Integration of biochemical signalling in spines

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Nature Reviews Neuroscience

• Publication date

  2005-06-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1038/nrn1685PMID 15928715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ca(2+) signaling in dendritic spines.

  2007cited by this paper
• Modulation of NMDA Receptor-Dependent Calcium Influx and Gene Expression Through EphB Receptors

  2005cited by this paper
• The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines.

  2005cited by this paper
• Physiological functions for brain NF-κB

  2005cited by this paper
• Theta Stimulation Polymerizes Actin in Dendritic Spines of Hippocampus

  2005cited by this paper
• Spine architecture and synaptic plasticity.

  2005cited by this paper
• Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein

  2005cited by this paper
• Physiological functions for brain NF-kappaB.

  2005cited by this paper
• A role for synGAP in regulating neuronal apoptosis

  2005cited by this paper
• NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD.

  2005cited by this paper
• Computational approaches for modeling regulatory cellular networks.

  2004cited by this paper
• PDZ domain proteins of synapses

  2004cited by this paper
• Induction of neuronal death by ER stress in Alzheimer's disease.

  2004cited by this paper
• Biochemical mechanisms for translational regulation in synaptic plasticity

  2004cited by this paper
• Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry*

  2004cited by this paper
• Rap1-induced p38 Mitogen-activated Protein Kinase Activation Facilitates AMPA Receptor Trafficking via the GDI·Rab5 Complex

  2004cited by this paper
• Involvement of ASK1 in Ca2+‐induced p38 MAP kinase activation

  2004cited by this paper
• Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca2+/Calmodulin-dependent Protein Kinase II*

  2004cited by this paper
• Spike timing-dependent plasticity of neural circuits.

  2004cited by this paper
• Src kinases: a hub for NMDA receptor regulation

  2004cited by this paper
• Spike Timing-Dependent Plasticity of Neural Circuits

  2004cited by this paper
• SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.

  2004cited by this paper
• Human RAS Superfamily Proteins and Related GTPases

  2004cited by this paper
• SynGAP Regulates Spine Formation

  2004cited by this paper
• Developmentally regulated role for Ras‐GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB

  2004cited by this paper
• Why calcium-stimulated adenylyl cyclases?

  2004cited by this paper
• The Role of Synaptic GTPase-Activating Protein in Neuronal Development and Synaptic Plasticity

  2003cited by this paper
• Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory.

  2003cited by this paper
• Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus

  2003cited by this paper
• Coupling of neuronal 5‐HT7 receptors to activation of extracellular‐regulated kinase through a protein kinase A‐independent pathway that can utilize Epac

  2003cited by this paper
• Does Rap1 deserve a bad Rap?

  2003cited by this paper
• Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD

  2003cited by this paper
• Independent Sources of Quantal Variability at Single Glutamatergic Synapses

  2003cited by this paper
• Introduction. Long-term potentiation and structure of the issue.

  2003cited by this paper
• Compartmentalized Synthesis and Degradation of Proteins in Neurons

  2003cited by this paper
• Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo.

  2003cited by this paper
• A journey from neocortex to hippocampus.

  2003cited by this paper
• The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.

  2003cited by this paper
• Trk receptors: roles in neuronal signal transduction.

  2003cited by this paper
• Biology of the p21-activated kinases.

  2003cited by this paper
• Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein Kinase

  2003cited by this paper
• Structural changes at dendritic spine synapses during long-term potentiation.

  2003cited by this paper
• Kalirin, a Multifunctional Rho Guanine Nucleotide Exchange Factor, Is Necessary for Maintenance of Hippocampal Pyramidal Neuron Dendrites and Dendritic Spines

  2003cited by this paper
• Fas Ligand-Mediated Apoptosis in Degenerative Disorders of the Brain

  2003cited by this paper
• Compartmentalized synthesis and degradation of proteins in neurons.

  2003cited by this paper
• Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin.

  2003cited by this paper
• Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.

  2003cited by this paper
• Rho proteins, mental retardation and the cellular basis of cognition.

  2002cited by this paper
• Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.

  2002cited by this paper
• AMPA receptor trafficking and synaptic plasticity.

  2002cited by this paper
• Spike timing, calcium signals and synaptic plasticity.

  2002cited by this paper
• SynGAP Regulates ERK/MAPK Signaling, Synaptic Plasticity, and Learning in the Complex with Postsynaptic Density 95 and NMDA Receptor

  2002cited by this paper
• Modeling Signaling Networks

  2002cited by this paper
• Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

  2002cited by this paper
• Synaptic tagging — who's it?

