Orexins activate histaminergic neurons via the orexin 2 receptor.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2002-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1006/BBRC.2001.6318PMID 11811995
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of H1- and H2-histamine receptor agonists and antagonists on sleep and wakefulness in the rat

  2005cited by this paper
• To eat or to sleep? Orexin in the regulation of feeding and wakefulness.

  2001cited by this paper
• Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.

  2001cited by this paper
• Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation

  2001cited by this paper
• Differential expression of orexin receptors 1 and 2 in the rat brain

  2001cited by this paper
• Arousal effect of orexin A depends on activation of the histaminergic system

  2001cited by this paper
• Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

  2001cited by this paper
• A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

  2000cited by this paper
• Hypocretin (orexin) deficiency in human narcolepsy.

  2000cited by this paper
• Reduced Number of Hypocretin Clinical Study Neurons in Human Narcolepsy

  2000cited by this paper
• Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system 1 1 Published

  2000cited by this paper
• Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system.

  2000cited by this paper
• L-Histidine decarboxylase protein and activity in rat brain microvascular endothelial cells

  2000cited by this paper
• Distribution of orexin neurons in the adult rat brain.

  1999cited by this paper
• Distribution of orexin neurons in the adult rat brain.

  1999cited by this paper
• Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

  1999cited by this paper
• Orexins/hypocretins regulate drinking behaviour.

  1999cited by this paper
• Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.

  1999cited by this paper
• The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.

  1999cited by this paper
• Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

  1998cited by this paper
• Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

  1998cited by this paper
• The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

  1998cited by this paper
• Neurogenesis and Commitment of Corticospinal Neurons inreeler

  1998cited by this paper
• Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

  1998cited by this paper
• Oxidized glutathione regulates physiological sleep in unrestrained rats.

  1994cited by this paper
• Involvement of histamine in the control of the waking state.

  1993cited by this paper
• Effects of locus coeruleus lesions on vigilance and attentive behaviour in cat.

  1993cited by this paper
• Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems

  1993cited by this paper
• The Diencephalon and Sleep

  1990cited by this paper
• Excitatory effect of histamine on EEGs of the cortex and thalamus in rats

  1989cited by this paper
• Membrane properties of histaminergic tuberomammillary neurones of the rat hypothalamus in vitro.

  1988cited by this paper
• Origins of histamine-containing fibers in the cerebral cortex of rats studied by immunohistochemistry with histidine decarboxylase as a marker and transection.

  1984cited by this paper
• Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker.

  1984cited by this paper
• Histamine-containing neurons in the rat hypothalamus.

  1984cited by this paper
• Amine pathways and sleep regulation.

  1982cited by this paper
• Histamine: a stimulatory effect on drinking behavior in the rat.

  1973cited by this paper
• Studies on the possible role of brain histamine in behaviour

  1972cited by this paper

• Samelisant (SUVN-G3031), a histamine H3 receptor inverse agonist, as a potential treatment for narcolepsy: a phase-2 Drug evaluation.

  2026cites this paper
• Syntheses and preclinical evaluations of 11C-labeled radioligands for imaging brain orexin-1 and orexin-2 receptors with positron emission tomography.

  2025cites this paper
• An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions.

  2025cites this paper
• Preclinical pharmacological profiles of vornorexant, a novel potent dual orexin receptor antagonist.

  2025cites this paper
• Orexin increases the neuronal excitability of several brain areas associated with maintaining of arousal

  2024cites this paper
• Modafinil, an atypical CNS stimulant?

  2024cites this paper
• The mechanism of different orexin/hypocretin neuronal projections in wakefulness and sleep.

  2024cites this paper
• Abnormal hypothalamic functional connectivity and serum arousal-promoting neurotransmitters in insomnia disorder patients: a pilot study

  2024cites this paper
• Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control

  2023cites this paper
• Orexin and MCH neurons: regulators of sleep and metabolism

  2023cites this paper
• New pharmaceuticals in the treatment of insomnia

  2023cites this paper
• Effect of Kisspeptin-Type Neuropeptide on Locomotor Behavior and Muscle Physiology in the Sea Cucumber Apostichopus japonicus

  2023cites this paper
• The 5-Hydroxytryptaminergic Neurons in the Dorsal Raphe Nucleus and Different 5-HT Receptors are Implicated in Mediating the Awakening from Sevoflurane Anesthesia

  2022cites this paper
• The pathophysiology of major depressive disorder through the lens of systems biology: Network analysis of the psycho-immune-neuroendocrine physiome.

