Human N-ras: cDNA cloning and gene structure.

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Nucleic Acids Research

• Publication date

  1985-07-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/NAR/13.14.5255PMID 2991860PMCID PMC321863
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.

  1985cited by this paper
• Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

  1984cited by this paper
• Activation of N-ras gene in bone marrow cells from a patient with acute myeloblastic leukaemia

  1984cited by this paper
• HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions.

  1984cited by this paper
• Analysis of the transforming potential of the human H-ras gene by random mutagenesis.

  1984cited by this paper
• Mechanism of activation of an N‐ras gene in the human fibrosarcoma cell line HT1080.

  1984cited by this paper
• Effect of the 21‐bp repeat upstream element on in vitro transcription from the early and late SV40 promoters.

  1984cited by this paper
• The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions.

  1984cited by this paper
• Transcription of the mouse dihydrofolate reductase gene proceeds unabated through seven polyadenylation sites and terminates near a region of repeated DNA

  1984cited by this paper
• Homologies between signal transducing G proteins and ras gene products.

  1984cited by this paper
• Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

  1984cited by this paper
• Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

  1984cited by this paper
• Comparative biochemical properties of normal and activated human ras p21 protein

  1984cited by this paper
• Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

  1983cited by this paper
• Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

  1983cited by this paper
• Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

  1983cited by this paper
• The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter.

  1983cited by this paper
• Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

  1983cited by this paper
• Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas.

  1983cited by this paper
• A simple and very efficient method for generating cDNA libraries.

  1983cited by this paper
• Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells.

  1983cited by this paper
• The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors.

  1983cited by this paper
• Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype.

  1983cited by this paper
• Structure and activation of the human N-ras gene.

  1983cited by this paper
• Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

  1982cited by this paper
• T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

  1982cited by this paper
• Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

  1982cited by this paper
• High-efficiency cloning of full-length cDNA

  1982cited by this paper
• Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

  1982cited by this paper
• Mechanism of activation of a human oncogene

  1982cited by this paper
• Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses.

  1982cited by this paper
• Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.

  1982cited by this paper
• Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

  1982cited by this paper
• Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

  1982cited by this paper
• A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

  1982cited by this paper
• Transforming activity of human tumor DNAs.

  1981cited by this paper
• Speculations on RNA splicing.

  1981cited by this paper
• Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

  1981cited by this paper
• Organization and expression of eucaryotic split genes coding for proteins.

  1981cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• 3′ Non-coding region sequences in eukaryotic messenger RNA

  1976cited by this paper

• The Biology of 3’-Utrs and Ran Gtpase in Mammalian Cell Growth and Development

  2019cites this paper
• Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma

  2017cites this paper
• Functional analysis of a rare disease variant in human NRAS causing Noonan-Like syndrome

  2016cites this paper
• Immunogenicity of self tumor associated proteins is enhanced through protein truncation

  2016cites this paper
• Regulation of the expression and activity of Unr in mammalian cells.

  2015cites this paper
• NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation

  2014cites this paper
• Activating kinase mutations in melanoma

  2013cites this paper
• Méthodes et matériaux de traitement du cancer

  2013cites this paper
• Insights of potential G-quadruplex sequences in telomeres and proto-oncogenes

  2013cites this paper
• Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma

  2012cites this paper
• The repair of melphalan-induced DNA adducts in the transcribed strand of active genes is subject to a strong polarity effect.

  2011cites this paper
• A partial cDNA clone for porcine glucosephosphate isomerase: isolation, characterization and use in detection of restriction fragment length polymorphisms.

  2009cites this paper
• An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation.

  2007cites this paper
• Expression of N-ras Gene in GliomasReceived December 20 , 1995 ; Accepted May 13 , 1996

  2006cites this paper
• Inhibition of Hras Expression by the Adeno-associated Virus Rep 78 Transformation Suppressor Gene Product 1

  2006cites this paper
• Line ANBL 6 Characteristics of the Interleukin 6-dependent Myeloma Cell Oncogene Alters the Growth ras Introduction of an Activated N-Updated

  2006cites this paper
• Analysis ofras mutations in human melanocytic lesions: activation of theras gene seems to be associated with the nodular type of human malignant melanoma

  2005cites this paper
• Cloning and genomic characterization of LST1: a new gene in the human TNF region

  2004cites this paper
• promoter and a negative regulatory element . regulatory sequences and identification of the Dissection of the mouse N-ras gene upstream

  2004cites this paper
• Aberrant G protein signaling in nervous system tumors.

