Specific recognition of the HIV-1 genomic RNA by the Gag precursor

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Nature Communications

• Publication date

  2014-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncomms5304PMID 24986025
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression and purification of soluble recombinant full length HIV-1 Pr55(Gag) protein in Escherichia coli.

  2014cited by this paper
• A cis-acting element in retroviral genomic RNA links Gag-Pol ribosomal frameshifting to selective viral RNA encapsidation.

  2013cited by this paper
• Cytoplasmic Utilization of Human Immunodeficiency Virus Type 1 Genomic RNA Is Not Dependent on a Nuclear Interaction with Gag

  2012cited by this paper
• Rfam 11.0: 10 years of RNA families

  2012cited by this paper
• A proposal for a new HIV-1 DLS structural model

  2012cited by this paper
• Comparative structural effects of HIV-1 Gag and nucleocapsid proteins in binding to and unwinding of the viral RNA packaging signal.

  2012cited by this paper
• Structural determinants and mechanism of HIV-1 genome packaging.

  2011cited by this paper
• Role of HIV-1 RNA and protein determinants for the selective packaging of spliced and unspliced viral RNA and host U6 and 7SL RNA in virus particles

  2011cited by this paper
• Diverse interactions of retroviral Gag proteins with RNAs.

  2011cited by this paper
• NMR Detection of Structures in the HIV-1 5′-Leader RNA That Regulate Genome Packaging

  2011cited by this paper
• Flexible nature and specific functions of the HIV-1 nucleocapsid protein.

  2011cited by this paper
• Analysis of the Initiating Events in HIV-1 Particle Assembly and Genome Packaging

  2010cited by this paper
• Dynamics of HIV-1 Assembly and Release

  2009cited by this paper
• Probing the HIV-1 Genomic RNA Trafficking Pathway and Dimerization by Genetic Recombination and Single Virion Analyses

  2009cited by this paper
• High-Throughput SHAPE Analysis Reveals Structures in HIV-1 Genomic RNA Strongly Conserved across Distinct Biological States

  2008cited by this paper
• Imaging the biogenesis of individual HIV-1 virions in live cells

  2008cited by this paper
• ShapeFinder: a software system for high-throughput quantitative analysis of nucleic acid reactivity information resolved by capillary electrophoresis.

  2008cited by this paper
• HIV controls the selective packaging of genomic, spliced viral and cellular RNAs into virions through different mechanisms

  2007cited by this paper
• Rev Proteins of Human and Simian Immunodeficiency Virus Enhance RNA Encapsidation

  2007cited by this paper
• In vitro dimerization of human immunodeficiency virus type 1 (HIV-1) spliced RNAs.

  2007cited by this paper
• The T12I mutation within the SP1 region of Gag restricts packaging of spliced viral RNA into human immunodeficiency virus type 1 with mutated RNA packaging signals and mutated nucleocapsid sequence.

  2006cited by this paper
• Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanism.

  2005cited by this paper
• HIV‐1 Gag–RNA Interaction Occurs at a Perinuclear/Centrosomal Site; Analysis by Confocal Microscopy and FRET

  2005cited by this paper
• How retroviruses select their genomes

  2005cited by this paper
• The R362A mutation at the C-terminus of CA inhibits packaging of human immunodeficiency virus type 1 RNA.

  2005cited by this paper
• Structural Variability of the Initiation Complex of HIV-1 Reverse Transcription*

  2004cited by this paper
• Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?

  2004cited by this paper
• Dimerization of retroviral RNA genomes: an inseparable pair

  2004cited by this paper
• A Novel Long Distance Base-pairing Interaction in Human Immunodeficiency Virus Type 1 RNA Occludes the Gag Start Codon*

  2003cited by this paper
• Effects of a Single Amino Acid Substitution within thep2 Region of Human Immunodeficiency Virus Type 1 on Packagingof Spliced ViralRNA

  2003cited by this paper
• Tools for the automatic identification and classification of RNA base pairs

  2003cited by this paper
• Sequences Downstream of the 5′ Splice Donor Site Are Required for both Packaging and Dimerization of Human Immunodeficiency Virus Type 1 RNA

  2003cited by this paper
• RNA Incorporation Is Critical for Retroviral Particle Integrity after Cell Membrane Assembly of Gag Complexes

  2002cited by this paper
• Deficient dimerization of human immunodeficiency virus type 1 RNA caused by mutations of the u5 RNA sequences.

