Ventromedial prefrontal cortex is critical for the regulation of amygdala activity in humans.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Biological Psychiatry

• Publication date

  2015-02-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.biopsych.2014.02.014PMID 24673881PMCID PMC4145052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease.

  2014cited by this paper
• Synaptic Mechanisms Underlying Strong Reciprocal Connectivity between the Medial Prefrontal Cortex and Basolateral Amygdala

  2013cited by this paper
• The secret lives of experiments: Methods reporting in the fMRI literature

  2012cited by this paper
• Gating of fear in prelimbic cortex by hippocampal and amygdala inputs.

  2012cited by this paper
• Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion

  2012cited by this paper
• Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders

  2012cited by this paper
• Evidence for coordinated functional activity within the extended amygdala of non-human and human primates

  2012cited by this paper
• How is our self related to midline regions and the default-mode network?

  2011cited by this paper
• Uncertainty during anticipation modulates neural responses to aversion in human insula and amygdala.

  2010cited by this paper
• Wide‐Range Achievement Test

  2010cited by this paper
• Deep brain stimulation for treatment-resistant depression.

  2010cited by this paper
• Reliability and precision of pseudo‐continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O‐water PET in elderly subjects at risk for Alzheimer's disease

  2010cited by this paper
• The Timing of Emotional Discrimination in Human Amygdala and Ventral Visual Cortex

  2009cited by this paper
• Coping with emotions past: the neural bases of regulating affect associated with negative autobiographical memories.

  2009cited by this paper
• Neural markers of symptomatic improvement during antidepressant therapy in severe depression: subgenual cingulate and visual cortical responses to sad, but not happy, facial stimuli are correlated with changes in symptom score

  2009cited by this paper
• The amygdala response to images with impact.

  2009cited by this paper
• Posttraumatic Stress Disorder: The Role of Medial Prefrontal Cortex and Amygdala

  2009cited by this paper
• Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder.

  2008cited by this paper
• Neural circuitry underlying the regulation of conditioned fear and its relation to extinction.

  2008cited by this paper
• Continuous flow‐driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields

  2008cited by this paper
• Predictors of amygdala activation during the processing of emotional stimuli: a meta-analysis of 385 PET and fMRI studies.

  2008cited by this paper
• Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression

  2008cited by this paper
• Focal brain damage protects against post-traumatic stress disorder in combat veterans

  2008cited by this paper
• Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus.

  2007cited by this paper
• Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala

  2007cited by this paper
• Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression

  2007cited by this paper
• Region of interest analysis for fMRI.

  2007cited by this paper
• Fear extinction in rats: implications for human brain imaging and anxiety disorders.

  2006influential reference
• Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future.

  2006cited by this paper
• Motion correction and the use of motion covariates in multiple‐subject fMRI analysis

  2006cited by this paper
• Amygdala and Ventromedial Prefrontal Cortex Are Inversely Coupled during Regulation of Negative Affect and Predict the Diurnal Pattern of Cortisol Secretion among Older Adults

  2006cited by this paper
• Prefrontal involvement in the regulation of emotion: convergence of rat and human studies.

  2006cited by this paper
• Prefrontal mechanisms in extinction of conditioned fear.

  2006cited by this paper
• International affective picture system (IAPS) : affective ratings of pictures and instruction manual

  2005cited by this paper
• Deep brain stimulation for treatment-resistant depression.

  2005cited by this paper
• Lateralization of amygdala activation: a systematic review of functional neuroimaging studies.

  2004cited by this paper
• Extinction learning in humans: role of the amygdala and vmPFC.

  2004cited by this paper
• Geodesic estimation for large deformation anatomical shape averaging and interpolation.

  2004cited by this paper
• The Involvement of the Orbitofrontal Cortex in the Experience of Regret

  2004cited by this paper
• Serial pathways from primate prefrontal cortex to autonomic areas may influence emotional expression

  2003cited by this paper
• Inhibition of the Amygdala: Key to Pathological States?

  2003cited by this paper
• Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging

  2003cited by this paper
• Stimulation of Medial Prefrontal Cortex Decreases the Responsiveness of Central Amygdala Output Neurons

  2003cited by this paper
• Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect

  2002cited by this paper
• Neurons in medial prefrontal cortex signal memory for fear extinction

  2002cited by this paper
• Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism.

  2002cited by this paper
• Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey.

