TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Circulation Research

• Publication date

  2009-05-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.108.192930PMID 19359599PMCID PMC2754067
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vanilloid transient receptor potential cation channels: an overview.

  2008cited by this paper
• TRP channel and cardiovascular disease.

  2008cited by this paper
• Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation.

  2008cited by this paper
• Interaction of Transient Receptor Potential Vanilloid 4, Integrin, and Src Tyrosine Kinase in Mechanical Hyperalgesia

  2008cited by this paper
• Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro

  2008cited by this paper
• Frequency-Dependent Phenotype Modulation of Vascular Smooth Muscle Cells under Cyclic Mechanical Strain

  2007cited by this paper
• Tensile Forces Stimulate Vascular Remodeling and Epidermal Cell Proliferation in Living Skin

  2007cited by this paper
• Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts

  2007cited by this paper
• Arterial Response to Shear Stress Critically Depends on Endothelial TRPV4 Expression

  2007cited by this paper
• Mechanical Strain Regulates Endothelial Cell Patterning In Vitro

  2007cited by this paper
• Revisiting TRPC1 and TRPC6 mechanosensitivity

  2007cited by this paper
• TRP channels in endothelial function and dysfunction.

  2007cited by this paper
• Cyclic strain modulates tubulogenesis of endothelial cells in a 3D tissue culture model.

  2006cited by this paper
• Evidence for a Functional Role of Endothelial Transient Receptor Potential V4 in Shear Stress–Induced Vasodilatation

  2006cited by this paper
• Threonine 788 in integrin subunit beta1 regulates integrin activation.

  2006cited by this paper
• Matrix-specific suppression of integrin activation in shear stress signaling.

  2006cited by this paper
• Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels

  2006cited by this paper
• A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

  2005cited by this paper
• Modulation of the Ca2 Permeable Cation Channel TRPV4 by Cytochrome P450 Epoxygenases in Vascular Endothelium

  2005cited by this paper
• Recent developments in vascular endothelial cell transient receptor potential channels.

  2005cited by this paper
• TRPC1 forms the stretch-activated cation channel in vertebrate cells

  2005cited by this paper
• TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals

  2005cited by this paper
• Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts.

  2005cited by this paper
• Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*

  2005cited by this paper
• Cooperative effects of Rho and mechanical stretch on stress fiber organization.

  2005cited by this paper
• Regulation of mechanical interactions between fibroblasts and the substratum by stretch-activated Ca2+ entry

  2004cited by this paper
• Monoclonal antibodies as probes of integrin priming and activation.

  2004cited by this paper
• Cellular/molecular Transient Receptor Potential Vanilloid 4 Is Essential in Chemotherapy-induced Neuropathic Pain in the Rat

  2004cited by this paper
• Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans

  2003cited by this paper
• Transient receptor potential channels in endothelium: solving the calcium entry puzzle?

  2003cited by this paper
• ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating β1 integrin function

  2003cited by this paper
• TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes

  2003cited by this paper
• Calcium regulates the PI3K‐Akt pathway in stretched osteoblasts

  2003cited by this paper
• Beta1-integrins co-localize with Na, K-ATPase, epithelial sodium channels (ENaC) and voltage activated calcium channels (VACC) in mechanoreceptor complexes of mouse limb-bud chondrocytes.

  2003cited by this paper
• Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology.

  2002cited by this paper
• Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology

  2002cited by this paper
• Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives*

  2002cited by this paper
• ADAM12/Syndecan-4 Signaling Promotes β1Integrin-dependent Cell Spreading through Protein Kinase Cα and RhoA*

  2002cited by this paper
• Heat-Evoked Activation of the Ion Channel, TRPV4

  2002cited by this paper
• Activation of integrins in endothelial cells by fluid shear stress mediates Rho‐dependent cytoskeletal alignment

  2001cited by this paper
• Polycystin: new aspects of structure, function, and regulation.

