In vivo role of NAD(P)H:quinone oxidoreductase 1 in metabolic activation of mitomycin C and bone marrow cytotoxicity.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cancer Research

• Publication date

  2007-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-06-4480PMID 17804703
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activity

  2007cited by this paper
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  2006cited by this paper
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  2003cited by this paper
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  2001cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1996cited by this paper
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  1995cited by this paper
• Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.

  1994influential reference
• NAD(P)H:quinone oxidoreductase1 (DT-diaphorase): expression, regulation, and role in cancer.

  1994cited by this paper
• NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

  1993cited by this paper
• Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.

  1991cited by this paper
• High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin.

  1991cited by this paper
• Cancer chemotherapy and biological response modifiers annual

  1987cited by this paper
• Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

  1984influential reference
• Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

  1964cited by this paper

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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper