Joseph Rudinger memorial lecture: Discovery and applications of cyclotides

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Peptide Science

• Publication date

  2013-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/psc.2523PMID 23737440
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Discovery and Characterization of Novel Cyclotides Originated from Chimeric Precursors Consisting of Albumin-1 Chain a and Cyclotide Domains in the Fabaceae Family 1 , 2

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• Cyclotides as grafting frameworks for protein engineering and drug design applications.

  2013cited by this paper
• Design of a cyclotide antagonist of neuropilin-1 and -2 that potently inhibits endothelial cell migration.

  2013cited by this paper
• Expression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide-protein interactions.

  2013cited by this paper
• Discovery of Linear Cyclotides in Monocot Plant Panicum laxum of Poaceae Family Provides New Insights into Evolution and Distribution of Cyclotides in Plants*

  2012cited by this paper
• Circular Proteins from Plants and Fungi*

  2012cited by this paper
• Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.

  2012cited by this paper
• Chemical synthesis of a cyclotide via intramolecular cyclization of peptide O-esters

  2012cited by this paper
• Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment.

  2012cited by this paper
• Cyclotides Associate with Leaf Vasculature and Are the Products of a Novel Precursor in Petunia (Solanaceae)*

  2012cited by this paper
• Cyclic Peptides Arising by Evolutionary Parallelism via Asparaginyl-Endopeptidase–Mediated Biosynthesis[C][W]

  2012cited by this paper
• Plant Cyclotides: An Unusual Protein Family with Multiple Functions

  2012cited by this paper
• Insights into Processing and Cyclization Events Associated with Biosynthesis of the Cyclic Peptide Kalata B1*

  2012cited by this paper
• Cyclotide isolation and characterization.

  2012cited by this paper
• Do plant cyclotides have potential as immunosuppressant peptides?

  2012cited by this paper
• Phosphatidylethanolamine Binding Is a Conserved Feature of Cyclotide-Membrane Interactions*

  2012cited by this paper
• Cyclotides Insert into Lipid Bilayers to Form Membrane Pores and Destabilize the Membrane through Hydrophobic and Phosphoethanolamine-specific Interactions*

  2012cited by this paper
• Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1*

  2012cited by this paper
• Biological Synthesis of Circular Polypeptides*

  2012cited by this paper
• Host-Defense Activities of Cyclotides

  2012cited by this paper
• Cyclotides as a basis for drug design

  2012cited by this paper
• Importance of the cell membrane on the mechanism of action of cyclotides.

  2012cited by this paper
• The bountiful biological activities of cyclotides

  2012cited by this paper
• Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides

  2012cited by this paper
• Protease-resistant peptide ligands from a knottin scaffold library.

  2011cited by this paper
• Identification and Structural Characterization of Novel Cyclotide with Activity against an Insect Pest of Sugar Cane*

  2011cited by this paper
• Albumins and their processing machinery are hijacked for cyclic peptides in sunflower.

  2011cited by this paper
• Discovery and Characterization of Novel Cyclotides Originated from Chimeric Precursors Consisting of Albumin-1 Chain a and Cyclotide Domains in the Fabaceae Family*

  2011cited by this paper
• The chemistry of cyclotides.

  2011cited by this paper
• Cyclotides: a patent review

  2011cited by this paper
• Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer

  2011cited by this paper
• Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.

  2011cited by this paper
• Subcellular targeting and biosynthesis of cyclotides in plant cells.

  2011cited by this paper
• Identification and Characterization of a New Family of Cell-penetrating Peptides

  2011cited by this paper
• Discovery of a Linear Cyclotide from the Bracelet Subfamily and Its Disulfide Mapping by Top-down Mass Spectrometry*

  2011cited by this paper
• Decoding the Membrane Activity of the Cyclotide Kalata B1

  2011cited by this paper
• Cyclotides from an extreme habitat: characterization of cyclic peptides from Viola abyssinica of the Ethiopian highlands.

  2011cited by this paper
• Cyclotide-membrane interactions: defining factors of membrane binding, depletion and disruption.

  2011cited by this paper
• Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds.

  2011cited by this paper
• Isolation and characterization of cytotoxic cyclotides from Viola philippica.

  2011cited by this paper
• NMR and protein structure in drug design: application to cyclotides and conotoxins

  2011cited by this paper
• Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins.

  2011cited by this paper
• Isolation and characterization of cytotoxic cyclotides from Viola tricolor.

  2010cited by this paper
• Global cyclotide adventure: A journey dedicated to the discovery of circular peptides from flowering plants

  2010cited by this paper
• The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria.

  2010cited by this paper
• Cyclotide synthesis and supply: From plant to bioprocess

  2010cited by this paper
• Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa.

  2010cited by this paper
• Analysis and classification of circular proteins in CyBase.

  2010cited by this paper
• Isolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa.

  2010cited by this paper
• Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics.

  2010cited by this paper
• Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta.

  2010cited by this paper
• Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice.

  2010cited by this paper
• Isolation, sequencing, and structure-activity relationships of cyclotides.

  2010cited by this paper
• Cyclotide proteins and precursors from the genus Gloeospermum: filling a blank spot in the cyclotide map of Violaceae.

  2010cited by this paper
• Hybanthus parviflorus (Violaceae): Insecticidal activity of a South American plant

  2010cited by this paper
• Lysine-scanning Mutagenesis Reveals an Amendable Face of the Cyclotide Kalata B1 for the Optimization of Nematocidal Activity*

  2010cited by this paper
• Isolation and characterization of bioactive cyclotides from Viola labridorica.

