Lysophosphatidic acid effects on atherosclerosis and thrombosis.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Clinical Lipidology

• Publication date

  2011-08-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2217/CLP.11.38PMID 22162980PMCID PMC3230858
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium.

  2011cited by this paper
• LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1-regulated, PKC-dependent, and p38alpha-mediated pathway.

  2010cited by this paper
• Rho Kinase-2 Activation in Human Endothelial Cells Drives Lysophosphatidic Acid-mediated Expression of Cell Adhesion Molecules via NF-κB p65*

  2010cited by this paper
• Regulation of Cerebromicrovascular Permeability by Lysophosphatidic Acid

  2010cited by this paper
• Lysophosphatidic Acid Receptors LPA1 and LPA3 Promote CXCL12-Mediated Smooth Muscle Progenitor Cell Recruitment in Neointima Formation

  2010cited by this paper
• Atherosclerotic lesion progression changes lysophosphatidic acid homeostasis to favor its accumulation.

  2010cited by this paper
• Biological roles of lysophosphatidic acid signaling through its production by autotaxin.

  2010cited by this paper
• Lysophosphatidic acid-induced arterial wall remodeling: requirement of PPARgamma but not LPA1 or LPA2 GPCR.

  2009cited by this paper
• Vascular smooth muscle-derived tissue factor is critical for arterial thrombosis after ferric chloride-induced injury.

  2009cited by this paper
• Autotaxin/Lysopholipase D and Lysophosphatidic Acid Regulate Murine Hemostasis and Thrombosis*

  2009cited by this paper
• Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk?

  2009cited by this paper
• Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis

  2009cited by this paper
• Angiogenesis as risk factor for plaque vulnerability.

  2009cited by this paper
• Unique Ligand Selectivity of the GPR92/LPA5 Lysophosphatidate Receptor Indicates Role in Human Platelet Activation*

  2009cited by this paper
• G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

  2008cited by this paper
• Lysophosphatidic acid-induced interleukin-1 beta expression is mediated through Gi/Rho and the generation of reactive oxygen species in macrophages.

  2008cited by this paper
• Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

  2008cited by this paper
• Prostaglandins and Other Lipid Mediators ysophosphatidic acid-induced oxidized low-density lipoprotein ptake is class A scavenger receptor-dependent in macrophages

  2008cited by this paper
• The early- and late stages in phenotypic modulation of vascular smooth muscle cells: differential roles for lysophosphatidic acid.

  2008cited by this paper
• The role of smooth muscle derived tissue factor in mediating thrombosis and arterial injury.

  2008cited by this paper
• Absence of LPA1 signaling results in defective cortical development.

  2008cited by this paper
• Impact of Plasma Oxidized Low-Density Lipoprotein Removal on Atherosclerosis

  2008cited by this paper
• Individual Heterogeneity in Platelet Response to Lysophosphatidic Acid: Evidence for a Novel Inhibitory Pathway

  2008cited by this paper
• Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair

  2008cited by this paper
• Lysophosphatidic acid (LPA) and angiogenesis

  2008cited by this paper
• Upregulation of pentraxin-3 in human endothelial cells after lysophosphatidic acid exposure.

  2008cited by this paper
• LPA modulates monocyte migration directly and via LPA-stimulated endothelial cells.

  2008cited by this paper
• Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure

  2008cited by this paper
• LysoPtdOH Enhances CXCL16 Production Stimulated by LPS from Macrophages and Regulates T cell Migration

  2008cited by this paper
• Angiogenesis and inflammation in carotid atherosclerosis.

  2008cited by this paper
• Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA(1/3), COX-2, and NF-kappaB activation- and EGFR transactivation-dependent mechanisms.

  2008cited by this paper
• LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)

  2007cited by this paper
• Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation.

  2007cited by this paper
• Regulation and biological activities of the autotaxin-LPA axis.

  2007cited by this paper
• Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3.

  2007cited by this paper
• Elimination of neoangiogenesis for plaque stabilization: is there a role for local drug therapy?

  2007cited by this paper
• Plaque neovascularization and antiangiogenic therapy for atherosclerosis.

  2007cited by this paper
• Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha.

  2007cited by this paper
• Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells.