  2002cited by this paper
• Affective reactions to briefly presented pictures.

  2001cited by this paper
• Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study.

  2001cited by this paper
• Emotion and motivation I: defensive and appetitive reactions in picture processing.

  2001cited by this paper
• Spatial Normalization of Brain Images with Focal Lesions Using Cost Function Masking

  2001cited by this paper
• Acquired Personality Disturbances Associated With Bilateral Damage to the Ventromedial Prefrontal Region

  2000cited by this paper
• The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans.

  2000cited by this paper
• Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response.

  2000cited by this paper
• Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness.

  1999cited by this paper
• Prefrontal Cortical Networks Related to Visceral Function and Mood

  1999cited by this paper
• Sources of distortion in functional MRI data

  1999cited by this paper
• Deciding Advantageously Before Knowing the Advantageous Strategy

  1997cited by this paper
• The somatic marker hypothesis and the possible functions of the prefrontal cortex.

  1996cited by this paper
• AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.

  1996influential reference
• Projections of the medial and lateral prefrontal cortices to the amygdala: a Phaseolus vulgaris leucoagglutinin study in the rat.

  1996cited by this paper
• Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold

  1995cited by this paper
• Prefrontal cortical control of the autonomic nervous system: anatomical and physiological observations.

  1990cited by this paper
• Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli.

  1990cited by this paper
• Development and validation of brief measures of positive and negative affect: the PANAS scales.

  1988influential reference
• Severe disturbance of higher cognition after bilateral frontal lobe ablation: Patient EVR

  1986cited by this paper
• Severe disturbance of higher cognition after bilateral frontal lobe ablation

  1985cited by this paper
• An autoradiographic study of the projections of the central nucleus of the monkey amygdala

  1981cited by this paper
• Psychiatric Aspects of Neurological Disease

  1975cited by this paper
• Manual for the State-Trait Anxiety Inventory

  1970cited by this paper
• Annals of the New York Academy of Sciences Orbitofrontal Contributions to Value-based Decision Making: Evidence from Humans with Frontal Lobe Damage Is Economic Value Represented in the Brain?

  year unknowncited by this paper

• Abstract Moral Decisions Are Unchanged After Oxytocin Administration

  2026cites this paper
• Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation

  2026cites this paper
• Evidencia empírica en la toma de decisiones en docentes universitarios

  2026cites this paper
• Moral emotions in mental health: regulation and mediation

  2026cites this paper
• Functional neuroimaging of fatty acid amide hydrolase inhibition in posttraumatic stress disorder: a randomized clinical trial

  2026cites this paper
• Emotional body odor: Mechanisms in emotional communication and biological significance

  2026cites this paper
• Non-obese genetic type 2 diabetes causes brain and behavioral hallmarks of chronic stress

  2025cites this paper
• A-SMiLE: Affective Sparse Mixture-of-Experts Adapter with Multi-Task Learning for Spoken Dialogue Models

  2025cites this paper
• Infrared Thermal Imaging (ITI), a Non‐invasive Window Into Early Emotion Regulation: A Systematic Review

  2025cites this paper
• Depression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways.

  2025cites this paper
• Exploring the Temporal Dynamics and Causal Interactions Between the Amygdala and vmPFC: A Multidimensional Approach Using Time-Lagged Correlation, Granger Causality, and Entropy Analysis

  2025cites this paper
• Mobile Mental Health Screening in EmotiZen via the Novel Brain-Inspired MCoG-LDPSNet

  2025cites this paper
• Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

  2025cites this paper
• The Impact of Task Context on Pleasantness and Softness Estimations: A Study Based on Three Touch Strategies

  2025cites this paper
• Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders.

  2025cites this paper
• Predictors of risk and resilience to psychopathology in refugee youth: A longitudinal study.

  2025cites this paper
• Stress-related genetic factors modify the effect of socioeconomic status on cardiovascular risk

  2025cites this paper
• The CB1R of mPFC is involved in anxiety-like behavior induced by 0.8/2.65 GHz dual-frequency electromagnetic radiation

  2025cites this paper
• Emotional characteristics and intrinsic brain network functional connectivity among adults aged 75+

  2025cites this paper
• Identifying molecular signatures of post-traumatic stress disorder vulnerability and progression in a longitudinal study: a study protocol

  2025cites this paper
• Studying Programmers Without Programming: Investigating Expertise Using Resting State fMRI

  2025cites this paper
• PTSD and Appetite Dysregulation: mTOR-Dependent Modulation of Fear Memory and Satiety Circuits.