  2010cited by this paper
• Cyclotides, a promising molecular scaffold for peptide‐based therapeutics

  2010cited by this paper
• Cyclotides as templates in drug design.

  2010cited by this paper
• Circular proteins and mechanisms of cyclization

  2010cited by this paper
• Cyclotide Interactions with the Nematode External Surface

  2010cited by this paper
• Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides.

  2009cited by this paper
• Biosynthesis and Biological Screening of a Genetically Encoded Library Based on the Cyclotide MCoTI‐I

  2009cited by this paper
• Cyclotides: macrocyclic peptides with applications in drug design and agriculture

  2009cited by this paper
• The Biological Activity of the Prototypic Cyclotide Kalata B1 Is Modulated by the Formation of Multimeric Pores*

  2009cited by this paper
• Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms.

  2009cited by this paper
• Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes.

  2009cited by this paper
• Folding motifs of cystine-rich peptides

  2009cited by this paper
• A transcriptional profile of metallophyte Viola baoshanensis involved in general and species-specific cadmium-defense mechanisms.

  2009cited by this paper
• Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold.

  2009cited by this paper
• Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold*

  2009cited by this paper
• Design and therapeutic applications of cyclotides.

  2009cited by this paper
• Alternative binding proteins: Biological activity and therapeutic potential of cystine‐knot miniproteins

  2008cited by this paper
• Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail).

  2008cited by this paper
• Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

  2008cited by this paper
• Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.

  2008cited by this paper
• Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides.

  2008cited by this paper
• The Anthelmintic Activity of the Cyclotides: Natural Variants with Enhanced Activity

  2008cited by this paper
• Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

  2008cited by this paper
• Microwave‐assisted Boc‐solid phase peptide synthesis of cyclic cysteine‐rich peptides

  2008cited by this paper
• Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis.

  2008cited by this paper
• Alanine Scanning Mutagenesis of the Prototypic Cyclotide Reveals a Cluster of Residues Essential for Bioactivity*

  2008cited by this paper
• Distribution and Evolution of Circular Miniproteins in Flowering Plants[W]

  2008cited by this paper
• Cyclotides as natural anti‐HIV agents

  2008cited by this paper
• Head‐to‐Tail Cyclized Cystine‐Knot Peptides by a Combined Recombinant and Chemical Route of Synthesis

  2008cited by this paper
• The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity.

  2008cited by this paper
• An Asparaginyl Endopeptidase Mediates in Vivo Protein Backbone Cyclization*

  2007cited by this paper
• Immobilized Protease‐Assisted Synthesis of Engineered Cysteine‐Knot Microproteins

  2007cited by this paper
• CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering

  2007cited by this paper
• Biosynthesis of circular proteins in plants.

  2007cited by this paper
• The chemistry and biology of cyclotides.

  2007cited by this paper
• Plant cyclotides: an unusual class of defense compounds.

  2007cited by this paper
• Biosynthesis of a Fully Functional Cyclotide inside Living Bacterial Cells

  2007cited by this paper
• A Cell-Based Approach for the Biosynthesis/Screening of Cyclic Peptide Libraries against Bacterial Toxins

  2007cited by this paper
• Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.

  2006cited by this paper
• Chemical synthesis and biosynthesis of the cyclotide family of circular proteins

  2006cited by this paper
• Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif.

  2006cited by this paper
• Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II.

  2006cited by this paper
• Biosynthesis of the cyclotide Kalata B1 by using protein splicing.

  2006cited by this paper
• Seamless Proteins Tie Up Their Loose Ends

  2006cited by this paper

• Dual Anticancer and Antimicrobial Activity of A Novel Dual-Drug Nanosystem for Co-Delivery of Curcumin and Cyclotides Derived from Viola Dalatensis Gagnep

  2025cites this paper
• Design and In Silico Evaluation of a Novel Cyclic Disulfide-Rich anti-VEGF Peptide as a Potential Antiangiogenic Drug

  2021cites this paper
• Disulfide-rich peptides in drug development

  2020cites this paper
• Discovery of Cyclotides from Australasian Plants

  2020cites this paper
• Cyclotides: disulfide-rich peptide toxins in plants.

  2019cites this paper
• Cyclotides: From Structure to Function.

  2019cites this paper
• Discovery of peptide probes to modulate oxytocin-type receptors of insects

  2018cites this paper
• 8 – Peptides as therapeutics

  2018cites this paper
• Cyclotides as drug design scaffolds.

  2017cites this paper
• Development of Linear and Branched Pre-pegylated Amino Acids for Site-specific Peptide Incorporation

  2017cites this paper
• Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy

  2016cites this paper
• Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications.

  2016cites this paper
• Anionic Host Defence Peptides from the Plant Kingdom: Their Anticancer Activity and Mechanisms of Action.

  2016cites this paper
• Engineering growth factors for regenerative medicine applications.

  2016cites this paper
• Chapter Four - Cyclotides from Chinese Plants

  2015cites this paper
• Review seed biopharmaceutical cyclic peptides: From discovery to applications

  2015cites this paper
• Antiviral Cystine Knot α-Amylase Inhibitors from Alstonia scholaris*

  2015cites this paper
• The increasing role of phosphatidylethanolamine as a lipid receptor in the action of host defence peptides.

  2015cites this paper
• The evolution of Momordica cyclic peptides.

  2015cites this paper
• Biosynthese und molekulare Wirkung von zyklischen Pflanzenpeptiden

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