NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Cancer Metastasis Review

• Publication date

  1993-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF00689804PMID 8375015
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DT-diaphorase

  1995cited by this paper
• Identification of a glycine-rich sequence as an NAD(P)H-binding site and tyrosine 128 as a dicumarol-binding site in rat liver NAD(P)H:quinone oxidoreductase by site-directed mutagenesis.

  1992cited by this paper
• Identification of jun-B as third member in human antioxidant response element-nuclear proteins complex.

  1992cited by this paper
• Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.

  1992cited by this paper
• NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

  1992cited by this paper
• DT-diaphorase and cancer chemotherapy.

  1992cited by this paper
• Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme.

  1992cited by this paper
• A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

  1992cited by this paper
• Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol.

  1992cited by this paper
• Rapid detection of inducers of enzymes that protect against carcinogens.

  1992cited by this paper
• Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

  1992cited by this paper
• High levels of expression of the NAD(P)H:quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin.

  1991cited by this paper
• Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

  1991cited by this paper
• Redox redux: the control of oxidative stress responses.

  1991cited by this paper
• The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.

  1991cited by this paper
• Primary response genes induced by growth factors and tumor promoters.

  1991cited by this paper
• Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants.

  1991cited by this paper
• Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin.

  1991influential reference
• The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4.

  1991cited by this paper
• Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

  1990cited by this paper
• Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action.

  1990cited by this paper
• Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas.

  1990cited by this paper
• Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds.

  1990cited by this paper
• Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol

  1990influential reference
• Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.

  1990cited by this paper
• Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6.

  1990influential reference
• Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.

  1990cited by this paper
• ACTIVATION AND DEACTIVATION OF QUINONES BIOREDUCTIVE ACTIVATION OF DIAZIQUONE (AZQ) IN HUMAN TUMOR CELLS AND DETOXIFICATION OF BENZENE METABOLITES IN BONE MARROW STROMA CATALYZED BY DT-DIAPHORASE. EVIDENCE FOR

  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
• Rat liver NAD(P)H: Quinone reductase. Regulation of quinone reductase gene expression by planar aromatic compounds and determination of the exon structure of the quinone reductase structural gene.

  1989cited by this paper
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  1989cited by this paper
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  1989cited by this paper
• Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

  1988cited by this paper
• DNA transfection of a gene repressing aryl hydrocarbon hydroxylase induction.

  1988cited by this paper
• Human DT-diaphorase, a potential cancer protecting enzyme. Its purification from abdominal adipose tissue.

  1988cited by this paper
• Influence of DT diaphorase on the mutagenicity of organic and inorganic compounds.

  1988cited by this paper
• The molecular biology of cytochrome P450s.

  1988cited by this paper
• Purification of the Ah receptor from C57BL/6J mouse liver.

  1988cited by this paper
• The anticancer enzyme DT diaphorase is induced selectively in liver during ascites hepatoma growth.

  1988cited by this paper
• Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16.

  1988cited by this paper
• P450 genes: structure, evolution, and regulation.

  1987cited by this paper
• The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  1987cited by this paper
• Rat liver NAD(P)H: quinone reductase nucleotide sequence analysis of a quinone reductase cDNA clone and prediction of the amino acid sequence of the corresponding protein.

  1987cited by this paper
• Direct protective effect of NAD(P)H:quinone reductase against menadione-induced chemiluminescence of postmitochondrial fractions of mouse liver.

  1987cited by this paper
• Role of cytochrome P1-450 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants.

  1987influential reference
• DT-diaphorase in morbidly obese patients.

  1987cited by this paper
• Preliminary crystallographic X-ray data for an NAD(P)H:quinone reductase from mouse liver.

  1986cited by this paper
• Rat liver NAD(P)H:quinone reductase. Construction of a quinone reductase cDNA clone and regulation of quinone reductase mRNA by 3-methylcholanthrene and in persistent hepatocyte nodules induced by chemical carcinogens.

  1986cited by this paper
• NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation.

  1986cited by this paper
• Purification and characterization of two isofunctional forms of NAD(P)H: quinone reductase from mouse liver.

  1986cited by this paper
• On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

  1985cited by this paper
• Prominent role of DT-diaphorase as a cellular mechanism reducing chromium(VI) and reverting its mutagenicity.

  1985cited by this paper
• Increased glutathione S-transferase activity (GST) in drug treated human breast cancer cells

  1985cited by this paper
• Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes.

  1985cited by this paper
• Mutagenicity of quinones: pathways of metabolic activation and detoxification.

  1984cited by this paper
• DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene.

  1984cited by this paper
• A constitutive deficiency in the monooxygenase system of spontaneous mouse liver tumors.

  1984cited by this paper
• Biochemical and quantitative histochemical study of reduced pyridine nucleotide dehydrogenation by human colonic carcinomas.

  1983cited by this paper
• Possible role of DT-diaphorase in the bioactivation of antitumor quinones.

  1983cited by this paper
• Distribution of newly synthesized DT-diaphorase in rat liver

  1982cited by this paper
• The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

  1982cited by this paper
• DT Diaphorase: Properties, Reaction Mechanism, Metabolic Function. A Progress Report*

  1982cited by this paper
• Biospecific adsorption of hepatic DT-diaphorase on immobilized dicoumarol. II. Purification of mitochondrial and microsomal DT-diaphorase from 3-methylcholanthrene-treated rats.

  1981cited by this paper
• Biospecific adsorption of hepatic DT-diaphorase on immobilized dicoumarol. I. Purification of cytosolic DT-diaphorase from control and 3-methylcholanthrene-treated rats.

  1981cited by this paper
• Human FAD-dependent NAD(P)H diaphorase.

  1980influential reference
• Immunochemical studies on two DT diaphorase active antigens isolated from rat liver cytosol by affinity chromatography.

  1980cited by this paper
• The use of the D-T diaphorase for the detection of foci of early neoplastic transformation in rat liver.

  1978cited by this paper
• The activity of the D-T diaphorase in experimental hepatomas.

  1977cited by this paper
• The activity of the D-T diaphorase in experimental hepatomas.

  1977cited by this paper
• Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.

  1977cited by this paper
• Induction of DT-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (ICDD).

  1976cited by this paper
• Dehydrogenation of Reduced Pyridine Nucleotides by Leydig Cell Tumors of the Rat Testis

  1976cited by this paper
• Enzyme histochemical pattern in human tumours. II. Oxidoreductases in carcinoma of the colon and the breast.

  1975cited by this paper
• [56] DT diaphorase

  1967cited by this paper
• DT diaphorase. IV. Coupling of extramitochondrial reduced pyridine nucleotide oxidation to mitochondrial respiratory chain.

  1963cited by this paper
• Purification and some properties of a highly dicumarol-sensitive liver diaphorase☆☆☆

  1960cited by this paper
• Selective Extraction of DT Diaphorase from Mitochondria and Microsomes.

  1960cited by this paper
• Soluble Diaphorase in Animal Tissues.

  1958cited by this paper

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