  2002cites this paper
• Rapid mutational analysis of N-ras proto-oncogene in hematologic malignancies: study of 77 Greek patient.

  2001cites this paper
• Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: Identification of factor specific requirements

  2001cites this paper
• Application of fluorescently labeled poly(dU) for gene expression profiling on cDNA microarrays.

  2001cites this paper
• Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI.

  2001cites this paper
• Gene reorganisations and expression of c-ras, c-src, c-mos and c-fos oncogenes in Namalwa, Wish and C6 cells.

  2000cites this paper
• High sequence similarity within ras exons 1 and 2 in different mammalian species and phylogenetic divergence of the ras gene family

  1998cites this paper
• A dynamin‐like protein in Arabidopsis thaliana is involved in biogenesis of thylakoid membranes

  1998cites this paper
• Transcription of unr ( pstream of ‐ as) down‐modulates N‐ras expression in vivo

  1997cites this paper
• Specific Hammerhead Ribozyme-mediated Cleavage of Mutant N-ras mRNA in Vitro and ex Vivo

  1997cites this paper
• The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice

  1997cites this paper
• Establishment and characterization of an epithelioid sarcoma cell line with an autocrine response to interleukin-6

  1997influential citation
• Structure of the human ARHG locus encoding the Rho/Rac-like RhoG GTPase.

  1997cites this paper
• Characterization of N-RAS Promoter Mutations In Leukemia

  1996cites this paper
• N‐ras oncogene expression changes the growth characteristics of human melanoma in two independent SCID‐hu mouse models

  1996cites this paper
• Expression of N-ras gene in gliomas.

  1996cites this paper
• The use of alpha-DNA as an internal standard in the detection and quantitation of DNA damage in specific genes using Southern blotting.

  1996cites this paper
• Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

  1995cites this paper
• N-ras mRNA expression is unaffected in glutathione-depleted cells of hematopoietic origin.

  1995cites this paper
• Retroviruses and Oncogenes

  1995cites this paper
• Regulation of pre-mRNA processing by src.

  1995cites this paper
• SSCP detection of N-ras promoter mutations in AML patients.

  1995cites this paper
• The Retroviridae

  1995cites this paper
• Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma.

  1995cites this paper
• ras oncogene activation does not induce sensitivity to natural killer cell-mediated lysis in human melanoma.

  1994cites this paper
• DNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells.

  1994cites this paper
• Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth

  1994cites this paper
• DNA damage by anticancer agents and its repair: mapping in cells at the subgene level with quantitative polymerase chain reaction.

  1994cites this paper
• Quantitation of NM23 expression in human prostate tissues.

  1994cites this paper
• Generation of an ovine bone marrow‐derived myelomonocyte‐like cell line by retroviral‐mediated transformation. Immunological characterization and the effect of cytokines and lipopolysaccharides

  1994cites this paper
• Conserved cis-elements bind a protein complex that regulates Drosophila ras2/rop bidirectional expression.

  1994cites this paper
• Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.

  1993cites this paper
• Characterization of a novel Hodgkin cell line, HD-MyZ, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice

  1993cites this paper
• Separation of transforming N-ras mutations in codons 12, 13 and 61 by denaturing gradient gel electrophoresis: investigation based on a set of phagemid constructs.

  1993cites this paper
• Function and regulation of ras.

  1993cites this paper
• Characterization of the transcriptional regulatory region of the human WT1 gene.

  1993cites this paper
• Reassignment of the human ARH9 RAS-related gene to chromosome 1p13-p21.

  1993cites this paper
• GTP-binding proteins in plants

  1993cites this paper
• Molecular cloning and characterization of the promoter region of the human c-erbA alpha gene.

  1993cites this paper
• Characterization of the promoter region of the basidiomyceteLentinus edodes Le.rasgene

  1992cites this paper
• Calcitonin Gene—Related Peptide: A Neuropeptide Generated as a Consequence of Tissue‐Specific, Developmentally Regulated Alternative RNA Processing Events

  1992cites this paper
• Inactivation of the murine N-ras gene by gene targeting.

  1992cites this paper
• 44. Growth factor-dependent inhibition of normal hematopoiesis by N-ras antisens oligodeoxynucieotides

  1992cites this paper
• Multiple intragenic elements regulate the expression of the murine N-ras gene.

  1992cites this paper
• Growth factor-dependent inhibition of normal hematopoiesis by N-ras antisense oligodeoxynucleotides

  1992cites this paper
• Characterization of the promoter region of the basidiomycete Lentinus edodes Le.ras gene.

  1992cites this paper
• N‐ras gene mutations in acute myeloid leukemia: Accurate detection by solid‐phase minisequencing

  1992cites this paper
• Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver.

  1992cites this paper
• Nucleotide sequence of canine c-N-ras: codons 1 to 71.

  1992cites this paper
• Cloning and characterization of the Dictyostelium discoideum rasG genomic sequences.

  1992cites this paper
• Protooncogenes in the Regulation of Normal Hematopoiesis. An Antisense Approach a

  1992cites this paper
• A polymorphic region defined by pCN2 (the 3′ nontranslated region of N-ras) maps to chromosome 9cen-p12

  1991cites this paper
• Improved efficiency for single-sided PCR by creating a reusable pool of first-strand cDNA coupled to a solid phase.

  1991cites this paper
• Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.

  1991cites this paper
• Characterization of the human N-ras promoter region.

  1991cites this paper
• Characterization of the promoter region of the c-yes proto-oncogene: the importance of the GC boxes on its promoter activity.

  1991cites this paper
• Transcriptional Regulation of c-Ha- ras 1 Gene

  1991cites this paper
• In Vitro Cleavage of an N-ras Messenger-Like RNA by a Ribozyme

  1991cites this paper
• Characterization of the human N-ras promoter region.

  1991cites this paper
• Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene

  1991cites this paper
• Posttranscriptional down-regulation of fibronectin in N-ras-transformed cells.

  1991cites this paper
• Sequence analysis of DNA from formalin‐fixed, paraffin‐embedded human malignant melanoma

  1991cites this paper
• Dissection of the mouse N-ras gene upstream regulatory sequences and identification of the promoter and a negative regulatory element

  1991influential citation
• Organization of the human N-ras locus: characterization of a gene located immediately upstream of N-ras.

  1991cites this paper
• The Drosophila ras2/cs1 Bidirectional Promoter Shares Consensus Sequences with the Human c-Ha-ras1 Promoter

  1991cites this paper
• A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region.

  1991cites this paper
• Structure and autoregulation of the c-rel promoter.

  1990cites this paper
• Characterization of unr; a gene closely linked to N-ras.

  1990cites this paper
• Molecular cloning of a cDNA encoding rat NADH-cytochrome b5 reductase and the corresponding gene.

  1990cites this paper
• Mouse opsin. Gene structure and molecular basis of multiple transcripts.

  1990cites this paper
• Mutational analysis of human NRAS genes in malignant melanoma: Rapid methods for oligonucleotide hybridization and manual and automated direct sequencing of products generated by the polymerase chain reaction

  1990cites this paper
• Report of the DNA committee and catalogues of cloned and mapped genes and DNA polymorphisms.

  1990cites this paper
• Molecular organization of the human Raf-1 promoter region

  1990cites this paper
• Transcriptional control of the human Harvey ras proto-oncogene: role of multiple elements in the promoter region.

  1990cites this paper
• c-Ha-ras gene bidirectional promoter expressed in vitro: location and regulation

  1989cites this paper
• Sodium butyrate suppresses the transforming activity of an activated N-ras oncogene in human colon carcinoma cells.

  1989cites this paper
• Activated N-ras gene was found in human hepatoma tissue but only in a small fraction of the tumor cells.

  1989cites this paper
• Suppression of tumorigenicity in human cell hybrids derived from cell lines expressing different activated ras oncogenes.

  1989influential citation
• Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms.

  1989cites this paper
• Oncogenicity of human N-ras oncogene and proto-oncogene introduced into retroviral vectors

  1989cites this paper
• The N-ras oncogene is activated in a human medulloblastoma cell line.

  1989cites this paper