Comparison of minipig, dog, monkey and human drug metabolism and disposition.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of pharmacological and toxicological methods

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.vascn.2014.12.005PMID 25545337
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Minipig in Biomedical Research

  2025cited by this paper
• Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

  2014cited by this paper
• Ontogeny of CYP3A and P‐Glycoprotein in the Liver and the Small Intestine of the Göttingen Minipig: An Immunohistochemical Evaluation

  2014cited by this paper
• Primary Porcine Brain Microvessel Endothelial Cell Isolation and Culture

  2014cited by this paper
• Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications

  2014cited by this paper
• In vitro platforms for evaluating liver toxicity

  2014cited by this paper
• State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.

  2014cited by this paper
• N-Acetylation of Etamicastat, a Reversible Dopamine-β-Hydroxylase Inhibitor

  2013cited by this paper
• Combined in vitro-in vivo approach to assess the hepatobiliary disposition of a novel oral thrombin inhibitor.

  2013cited by this paper
• Establishment of a simplified in vitro porcine blood–brain barrier model with high transendothelial electrical resistance

  2013cited by this paper
• Central nervous system disposition and metabolism of Fosdevirine (GSK2248761), a non-nucleoside reverse transcriptase inhibitor: an LC-MS and Matrix-assisted laser desorption/ionization imaging MS investigation into central nervous system toxicity.

  2013cited by this paper
• Animal models of toxicology testing: the role of pigs

  2013cited by this paper
• Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development.

  2013cited by this paper
• Transporters in Drug Development and Clinical Pharmacology

  2013cited by this paper
• A detailed method for preparation of a functional and flexible blood–brain barrier model using porcine brain endothelial cells☆

  2013cited by this paper
• Cloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2

  2013cited by this paper
• A high content screening assay to predict human drug-induced liver injury during drug discovery.

  2013cited by this paper
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

  2013cited by this paper
• Aldehyde oxidase and its importance in novel drug discovery: present and future challenges

  2013cited by this paper
• In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

  2012cited by this paper
• Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?

  2012cited by this paper
• Meeting the MIST regulations: human metabolism in Phase I using AMS and a tiered bioanalytical approach.

  2012cited by this paper
• Preclinical in vivo ADME studies in drug development: a critical review

  2012cited by this paper
• Analyses of pig genomes provide insight into porcine demography and evolution

  2012cited by this paper
• Identification of the Cytochrome P450 and Other Enzymes Involved in the In Vitro Oxidative Metabolism of a Novel Antidepressant, Lu AA21004

  2012cited by this paper
• The role of aldehyde oxidase in drug metabolism

  2012cited by this paper
• A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation

  2012cited by this paper
• The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport.

  2012cited by this paper
• Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

  2011cited by this paper
• Pharmacology and ADME Studies in the Minipig

  2011cited by this paper
• Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function

  2011cited by this paper
• Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.

  2011cited by this paper
• Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs

  2011cited by this paper
• Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model.

  2011cited by this paper
• Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans.

  2011cited by this paper
• N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases

  2011cited by this paper
• Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice

  2011cited by this paper
• Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment.

  2011cited by this paper
• The fourth mammalian molybdenum enzyme mARC: current state of research

  2011cited by this paper
• Drug‐induced cholestasis

  2011cited by this paper
• Welfare of the minipig with special reference to use in regulatory toxicology studies.

  2010cited by this paper
• Addressing metabolite safety during first-in-man studies using ¹⁴C-labeled drug and accelerator mass spectrometry.

  2010cited by this paper
• Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine

  2010cited by this paper
• Aldehyde oxidase: an enzyme of emerging importance in drug discovery.

  2010cited by this paper
• Hepatic Disposition of Ximelagatran and Its Metabolites in Pig; Prediction of the Impact of Membrane Transporters Through a Simple Disposition Model

  2010cited by this paper
• Effects of Hepatic Drug-metabolizing Enzyme Induction on Clinical Pathology Parameters in Animals and Man

  2010cited by this paper
• A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments

  2010cited by this paper
• The utility of the minipig as an animal model in regulatory toxicology.