  2022cites this paper
• Daridorexant for the Treatment of Insomnia.

  2022cites this paper
• A molecular network map of orexin-orexin receptor signaling system

  2022cites this paper
• Sleep-mediated regulation of reward circuits: implications in substance use disorders

  2022cites this paper
• Orexin enhances neuronal synchronization in adult rat hypothalamic culture: A model to study hypothalamic function.

  2022cites this paper
• A study on the effect of JNJ-10397049 on proliferation and differentiation of neural precursor cells

  2022cites this paper
• Orexin action on the dopaminergic system modulates theta during REM sleep and wakefulness

  2022cites this paper
• Daridorexant: A New Dual Orexin Receptor Antagonist for Insomnia

  2022cites this paper
• Headache and Sleep

  2021cites this paper
• Interaction between Orexin Neurons and Monoaminergic Systems.

  2021cites this paper
• A deep learning algorithm for sleep stage scoring in mice based on a multimodal network with fine-tuning technique.

  2021cites this paper
• [Effects of Histamine and Related Compounds on the Central Nervous System].

  2021cites this paper
• Brain Circuits Underlying Narcolepsy

  2021cites this paper
• The 3-iodothyronamine (T1AM) and the 3-iodothyroacetic acid (TA1) indicate a novel connection with the histamine system for neuroprotection.

  2021cites this paper
• Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia

  2021cites this paper
• Differential Effects of the Lateral Hypothalamus Lesion as an Origin of Orexin and Blockade of Orexin-1 Receptor in the Orbitofrontal Cortex and Anterior Cingulate Cortex on Their Neuronal Activity

  2021cites this paper
• Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states

  2020cites this paper
• Involvement of the tuberomammillary nucleus of the hypothalamus in the modulation of nociception and joint edema in a model of monoarthritis.

  2020cites this paper
• Pitolisant to Treat Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy: Rationale and Clinical Utility

  2020cites this paper
• The orexin (hypocretin) neuropeptide system is a target for novel therapeutics to treat cocaine use disorder with alcohol co-abuse.

  2020cites this paper
• Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.

  2020cites this paper
• NSS_A_264140 709..719

  2020cites this paper
• Orexin and Psychoneurobiology: A Hidden Treasure

  2020cites this paper
• Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review

  2020cites this paper
• Histaminergic neurons in the tuberomammillary nucleus as a control centre for wakefulness

  2020cites this paper
• Circuit mechanisms and computational models of REM sleep

  2019cites this paper
• Neurophysiology and Treatment of Disorders of Consciousness Induced by Traumatic Brain Injury: Orexin Signaling as a Potential Therapeutic Target.

  2019cites this paper
• Serotonergic Systems in Sleep and Waking

  2019cites this paper
• Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy

  2019cites this paper
• Hypocretins (Orexins): Twenty Years of Dissecting Arousal Circuits

  2019cites this paper
• Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

  2019cites this paper
• University of Manchester

  2019cites this paper
• Behavioral / Systems / Cognitive Neuronal Activity of Histaminergic Tuberomammillary Neurons During Wake – Sleep States in the Mouse

  2018cites this paper
• 2 Orexin and Orexin Receptors

  2018cites this paper
• Targeted Orexin and Hypothalamic Neuropeptides for Migraine

  2018cites this paper
• Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy

  2018cites this paper
• Synaptic and Intrinsic Plasticity in Lateral Hypothalamic Sleep/Wake Regulatory Neurons Following Acute Sleep Deprivation: Implications for Sleep Homeostasis

  2018cites this paper
• Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of “Chronoconnectivity”

  2018cites this paper
• THE ROLE OF HYPOCRETIN IN POST-TRAUMATIC BRAIN INJURY SLEEP-WAKE DISTURBANCE

  2018cites this paper
• Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats

  2018cites this paper
• Melatonin promotes sleep in mice by inhibiting orexin neurons in the perifornical lateral hypothalamus

  2018cites this paper
• A comparison of the orexin receptor distribution in the brain between diurnal Nile grass rats (Arvicanthis niloticus) and nocturnal mice (Mus musculus).