  2001cited by this paper
• Activated R-Ras, Rac1, Pi 3-Kinase and Pkcε Can Each Restore Cell Spreading Inhibited by Isolated Integrin β1 Cytoplasmic Domains

  2000cited by this paper
• Tensional forces in fibrillar extracellular matrices control directional capillary sprouting.

  1999cited by this paper
• Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction.

  1999cited by this paper
• Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates

  1999cited by this paper
• Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation.

  1998cited by this paper
• Effects of mechanical forces on signal transduction and gene expression in endothelial cells.

  1998cited by this paper
• Up-regulation of COX2 expression by uni-axial cyclic stretch in human lung fibroblast cells.

  1998cited by this paper
• Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch.

  1998cited by this paper
• Geometric control of cell life and death.

  1997cited by this paper
• The regulation of growth and intracellular signaling by integrins.

  1996cited by this paper
• A mechanism for heterogeneous endothelial responses to flow in vivo and in vitro.

  1995cited by this paper
• Extracellular matrix as a solid-state regulator in angiogenesis: identification of new targets for anti-cancer therapy.

  1992cited by this paper
• Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix

  1989cited by this paper
• Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions.

  1989cited by this paper
• Long-term culture of capillary endothelial cells.

  1979cited by this paper
• Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis.

  1977cited by this paper

• Cellular and Molecular Mechanisms of SARS-CoV-2 Spike Protein-Induced Endothelial Dysfunction

  2026cites this paper
• A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration.

  2026cites this paper
• An update on regulation of the polymodal TRPV4 channel by protein phosphorylation

  2026cites this paper
• Thermosensitivity of the Microvasculature: Molecular and physiological mechanisms in skeletal muscle - A narrative review.

  2025cites this paper
• TRPV4 Dominates High Shear-Induced Initial Traction Response and Long-Term Relaxation Over Piezo1

  2025cites this paper
• Transforming destructive mechanical cues into therapeutic power: Activation of PIEZO1 and TRPV4 counteracts mechano-induced damage of cellular junctions in Hailey-Hailey disease.

  2025cites this paper
• Role of Transient Receptor Potential Vanilloid Channels in Gastrointestinal Physiology and Pathology

  2025cites this paper
• Osmotic stress inhibits osteoblast differentiation and mineralization by suppressing TRPV4-mediated calcium influx

  2025cites this paper
• Ca2+ Signaling in Cardiac Fibroblasts: An Emerging Signaling Pathway Driving Fibrotic Remodeling in Cardiac Disorders

  2025cites this paper
• A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration

  2025cites this paper
• Piezo1 mediates calcium ion influx, glucose transporter 4 translocation, and glucose uptake in adipocytes under low-frequency vibration.

  2025cites this paper
• Alveolar epithelial paxillin in postnatal lung alveolar development

  2025cites this paper
• A QUARTER CENTURY OF CALCIUM-PERMEABLE ION CHANNEL, TRPV4: PERSPECTIVES ON EXPRESSION AND FUNCTION IN ENDOTHELIAL CELLS-TIME TO TRANSLATE.

  2025cites this paper
• Biomechanical properties of the trabecular meshwork in intraocular pressure regulation: a review

  2025cites this paper
• TRPV4 in cerebral small vessel disease: A key interacting partner.

  2025cites this paper
• Mechanosensitive apoptosis in Alzheimer’s disease

  2025cites this paper
• TRPV4 Channels Mediate Bladder Cancer Cell Proliferation, Migration and Chemoresistance

  2025cites this paper
• Endothelial cell elongation and alignment in response to shear stress requires acetylation of microtubules

  2024cites this paper
• Impact of TRP Channels on Extracellular Matrix Remodeling: Focus on TRPV4 and Collagen

  2024cites this paper
• A TRP to Pathological Angiogenesis and Vascular Normalization.