  2025cites this paper
• Targeting VMPFC‐amygdala circuit with TMS in substance use disorder: A mechanistic framework

  2025cites this paper
• Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry

  2025cites this paper
• Relationships and representations of brain structures, connectivity, dynamics and functions.

  2025cites this paper
• A biopsychosocial model of MDMA-assisted therapy in application: Dyadic One Session Treatment for specific phobia

  2025cites this paper
• The triune brain- linked by neuroeconomics and operated as socioeconomics (SE)

  2025cites this paper
• Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.

  2025cites this paper
• Clinical conceptualisation of PTSD in psilocybin treatment: disrupting a pre-determined and over-determined maladaptive interpretive framework

  2025cites this paper
• Emotion Regulation in the Preadolescent Brain and the Role of Individual Temperamental Differences

  2025cites this paper
• The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health

  2025cites this paper
• The medial amygdala's neural circuitry: Insights into social processing and sex differences.

  2025cites this paper
• Art Therapy Studio at a Time of Emergency

  2025cites this paper
• Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis

  2025cites this paper
• Heart Rate Variability Predicts Therapy Outcome in Anxiety Disorders: The Role of Inhibitory Learning

  2025cites this paper
• Longitudinal patterns and group heterogeneity of depressive symptoms during menopausal transition in middle-aged Korean women

  2025cites this paper
• Frontoamygdala hyperconnectivity predicts autonomic dysregulation and persisting symptoms in sports-related concussion

  2025cites this paper
• Multi-modal brain properties are associated with interindividual differences in fear acquisition and extinction

  2025cites this paper
• How Fear Memory is Updated: From Reconsolidation to Extinction?

  2025cites this paper
• A Digital Tool for Assessing the Distinct Effects of Depression, Anxiety, and Attention-Deficit/Hyperactivity Disorder (ADHD) on Children's Emotional Cognitive Bias: Cross-Sectional Study.

  2025cites this paper
• The interplay of hot and cool executive functions: Implications for a unified executive framework

  2025cites this paper
• Underlying biological mechanisms of emotion dysregulation in bipolar disorder

  2025cites this paper
• S-ketamine ameliorates post-stroke depression in mice via attenuation of neuroinflammation, synaptic restoration, and BDNF pathway activation.

  2025cites this paper
• A visual generalization gradient of conceptual stimuli based on fear acquisition in visual and auditory modalities

  2025cites this paper
• The relation between stress-related neural activity assessed by brain 18F-FDG-PET/CT and cardiovascular outcomes: a systematic review and meta-analysis

  2025cites this paper
• The default mode network and emotion — dual roles of the medial prefrontal cortex in emotional experience and regulation

  2025cites this paper
• Trialing addiction neurocircuitry targets and directionality of brain stimulation effects: A deep TMS/fMRI trial in people with alcohol use disorder

  2025cites this paper
• Obesity and Insulin Resistance Alter Neural Processing of Unpleasant, but Not Pleasant, Visual Stimuli in Young Adults

  2025cites this paper
• Advancements in diagnosing Post-concussion Syndrome: insights into epidemiology, pathophysiology, neuropathology, neuroimaging, and salivary biomarkers

  2025cites this paper
• Discrimination Exposure, Neural Reactivity to Stress, and Psychological Distress.

  2024cites this paper
• Botulinum Toxin A Therapy for Glabellar Lines Improves Emotional States: Evaluation of 47 Cases without Mental Disorders

  2024cites this paper
• State and trait serotonin variations interact to shape the intrinsic connectivity and gradient architecture of the brain – a combined TPH2 genetics and tryptophan depletion study

  2024cites this paper
• Association of Anxiety with Uncinate Fasciculus Lesion Burden in Multiple Sclerosis

  2024cites this paper
• The Impact of Early Life Experiences on Stress Neurobiology and the Development of Anxiety.

  2024cites this paper
• How does the "default mode" network contribute to semantic cognition?

  2024cites this paper
• Emotional dysregulation and stimulant medication in adult ADHD

  2024cites this paper
• Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence.