  2002cited by this paper
• Ras and relatives--job sharing and networking keep an old family together.

  2002cited by this paper
• Alzheimer's Disease Is a Synaptic Failure

  2002cited by this paper
• Calmodulin is a limiting factor in the cell.

  2002cited by this paper
• Regulation of transcription factors by neuronal activity

  2002cited by this paper
• Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons

  2002cited by this paper
• The molecular basis of CaMKII function in synaptic and behavioural memory

  2002cited by this paper
• Phosphodiesterase 1B Knock-Out Mice Exhibit Exaggerated Locomotor Hyperactivity and DARPP-32 Phosphorylation in Response to Dopamine Agonists and Display Impaired Spatial Learning

  2002cited by this paper
• Complexity of calcium signaling in synaptic spines.

  2002cited by this paper
• The Life Cycle of Ca 2 Ions in Dendritic Spines and

  2002cited by this paper
• Ras and Rap control AMPA receptor trafficking during synaptic plasticity.

  2002cited by this paper
• Morphological changes in dendritic spines associated with long-term synaptic plasticity.

  2001cited by this paper
• Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP.

  2001cited by this paper
• A decade of CDK5

  2001cited by this paper
• Laminar Organization of the NMDA Receptor Complex within the Postsynaptic Density

  2001cited by this paper
• Ca(2+) signaling in dendritic spines.

  2001cited by this paper
• Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.

  2001cited by this paper
• An MCell model of calcium dynamics and frequency-dependence of calmodulin activation in dendritic spines

  2001cited by this paper
• Modulation of NMDA Receptor- Dependent Calcium Influx and Gene Expression Through EphB Receptors

  2001cited by this paper
• Synthesis and function of 3-phosphorylated inositol lipids.

  2001cited by this paper
• Guanine nucleotide exchange factors CalDAG‐GEFI and CalDAG‐GEFII are colocalized in striatal projection neurons

  2001cited by this paper
• Biochemical networks in nervous systems: expanding neuronal information capacity beyond voltage signals.

  2001cited by this paper
• The Ste5p scaffold.

  2001cited by this paper
• PDZ domains and the organization of supramolecular complexes.

  2001cited by this paper
• Compartmentalization of Ras proteins.

  2001cited by this paper
• Neurotrophins as synaptic modulators

  2001cited by this paper
• Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

  2001cited by this paper
• Calmodulin: a prototypical calcium sensor.

  2000cited by this paper
• Induction of Rac-Guanine Nucleotide Exchange Activity of Ras-GRF1/CDC25Mm following Phosphorylation by the Nonreceptor Tyrosine Kinase Src*

  2000cited by this paper
• Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase*

  2000cited by this paper
• The Shank family of scaffold proteins.

  2000cited by this paper
• Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.

  2000cited by this paper
• Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex.

  2000cited by this paper
• The Ras branch of small GTPases: Ras family members don't fall far from the tree.

  2000cited by this paper
• Local protein synthesis and its role in synapse-specific plasticity.

  2000cited by this paper
• Intracellular signaling pathways that regulate dendritic spine morphogenesis

  2000cited by this paper
• EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.

  2000cited by this paper
• Signal-processing machines at the postsynaptic density.

  2000cited by this paper
• Postsynaptic organisation and regulation of excitatory synapses

  2000cited by this paper
• Actin-based plasticity in dendritic spines.

  2000cited by this paper
• Hebb and homeostasis in neuronal plasticity.

  2000cited by this paper
• Four Human Ras Homologs Differ in Their Abilities to Activate Raf-1, Induce Transformation, and Stimulate Cell Motility*

  1999cited by this paper
• AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation.

  1999cited by this paper
• Ca2+/Calmodulin-dependent Protein Kinase II Regulates Tiam1 by Reversible Protein Phosphorylation*

  1999cited by this paper
• Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

  1999cited by this paper
• The role of neural activity in synaptic development and its implications for adult brain function.

  1999cited by this paper

• Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review

  2025cites this paper
• A spatial model of autophosphorylation of CaMKII predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping

  2025cites this paper
• From synaptic dynamics to cognitive decline: Molecular insights into neuroplasticity.

  2025cites this paper
• A spatial model of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping

  2024cites this paper
• Microglial activation in the medial prefrontal cortex after remote fear recall participates in the regulation of auditory fear extinction.