  2002cited by this paper
• In Vitro Evidence for a Long Range Pseudoknot in the 5′-Untranslated and Matrix Coding Regions of HIV-1 Genomic RNA*

  2002cited by this paper
• RNA Structure and Packaging Signals in the 5′ Leader Region of the Human Immunodeficiency Virus Type 1 Genome

  2002cited by this paper
• Role of Stem B, Loop B, and Nucleotides next to the Primer Binding Site and the Kissing-Loop Domain in Human Immunodeficiency Virus Type 1 Replication and Genomic-RNA Dimerization

  2001cited by this paper
• The Protein Data Bank

  2000cited by this paper
• NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition.

  2000cited by this paper
• Human Immunodeficiency Virus Type 1 Virion Density Is Not Determined by Nucleocapsid Basic Residues

  2000cited by this paper
• An Intact TAR Element and Cytoplasmic Localization Are Necessary for Efficient Packaging of Human Immunodeficiency Virus Type 1 Genomic RNA

  1999cited by this paper
• Functional Analysis of the Core Human Immunodeficiency Virus Type 1 Packaging Signal in a Permissive Cell Line

  1998cited by this paper
• Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element.

  1998cited by this paper
• Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging

  1998cited by this paper
• Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions.

  1998cited by this paper
• Nonreciprocal Packaging of Human Immunodeficiency Virus Type 1 and Type 2 RNA: a Possible Role for the p2 Domain of Gag in RNA Encapsidation

  1998cited by this paper
• Effects of nucleocapsid mutations on human immunodeficiency virus assembly and RNA encapsidation

  1997cited by this paper
• Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation

  1997cited by this paper
• A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis

  1996cited by this paper
• Dimerization of retroviral genomic RNAs: structural and functional implications.

  1996cited by this paper
• A loop-loop "kissing" complex is the essential part of the dimer linkage of genomic HIV-1 RNA.

  1996cited by this paper
• Structure and function of the human immunodeficiency virus leader RNA.

  1996cited by this paper
• Role of the DIS hairpin in replication of human immunodeficiency virus type 1

  1996cited by this paper
• Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA

  1994cited by this paper
• Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA.

  1994cited by this paper
• Functional sites in the 5' region of human immunodeficiency virus type 1 RNA form defined structural domains.

  1993cited by this paper
• Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus

  1990cited by this paper
• A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphology

  1990cited by this paper
• Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA

  1990cited by this paper
• Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions

  1989cited by this paper
• Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a "zinc finger-like" protein sequence.

  1988cited by this paper
• Structural Bioinformatics

  year unknowncited by this paper
• Electronic Reprint Biological Crystallography the Protein Data Bank Biological Crystallography the Protein Data Bank

  year unknowncited by this paper

• GABARAP proteins regulate the packaging of HIV-1 genomic RNA into virions

  2025cites this paper
• Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication

  2025cites this paper
• Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging

  2025cites this paper
• Efficient packaging of HIV-1 genomes via recognition of its adenosine-rich content by a heterologous RNA-binding domain

  2025cites this paper
• Isoform-specific RNA structure determination using Nano-DMS-MaP

  2024cites this paper
• HIV-1 RNA genome packaging: it’s G-rated

  2024cites this paper
• MMTV RNA packaging requires an extended long-range interaction for productive Gag binding to packaging signals

  2024cites this paper
• Transcription start site choice regulates HIV-1 RNA conformation and function.

  2024cites this paper
• HIV-1 Gag Compact Form stabilized by Intramolecular Interactions is crucial for Infectious Particle Production.

  2024cites this paper
• Expression, purification, and functional characterization of soluble recombinant full-length simian immunodeficiency virus (SIV) Pr55Gag

  2023influential citation
• Long way up: rethink diseases in light of phase separation and phase transition

  2023cites this paper
• Identification of a putative Gag binding site critical for feline immunodeficiency virus genomic RNA packaging

  2023cites this paper
• Structural diversity of the region encompassing DIS, SD and Psi hairpins in HIV and SIV genomes

  2023cites this paper
• Nano-DMS-MaP allows isoform-specific RNA structure determination

  2023cites this paper
• Plasma-Derived HIV-1 Virions Contain Considerable Levels of Defective Genomes

  2022cites this paper
• Specific Interaction of DARPin with HIV-1 CANTD Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane

  2022cites this paper
• Upstream of N-Ras (Unr/CSDE1) Interacts with NCp7 and Gag, Modulating HIV-1 IRES-Mediated Translation Initiation

  2022cites this paper
• Genome Sequence Analysis Suggests Coevolution of the DIS, SD, and Psi hairpins in HIV-1 genomes.