  2010cited by this paper
• Drug-induced liver injury in humans: the case of ximelagatran.

  2010cited by this paper
• Membrane transporters in drug development

  2010cited by this paper
• Reduction of N-Hydroxy-sulfonamides, Including N-Hydroxy-valdecoxib, by the Molybdenum-Containing Enzyme mARC

  2010cited by this paper
• Ethical implications of using the minipig in regulatory toxicology studies.

  2010cited by this paper
• Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products.

  2010cited by this paper
• Hepatic Enzyme Induction

  2010cited by this paper
• Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion

  2009cited by this paper
• Biotransformation of Xenobiotics

  2009cited by this paper
• Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment.

  2009cited by this paper
• The uPA(+/+)-SCID Mouse with Humanized Liver as a Model for in Vivo Metabolism of 4-Androstene-3,17-dione

  2009cited by this paper
• Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

  2009cited by this paper
• A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

  2009cited by this paper
• The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans

  2008cited by this paper
• The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs.

  2008cited by this paper
• Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human.

  2008cited by this paper
• Intestinal and Hepatobiliary Transport of Ximelagatran and Its Metabolites in Pigs

  2008cited by this paper
• Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative study in vitro

  2007cited by this paper
• What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs

  2007cited by this paper
• Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles

  2007cited by this paper
• Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications

  2007cited by this paper
• Drug Interaction Studies: Study Design, Data Analysis, and Implications for Dosing and Labeling

  2007cited by this paper
• CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans

  2007cited by this paper
• Is bupropion a more specific substrate for porcine CYP2E than chlorzoxazone and p-nitrophenol?

  2007cited by this paper
• N-acetyltransferase phenotype and risk in urinary bladder cancer: approaches in molecular epidemiology. Preliminary results in Sweden and Denmark. Environmental Health Perspectives;1979:71-79.

  2007cited by this paper
• Is the Monkey an Appropriate Animal Model to Examine Drug-Drug Interactions Involving Renal Clearance? Effect of Probenecid on the Renal Elimination of H2 Receptor Antagonists

  2006cited by this paper
• Avian and Canine Aldehyde Oxidases

  2006cited by this paper
• Use of nontraditional animals for evaluation of pharmaceutical products

  2006cited by this paper
• Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR.

  2006cited by this paper
• Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition

  2006cited by this paper
• Molecular physiology of renal organic anion transporters.

  2006cited by this paper
• Functional expression of pig renal organic anion transporter 3 (pOAT3).

  2005cited by this paper
• Validation of a high-throughput absorption, distribution, metabolism, and excretion (ADME) system and results for 60 literature compounds.

  2005cited by this paper
• Molecular Cloning and Functional Analyses of OAT1 and OAT3 from Cynomolgus Monkey Kidney

  2005cited by this paper
• Comparative expression of liver cytochrome P450-dependent monooxygenases in the horse and in other agricultural and laboratory species.

  2003cited by this paper
• Cloning of the pig renal organic anion transporter 1 (pOAT1).

  2002cited by this paper
• Is cytochrome P450 CYP2D activity present in pig liver?

  2002cited by this paper
• Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.

  2001cited by this paper
• Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine.

  2001cited by this paper
• Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man

  2000cited by this paper
• A Greedy Algorithm for Aligning DNA Sequences

  2000cited by this paper
• Xenobiotic Metabolism by Cultured Primary Porcine Hepatocytes

  2000cited by this paper
• Porcine kidney microsomal cysteine S-conjugate N-acetyltransferase-catalyzed N-acetylation of haloalkene-derived cysteine S-conjugates.

  2000cited by this paper
• Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs.

  2000cited by this paper
• Interspecies differences in cancer susceptibility and toxicity.

  1999cited by this paper
• Detoxifying activity in pig livers and hepatocytes intended for xenotherapy.