  2018cites this paper
• The roles of orexins in sleep/wake regulation.

  2017influential citation
• The roles of histamine and its receptor ligands in central nervous system disorders: An update

  2017cites this paper
• Partial Sleep Deprivation Reduces the Efficacy of Orexin‐A to Stimulate Physical Activity and Energy Expenditure

  2017cites this paper
• Role of orexin-A in the ventrolateral preoptic area on components of total energy expenditure

  2017cites this paper
• Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep

  2017influential citation
• Optogenetic Investigation of Arousal Circuits

  2017cites this paper
• Running title : Orexin ( Hypocretin ) Receptor Agonists and Antagonists for Treatment of Sleep Disorders Orexin ( Hypocretin ) Receptor Agonists and Antagonists for Treatment of Sleep Disorders Rationale for Development and Current Status

  2017cites this paper
• Posterior hypothalamus glutamate infusion decreases pentylenetetrazol‐induced seizures of male rats through hippocampal histamine increase

  2017cites this paper
• Regulation of angiotensin II type receptor by its messenger RNA-binding proteins

  2016cites this paper
• Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response

  2016influential citation
• Interaction of tau proteins and orexin receptors in dementia and allied syndromes

  2016cites this paper
• Orexin (Hypocretin) and Narcolepsy

  2016cites this paper
• Circadian and histaminergic regulation of the sleep-wakefulness cycle

  2016cites this paper
• The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems

  2016cites this paper
• Progressive Loss of the Orexin Neurons Reveals Dual Effects on Wakefulness.

  2016cites this paper
• Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs

  2016cites this paper
• Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain.

  2016cites this paper
• Histamine elimination from the cerebrospinal fluid across the blood–cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4)

  2016cites this paper
• Brain Orexin Receptors and Nicotine

  2016cites this paper
• The Neurobiology of Sleep and Wakefulness.

  2015cites this paper
• Interactions of the orexin/hypocretin neurones and the histaminergic system

  2015cites this paper
• Comprehensive Behavioral Analysis of Male Ox1r−/− Mice Showed Implication of Orexin Receptor-1 in Mood, Anxiety, and Social Behavior

  2015cites this paper
• Pharmacogenetic Dissection of Neural Mechanisms Underlying the Regulation of Sleep–Wakefulness Using DREADDs

  2015influential citation
• History of Orexin Research

  2015cites this paper
• Narcolepsie chez l'enfant : caractéristiques cliniques et approches thérapeutiques

  2015cites this paper
• Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists

  2015cites this paper
• Interactions of the histamine and hypocretin systems in CNS disorders

  2015cites this paper
• Physiological Roles of Orexin Receptors on Sleep/Wakefulness Regulation

  2015influential citation
• Elucidation of Neuronal Circuitry Involved in the Regulation of Sleep/Wakefulness Using Optogenetics

  2015cites this paper
• Orexinergic theta rhythm in the rat hippocampal formation: In vitro and in vivo findings

  2015cites this paper
• Role of adenosine and the orexinergic perifornical hypothalamus in sleep-promoting effects of ethanol.

  2014cites this paper
• A unifying computational framework for stability and flexibility of arousal

  2014cites this paper
• Orexin modulation of adipose tissue.

  2014cites this paper
• Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.

  2014cites this paper
• The role of orexin neurons in the regulation of sleep and wakefulness

  2014cites this paper
• Coreleased Orexin and Glutamate Evoke Nonredundant Spike Outputs and Computations in Histamine Neurons

  2014cites this paper
• Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function

  2014cites this paper
• Role of cardiorespiratory synchronization and sleep physiology: effects on membrane potential in the restorative functions of sleep.

  2014cites this paper
• Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance

  2014cites this paper
• Catestatin and orexin-A neuronal signals alter feeding habits in relation to hibernating states.

  2014cites this paper
• Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT‐462206: a Potent, Brain‐Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist

  2014cites this paper
• Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice

  2014cites this paper
• [Role of orexin-A-mediated communication system between brain and peripheral tissues on the development of post-ischemic glucose intolerance-induced neuronal damage].

  2014cites this paper
• Headache and sleep: Shared pathophysiological mechanisms

  2014cites this paper
• Molecular Determinants of Orexin Receptor Ligand Interaction : Studies on Ligand Selectivity and Impact of Calcium

  2014cites this paper