  2022cites this paper
• Advances in HIV-1 Assembly

  2022cites this paper
• Distinct Gag interaction properties of HIV-1 RNA 5′ leader conformers reveal a mechanism for dimeric genome selection

  2022cites this paper
• Understanding Retroviral Life Cycle and its Genomic RNA Packaging.

  2022cites this paper
• Structural maturation of the HIV-1 RNA 5’ untranslated region by Pr55Gag and its maturation products

  2022cites this paper
• Visualization of Retroviral Gag-Genomic RNA Cellular Interactions Leading to Genome Encapsidation and Viral Assembly: An Overview

  2022cites this paper
• Human Retrovirus Genomic RNA Packaging

  2022cites this paper
• Epitranscriptomic regulation of HIV-1 full-length RNA packaging

  2022cites this paper
• RNA Structures and Their Role in Selective Genome Packaging

  2021cites this paper
• A Stretch of Unpaired Purines in the Leader Region of Simian Immunodeficiency Virus (SIV) Genomic RNA is Critical for its Packaging into Virions.

  2021cites this paper
• The Zinc Content of HIV-1 NCp7 Affects Its Selectivity for Packaging Signal and Affinity for Stem-Loop 3

  2021cites this paper
• HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio

  2021cites this paper
• The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation

  2021cites this paper
• HIV-1 Packaging Visualised by In-Gel SHAPE

  2021cites this paper
• Selective packaging of HIV-1 RNA genome is guided by the stability of 5′ untranslated region polyA stem

  2021cites this paper
• Short- and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging

  2021cites this paper
• Quantitative analysis of the formation of nucleoprotein complexes between HIV-1 Gag protein and genomic RNA using transmission electron microscopy

  2021cites this paper
• Identification of Pr78Gag binding sites on the Mason-Pfizer monkey virus genomic RNA packaging determinants.

  2021influential citation
• Post-Translational Modifications of Retroviral HIV-1 Gag Precursors: An Overview of Their Biological Role

  2021cites this paper
• A purine loop and the primer binding site are critical for the selective encapsidation of mouse mammary tumor virus genomic RNA by Pr77Gag

  2021influential citation
• RNA Binding Properties of the Ty1 LTR-Retrotransposon Gag Protein

  2021influential citation
• Importance of Viral Late Domains in Budding and Release of Enveloped RNA Viruses

  2021cites this paper
• The two zinc fingers in the nucleocapsid domain of the HIV-1 Gag precursor are equivalent for the interaction with the genomic RNA in the cytoplasm, but not for the recruitment of the complexes at the plasma membrane

  2020cites this paper
• Thermal stressed human immunodeficiency virus type 1 nucleocapsid protein NCp7 maintains nucleic acid-binding activity.

  2020cites this paper
• HIV-1 Gag protein with or without p6 specifically dimerizes on the viral RNA packaging signal

  2020cites this paper
• Zinc Fingers in HIV-1 Gag Precursor Are Not Equivalent for gRNA Recruitment at the Plasma Membrane.

  2020cites this paper
• Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal

  2020cites this paper
• Unpaired Guanosines in the 5′ Untranslated Region of HIV-1 RNA Act Synergistically To Mediate Genome Packaging

  2020cites this paper
• How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain

  2020cites this paper
• Comparison of HIV-1 Gag and NCp7 in their selectivity for package signal, affinity for stem-loop 3, and Zn2+ content.

  2020cites this paper
• Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

  2020cites this paper
• Role of Purine-Rich Regions in Mason-Pfizer Monkey Virus (MPMV) Genomic RNA Packaging and Propagation

  2020cites this paper
• Specific Guanosines in the HIV-2 Leader RNA Are Essential for Efficient Viral GenomePackaging.

  2020cites this paper
• Dynamic Light Scattering Analysis on RNA Associated to Proteins.

  2020cites this paper
• An epitranscriptomic switch at the 5′-UTR controls genome selection during HIV-1 genomic RNA packaging

  2019cites this paper
• Purification and Functional Characterization of a Biologically Active Full-Length Feline Immunodeficiency Virus (FIV) Pr50Gag

  2019cites this paper
• Retroviral-like determinants and functions required for dimerization of Ty1 retrotransposon RNA

  2019cites this paper
• Packaging of Genomic RNA in Positive-Sense Single-Stranded RNA Viruses: A Complex Story

  2019cites this paper
• The HIV-1 ribonucleoprotein dynamically regulates its condensate behavior and drives acceleration of protease activity through membraneless granular phase separation

  2019cites this paper
• Structural Explorations of NCp7-Nucleic Acid Complexes Give Keys to Decipher the Binding Process.