  1999cited by this paper
• Metabolism and excretion of citalopram in man: identification of O-acyl- and N-glucuronides.

  1999cited by this paper
• Induction of the metabolism of midazolam by rifampin in cultured porcine hepatocytes: preliminary evidence for CYP3A isoforms in pigs.

  1999cited by this paper
• Cytochrome P450 sex differences in minipigs and conventional pigs.

  1999cited by this paper
• Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes.

  1998cited by this paper
• Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples.

  1998cited by this paper
• Binding of drugs to eye melanin is not predictive of ocular toxicity.

  1998cited by this paper
• Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes.

  1997cited by this paper

• A Large-Scale Concordance Study of Toxicity Findings Across Preclinical Species and Humans for Small Molecules and Biologics in Drug Development

  2026cites this paper
• Metabolite profiling and cross-species differentiation of 8α-tigloyloxyhirsutinolide-13-O-acetate metabolism using molecular networking and multivariate analysis

  2026cites this paper
• Identifying metabolites of new psychoactive substances using in silico prediction tools

  2025cites this paper
• Evaluating the value of entomotoxicology in forensic toxicology casework using the first minipig model

  2025cites this paper
• New opportunities and current challenges using animal models for the discovery of novel countermeasures for acute radiation syndrome

  2025cites this paper
• Assessing Minipigs as Superior Non-Rodent Pre-Clinical Models: Insights from Plasma Protein Binding and Metabolism of Marketed NSAIDs Compared Across Species

  2025cites this paper
• Pig as an Interorgan Communication Model and Its Applications in Biomaterials, Drug Delivery, and Bioengineering Research

  2025cites this paper
• A versatile toolkit for drug metabolism studies with GNPS2: from drug development to clinical monitoring.

  2025cites this paper
• Species differences in the hepatobiliary disposition of morphine-6-glucuronide mediated by hepatic transporters in rats and humans

  2025cites this paper
• Validation of a Göttingen Minipig Gene Therapy Biodistribution Assay for AVGN7 Using Droplet Digital Polymerase Chain Reaction

  2025cites this paper
• Unexpected effects of antibiotics on microbiota-mediated drug metabolism in a fistulated dog model.

  2025cites this paper
• Organ-on-a-Chip: A Roadmap for Translational Research in Human and Veterinary Medicine

  2025cites this paper
• Cannabidiol lymphatic transport after oral administration assessed using a novel thoracic lymph duct cannulated conscious pig model

  2025cites this paper
• Immunometabolism of Liver Xenotransplantation and Prospective Solutions

  2025cites this paper
• Pathway-based similarity measurement to quantify transcriptomics similarity between human tissues and preclinical models

  2024cites this paper
• Investigation of Minipigs as the Optimal Non-rodent Pre-clinical Species: Exploring Plasma Protein Binding of Marketed Cardiovascular Drugs Across Species

  2024influential citation
• Toxicokinetic modelling of the synthetic cannabinoid 5F-MDMB-P7AICA and its main metabolite in pigs following pulmonary administration.

  2024cites this paper
• Comparative pharmacokinetics of porcine and human anti-influenza hemagglutinin monoclonal antibodies in outbred pigs and minipigs

  2024cites this paper
• Opportunities and Challenges for Use of Minipigs in Nonclinical Pharmaceutical Development: Results of a Follow-Up IQ DruSafe Survey.

  2024cites this paper
• Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug

  2024cites this paper
• Urinary and Fecal Excretion of 121 Environmental Chemicals in Pet Dogs and Cats: Significance of Feces in Biomonitoring of Exposures.

  2024cites this paper
• Neuroprotective Efficacy and Complementary Treatment with Medicinal Herbs: A Comprehensive Review of Recent Therapeutic Approaches in Epilepsy Management.

  2024cites this paper
• Influential factors on stem cell therapy success in canine model of spinal cord Injury: A systematic review and meta-analysis.