  2007cited by this paper
• Lysophospholipids increase IL‐8 and MCP‐1 expressions in human umbilical cord vein endothelial cells through an IL‐1‐dependent mechanism

  2006cited by this paper
• IL‐6 and IL‐8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids

  2006cited by this paper
• The immune response in atherosclerosis: a double-edged sword

  2006cited by this paper
• Hydrolysis of Phosphatidylserine-exposing Red Blood Cells by Secretory Phospholipase A2 Generates Lysophosphatidic Acid and Results in Vascular Dysfunction*

  2006cited by this paper
• Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes

  2006cited by this paper
• Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid*

  2006cited by this paper
• Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells.

  2006cited by this paper
• Role of tissue factor in hemostasis and thrombosis.

  2006cited by this paper
• Lysophosphatidic Acid Induces Early Growth Response Gene 1 Expression in Vascular Smooth Muscle Cells: CRE and SRE Mediate the Transcription

  2006cited by this paper
• Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

  2006cited by this paper
• GPR92 as a New G12/13- and Gq-coupled Lysophosphatidic Acid Receptor That Increases cAMP, LPA5*

  2006cited by this paper
• Lipid Phosphate Phosphatase-1 Regulates Lysophosphatidate-induced Fibroblast Migration by Controlling Phospholipase D2-dependent Phosphatidate Generation*

  2006cited by this paper
• Lysophosphatidic Acid Modulates the Activation of Human Monocyte-Derived Dendritic Cells

  2006cited by this paper
• Activatory Properties of Lysophosphatidic Acid on Human THP-1 Cells

  2006cited by this paper
• Inflammation, atherosclerosis, and coronary artery disease.

  2005cited by this paper
• Oxidized phospholipids as triggers of inflammation in atherosclerosis.

  2005cited by this paper
• Activatory Properties of Lysophosphatidic Acid on Human THP-1 Cells

  2005cited by this paper
• Isolevuglandins, Oxidatively Truncated Phospholipids, and Atherosclerosis

  2005cited by this paper
• Monocyte cyclooxygenase-2 overactivity: a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors?

  2005cited by this paper
• Biomechanics and Mechanotransduction in Cells and Tissues Mechanical , biochemical , and extracellular matrix effects on vascular smooth muscle cell phenotype

  2005cited by this paper
• Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth

  2005cited by this paper
• 4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis.

  2005cited by this paper
• A role for oxidized phospholipids in atherosclerosis.

  2005cited by this paper
• Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells.

  2005cited by this paper
• The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors.

  2004cited by this paper
• Reactive oxygen species in hypertension; An update.

  2004cited by this paper
• Molecular regulation of vascular smooth muscle cell differentiation in development and disease.

  2004cited by this paper
• Modulation of atherogenesis by chemokines.

  2004cited by this paper
• Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques.

  2004cited by this paper
• Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation.

  2004cited by this paper
• Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism.

  2004cited by this paper
• Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation

  2004cited by this paper
• Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer

  2004cited by this paper
• Role of monocytes in atherogenesis.

  2003cited by this paper
• Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate.

  2003cited by this paper
• Transdifferentiation of Human Peripheral Blood CD34+-Enriched Cell Population Into Cardiomyocytes, Endothelial Cells, and Smooth Muscle Cells In Vivo

  2003cited by this paper
• Lysophosphatidic Acid Induction of Tissue Factor Expression in Aortic Smooth Muscle Cells

  2003cited by this paper
• Oxidative and nitrosative events in asthma.

  2003cited by this paper
• Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

  2003cited by this paper
• Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family*

  2003cited by this paper
• Lack of Interleukin-1&bgr; Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

  2003cited by this paper
• Molecular mechanisms of lysophosphatidic acid action.

  2003cited by this paper
• Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques

  2003cited by this paper
• Reactive oxygen species mediate cyclooxygenase-2 induction during monocyte to macrophage differentiation: critical role of NADPH oxidase.

  2003cited by this paper
• Vascular Remodeling Induced by Naturally Occurring Unsaturated Lysophosphatidic Acid In Vivo

  2003cited by this paper
• The Influence of Lysophosphatidic Acid on the Functions of Human Dendritic Cells

  2002cited by this paper
• Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response.

