophil Hypersensitivity

  1986cites this paper
• Higher susceptibility of mast-cell-deficient W/WV mutant mice to brain thromboembolism and mortality caused by intravenous injection of India ink.

  1986cites this paper
• Anticoagulantly active heparin-like molecules from mast cell-deficient mice.

  1986cites this paper
• Gut mucosal mast cells: origin, traffic and differentiation in mice and rats.

  1986cites this paper
• Development of mucosal mast cells after injection of a single connective tissue-type mast cell in the stomach mucosa of genetically mast cell-deficient W/Wv mice.

  1986cites this paper
• Basophil/mast cell precursors in mast cell proliferative disorders.

  1986cites this paper
• Differentiation processes of connective tissue mast cells in living mice.

  1985cites this paper
• Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell- deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells

  1985influential citation
• Mast-cell precursors in the skin of mouse embryos and their deficiency in embryos of Sl/Sld genotype.

  1985cites this paper
• Regulation by the skin of lymphoid cell recirculation and localization properties.

  1985cites this paper