  2024cites this paper
• Rasal1 regulates calcium dependent neuronal maturation by modifying microtubule dynamics

  2024cites this paper
• Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells

  2024cites this paper
• Adaptive rewiring: a general principle for neural network development

  2024cites this paper
• Transcriptomic analysis identifies synapse-enriched lncRNAs required for excitatory synapse development and fear memory

  2023cites this paper
• Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice

  2023cites this paper
• Crosstalk between biochemical signalling network architecture and trafficking governs AMPAR dynamics in synaptic plasticity

  2023cites this paper
• Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

  2023cites this paper
• Transcriptomic analysis identifies synapse-enriched lncRNAs required for glutamatergic synapse development and fear memory consolidation

  2023cites this paper
• RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease

  2022cites this paper
• Network Neuroscience Untethered: Brain-Wide Immediate Early Gene Expression for the Analysis of Functional Connectivity in Freely Behaving Animals

  2022cites this paper
• A genome wide association study of chronic spontaneous urticaria risk and heterogeneity.

  2022cites this paper
• Cdc42 signaling regulated by dopamine D2 receptor correlatively links specific brain regions of hippocampus to cocaine addiction.

  2022cites this paper
• Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability

  2022cites this paper
• Early-life adversity selectively interrupts the dendritic differentiation of dorsolateral striatal neurons in male mice

  2021cites this paper
• The Microtubule Cytoskeleton at the Synapse.

  2021cites this paper
• An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?

  2021cites this paper
• miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons

  2021cites this paper
• High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors

  2021cites this paper
• Novel Structural Annotation and Functional Expression Analysis of GTP_EFTU Conserved Genes in Pepper Based on the PacBio Sequencing Data

  2021cites this paper
• Opioid-induced Structural and Functional Plasticity of Medium-Spiny Neurons in the Nucleus Accumbens.

  2020cites this paper
• Splicing of the SynGAP Carboxyl-Terminus Enables Isoform-Specific Tuning of NMDA Receptor Signaling Linked to Cognitive Function

  2020cites this paper
• Biological effects of inhaled hydraulic fracturing sand dust VII. Neuroinflammation and altered synaptic protein expression.

  2020cites this paper
• Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer’s disease

  2020cites this paper
• Scribble controls social behaviors through the regulation of the ERK/Mnk1 pathway

  2020cites this paper
• A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency

  2020cites this paper
• Neurogranin Regulates Metaplasticity

  2020cites this paper
• The impact of two autism related genes on amygdala physiology

  2019influential citation
• Translating preclinical findings in clinically relevant new antipsychotic targets: focus on the glutamatergic postsynaptic density. Implications for treatment resistant schizophrenia.

  2019cites this paper
• Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity

  2019cites this paper
• Principle and Application of Fluorescence Lifetime Imaging for Neuroscience

  2019cites this paper
• HuR in the Medial Prefrontal Cortex is Critical for Stress-Induced Synaptic Dysfunction and Depressive-Like Symptoms in Mice.

  2019cites this paper
• Intensiometric biosensors visualize the activity of multiple small GTPases in vivo

  2019cites this paper
• Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus

  2019cites this paper
• A sex difference in the composition of the rodent postsynaptic density

  2019cites this paper
• Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation

  2018cites this paper
• Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.

  2018cites this paper
• Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases.

  2018cites this paper
• Molecular mechanisms of detection and discrimination of dynamic signals

  2018cites this paper
• Active dendrites regulate the spatiotemporal spread of signaling microdomains

  2018cites this paper
• Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory

  2018cites this paper
• Genome-wide association study of alcohol consumption in Russian population

  2018cites this paper
• Genetic association between SHANK2 polymorphisms and susceptibility to autism spectrum disorder

  2018cites this paper
• Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders.

  2018cites this paper
• Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination

  2018cites this paper
• Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway

  2018cites this paper
• Metabolic syndrome causes recognition impairments and reduced hippocampal neuronal plasticity in rats.

  2017cites this paper
• A Comparative Perspective on Wnt/β-Catenin Signalling in Cell Fate Determination.