  2002cited by this paper
• Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase*

  2002cited by this paper
• Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

  2002cited by this paper
• Atherosclerosis: the new view.

  2002cited by this paper
• Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies

  2002cited by this paper
• Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood*

  2002cited by this paper
• Lysophosphatidic acid stimulates p21-activated kinase in vascular smooth muscle cells.

  2002cited by this paper
• Characterization of lpa2 (Edg4) and lpa1/lpa2 (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa2

  2002cited by this paper
• Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids.

  2002cited by this paper
• Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists.

  2001cited by this paper
• Contribution of Adventitial Fibroblasts to Neointima Formation and Vascular Remodeling: From Innocent Bystander to Active Participant

  2001cited by this paper
• Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane1

  2001cited by this paper
• Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways.

  2001cited by this paper
• Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

  2001cited by this paper
• Atherosclerosis The Road Ahead

  2001cited by this paper

• Lysophosphatidic acid: a promising biomarker for diagnosing sepsis and predicting in-hospital mortality

  2026cites this paper
• Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation

  2024cites this paper
• Large-scale, comprehensive plasma metabolomic analyses reveal potential biomarkers for the diagnosis of early-stage coronary atherosclerosis.

  2024cites this paper
• The Autotaxin-LPA Axis Emerges as a Novel Regulator of Smooth Muscle Cell Phenotypic Modulation during Intimal Hyperplasia

  2023cites this paper
• Melatonin and TGF-β-Mediated Release of Extracellular Vesicles

  2023cites this paper
• Lysophosphatidic Acid Promotes Epithelial–Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy

  2022cites this paper
• Crocin ameliorates atherosclerosis by promoting the reverse cholesterol transport and inhibiting the foam cell formation via regulating PPARγ/LXR-α

  2022cites this paper
• Autotaxin Activity in Chronic Subdural Hematoma: A Prospective Clinical Study

  2022cites this paper
• Disrupted Blood‐Brain Barrier and Mitochondrial Impairment by Autotaxin–Lysophosphatidic Acid Axis in Postischemic Stroke

  2021cites this paper
• Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension?

  2021cites this paper
• Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease

  2021cites this paper
• Hypercholesterolemia and Lymphatic Defects: The Chicken or the Egg?

  2021cites this paper
• The lysophosphatidic acid axis in fibrosis: Implications for glaucoma

  2021cites this paper
• Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho

  2021cites this paper
• TRPV1 Ion Channel: Structural Features, Activity Modulators, and Therapeutic Potential

  2021cites this paper
• Lysophosphatidic acid promotes thrombus stability by inducing rapid formation of neutrophil extracellular traps: A new mechanism of thrombosis

  2020cites this paper
• "Modeling-Prediction" Strategy for Deep Profiling of Lysophosphatidic Acids by Liquid Chromatography-Mass Spectrometry: Exploration Biomarkers of Breast Cancer.

  2020cites this paper
• Lysophosphatidic acid-induced pro-thrombotic phosphatidylserine exposure and ionophore-induced microvesiculation is mediated by the scramblase TMEM16F in erythrocytes.

  2020cites this paper
• TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure

  2020cites this paper
• TRPV1 expressed throughout the arterial circulation enables inflammatory vasoconstriction

  2020cites this paper
• Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration

  2020cites this paper
• Lysophosphatidic acid decreased macrophage foam cell migration correlated with downregulation of fucosyltransferase 8 via HNF1α.

  2019cites this paper
• Lysophospholipid profiles of apolipoprotein E-deficient mice reveal potential lipid biomarkers associated with atherosclerosis progression using validated UPLC-QTRAP-MS/MS-based lipidomics approach.

  2019cites this paper
• Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease.

  2019cites this paper
• Hydroxytyrosol Decreases Phosphatidylserine Exposure and Inhibits Suicidal Death Induced by Lysophosphatidic Acid in Human Erythrocytes.

  2019cites this paper
• Lysophosphatidic acid acts on LPA1 receptor to increase H2O2 during flow‐induced dilation in human adipose arterioles

  2018cites this paper
• Targeting the RhoA-ROCK pathway to regulate T-cell homeostasis in hypoxia-induced pulmonary arterial hypertension.

