The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cancer Research

• Publication date

  2006-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-05-1716PMID 16424011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prostate cancer.

  2019cited by this paper
• Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1

  2007cited by this paper
• Characterization of VIK-1: a new Vav-interacting Kruppel-like protein

  2005cited by this paper
• Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells

  2005cited by this paper
• Cooperation of Amphiregulin and Insulin-like Growth Factor-1 Inhibits Bax- and Bad-mediated Apoptosis via a Protein Kinase C-dependent Pathway in Non-small Cell Lung Cancer Cells*

  2005cited by this paper
• The signals and pathways activating cellular senescence.

  2005cited by this paper
• Increase in amphiregulin and epiregulin in prostate cancer xenograft after androgen deprivation—impact of specific HER1 inhibition

  2005cited by this paper
• The somatic mutation theory of cancer: growing problems with the paradigm?

  2004cited by this paper
• TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

  2004influential reference
• Reconstruction of functionally normal and malignant human breast tissues in mice.

  2004cited by this paper
• The stroma as a crucial target in rat mammary gland carcinogenesis

  2004cited by this paper
• Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

  2004cited by this paper
• Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events

  2004cited by this paper
• Mechanisms of cellular senescence in human and mouse cells

  2004cited by this paper
• Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: A study of 93 cases

  2004cited by this paper
• Cellular senescence in the pathogenesis of benign prostatic hyperplasia

  2003cited by this paper
• Hepatocyte growth factor: from diagnosis to clinical applications.

  2003cited by this paper
• Tumor reversion: Correction of malignant behavior by microenvironmental cues

  2003cited by this paper
• Prognostic value of ERBB family mRNA expression in breast carcinomas

  2003cited by this paper
• TACE cleavage of proamphiregulin regulates GPCR‐induced proliferation and motility of cancer cells

  2003cited by this paper
• Immunohistochemical expression of hepatocyte growth factor and c-Met/HGF receptor in benign and malignant human prostate tissue.

  2003cited by this paper
• Molecular effects of the herbal compound PC-SPES: identification of activity pathways in prostate carcinoma.

  2002cited by this paper
• The program of androgen-responsive genes in neoplastic prostate epithelium

  2002cited by this paper
• Cancer and aging: a model for the cancer promoting effects of the aging stroma.

  2002cited by this paper
• Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

  2001cited by this paper
• Normal and malignant prostate epithelial cells differ in their response to hepatocyte growth factor/scatter factor.

  2001cited by this paper
• Putting tumours in context

  2001cited by this paper
• Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

  2000cited by this paper
• Hepatocyte growth factor secreted by prostate-derived stromal cells stimulates growth of androgen-independent human prostatic carcinoma cells.

  2000cited by this paper
• International trends and patterns of prostate cancer incidence and mortality

  2000cited by this paper
• PEDB: the Prostate Expression Database

  1999cited by this paper
• The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.

  1999cited by this paper
• Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate.

  1999cited by this paper
• A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

  1999cited by this paper
• Metastatic sublines of an SV40 large T antigen immortalized human prostate epithelial cell line

  1998cited by this paper
• Increased hepatocyte growth factor production by aging human fibroblasts mainly due to autocrine stimulation by interleukin-1.

  1998cited by this paper
• Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication.

  1998cited by this paper
• Expression of amphiregulin in the sheep mammary gland.

  1997cited by this paper
• Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells.

  1997cited by this paper
• Insulin-Like Growth Factors Stimulate Expression of Hepatocyte Growth Factor But Not Transforming Growth Factor β1 in Cultured Hepatic Stellate Cells.

  1997cited by this paper
• Characterization of a novel amphiregulin‐related molecule in 12‐O‐tetradecanoylphorbol‐13‐acetate‐treated breast cancer cells

  1996cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Replicative senescence and cell death.

  1995cited by this paper
• Induction and expression of amphiregulin in human pancreatic cancer.

  1994cited by this paper
• Proteolytic activation of hepatocyte growth factor in response to tissue injury.

  1994cited by this paper
• The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients.

  1993cited by this paper
• Gradient fields and homeobox genes.

  1991cited by this paper
• Purification and characterization of a newly identified growth factor specific for epithelial cells.

  1989cited by this paper
• Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.

  1986cited by this paper
• Cancer as a dynamic developmental disorder.

  1985cited by this paper
• The developmental field concept.

  1985cited by this paper
• Successive generations of mice produced from an established culture line of euploid teratocarcinoma cells.

  1981cited by this paper
• Formal discussion of: somatic mutations and carcinogenesis.

  1965cited by this paper
• Carcinoma-associated Fibroblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium

  year unknowncited by this paper

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