  2017cites this paper
• NMDA receptors: linking physiological output to biophysical operation

  2017cites this paper
• Neuron NeuroResource Imaging ERK and PKA Activation in Single Dendritic Spines during Structural Plasticity

  2017cites this paper
• Degeneracy in hippocampal physiology and plasticity

  2017cites this paper
• Shank Proteins Differentially Regulate Synaptic Transmission

  2017influential citation
• Chapter 1 NMDA Receptors and Brain Development

  2016cites this paper
• Location-dependent synaptic plasticity rules by dendritic spine cooperativity

  2016cites this paper
• The PSD: A Microdomain for Converging Molecular Abnormalities in Schizophrenia

  2016cites this paper
• Identification of an elaborate complex mediating postsynaptic inhibition

  2016cites this paper
• A GAP in Form and Function: The Rac-GAP Alpha2-Chimaerin Regulates Dendrite Morphogenesis and Synaptic Plasticity.

  2016cites this paper
• SYNGAP1: Mind the Gap

  2016cites this paper
• Proteome rearrangements after auditory learning: high‐resolution profiling of synapse‐enriched protein fractions from mouse brain

  2016cites this paper
• Synaptic Signaling in Learning and Memory.

  2016influential citation
• Functional Neural Network Connectivity in Myalgic Encephalomyelitis

  2016cites this paper
• The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis.

  2016cites this paper
• Modelling intracellular competition for calcium: kinetic and thermodynamic control of different molecular modes of signal decoding

  2016influential citation
• MOLECULAR ASPECTS OF ALZHEIMER'S DISEASE PATHOGENESIS: FROM LOCAL SPINE TRAFFICKING TO LONG DISTANCE SPINE TO NUCLEUS SIGNALLING.'TOWARDS NEW THERAPEUTICS INTERVENTION'

  2016cites this paper
• Organization of Postsynaptic Assembly by Filamin at the Drosophila Neuromuscular Junction

  2016influential citation
• Synaptic proteome changes after learning

  2016cites this paper
• NMDA Receptors Control Arf6 Activity via BRAG1 and BRAG2 in Spines of Neuronal Dendrites

  2016cites this paper
• An Exploration of the Mechanisms of Object Memory Destabilization: Involvement of the Cholinergic and Ubiquitin Proteasome Systems

  2016cites this paper
• Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF

  2016cites this paper
• The role of schizophrenia susceptibility genes in associative learning

  2016cites this paper
• Activation of InsP₃ receptors is sufficient for inducing graded intrinsic plasticity in rat hippocampal pyramidal neurons.

  2015cites this paper
• Model reduction for stochastic CaMKII reaction kinetics in synapses by graph-constrained correlation dynamics

  2015cites this paper
• Hippocampal Spine Head Sizes Are Highly Precise

  2015cites this paper
• The role of Wnt signalling in actin dynamics during synapse formation

  2015cites this paper
• The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons.

  2015cites this paper
• The new nanophysiology: regulation of ionic flow in neuronal subcompartments

  2015cites this paper
• Nanoconnectomic upper bound on the variability of synaptic plasticity

  2015influential citation
• Diverse functional roles of lipocalin-2 in the central nervous system.

  2015cites this paper
• Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory

  2015cites this paper
• Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse‐related proteins in a transgenic model of Alzheimer's Disease

  2015cites this paper
• Regulation of ionic flow in neuronal subcompartments : the new nanophysiology

  2015cites this paper
• Hippocampal plasticity during the progression of Alzheimer's disease.

  2015cites this paper
• Axon-glia interactions during central nervous system myelination

  2015cites this paper
• Integration of G Protein α (Gα) Signaling by the Regulator of G Protein Signaling 14 (RGS14)*

  2015cites this paper
• Importance of the GluN2B carboxy-terminal domain for enhancement of social memories

  2015cites this paper
• Distribution of Neuronal and Glial Antigens in Somatosensory Cortex Columns in the Rat Brain (an immunohistochemical study)

  2015cites this paper
• PDZ affinity chromatography: a general method for affinity purification of proteins based on PDZ domains and their ligands.

  2014cites this paper
• Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats

  2014cites this paper
• RanBP9 overexpression reduces dendritic arbor and spine density.

  2014cites this paper
• Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases*

  2014cites this paper
• A molecular brake controls the magnitude of long-term potentiation

  2014cites this paper
• Molecular and Genetic Determinants of the NMDA Receptor for Superior Learning and Memory Functions

  2014cites this paper
• Barriers in the brain: resolving dendritic spine morphology and compartmentalization

  2014influential citation
• The role of BDNF and Nogo-A signalling in modulating the architecture of mature hippocampal neurons

  2014cites this paper
• Activation of InsP 3 receptors is sufficient for inducing graded intrinsic plasticity in rat hippocampal pyramidal neurons

  2014cites this paper
• On the resemblance of synapse formation and CNS myelination.

  2014cites this paper