  2018cites this paper
• The AGP-PPARγ axis promotes oxidative stress and diabetic endothelial cell dysfunction.

  2018cites this paper
• Lysophosphatidic Acid Promotes Expression and Activation of Matrix Metalloproteinase 9 (MMP9) in THP-1 Cells via Toll-Like Receptor 4/Nuclear Factor-κB (TLR4/NF-κB) Signaling Pathway

  2018cites this paper
• The interaction of β2-glycoprotein I with lysophosphatidic acid in platelet aggregation and blood clotting.

  2018cites this paper
• Mechanism of LPA ‐ induced lipid uptake in macrophages

  2018cites this paper
• CD14 is a key mediator of both lysophosphatidic acid and lipopolysaccharide induction of foam cell formation

  2017cites this paper
• CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells.

  2017cites this paper
• mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway

  2017cites this paper
• Study of the metabolomics characteristics of patients with metabolic syndrome based on liquid chromatography quadrupole time-of-flight mass spectrometry.

  2017cites this paper
• Lysophosphatidic acid directly induces macrophage-derived foam cell formation by blocking the expression of SRBI.

  2017cites this paper
• The AGP-PPARγ axis promotes oxidative stress and diabetic endothelial cell dysfunction

  2017cites this paper
• Studying platelet and monocyte function in atherosclerosis by employing quantitative proteomics

  2017cites this paper
• Plasma Phospholipids are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients.

  2017cites this paper
• Research progress in early test indexes of deep venous thrombosis

  2016cites this paper
• INFLUENCE OF CHRONIC KIDNEY DISEASE ON THE HAEMOSTATIC PROPERTIES, THE PLATELET TRANSCRIPTOMIC AND PLASMA PROTEOMIC PROFILES OF CORONARY ARTERY DISEASE PATIENTS

  2016cites this paper
• Lysophospholipids and their G protein-coupled receptors in atherosclerosis.

  2016influential citation
• Lysophospholipids and their G protein-coupled receptors in atherosclerosis.

  2016influential citation
• Facile Methods for the Analysis of Lysophosphatidic Acids in Human Plasma

  2015cites this paper
• Polymorphism rs7023923 and monocyte count in blood donors and coronary artery disease patients.

  2015cites this paper
• Lysophosphatidylserine has Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis.

  2015cites this paper
• Identification of total reversible cysteine oxidation in an atherosclerosis model using a modified biotin switch assay.

  2015cites this paper
• EVALUATION OF THE SIGNALLING MECHANISMS OF LYSOPHOSPHATIDIC ACID AND ITS ROLE IN THE CENTRAL NERVOUS SYSTEM

  2014cites this paper
• Regulation of T Cell Motility In Vitro and In Vivo by LPA and LPA2

  2014cites this paper
• Methods for quantifying lysophosphatidic acid in body fluids: a review.

  2014cites this paper
• Lysophosphatidic Acid (LPA) Signaling in Human and Ruminant Reproductive Tract

  2014cites this paper
• Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

  2014cites this paper
• Matricellular Protein Cyr61 Bridges Lysophosphatidic Acid and Integrin Pathways Leading to Cell Migration*

  2013cites this paper
• Mechanism of LPA-induced lipid uptake in macrophages

  2013cites this paper
• Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes.

  2013cites this paper
• Lysophosphatidic acid induces increased BACE1 expression and Aβ formation.

  2013influential citation
• Inhibition of lysophosphatidic acid increase by prestorage whole blood leukoreduction in autologous CPDA‐1 whole blood

  2013cites this paper
• Lipid phosphate phosphatase (LPP3) and vascular development.

  2013cites this paper
• Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation[S]

  2013cites this paper
• Alteration of the platelet transcriptome in chronic kidney disease

  2012cites this paper
• Lysophosphatidic Acid Induces Early Growth Response-1 (Egr-1) Protein Expression via Protein Kinase Cδ-regulated Extracellular Signal-regulated Kinase (ERK) and c-Jun N-terminal Kinase (JNK) Activation in Vascular Smooth Muscle Cells*

  2012cites this paper
• Arteriosclerosis, Thrombosis, and Vascular Biology

  year unknowncites this paper