  2024cites this paper
• Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4

  2024cites this paper
• The Enigma of Norbormide, a Rattus-Selective Toxicant

  2024cites this paper
• Single-dose Administration of Recombinant Human Thrombopoietin Enhances Survival and Hematopoietic Reconstruction in Canines Irradiated with 3 Gy Gamma Radiation

  2024cites this paper
• Interest of molecular networking in fundamental, clinical and forensic toxicology: A state-of-the-art review

  2024cites this paper
• A thioacetamide-induced liver fibrosis model for pre-clinical studies in microminipig

  2023cites this paper
• Cross-Species Variability in Lobular Geometry and Cytochrome P450 Hepatic Zonation: Insights into CYP1A2, CYP2E1, CYP2D6 and CYP3A4

  2023cites this paper
• Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization.

  2023cites this paper
• Nine decades of data on environmental chemical pollutant exposure in dogs: a bibliometric analysis

  2023cites this paper
• Model of small-focal ischemic cerebral infarction as a basis for the development of new methods of stroke therapy

  2023cites this paper
• Göttingen pigs as a potential model for natalizumab pharmacokinetics, pharmacodynamics, and immunogenicity evaluation.

  2022cites this paper
• Multiplex quantitation of 17 drug-derived components in human plasma after administration of a fixed herbal preparation of Sailuotong using combined online SPE-LC-MS/MS methods.

  2022cites this paper
• Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model

  2022cites this paper
• Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

  2022cites this paper
• A comparative review of the activity of enzymes of the cytochrome P450 system in humans and laboratory animals. Prognostic value of preclinical models in vivo

  2022cites this paper
• Characterization of the immune system of Ellegaard Göttingen Minipigs - An important large animal model in experimental medicine

  2022cites this paper
• Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies

  2022cites this paper
• Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer

  2022cites this paper
• Transplantation of human cells into Interleukin-2 receptor gamma gene knockout pigs under several conditions

  2022cites this paper
• Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epithelium

  2022cites this paper
• Animal Models in Toxicologic Research: Pig

  2022cites this paper
• Large Animal Models of Breast Cancer

  2022cites this paper
• Exploration on different animal models used in drug-induced adverse reactions research; current scenario and further prospectives

  2022cites this paper
• Development of a Pediatric Mini-Tablet Formulation for Expedited Preclinical Studies

  2021cites this paper
• Establishment of porcine and monkey colonic organoids for drug toxicity study

  2021cites this paper
• Ocular metabolism and distribution of drugs in the rabbit eye: quantitative assessment after intracameral and intravitreal administrations.

  2021cites this paper
• Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig

  2021cites this paper
• Ustekinumab pharmacokinetics after subcutaneous administration in swine model

  2021cites this paper
• Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-Mediated Drug-Drug Interactions Using Statins

  2021cites this paper
• Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration.

  2021cites this paper
• Analysis of elimination half-lives in MamTKDB 1.0 related to bioaccumulation: Requirement of repeated administration and blood plasma values underrepresent tissues.

  2021cites this paper
• Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs☆

  2021cites this paper
• Translational Block in Stroke: A Constructive and “Out-of-the-Box” Reappraisal

  2021cites this paper
• Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain

  2021cites this paper
• Comparison of Genetically Engineered Immunodeficient Animal Models for Nonclinical Testing of Stem Cell Therapies

  2021cites this paper
• A new group housing approach for non-human primate metabolism studies.

  2021cites this paper
• Developing Successful Neuroprotective Treatments for TBI: Translational Approaches, Novel Directions, Opportunities and Challenges

  2020cites this paper
• Aldehyde oxidase; new approaches to old problems

  2020cites this paper
• In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species

  2020cites this paper
• A novel welfare and scientific approach to conducting dog metabolism studies allowing dogs to be pair housed

  2020cites this paper
• Antiretroviral drugs found in pork on Ugandan market: Implications for HIV/AIDS treatment

  2020cites this paper
• Effect of siltuximab, omalizumab, infliximab, pembrolizumab and vedolizumab on selected haematological and biochemical parameters in a pig model.