  2024cites this paper
• Role of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction

  2024cites this paper
• An Insight on Microfluidic Organ-on-a-Chip Models for PM2.5-Induced Pulmonary Complications

  2024cites this paper
• Increased TRPV4 Channel Expression Enhances and Impairs Blood Vessel Function in Hypertension

  2024cites this paper
• Honokiol targeting ankyrin repeat domain of TRPV4 ameliorates endothelial permeability in mice inflammatory bowel disease induced by DSS.

  2024cites this paper
• Cyclic strain alters the transcriptional and migratory response of scleral fibroblasts to TGFβ.

  2024cites this paper
• Viscoelastic hydrogels regulate adipose-derived mesenchymal stem cells for nucleus pulposus regeneration.

  2024cites this paper
• Targeting the Ca2+ signaling toolkit as an alternative strategy to mitigate SARS-CoV-2-induced cardiovascular adverse events.

  2024cites this paper
• Mechanosensory entities and functionality of endothelial cells

  2024cites this paper
• Tension at the gate: sensing mechanical forces at the blood–brain barrier in health and disease

  2024cites this paper
• Glycocalyx disruption, endothelial dysfunction and vascular remodeling as underlying mechanisms and treatment targets of chronic venous disease.

  2024cites this paper
• Pathological mechanisms of cold and mechanical stress in modulating cancer progression

  2024cites this paper
• Advances in mechanotransduction and sonobiology: effects of audible acoustic waves and low-vibration stimulations on mammalian cells

  2024cites this paper
• Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells

  2024cites this paper
• Mechanosensitive FHL2 tunes endothelial function

  2024cites this paper
• Peptide Lv and Angiogenesis: A Newly Discovered Angiogenic Peptide

  2024cites this paper
• Calcium-activated Potassium Channels as Amplifiers of TRPV4-mediated Pulmonary Edema Formation in Male Mice

  2024cites this paper
• Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications

  2023cites this paper
• Modelling Cell Orientation Under Stretch: The Effect of Substrate Elasticity

  2023cites this paper
• The Cellular Mechanism of Acupuncture for Ulcerative Colitis based on the Communication of Telocytes.

  2023cites this paper
• Vascular Mechanotransduction.

  2023cites this paper
• Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel

  2023cites this paper
• Angiotensin II induces endothelial dysfunction and vascular remodeling by downregulating TRPV4 channels

  2023cites this paper
• TRPV4 regulates β1 integrin‐mediated cell–matrix adhesions and collagen remodeling

  2023cites this paper
• Mechanosensing in Metabolism.

  2023cites this paper
• Mechanical Intercellular Communication via Matrix‐Borne Cell Force Transmission During Vascular Network Formation

  2023cites this paper
• Role of TRPV4 on vascular tone regulation in pathophysiological states.

  2023cites this paper
• Deletion of Endothelial TRPV4 Protects Heart From Pressure Overload–Induced Hypertrophy

  2023cites this paper
• Mechanosensitive Channels in Lung Health and Disease.

  2023cites this paper
• Kindlin-2 controls angiogenesis through modulating Notch1 signaling

  2023cites this paper
• Hydrogel platform facilitating astrocytic differentiation through cell mechanosensing and YAP-mediated transcription

  2023cites this paper
• Hippo pathway in intestinal diseases: focusing on ferroptosis

  2023cites this paper
• In vitro cell stretching devices and their applications: From cardiomyogenic differentiation to tissue engineering

  2023cites this paper
• Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation

  2023cites this paper
• Dynamics of Endothelial Cell Generation and Turnover in Arteries During Homeostasis and Diseases

  2023cites this paper
• Cell orientation under stretch: A review of experimental findings and mathematical modelling.