  2019cites this paper
• Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels

  2019cites this paper
• Retroviral Gag protein-RNA interactions: Implications for specific genomic RNA packaging and virion assembly.

  2019cites this paper
• Investigating the role of stem-loop 1 in the assembly process of HIV-1

  2019cites this paper
• Expression, purification, and characterization of biologically active full-length Mason-Pfizer monkey virus (MPMV) Pr78Gag

  2018cites this paper
• The bifurcated stem loop 4 (SL4) is crucial for efficient packaging of mouse mammary tumor virus (MMTV) genomic RNA

  2018cites this paper
• Biochemical and Functional Characterization of Mouse Mammary Tumor Virus Full-Length Pr77Gag Expressed in Prokaryotic and Eukaryotic Cells

  2018cites this paper
• N6-methyladenosine binding proteins negatively regulate HIV-1 infectivity and viral production

  2018cites this paper
• Regulatory Elements in the HIV-1 5'UTR that Modulate Gag Binding Specificity

  2018cites this paper
• New windows into retroviral RNA structures

  2018cites this paper
• Caractérisation et ciblage de la reconnaissance dynamique de Trp37-G lors de l’interaction de la protéine NCp7 de HIV-1 avec des acides nucléiques

  2018cites this paper
• The roles of five conserved lentiviral RNA structures in HIV-1 replication.

  2018cites this paper
• Retroviral RNA Dimerization: From Structure to Functions

  2018cites this paper
• An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

  2018cites this paper
• In cell mutational interference mapping experiment (in cell MIME) identifies the 5′ polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging

  2018cites this paper
• Regulatory Elements in the HIV-1 5‘UTR that Modulate Gag Binding Specificity

  2018influential citation
• The C-terminal p6 domain of the HIV-1 Pr55Gag precursor is required for specific binding to the genomic RNA

  2018cites this paper
• N6-Methyladenosine–binding proteins suppress HIV-1 infectivity and viral production

  2018cites this paper
• Multiple, Switchable Protein:RNA Interactions Regulate Human Immunodeficiency Virus Type 1 Assembly.

  2018cites this paper
• Efficient support of virus-like particle assembly by the HIV-1 packaging signal

  2018cites this paper
• HIV-1 Pr55Gag binds genomic and spliced RNAs with different affinity and stoichiometry

  2017influential citation
• A review on architecture of the gag-pol ribosomal frameshifting RNA in human immunodeficiency virus: a variability survey of virus genotypes

  2017influential citation
• Inhibition of HIV-1 Gag–membrane interactions by specific RNAs

  2017cites this paper
• Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA

  2017cites this paper
• The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV

  2017cites this paper
• HIV-1 Sequence Necessary and Sufficient to Package Non-viral RNAs into HIV-1 Particles.

  2017cites this paper
• Exosomes from uninfected cells activate transcription of latent HIV-1

  2017cites this paper
• Immature HIV-1 lattice assembly dynamics are regulated by scaffolding from nucleic acid and the plasma membrane

  2017cites this paper
• HIV-1 Gag Binding Specificity for Psi: Implications for Virus Assembly THESIS

  2017influential citation
• Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling

  2016cites this paper
• The Life-Cycle of the HIV-1 Gag–RNA Complex

  2016influential citation
• On the Selective Packaging of Genomic RNA by HIV-1

  2016influential citation
• Cross- and Co-Packaging of Retroviral RNAs and Their Consequences

  2016influential citation
• Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies

  2016cites this paper
• Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag

  2016cites this paper
• Requirements for nucleocapsid-mediated regulation of reverse transcription during the late steps of HIV-1 assembly

  2016cites this paper
• Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1

  2016influential citation
• HIV-1 Pr 55 Gag binding to viral RNAs HIV-1 Pr 55 Gag binds genomic and spliced RNAs with different affinity and stoichiometry

  2016influential citation
• Comprendre la flexibilité génétique de la protéine d’enveloppe de VIH-1 à travers l’étude du réseau de coévolution de ses acides aminés

  2016influential citation
• Relations structure-fonction du premier transfert de brin chez le vih-1

  2016influential citation
• Controllable synthesis of conjugated thio-phenylethyne-based compounds with different chain lengths

  2016cites this paper
• Recherche de signaux d'empaquetage spécifiques du génome des virus influenza A

  2016cites this paper
• Packaging of Mason-Pfizer monkey virus (MPMV) genomic RNA depends upon conserved long-range interactions (LRIs) between U5 and gag sequences

  2016cites this paper
• SL1 revisited: functional analysis of the structure and conformation of HIV-1 genome RNA

  2016cites this paper