  2024cites this paper
• Modulating prefrontal cortex activity to alleviate stress-induced working memory deficits: A transcranial direct current (tDCS) study

  2024cites this paper
• Neural Basis of Agitated Behaviors in Patients with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

  2024cites this paper
• Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT.

  2024cites this paper
• Anxiety and Depression Associated With Increased Cardiovascular Disease Risk Through Accelerated Development of Risk Factors

  2024cites this paper
• Imaging of the brain–heart axis: prognostic value in a European setting

  2024cites this paper
• Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear

  2024cites this paper
• Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders

  2024cites this paper
• GABAergic implications in anxiety and related disorders.

  2024cites this paper
• Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior.

  2024cites this paper
• The human social cognitive network contains multiple regions within the amygdala

  2024cites this paper
• A Neural Signature for Reappraisal as an Emotion Regulation Strategy: Relationship to Stress-Related Suicidal Ideation and Negative Affect in Major Depression.

  2024cites this paper
• Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate-amygdala regulation and brain-wide connectivity

  2024cites this paper
• Neurocognitive profiles in a community sample of children & adolescents: sociodemographic, behavioral and emotional correlates

  2024cites this paper
• Facial expression recognition ability and its neuropsychological mechanisms in children with attention deficit and hyperactive disorder.

  2024cites this paper
• A theory of the neural mechanisms underlying negative cognitive bias in major depression

  2024cites this paper
• Effects of repetitive transcranial magnetic stimulation on fear of cancer recurrence and its underlying neuromechanism

  2024cites this paper
• The emotion paradox in the aging body and brain

  2024cites this paper
• Identifying Potential Scalp Acupuncture Targets for Chronic Pain and Comorbid Disorders Using Functional and Anatomical Connectivity of Critical Deep Brain Structures

  2024cites this paper
• Multimodal Associations of FKBP5 Methylation with Emotion-Regulatory Brain Circuits.

  2024cites this paper
• Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions

  2024cites this paper
• An intracranial dissection of human escape circuits

  2024cites this paper
• Systematic reduction of gray matter volume in anorexia nervosa, but relative enlargement with clinical symptoms in the prefrontal and posterior insular cortices: a multicenter neuroimaging study

  2024cites this paper
• Evidence for distinct networks underlying symptom clusters of posttraumatic stress disorder

  2024cites this paper
• Accelerated development of cardiovascular risk factors mediates risk for major adverse cardiovascular events in posttraumatic stress disorder.

  2024cites this paper
• Intermittent theta burst stimulation over the left prefrontal cortex: no additional effect for virtual reality exposure therapy in acrophobia—a randomized trial

  2024cites this paper
• Sex differences in neuronal activation in the cortex and midbrain during quinine-adulterated alcohol intake.

  2024cites this paper
• Curiosity and the Regulation of Affective Memory

  2024cites this paper
• Neuromodulation as a therapeutic approach for post-traumatic stress disorder: the evidence to date

  2024cites this paper
• fMRI BOLD responses to film stimuli and their association with exhaled nitric oxide in asthma and health.

  2024cites this paper
• Gender effects on autism spectrum disorder: a multi-site resting-state functional magnetic resonance imaging study of transcriptome-neuroimaging

  2023cites this paper
• Anatomical and Functional Connectivity of Critical Deep Brain Structures and Their Potential Clinical Application in Brain Stimulation

  2023cites this paper
• Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk.

  2023cites this paper
• An fNIRS investigation of novel expressed emotion stimulations in schizophrenia

  2023cites this paper
• Depressive symptoms moderate functional connectivity within the emotional brain in chronic pain

  2023cites this paper
• Influence of exercise on pain is associated with resting-state functional connections: A cross-sectional functional brain imaging study.

  2023cites this paper
• Effects of acute stress and depression on functional connectivity between prefrontal cortex and the amygdala

  2023cites this paper
• A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity

  2023cites this paper
• Medial prefrontal cortex stimulation abolishes implicit reactions to threats and prevents the return of fear

  2023cites this paper
• A lesion-derived brain network for emotion regulation.

  2023cites this paper
• Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review

  2023cites this paper
• Fronto-amygdala resting state functional connectivity is associated with anxiety symptoms among adolescent girls more advanced in pubertal maturation.

  2023cites this paper
• Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder.

  2023cites this paper
• Decontextualized fear memories? Stronger conditioned fear responses during extinction learning and extinction recall in a safe context predict the development of long-term analog intrusions.

  2023cites this paper