  2023cites this paper
• 3D Volumetric Mechanosensation of MCF7 Breast Cancer Spheroids in a Linear Stiffness Gradient GelAGE

  2023cites this paper
• Integrin ligands block mechanical signal transduction in baroreceptors

  2022cites this paper
• Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions

  2022cites this paper
• Biological role of matrix stiffness in tumor growth and treatment

  2022cites this paper
• Systems Biology Analysis of Temporal Dynamics That Govern Endothelial Response to Cyclic Stretch

  2022cites this paper
• Function and regulation of thermosensitive ion channel TRPV4 in the immune system.

  2022cites this paper
• Advanced Microfluidic Vascularized Tissues as Platform for the Study of Human Diseases and Drug Development

  2022cites this paper
• New Insights into TRP Ion Channels in Stem Cells

  2022cites this paper
• Pulsatile parallel flow of air and a viscoelastic fluid with multiple characteristic times. An application to mucus in the trachea and the frequency of cough

  2022cites this paper
• Mechanical regulation of signal transduction in angiogenesis

  2022cites this paper
• Calcium influx through TRPV4 channels involve in hyperosmotic stress-induced epithelial-mesenchymal transition in tubular epithelial cells.

  2022cites this paper
• Hydrogel cultures reveal Transient Receptor Potential Vanilloid 4 regulation of myofibroblast activation and proliferation in valvular interstitial cells

  2022cites this paper
• TRPV4: A trigger of pathological RhoA activation in neurological disease

  2022cites this paper
• Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration

  2022cites this paper
• TRPV4-dependent signaling mechanisms in systemic and pulmonary vasculature.

  2022cites this paper
• The Role of Systemic Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction

  2022cites this paper
• Expression of CD98hc in Pancreatic Cancer and Its Role in Cancer Cell Behavior

  2022influential citation
• WNK1–OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy

  2022cites this paper
• A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts

  2021cites this paper
• ENDOTHELIAL CONTROL OF CEREBRAL BLOOD FLOW.

  2021cites this paper
• Cellular and molecular pathways controlling muscle size in response to exercise

  2021cites this paper
• Vascularisation of pluripotent stem cell–derived myocardium: biomechanical insights for physiological relevance in cardiac tissue engineering

  2021cites this paper
• Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity

  2021cites this paper
• Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation

  2021cites this paper
• Endothelial β1 Integrin-Mediated Adaptation to Myocardial Ischemia

  2021cites this paper
• Spatiotemporal and functional characterisation of transient receptor potential vanilloid 4 (TRPV4) in the murine intervertebral disc.

  2021cites this paper
• TRPV4 Mechanotransduction in Fibrosis

  2021cites this paper
• Towards Novel Geneless Approaches for Therapeutic Angiogenesis

  2021cites this paper
• Mechanical loading and the control of stem cell behavior.

  2021cites this paper
• Low-intensity pulsed ultrasound promotes angiogenesis via the AKT pathway and DNA methylation in human umbilical vein endothelial cells.

  2021cites this paper
• The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors

  2021cites this paper
• The Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease

  2021cites this paper
• Mechanisms of Lower Extremity Vein Dysfunction in Chronic Venous Disease and Implications in Management of Varicose Veins.

  2021cites this paper
• Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

  2021cites this paper
• TRPV Protein Family—From Mechanosensing to Cancer Invasion

  2021cites this paper
• Blocking endothelial TRPV4-Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice.

  2021cites this paper
• Role of TRPV4 channel in vasodilation and neovascularization

  2021cites this paper
• Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes

  2021cites this paper
• Role of Transient Receptor Potential Vanilloid 4 in Vascular Function

  2021cites this paper
• Recent Advances in Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Promoted by Mechanical Stretch

  2021cites this paper
• Vascular Normalization: A New Window Opened for Cancer Therapies

  2021cites this paper
• Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability

  2021cites this paper
• CFTR limits F‐actin formation and promotes morphological alignment with flow in human lung microvascular endothelial cells

  2021cites this paper
• Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread

  2021cites this paper
• Tubeimoside I Antagonizes Yoda1-Evoked Piezo1 Channel Activation

  2020cites this paper