  2020cites this paper
• Plasma Erythropoietin, IL-17A, and IFNγ as Potential Biomarkers of Motor Function Recovery in a Canine Model of Spinal Cord Injury

  2020cites this paper
• Considerations in the extrapolation of drug toxicity between humans and dogs

  2020cites this paper
• Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

  2020cites this paper
• Prediction of the Oral Bioavailability Correlation Between Humans and Preclinical Animals

  2020cites this paper
• Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do

  2020cites this paper
• Can A Recently Developed Pig Model Be Used for In Vivo Metabolism Studies of 7-Azaindole Derived Synthetic Cannabinoids? A Study Using 5F-MDMB-P7AICA.

  2020cites this paper
• What are the practical, ethical, and pathobiological considerations in the use of minipigs as an animal model in drug discovery for acute radiation syndrome and delayed effects of acute radiation exposure?

  2020cites this paper
• Advances in selecting appropriate non-rodent species for regulatory toxicology research: Policy, ethical, and experimental considerations.

  2020cites this paper
• Identification of potential oxidative stress biomarkers for spinal cord injury in erythrocytes using mass spectrometry

  2020cites this paper
• Minipig Specialty Capabilities | Charles River

  2020cites this paper
• In Vitro and In Vivo Culture Systems for Development of Porcine Testis Cells and Tissue

  2019cites this paper
• Perspectives From the 12th Annual Minipig Research Forum: Early Inclusion of the Minipig in Safety Assessment Species Selection Should be the Standard Approach

  2019cites this paper
• Ustekinumab pharmacokinetics after subcutaneous administration in pig

  2019cites this paper
• Personalized medicine: going to the dogs?

  2019cites this paper
• A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model.

  2019cites this paper
• Göttingen Minipigs as Large Animal Model in Toxicology

  2019cites this paper
• Comparative Pharmacokinetics and Pharmacodynamics

  2019cites this paper
• Human Ovarian Cancer Tumor Formation in Severe Combined Immunodeficient (SCID) Pigs

  2019cites this paper
• A dual functional probe for assessing human CYP450 3A5 and 3A enzymes bioactivities.

  2019cites this paper
• The “rights” of precision drug development for Alzheimer’s disease

  2019cites this paper
• Animal to human translation: a systematic scoping review of reported concordance rates

  2019cites this paper
• Arenobufagin is a novel isoform-specific probe for sensing human sulfotransferase 2A1

  2018cites this paper
• Intestinal absorption differences of major bioactive compounds of Gegenqinlian Decoction between normal and bacterial diarrheal mini-pigs in vitro and in situ.

  2018cites this paper
• Drug Transporters in Xenobiotic Disposition and Pharmacokinetic Prediction

  2018cites this paper
• Animal Pharmacokinetic/Pharmacodynamic Studies (APPS) Reporting Guidelines

  2018cites this paper
• Intramuscular administration of hexachloroplatinate reverses cyanide‐induced metabolic derangements and counteracts severe cyanide poisoning

  2018cites this paper
• Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond

  2018cites this paper
• Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research

  2018cites this paper
• Comparison of In Vitro Stereoselective Metabolism of Bupropion in Human, Monkey, Rat, and Mouse Liver Microsomes

  2018cites this paper
• Opportunities and challenges with animal models for acute radiation syndrome drug discovery

  2018cites this paper
• A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry

  2018cites this paper
• Translation durch Konvergenz: Drug‐Delivery‐Forschung in multidisziplinären Teams

  2018cites this paper
• Convergence for Translation: Drug-Delivery Research in Multidisciplinary Teams.

  2018cites this paper
• Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro–In Vivo Comparisons

  2017cites this paper
• Pharmacokinetics of 14C‐ortho‐phenylphenol following intravenous administration in pigs

  2017cites this paper
• Pharmacokinetics of intravenous and oral metformin and r,s-verapamil in Sinclair, Hanford, Yucatan and Göttingen minipigs

  2017cites this paper